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Formic acid, ethyl ester

RTECS #: LQ8400000

CAS #: 109-94-4


UPDATE: May 2009 MW: 74.09 MF: C3H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aethylformiat (German)
  2. Areginal
  3. Ethyl formate
  4. Ethyl formate (ACGIH:OSHA)
  5. Ethyl formic ester
  6. Ethyl methanoate
  1. Ethyle (formiate d') (French)
  2. Ethylester kyseliny mravenci (Czech)
  3. Ethylformiaat (Dutch)
  4. Etile (formiato di) (Italian)
  5. Formic ether
  6. Mrowczan etylu (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
460 mg open irritation test mild UCDS** 4/10/1968


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 110 gm/kg/9 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
BJCAAI 9,177,1955


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 8,000 ppm/4 hour N/R AMIHBC 10,61,1954
inhalation
rat
lethal concentration (50 percent kill): 28,950 mg/m3 N/R TOVEFN (1),61,1995
inhalation
rat
lowest published toxic concentration: 300 mg/m3 Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOVEFN (1),61,1995
inhalation
rat
lowest published toxic concentration: 300 mg/m3 Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
TOVEFN (1),61,1995
oral
guinea pig
lethal dose (50 percent kill): 1,110 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Gastritis
FCTXAV 2,327,1964
oral
rat
lethal dose (50 percent kill): 1,850 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
FCTXAV 2,327,1964
oral
rat
lethal dose (50 percent kill): 2,699 mg/kg Behavioral: General anesthetic

Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Dyspnea
TOVEFN (1),61,1995
oral
rabbit
lethal dose (50 percent kill): 2,075 mg/kg N/R IMSUAI 41,31,1972
subcutaneous
rabbit
lowest published lethal dose: 1 gm/kg N/R FCTXAV 16,737,1978
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rabbit
lowest published toxic dose: 619 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Proteinuria

Blood: Other changes
FAONAU 44A,1,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AMIHAB 20,517,1959


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (300 mg/m3) DTLVS* 3,107,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (303 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (307 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (300 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (300 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (300 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 310 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 100 ppm (300 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (300 mg/m3);
short term exposure limit 150 ppm (450 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 300 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 100 ppm (303 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 450 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (310 mg/m3),KZG- week 100 ppm (310 mg/m3),Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (308 mg/m3);
short term exposure limit 150 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL FORMATE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 32610;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 1;
Total Number of Employees Exposed 124
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 32610;
Number of Industries 6;
Total Number of Facilities 99;
Number of Occupations 19;
Total Number of Employees Exposed 8,151;
Total Number of Female Employees Exposed 1,169


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent, emulsifier, food and feed additive, flavor, packaging material
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl formate, 1452


REFERENCES:

CODEN
REFERENCE

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a solvent, emulsifier, food and feed additive, flavor, packaging material

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Primary Irritant

Click Here for Additional Information about RTECS

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