2-Hexanone, 5-methyl-
RTECS #
MP3850000
CAS #
Updated
September 2013
Molecular Weight
114.21
Molecular Formula
C7H14O
Synonyms
2-Methyl-5-hexanone
5-Methyl-2-hexanone
Isoamyl methyl ketone
Isopentyl methyl ketone
Ketone, methyl isoamyl
Methyl isoamyl ketone
Methyl isoamyl ketone (ACGIH:OSHA)
Methyl isopentyl ketone
MIAK
5-Methyl-2-hexanone
Isoamyl methyl ketone
Isopentyl methyl ketone
Ketone, methyl isoamyl
Methyl isoamyl ketone
Methyl isoamyl ketone (ACGIH:OSHA)
Methyl isopentyl ketone
MIAK
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 100 µL/24H | mild | NTIS** OTS0535379 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lethal concentration (50 percent kill): 3813 ppm/6H | Cardiac: Other changes Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Other changes | NTIS** OTS0535379 |
| inhalation/rat | lethal concentration (50 percent kill): 17806 mg/m3/6H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression | HPV049 -,-,2001 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 800 mg/kg | Cardiac: Other changes Lung, Thorax, or Respiration: Other changes | NTIS** OTS0535379 |
| intraperitoneal/rat | lowest published lethal dose: 400 mg/kg | Cardiac: Other changes Lung, Thorax, or Respiration: Other changes | NTIS** OTS0535379 |
| oral/mouse | lethal dose (50 percent kill): 2542 mg/kg | TOLED5 30,13,1986 | |
| oral/rat | lethal dose (50 percent kill): 5657 mg/kg | Behavioral: Tremor Behavioral: Ataxia | HPV049 -,-,2001 |
| oral/rat | lethal dose (50 percent kill): 3200 mg/kg | Cardiac: Other changes Lung, Thorax, or Respiration: Other changes | NTIS** OTS0535379 |
| skin/guinea pig | Lethal dose: >20 mL/kg | Cardiac: Other changes Lung, Thorax, or Respiration: Other changes | NTIS** OTS0535379 |
| skin/rabbit | lethal dose (50 percent kill): 10 mL/kg | UCDS** 8/7/1963 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 1000 ppm/6H/16D- intermittent | Liver: Changes in liver weight | FAATDF 6,498,1986 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm/6H/96D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight | FAATDF 6,498,1986 |
| inhalation/rat | lowest published toxic concentration: 1000 ppm/96D- intermittent | Behavioral: Somnolence (general depressed activity) Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | HPV049 -,-,2001 |
| inhalation/rat | lowest published toxic concentration: 2000 ppm/96D- intermittent | Behavioral: Somnolence (general depressed activity) Liver: Hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | HPV049 -,-,2001 |
| oral/rat | lowest published toxic dose: 130000 mg/kg/13W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV049 -,-,2001 |
| oral/rat | lowest published toxic dose: 130000 mg/kg/13W- intermittent | Liver: Other changes | HPV275 -,-,2003 |
| oral/rat | lowest published toxic dose: 30 gm/kg/3W- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0571116 |
| oral/rat | lowest published toxic dose: 130 gm/kg/13W- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | NTIS** OTS0571116 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 20 ppm;short term exposure limit 50 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (475 mg/m3) | DTLWS* 3,22,1973 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 50 ppm (234 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 20 ppm (95 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 20 ppm (95 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 20 ppm (95 mg/m3), MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 95 mg/m3 (20 ppm), JUN2000 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 20 ppm (95 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 20 ppm (95 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 10 ppm (47 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 230 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 20 ppm (95 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 50 ppm (240 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 100 ppm (475 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 50 ppm (234 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 25 ppm (115 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 50 ppm, JUL2005 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 25 ppm (120 mg/m3);short term exposure limit 50 ppm (250 mg/m3), JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 20 ppm (94 mg/m3), KZG-week 40 ppm (188 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 233 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 20 ppm (95 mg/m3);short term exposure limit 100 ppm (475 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (475 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm (475 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (475 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOAMYL KETONE-air | 10H time-weighted average 50 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code M0430; Number of Industries 17; Total Number of Facilities 1132; Number of Occupations 22; Total Number of Employees Exposed 18834; Total Number of Female Employees Exposed 4071 | |
| National Occupational Hazard Survey 1974 | Hazard Code M0430; Number of Industries 44; Total Number of Facilities 3003; Number of Occupations 36; Total Number of Employees Exposed 25307 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health