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Germane

RTECS #: LY4900000

CAS #: 7782-65-2


UPDATE: May 2009 MW: 76.63 MF: GeH4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Germanium hydride
  2. Germanium tetrahydride
  1. Germanium tetrahydride (ACGIH)
  2. Monogermane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lethal concentration (50 percent kill): 260 mg/m3/4 hour Brain and Coverings: Other degenerative changes VCVN1* -,400,1988
inhalation
mouse
lethal concentration (50 percent kill): 1,380 mg/m3 Behavioral: Excitement

Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity
GTPZAB 18(2),56,1974
inhalation
mouse
lowest published lethal concentration: 2,000 mg/m3/2 hour Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease
HBTME* -,557,2007
inhalation
rat
lethal concentration (50 percent kill): 1,380 mg/m3 Behavioral: Coma

Brain and Coverings: Other degenerative changes
VCVN1* -,400,1988
inhalation
rat
lowest published lethal concentration: 2,000 mg/m3/4 hour Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease
HBTME* -,557,2007
oral
mouse
lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Excitement

Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity
GTPZAB 18(2),56,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 13 mg/m3/4 hour/30 day- intermittent Brain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes
VCVN1* -,400,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
HBTME* ,557,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 ppm (0.6 mg/m3) DTLWS* 3,20,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 ppm (0.63 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 ppm (0.64 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 ppm (0.6 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.2 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 ppm (0.6 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.2 ppm (0.6 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 ppm (0.6 mg/m3);
short term exposure limit 0.6 ppm (1.8 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.6 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 ppm (0.63 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.2 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 ppm (0.6 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 ppm (0.64 mg/m3);
short term exposure limit 0.6 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GERMANIUM TETRAHYDRIDE-air 10 hour time-weighted average 0.2 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTME*
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

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