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Ethylene, 1,2 - dichloro -

RTECS #: KV9360000

CAS #: 540-59-0


UPDATE: May 2009 MW: 96.94 MF: C2H2Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2 - Dichlor - aethen (German)
  2. 1,2 - Dichloroethene
  3. 1,2 - Dichloroethylene (ACGIH:OSHA)
  4. 1,2 - Dichloroethylene, sym -
  5. Acetylene dichloride (OSHA)
  6. Dichloro - 1,2 - ethylene (French)
  1. Dioform
  2. NCI - C56031
  3. cis - , trans - 1,2 - Dichloroethene
  4. sym - 1,2 - Dichloroethylene
  5. sym - Dichloroethylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
100 mg/24 hour moderate 85JCAE -,105,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human lymphocyte 2 mmol/L MUREAV 371,185,1996
micronucleus test human lymphocyte 20 mmol/L MUREAV 371,185,1996
sex chromosome loss and nondisjunction Aspergillus nidulans 750 ppm MUREAV 266,117,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 50,000 mg/m3 Behavioral: Excitement

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
VCVGH* -,437,1990
inhalation
frog
lowest published lethal concentration: 117 mg/m3/1 hour Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
AISFAR 15,1,1937
inhalation
mouse
lethal concentration (50 percent kill): 21,700 ppm/6 hour N/R VCVGH* -,437,1990
intraperitoneal
mouse
lethal dose (50 percent kill): 2 gm/kg N/R EJTXAZ 7,247,1974
oral
mouse
lethal dose (50 percent kill): 2,122 mg/kg N/R VCVGH* -,437,1990
oral
rat
lethal dose (50 percent kill): 770 mg/kg N/R VCVGH* -,437,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 9 mg/kg/90 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGH* -,437,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (790 mg/m3) DTLVS* 3,80,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (790 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (790 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (790 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (790 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (793 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (805 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (790 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (790 mg/m3), short term exposure limit 250 ppm (990 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 800 mg/m3 (200 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 790 mg/m3, short term exposure limit 3160 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 150 ppm (590 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 200 ppm (790 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 200 ppm (790 mg/m3);
short term exposure limit 250 ppm (1000 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 790 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 200 ppm (793 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (395 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (790 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 150 ppm, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (790 mg/m3),KZG- week 400 ppm (1580 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (790 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (806 mg/m3);
short term exposure limit 250 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2-DICHLOROETHYLENE-air 10 hour time-weighted average 200 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 03350;
Number of Industries 5;
Total Number of Facilities 896;
Number of Occupations 6;
Total Number of Employees Exposed 4,673
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 03350;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 7;
Total Number of Employees Exposed 216;
Total Number of Female Employees Exposed 10


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121081/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for fats, PHENOL, CAMPHOR
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AISFAR Archivio Italiano di Scienze Farmacologiche. (Modena, Italy) V.1-11, 1932-42; Series 2: V.1-3, 1948-50; Series 3: V.1-15, 1951-65. Discontinued.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a solvent for fats, PHENOL, CAMPHOR

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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