Ethyl alcohol
RTECS #
KQ6300000
CAS #
Updated
March 2019
Molecular Weight
46.08
Molecular Formula
C2H6O
Synonyms
Absolute ethanol
Aethanol (German)
Aethylalkohol (German)
Alcohol
Alcohol dehydrated
Alcohol, anhydrous
Alcool ethylique (French)
Alcool etilico (Italian)
Algrain
Alkohol (German)
Alkoholu etylowego (Polish)
Anhydrol
Cologne Spirit
Etanolo (Italian)
Ethanol
Ethanol (ACGIH:OSHA)
Ethyl alcohol (DOT:OSHA)
Ethyl alcohol anhydrous
Ethyl hydrate
Ethyl hydroxide
Etylowy alkohol (Polish)
Fermentation alcohol
Grain alcohol
Jaysol
Jaysol S
Methylcarbinol
Molasses alcohol
NCI-C03134
Potato alcohol
SD alcohol 23-hydrogen
Spirits of wine
Spirt
Tecsol
Aethanol (German)
Aethylalkohol (German)
Alcohol
Alcohol dehydrated
Alcohol, anhydrous
Alcool ethylique (French)
Alcool etilico (Italian)
Algrain
Alkohol (German)
Alkoholu etylowego (Polish)
Anhydrol
Cologne Spirit
Etanolo (Italian)
Ethanol
Ethanol (ACGIH:OSHA)
Ethyl alcohol (DOT:OSHA)
Ethyl alcohol anhydrous
Ethyl hydrate
Ethyl hydroxide
Etylowy alkohol (Polish)
Fermentation alcohol
Grain alcohol
Jaysol
Jaysol S
Methylcarbinol
Molasses alcohol
NCI-C03134
Potato alcohol
SD alcohol 23-hydrogen
Spirits of wine
Spirt
Tecsol
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 500 mg | severe | AJOPAA 29,1363,1946 |
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,189,1986 |
| eye /rabbit | 100 mg/4S rinse | moderate | FCTOD7 20,573,1982 |
| eye /rabbit | 100 µL | moderate | HPV112 -,-,2008 |
| skin /human | 70%/2D | CODEDG 61,163,2009 | |
| skin /rabbit | 400 mg open irritation test | mild | UCDS** 7/22/1970 |
| skin /rabbit | 20 mg/24H | moderate | 85JCAE -,189,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | lymphocyte/human | 1160 gm/L | AEMBAP 85A,25,1977 |
| Cytogenetic Analysis | fibroblast/human | 12000 ppm | ACYTAN 16,41,1972 |
| Cytogenetic Analysis | leukocyte/human | 1 pph/72H-continuous | TSITAQ 20,421,1978 |
| Cytogenetic Analysis | parenteral/grasshopper | 500 mmol/L | NATWAY 51,646,1964 |
| Cytogenetic Analysis | oral/rat | 2 gm/kg | TGANAK 14(5),48,1980 |
| Cytogenetic Analysis | oral/mouse | 40 gm/kg | NATUAS 302,258,1983 |
| Cytogenetic Analysis | ovary/hamster | 100 ppm | ENMUDM 8(Suppl 6),72,1986 |
| Cytogenetic Analysis | embryo/hamster | 1 pph | MUTAEX 3,207,1988 |
| Cytogenetic Analysis | ovary/hamster | 160 mmol/L | BIZNAT 106,169,1987 |
| Cytogenetic Analysis | lymphocyte/human | 2.5 pph/24H | MUREAV 537,117,2003 |
| Cytogenetic Analysis | intramuscular/other fish | 1 pph | MUREAV 542,1,2003 |
| Cytogenetic Analysis | oral/human | 49014 gm/kg/25Y | MUREAV 560,187,2004 |
| Cytogenetic Analysis | oral/rat | 504 gm/kg/6W- intermittent | HPV112 -,-,2008 |
| DNA adduct | oral/rat | 5 gm/kg | MUREAV 479,81,2001 |
| DNA adduct | oral/rat | 3 gm/kg/7D | MUREAV 479,81,2001 |
| DNA Damage | oral/rat | 4 gm/kg | MUREAV 345,191,1995 |
| DNA Damage | /Saccharomyes cerevisiae | 850 mmol/L | MUREAV 326,165,1995 |
| DNA Damage | /Salmonella typhimurium | 15 pph/120M | MUREAV 575,34,2005 |
| DNA Damage | oral/rat | 3150 gm/kg/1Y- intermittent | TXCYAC 254,11,2008 |
| DNA Damage | lymphocyte/human | 100 mmol/L/3H | MUREAV 721,171,2011 |
| DNA Damage | lymphocyte/human | 1000 mmol/L (-enzymatic activation step) | MUREAV 743,25,2012 |
| DNA Damage | lymphocyte/human | 10 mmol/L (+enzymatic activation step) | MUREAV 743,25,2012 |
| DNA Damage | sperm/human | 100 mmol/L (+/-enzymatic activation step) | MUREAV 743,25,2012 |
| DNA Damage | lymphocyte/human | 100 mmol/L | FCTOD7 50,168,2012 |
| DNA Damage | oral/mouse | 5 mg/kg | FCTOD7 50,1208,2012 |
| DNA Damage | oral/rat | 6000 mg/kg/3D- intermittent | MUREAV 786-788,104,2015 |
| DNA inhibition | lymphocyte/human | 220 mmol/L | PNASA6 79,1171,1982 |
| DNA repair | /Escherichia coli | 5 mg/well | MUREAV 133,161,1984 |
| DNA repair | /Salmonella typhimurium | 15 pph/120M | MUREAV 575,34,2005 |
| Dominant Lethal Test | oral/mouse | 3720 mg/kg/3D | AEMBAP 85A,25,1977 |
| gene conversion and mitotic recombination | /Aspergillus nidulans | 5 pph | MUREAV 48,51,1977 |
| gene conversion and mitotic recombination | other cell types/Drosophila melanogaster | 8.4 pph | EMMUEG 48,644,2007 |
| micronucleus test | lymphocyte/Dog | 400 µmol/L | NTIS** AD-A075-605 |
| micronucleus test | oral/human | 817.6 gm/kg/6Y- intermittent | MUREAV 615,134,2007 |
| micronucleus test | liver/human | 15 mmol/L/24H | TXCYAC 198,315,2004 |
| micronucleus test | other cell types/human | 4 gm/L | MUTAEX 17,509,2002 |
| micronucleus test | intraperitoneal/mouse | 1240 mg/kg/2D | AEMBAP 85A,25,1977 |
| micronucleus test | intramuscular/other fish | 1 pph | MUREAV 542,1,2003 |
| mutation in microorganisms | /Saccharomyes cerevisiae | 24 pph (-enzymatic activation step) | GNKAA5 15,927,1979 |
| mutation in microorganisms | /Aspergillus nidulans | 20 pph (-enzymatic activation step) | MUREAV 48,51,1977 |
| mutation in microorganisms | /Salmonella typhimurium | 11 pph (+enzymatic activation step) | ENVRAL 52,225,1990 |
| mutation in microorganisms | /Escherichia coli | 140 gm/L (-enzymatic activation step) | MUREAV 130,97,1984 |
| other mutation test systems | intraperitoneal/rat | 250 gm/kg/16D-continuous | CYTBAI 56,195,1988 |
| other mutation test systems | oral/rat | 3 gm/kg | APTOA6 49,125,1981 |
| other mutation test systems | other cell types/human | 0.05 pph/20H (+enzymatic activation step) | MUREAV 746,124,2012 |
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 10 pph | MUREAV 268,95,1992 |
| sex chromosome loss and nondisjunction | /Aspergillus nidulans | 30 gm/L | EVHPAZ 31,81,1979 |
| sex chromosome loss and nondisjunction | oral/mouse | 5 gm/kg | CGCGBR 44,7,1987 |
| sister chromatid exchange | oral/mouse | 420 mg/kg/3W | MUREAV 68,291,1979 |
| sister chromatid exchange | ovary/hamster | 3900 mg/L | MUREAV 124,85,1983 |
| sister chromatid exchange | lymphocyte/human | 500 ppm/72H-continuous | CGCGBR 27,66,1980 |
| sister chromatid exchange | ovary/hamster | 31.6 gm/L/1H (+enzymatic activation step) | HPV228 -,-,2001 |
| sister chromatid exchange | lymphocyte/human | 0.5 gm/L/72H (-enzymatic activation step) | HPV228 -,-,2001 |
| sister chromatid exchange | lymphocyte/human | 10 gm/L/24H (+enzymatic activation step) | HPV228 -,-,2001 |
| sister chromatid exchange | intraperitoneal/mouse | 0.6 mg/kg | HPV228 -,-,2001 |
| sister chromatid exchange | oral/mouse | 2800 gm/kg/10W- intermittent | HPV228 -,-,2001 |
| specific locus test | oral/rat | 56 gm/kg/4W | MUREAV 577S,1,2005 |
| sperm morphology | oral/mouse | 1500 mg/kg/50D | MUREAV 65,229,1979 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 20000 ppm/7H (1-22D pregnant) | Reproductive: Other developmental abnormalities | TJADAB 29(2),48A,1984 |
| inhalation/rat | 20000 ppm (1-19D pregnant) | Reproductive: Other effects on female | HPV112 -,-,2008 |
| inhalation/rat | 20000 ppm (1-19D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | HPV228 -,-,2001 |
| inhalation/rat | 5000 ppm (9-20D pregnant) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects | NETEEC 45,44,2014 |
| intracerebral/rat | 5 mg/kg (1D prior to copulation) | Reproductive: Effects on fertility: Other measures of fertility | JRPFA4 42,199,1975 |
| intraperitoneal/rat | 15 gm/kg (8-13D pregnant) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical | TJADAB 36,31A,1987 |
| intraperitoneal/rat | 2240 mg/kg (9-12D pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) | DABBBA 38,5835,1978 |
| intraperitoneal/rat | 600 mg/kg (8-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TJADAB 26(1),12A,1982 |
| intraperitoneal/rat | 600 mg/kg (8-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | IJEBA6 21,108,1983 |
| intraperitoneal/rat | 600 mg/kg (8-15D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | IJEBA6 21,108,1983 |
| intraperitoneal/rat | 3600 mg/kg (7-8D pregnant) | Reproductive: Effects on newborn: Behavioral | NELED5 289,13,2000 |
| intraperitoneal/mouse | 5800 mg/kg (10D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | TJADAB 27,231,1983 |
| intraperitoneal/mouse | 5800 mg/kg (7D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | TJADAB 27,231,1983 |
| intraperitoneal/mouse | 5622 µg/kg (10D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system | AJOGAH 124,676,1976 |
| intraperitoneal/mouse | 4 mg/kg (10D pregnant) | Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) | ANREAK 193,515,1979 |
| intraperitoneal/mouse | 4300 mg/kg (10D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | NETOD7 2,227,1980 |
| intraperitoneal/mouse | 30 mg/kg (7D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | BDERE* 79,513,2007 |
| intraperitoneal/rat | 18 gm/kg (5-22D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | BDERE* 85,791,2009 |
| intraperitoneal/mouse | 2.9 gm/kg (8D pregnant) | Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) | TOXID9 72,171,2003 |
| intraperitoneal/rat | 18000 mg/kg (5-21D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Other postnatal measures or effects | BDERE* 73,897,2005 |
| intraperitoneal/mouse | 2900 mg/kg (8D pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TERP2* -,368,2005 |
| intraperitoneal/mouse | 2900 mg/kg (8D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | TERST* -,315,2006 |
| intraperitoneal/mouse | 2900 mg/kg (8D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TERST* -,315,2006 |
| intraperitoneal/rat | 11.25 mg/kg (7-9D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Other developmental abnormalities | REPTED 17,475,2003 |
| intraperitoneal/mouse | 15 mg/kg (6-8D pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Other developmental abnormalities | REPTED 17,475,2003 |
| intraperitoneal/mouse | 22.8 gm/kg (6-8D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | REPTED 20,453,2005 |
| intraperitoneal/mouse | 22.8 gm/kg (6-8D pregnant) | Reproductive: Other effects to embryo or fetus Reproductive: Specific developmental abnormalities: Eye, ear | REPTED 20,453,2005 |
| intraperitoneal/mouse | 22.8 gm/kg (6-8D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Other developmental abnormalities | REPTED 22,263,2006 |
| intraperitoneal/mouse | 5.8 gm/kg (3-5D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | BDERE* 70,163,2004 |
| intraperitoneal/mouse | 22.8 gm/kg (6-8D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear | JTEHF8 67,2073,2004 |
| intraperitoneal/mouse | 5.8 gm/kg (7D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | NETEEC 33,231,2011 |
| intratesticular/rat | 400 mg/kg (1D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | FESTAS 24,884,1973 |
| intratesticular/Dog | 100 mg/kg (1D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FESTAS 24,884,1973 |
| intrauterine/rat | 2400 mg/kg (10D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | IJEBA6 14,316,1976 |
| intrauterine/woman | 200 mg/kg (5D prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | INJFA3 14,280,1969 |
| intravenous/rat | 4 gm/kg (6-7D pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Other effects to embryo or fetus Reproductive: Specific developmental abnormalities: Musculoskeletal system | RECYAR 8,105,1971 |
| intravenous/rat | 3 gm/kg (6-7D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | RECYAR 8,105,1971 |
| intravenous/rat | 4 gm/kg (6-7D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities | RECYAR 8,105,1971 |
| intravenous/rabbit | 15 mg/kg (15-29D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects to embryo or fetus | JPDSA3 29,1030,1994 |
| intravenous/domestic animal | 29000 mg/kg (106-134D pregnant) | Reproductive: Other effects on female Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Effects on newborn: Behavioral | NETEEC 22,205,2000 |
| intravenous/domestic animal | 94 gm/kg (14-21W pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | PBBHAU 12,329,1980 |
| intravenous/domestic animal | 40 gm/kg (14-17W pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Biochemical and metabolic | NTOTDY 3,105,1981 |
| intravenous/domestic animal | 1 gm/kg (18W pregnant) | Reproductive: Specific developmental abnormalities: Respiratory system | AJOGAH 151,859,1985 |
| intravenous/woman | 8 gm/kg (32W pregnant) | Reproductive: Effects on newborn: Apgar score (human only) Reproductive: Effects on newborn: Other neonatal measures or effects | AJDCAI 134,419,1980 |
| multiple/rat | 642 gm/kg (1-21D preg/23D after birth) | Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | DEPBA5 10,435,1977 |
| multiple/rat | 373 gm/kg (23D after birth) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical | DEPBA5 10,435,1977 |
| oral/mouse | 162 gm/kg (11-19D pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) | TJADAB 27,56A,1983 |
| oral/mouse | 21 gm/kg (1-21D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | JSALDP 38,1696,1977 |
| oral/mouse | 5800 mg/kg (7D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear | TJADAB 27,231,1983 |
| oral/mouse | 75600 mg/kg (5-11D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | RCOCB8 23,127,1979 |
| oral/mouse | 5500 mg/kg (9D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TJADAB 24(1),53A,1981 |
| oral/mouse | 1680 gm/kg (70D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | FEPRA7 39,542,1980 |
| oral/Dog | 21600 mg/kg (1-60D pregnant) | Reproductive: Effects on newborn: Stillbirth Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FEPRA7 36,285,1977 |
| oral/Dog | 260 gm/kg (1-62D pregnant) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | ACRSDM 4,123,1980 |
| oral/Dog | 221 gm/kg (1-47D pregnant) | Reproductive: Effects on fertility: Abortion | ACRSDM 4,123,1980 |
| oral/rat | 78 gm/kg (7-19D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | PBBHAU 59,577,1998 |
| oral/rat | 4 gm/kg (13D pregnant) | Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) | CYGEDX 15(2),23,1981 |
| oral/rat | 322 gm/kg (35D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | INJFA3 23,176,1978 |
| oral/rat | 12 gm/kg (9-12D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | PLPSAX 7,311,1979 |
| oral/rat | 132 gm/kg (1-22D pregnant) | Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | TJADAB 23,217,1981 |
| oral/rat | 24 gm/kg (14-16D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Other developmental abnormalities | TJADAB 23,41A,1981 |
| oral/rat | 354 gm/kg (10D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic | RCPBDC 2,119,1977 |
| oral/rat | 4 gm/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Urogenital system | JTEHD6 10,267,1982 |
| oral/rat | 35295 mg/kg (1-15D pregnant) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | ONGZAC 22(1),71,1991 |
| oral/rat | 44 gm/kg (7-17D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Urogenital system | ESKHA5 (103),10,1985 |
| oral/rat | 30 gm/kg (1-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Other neonatal measures or effects | TJADAB 163,15,2001 |
| oral/mouse | 20 gm/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB85118651 |
| oral/mouse | 20 gm/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB85118651 |
| oral/mouse | 20 gm/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Urogenital system | NTIS** #PB85118651 |
| oral/rat | 22.5 gm/kg (11-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Other postnatal measures or effects | NETEEC 24,719,2002 |
| oral/rat | 40 gm/kg (1-20D pregnant) | Reproductive: Other developmental abnormalities Reproductive: Specific developmental abnormalities: Central nervous system | FATOAO 45,68,1982 |
| oral/rat | 42 gm/kg (1-21D pregnant) | Reproductive: Other developmental abnormalities | FATOAO 45,66,1982 |
| oral/mouse | 700 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB85118651 |
| oral/rat | 240 gm/kg (30D male) | Reproductive: Specific developmental abnormalities: Urogenital system | FATOAO 47,82,1984 |
| oral/rat | 65 gm/kg (7-19D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system | ENDOAO 138,389,1997 |
| oral/rat | 75 gm/kg (7-21D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system | ENDOAO 138,389,1997 |
| oral/rat | 112 mg/kg (14D male) | Reproductive: Effects on newborn: Biochemical and metabolic | FATOAO 48,86,1985 |
| oral/rat | 147 mg/kg (1-21D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Delayed effects | FATOAO 47,84,1984 |
| oral/rat | 60000 mg/kg (1-30D after birth) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Delayed effects | FATOAO 48,93,1985 |
| oral/rat | 900 mL/kg (19D pre-21D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic | NETEEC 24,275,2002 |
| oral/rat | 110 gm/kg (1-23D pregnant) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical | EKFAE9 59,44,1996 |
| oral/rat | 135 gm/kg (1D preg-7D after birth) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical | EKFAE9 59,44,1996 |
| oral/pig | 2648 gm/kg (78W prior to copulation/1-16W pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTOTDY 5,229,1983 |
| oral/guinea pig | 90 gm/kg (1-68D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | ANREAK 127,438,1957 |
| oral/guinea pig | 240 gm/kg (2-61D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system | DBRRDB 106,39,1998 |
| oral/guinea pig | 264 gm/kg (2-67D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Physical | ACRSDM 23,1816,1999 |
| oral/guinea pig | 72 gm/kg (45-62D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | FAJOEC 14,A1447,2000 |
| oral/woman | 41 gm/kg (41W pregnant) | Reproductive: Effects on newborn: Apgar score (human only) Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Effects on newborn: Drug dependence | AJDCAI 129,1075,1975 |
| oral/woman | 250 mg/kg (37W pregnant) | Reproductive: Other effects to embryo or fetus | AJOGAH 145,251,1983 |
| oral/monkey | 78 gm/kg (4-23W pregnant) | Reproductive: Effects on fertility: Abortion | TJADAB 35,345,1987 |
| oral/monkey | 400 mg/kg (2-21W pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TJADAB 29,49,1984 |
| oral/monkey | 206 gm/kg (90D prior to copulation) | Reproductive: Maternal effects: Menstrual cycle changes or disorders | SCIEAS 221,677,1983 |
| oral/monkey | 32400 mg/kg (2-19W pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | TJADAB 44,29,1991 |
| oral/monkey | 43200 mg/kg (1-24W pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) | TJADAB 44,29,1991 |
| oral/rabbit | 3945 mg/kg (1D prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | JOENAK 34,275,1966 |
| oral/rabbit | 3750 mg/kg (1D prior to copulation) | Reproductive: Effects on fertility: Other measures of fertility | IJMRAQ 58,501,1970 |
| oral/mammal (species unspecified) | 31500 mg/kg (15-35D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | TJADAB 30,203,1984 |
| oral/guinea pig | 76000 mg/kg (43-62D pregnant) | Reproductive: Other effects on female Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Other effects to embryo or fetus | NETEEC 23,355,2001 |
| oral/rat | 191220 mg/kg (2-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Other postnatal measures or effects | NETEEC 23,453,2001 |
| oral/guinea pig | 264000 mg/kg (2-67D pregnant) | Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Physical | NETEEC 22,183,2000 |
| oral/rat | 21 gm/kg (8-14D pregnant) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Other postnatal measures or effects Reproductive: Effects on newborn: Delayed effects | ALCOH* 6,353,1989 |
| oral/guinea pig | 260 gm/kg (2-67D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Behavioral | ALCOH* 41,577,2007 |
| oral/mouse | 360 gm/kg (60D male/60D prior to copulation) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | BDERB* 71,135,2004 |
| oral/mouse | 180 gm/kg (60D prior to copulation) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | BDERB* 71,135,2004 |
| oral/mouse | 3270 gm/kg (13W pre-3W pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | BDERE* 73,980,2005 |
| oral/rat | 94500 mg/kg (1-21D pregnant) | Reproductive: Effects on newborn: Stillbirth Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | TOVEFN (5),13,2002 |
| oral/rat | 94500 mg/kg (1-21D pregnant) | Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Other postnatal measures or effects | TOVEFN (5),13,2002 |
| oral/woman | 5860 mL/kg (3Y pre-100D after birth) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects | INJPD2 37,129,2005 |
| oral/rat | 99000 mg/kg (multigeneration) | Reproductive: Effects on newborn: Biochemical and metabolic | NETEEC 28,238,2006 |
| oral/guinea pig | 264 gm/kg (2-67D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Behavioral | NETEEC 28,333,2006 |
| oral/rat | 1188 gm/kg (55D male) | Reproductive: Paternal effects: Impotence Reproductive: Other effects on male Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | REPTED 22,599,2006 |
| oral/rat | 1188 gm/kg (55D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | REPTED 22,599,2006 |
| oral/mouse | 60 gm/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | MUREAV 577S,1,2005 |
| oral/rat | 36.5 gm/kg (30D pre-21D after birth) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Behavioral | NETEEC 27,585,2005 |
| oral/rat | 292 gm/kg (30D pre-21D after birth) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | NETEEC 27,585,2005 |
| oral/guinea pig | 204 gm/kg (0-67D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Behavioral | JPETAB 308,650,2004 |
| oral/mouse | 50 gm/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death | REPTED 22,61,2006 |
| oral/mouse | 50 gm/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | REPTED 22,61,2006 |
| oral/rat | 90 mg/kg (30D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Other effects on male Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | LIFSAK 71,3059,2002 |
| oral/guinea pig | 264 gm/kg (2-67D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects | NETEEC 25,59,2003 |
| oral/rat | 30 gm/kg (16-20D pregnant) | Reproductive: Effects on newborn: Other postnatal measures or effects | NETEEC 25,447,2003 |
| oral/rat | 120 gm/kg (1-20D pregnant) | Reproductive: Effects on newborn: Other postnatal measures or effects | NETEEC 25,447,2003 |
| oral/guinea pig | 272 gm/kg (2-67D pregnant) | Reproductive: Effects on newborn: Other postnatal measures or effects Reproductive: Effects on newborn: Delayed effects | NETEEC 26,59,2004 |
| oral/guinea pig | 57 gm/kg (43-62D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NETEEC 26,543,2004 |
| oral/rat | 45 gm/kg (15-22D preg/7D after birth) | Reproductive: Effects on newborn: Behavioral | NEROEW 24,691,2001 |
| oral/rat | 45 gm/kg (15-22D preg/7D after birth) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Other postnatal measures or effects | NEROEW 26,191,2002 |
| oral/rat | 10400 mg/kg (7-19D pregnant) | Reproductive: Tumorigenic effects: Transplacental tumorigenesis Reproductive: Effects on newborn: Delayed effects | BJCAAI 90,2225,2004 |
| oral/rat | 110 gm/kg (10-20D pregnant) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Biochemical and metabolic | NETEEC 27,73,2005 |
| oral/rat | 120 gm/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TOXID9 44,57,2005 |
| oral/rat | 16.25 gm/kg (7-19D pregnant) | Reproductive: Other effects on female Reproductive: Other reproductive system tumors Reproductive: Effects on newborn: Biochemical and metabolic | BJCAAI 90,2225,2004 |
| oral/rat | 54 gm/kg (6-14D pregnant) | Reproductive: Other effects on female | TOXID9 78,280,2004 |
| oral/rat | 378 gm/kg (9W male) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | HPV112 -,-,2008 |
| oral/rat | 252 gm/kg (12D preg-10D after birth) | Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Effects on newborn: Delayed effects | HPV112 -,-,2008 |
| oral/mouse | 3210 gm/kg (13W pre-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | BDERE* 73,65,2005 |
| oral/mouse | 2900 mg/kg (8D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TERMG* -,234,2003 |
| oral/rat | 210 gm/kg (6-20D pregnant) | Reproductive: Effects on fertility: Abortion Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOXID9 72(Suppl 1),341,2003 |
| oral/mouse | 868 gm/kg (28D male) | Reproductive: Other effects on male Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HPV228 -,-,2001 |
| oral/mouse | 25200 mg/kg (8-14D pregnant) | Reproductive: Other effects on female | HPV228 -,-,2001 |
| oral/mouse | 35000 mg/kg (8-14D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | HPV228 -,-,2001 |
| oral/mouse | 2173.5 gm/kg (multigeneration) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | HPV228 -,-,2001 |
| oral/mouse | 1053.5 gm/kg (49D male) | Reproductive: Other effects on male | HPV228 -,-,2001 |
| oral/rat | 784 gm/kg (56D prior to copulation) | Reproductive: Other effects on female | HPV228 -,-,2001 |
| oral/rat | 43 gm/kg (1D preg-21D after birth) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | HPV112 -,-,2008 |
| oral/rat | 175000 mg/kg (28D pre-22D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | HPV112 -,-,2008 |
| oral/rat | 182250 mg/kg (6-20D pregnant) | Reproductive: Effects on newborn: Behavioral | HPV112 -,-,2008 |
| oral/rat | 273 gm/kg (21D preg-21D after birth) | Reproductive: Effects on newborn: Behavioral | NRTXDN 30,23,2009 |
| oral/mouse | 2398 mL/kg (60D prior to copulation/3W preg/4W after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Behavioral | NRTXDN 30,59,2009 |
| oral/mouse | 150 gm/kg (4-9D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system | HPV228 -,-,2001 |
| oral/rat | 96 gm/kg (5-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | NETEEC 31,303,2009 |
| oral/rat | 96 gm/kg (5-20D pregnant) | Reproductive: Effects on newborn: Physical | NETEEC 31,303,2009 |
| oral/guinea pig | 260 gm/kg (1-65D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Hepatobiliary system | NETEEC 32,164,2010 |
| oral/rat | 126 gm/kg (21D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects Reproductive: Effects on newborn: Delayed effects | FCLPH* 23(Suppl 1),16,2009 |
| oral/rat | 1680 gm/kg (8W pre-7D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FCTOD7 48,3486,2010 |
| oral/rat | 1960 gm/kg (8W pre-21D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FCTOD7 48,3486,2010 |
| oral/rat | 156 gm/kg (5-22D preg/21D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | FCTOD7 96,263,2016 |
| oral/rat | 48 gm/kg (9-20D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TXAPA9 305,234,2016 |
| oral/rat | 48 gm/kg (12D prior to copulation) | Reproductive: Other effects to embryo or fetus Reproductive: Specific developmental abnormalities: Endocrine system | TXAPA9 288,84,2015 |
| oral/rat | 40 gm/kg (11-20D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities | TOLED5 238,117,2015 |
| oral/mouse | 18 gm/kg (12-17D pregnant) | Reproductive: Other developmental abnormalities | NETEEC 61,138,2017 |
| oral/mouse | 4.8 gm/kg (7D pregnant) | Reproductive: Other developmental abnormalities | NETEEC 62,42,2017 |
| oral/mouse | 4.8 gm/kg (8D pregnant) | Reproductive: Other developmental abnormalities | NETEEC 62,42,2017 |
| oral/rat | 44 gm/kg (11-21D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | TOLED5 226,98,2014 |
| oral/mouse | 6 gm/kg (14D pregnant) | Reproductive: Other effects to embryo or fetus | TOLED5 228,140,2014 |
| unreported route/rat | 60 gm/kg (9-14D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death | FATOAO 45(1),83,1982 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 320 mg/kg/50W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Blood: Lymphoma including Hodgkin's disease | CALEDQ 13,345,1981 |
| oral/mouse | toxic dose: 400 gm/kg/57W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | ZIETA2 59,203,1928 |
| rectal/mouse | lowest published toxic dose: 120 gm/kg/18W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Liver: Tumors | ZIETA2 59,203,1928 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Chicken, brain (cerebrum) | Inhibitor Concentration Low: 100 mmol/L/3H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Apoptosis in vitro | NETEEC 33,422,2011 |
| In Vitro/Chicken, embryo | Inhibitor Concentration Low: 100 mmol/L/10H | Reproductive: Specific developmental abnormalities: Central nervous system | NETEEC 33,422,2011 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (50 percent kill): 200422 µmol/L/21H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (10 percent kill): 16072 µmol/L/21H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (50 percent kill): 134186 µmol/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (10 percent kill): 28898 µmol/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration Low: 2 pph/48H | In Vitro Toxicity Studies: Other assays | TOLED5 281,53,2017 |
| In Vitro/Hamster, lung fibroblast | Inhibitor Concentration (50 percent kill): 147.5 mmol/L/60H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,511,1993 |
| In Vitro/Hamster, lung fibroblast | Inhibitor Concentration (10 percent kill): 16 mmol/L/60H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,511,1993 |
| In Vitro/Hamster, lung fibroblast | Inhibitor Concentration Low: >478.8 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
| In Vitro/Hamster, ovary | Inhibitor Concentration Low: 5 pph/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 26,157,2012 |
| In Vitro/Human, bone marrow | Inhibitor Concentration Low: 10 mmol/L/72H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 38,8,2017 |
| In Vitro/Human, colon tumor | Inhibitor Concentration Low: 20 mmol/L | In Vitro Toxicity Studies: Other assays | TOLED5 237,79,2015 |
| In Vitro/Human, colon tumor | Inhibitor Concentration Low: 60 mmol/L/3H | Biochemical: Metabolism (intermediary): Effect on mitochondrial function In Vitro Toxicity Studies: Other assays | TOLED5 237,79,2015 |
| In Vitro/Human, colon tumor | Inhibitor Concentration Low: 5 pph/24H | In Vitro Toxicity Studies: Other assays | TOLED5 234,194,2015 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 25 mmol/L/72H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Apoptosis in vitro | TOLED5 225,216,2014 |
| In Vitro/Human, erythrocytes | Inhibitor Concentration Low: >10 pph/1.5H | In Vitro Toxicity Studies: Hemolysis in vitro | TIVIEQ 27,323,2013 |
| In Vitro/Human, HeLa cell | Inhibitor Concentration (50 percent kill): 157.5 mmol/L/60H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,511,1993 |
| In Vitro/Human, HeLa cell | Inhibitor Concentration (10 percent kill): 48 mmol/L/60H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,511,1993 |
| In Vitro/Human, kidney tumor | Inhibitor Concentration (50 percent kill): 96600 mg/L | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 5 mmol/L/72H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) Liver: Liver function tests impaired In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 38,8,2017 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 10 mmol/L/72H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. In Vitro Toxicity Studies: Other assays | TIVIEQ 38,8,2017 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 10 mmol/L/72H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. | TIVIEQ 38,8,2017 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 10 mmol/L/72H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) Liver: Liver function tests impaired | TIVIEQ 38,8,2017 |
| In Vitro/Human, liver | Inhibitor Concentration (50 percent kill): 59.3 gm/L/6H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver | Inhibitor Concentration (50 percent kill): 35.3 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 3.9 gm/L/15H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 3.9 gm/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 7.9 gm/L/24H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver | Inhibitor Concentration (50 percent kill): 303 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 6,47,1992 |
| In Vitro/Human, liver | Inhibitor Concentration (10 percent kill): 126 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 6,47,1992 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 50,363,2012 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 200 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Apoptosis in vitro Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FCTOD7 50,363,2012 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 200 mmol/L/45M | In Vitro Toxicity Studies: Other assays | FCTOD7 50,363,2012 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Other assays Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 50,485,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 mmol/L/24H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Lipids including transport In Vitro Toxicity Studies: Other assays | JOETD7 136,168,2011 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 mmol/L | In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays | FCTOD7 50,3264,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 mmol/L | In Vitro Toxicity Studies: Other assays | FCTOD7 50,3264,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. Biochemical: Effect on specific coenzyme: Other coenzymes Biochemical: Metabolism (intermediary): Lipids including transport | TXCYAC 302,34,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: >428.2 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 716 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays | TOLED5 267,1,2017 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 250 mmol/L/3D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | FCTOD7 108,298,2017 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 48.6 gm/L/6H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 30.2 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 3.9 gm/L/6H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 15.8 gm/L/1H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 3.9 gm/L/7D | In Vitro Toxicity Studies: Cell growth: Colony formation | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 3.9 gm/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 7.9 gm/L/24H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other | TIVIEQ 40,124,2017 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 61000 mg/L | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 50 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TOLED5 208,254,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 208,254,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 200 mmol/L/5H | In Vitro Toxicity Studies: Apoptosis in vitro Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TIVIEQ 27,1820,2013 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 50 mmol/L/5H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,1820,2013 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Other assays Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TOLED5 208,254,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 20 mmol/L/3D | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | TXCYAC 310,1,2013 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 nmol/L | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TXCYAC 311,87,2013 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 mmol/L/48H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. In Vitro Toxicity Studies: Apoptosis in vitro | FCTOD7 76,109,2015 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 200 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays | TIVIEQ 29,600,2015 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TIVIEQ 26,700,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 150 mmol/L/3D | Biochemical: Metabolism (intermediary): Other | TXCYAC 314,193,2013 |
| In Vitro/Human, lung | Inhibitor Concentration Low: 2 gm/L/6H | In Vitro Toxicity Studies: Cell protein synthesis | TXAPA9 292,85,2016 |
| In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 198 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
| In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 147 gm/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,174,2013 |
| In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 553 gm/L/3H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
| In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 150 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 27,174,2013 |
| In Vitro/Human, lung fibroblast | Inhibitor Concentration Low: 0.1 gm/L/7D | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | TIVIEQ 4,1,1990 |
| In Vitro/Human, lung tumor | Inhibitor Concentration (50 percent kill): 25 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 27,174,2013 |
| In Vitro/Human, lung tumor | Inhibitor Concentration (50 percent kill): 43 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration Low: 100 mmol/L/3H | In Vitro Toxicity Studies: Other assays | FCTOD7 50,168,2012 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 560 mmol/L/4M | In Vitro Toxicity Studies: Membrane currents | TXAPA9 245,191,2010 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 200 µmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro | TXCYAC 384,33,2017 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 50 mmol/L/12H | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 334,104,2015 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration (50 percent kill): 17500 mg/L | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Human, oral mucosa | Inhibitor Concentration (50 percent kill): 40 pph/60M | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 49,2524,2011 |
| In Vitro/Human, skin | Inhibitor Concentration (50 percent kill): 10300 mg/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Human, skin | Inhibitor Concentration (50 percent kill): 139000 mg/L/1M | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 6,367,1992 |
| In Vitro/Human, skin | Inhibitor Concentration Low: 60 µL/well/60M | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1476,2013 |
| In Vitro/ilb | Inhibitor Concentration Low: 10 mmol/L/72H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) Liver: Liver function tests impaired | TIVIEQ 38,8,2017 |
| In Vitro/jda | Inhibitor Concentration (50 percent kill): 154712 mg/L/1H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 212,198,2012 |
| In Vitro/jda | Inhibitor Concentration Low: 10 pph/2M | In Vitro Toxicity Studies: Other assays | TIVIEQ 25,1237,2011 |
| In Vitro/jrc | Inhibitor Concentration Low: 30 mmol/L/2H | In Vitro Toxicity Studies: Other assays | TOLED5 209,161,2012 |
| In Vitro/jzx | Inhibitor Concentration (50 percent kill): 12.2 pph/60M | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,150,2012 |
| In Vitro/max | Inhibitor Concentration Low: 200 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro | FCTOD7 72,228,2014 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 8620 mg/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 7100 mg/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 24 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 27,174,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration Low: >428.2 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 854 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 6,47,1992 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (10 percent kill): 521 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 6,47,1992 |
| In Vitro/Mouse, liver | Inhibitor Concentration (50 percent kill): 1372 mmol/L/2H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TIVIEQ 4,783,1990 |
| In Vitro/Mouse, liver | Inhibitor Concentration Low: 1 pph/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays | JOETD7 141,1071,2012 |
| In Vitro/Mouse, macrophage | Inhibitor Concentration Low: >513 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 1,3,1987 |
| In Vitro/Mouse, neurons | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro | NETEEC 46,26,2014 |
| In Vitro/Mouse, neurons | Inhibitor Concentration Low: 100 mmol/L/6H | Biochemical: Metabolism (intermediary): Other proteins | NETEEC 46,26,2014 |
| In Vitro/mqb | Inhibitor Concentration Low: 10 mmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,380,2015 |
| In Vitro/nac | Inhibitor Concentration Low: 0.5 pph/15M | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays | TIVIEQ 28,822,2014 |
| In Vitro/nac | Inhibitor Concentration Low: 0.25 pph/15M | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 28,822,2014 |
| In Vitro/nax | Inhibitor Concentration Low: 1 pph/15M | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays | TIVIEQ 28,822,2014 |
| In Vitro/nax | Inhibitor Concentration Low: 0.25 pph/15M | In Vitro Toxicity Studies: Other assays | TIVIEQ 28,822,2014 |
| In Vitro/Non-mammalian species, fibroblast | Inhibitor Concentration (50 percent kill): 254 mmol/L/24H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,537,1993 |
| In Vitro/paa | Inhibitor Concentration Low: 68.7 mmol/L/44H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,1416,2013 |
| In Vitro/Rabbit, ocular | Inhibitor Concentration (50 percent kill): 0.06 gm/L/10M | In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay | TIVIEQ 3,329,1989 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro | TXCYAC 287,124,2011 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 60 mmol/L/1H | Gastrointestinal: Changes in structure or function of exocrine pancreas | TXCYAC 326,44,2014 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 1 mmol/L/1H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 26,1040,2012 |
| In Vitro/Rat, liver | Inhibitor Concentration Low: 1 mmol/L/1H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Other assays | TIVIEQ 26,1040,2012 |
| In Vitro/Rat, liver | Inhibitor Concentration Low: 25 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TXAPA9 287,52,2015 |
| In Vitro/Rat, liver | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro | TXAPA9 287,52,2015 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 31100 mg/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Rat, liver | Inhibitor Concentration Low: 50 mmol/L/5H | In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay | FCTOD7 60,286,2013 |
| In Vitro/Rat, liver | Inhibitor Concentration Low: 50 mmol/L/1H | In Vitro Toxicity Studies: Other assays | FCTOD7 60,286,2013 |
| In Vitro/Rat, liver | Inhibitor Concentration Low: 50 mmol/L/5H | In Vitro Toxicity Studies: Other assays | FCTOD7 60,286,2013 |
| In Vitro/Rat, liver | Inhibitor Concentration Low: 100 mmol/L/8H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Other assays Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | TIVIEQ 26,74,2012 |
| In Vitro/Rat, liver | Inhibitor Concentration Low: 300 mmol/L/24H | In Vitro Toxicity Studies: Other assays | TXCYAC 270,150,2010 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 620 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 6,47,1992 |
| In Vitro/Rat, liver | Inhibitor Concentration (10 percent kill): 174 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 6,47,1992 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): >39450 mg/L/20H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): >39450 mg/L/20H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): >39450 mg/L/20H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): >39450 mg/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration (50 percent kill): >39450 mg/L/20H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration (50 percent kill): >39450 mg/L/20H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration (50 percent kill): >33450 mg/L/20H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration (50 percent kill): >39450 mg/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration Low: 100 mmol/L/24H | In Vitro Toxicity Studies: Other assays Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | FCTOD7 90,84,2016 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 1513.6 mmol/L/1H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 32,347,2016 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 3311.3 mmol/L/1H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 32,347,2016 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 1737.8 mmol/L/1H | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TIVIEQ 32,347,2016 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 3.8 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 12.9 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (10 percent kill): 0.26 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (75 percent kill): 20 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM) | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (10 percent kill): 0.62 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,111,1993 |
| In Vitro/Rat, lung | Inhibitor Concentration (75 percent kill): 85.1 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,111,1993 |
| In Vitro/Rat, myocard | Inhibitor Concentration Low: 150 mmol/L/6H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 26,849,2012 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 50 mmol/L/12H | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 334,104,2015 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 0.25 pph/5D | In Vitro Toxicity Studies: Other assays | NETOX* 47,62,2015 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 1 pph/5D | In Vitro Toxicity Studies: Membrane currents | NETOX* 47,62,2015 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 150 mg/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | FCTOD7 55,192,2013 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 150 mg/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro | FCTOD7 55,192,2013 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 150 mg/L/4H | In Vitro Toxicity Studies: Other assays | FCTOD7 55,192,2013 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 150 mg/L/24H | In Vitro Toxicity Studies: Other assays | FCTOD7 55,192,2013 |
| inhalation/guinea pig | lowest published toxic concentration: 12850 ppm/8.75H | Behavioral: General anesthetic | HPV112 -,-,2008 |
| inhalation/guinea pig | Lowest published lethal concentration: 21900 ppm/9.8H | Behavioral: General anesthetic | HPV112 -,-,2008 |
| inhalation/guinea pig | Lowest published lethal concentration: 21900 ppm | FAONAU 48A,99,1970 | |
| inhalation/guinea pig | lowest published toxic concentration: 12000 mg/m3/8H | Behavioral: General anesthetic | VCVGK* -,93,1984 |
| inhalation/human | lowest published toxic concentration: 2500 mg/m3/20M | Peripheral Nerve and Sensation: Recording from afferent nerve | VCVGK* -,93,1984 |
| inhalation/human | lowest published toxic concentration: 1800 ppm/30M | Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Lung, Thorax, or Respiration: Cough | HPV112 -,-,2008 |
| inhalation/mouse | lethal concentration (50 percent kill): 39000 mg/m3/4H | HPV112 -,-,2008 | |
| inhalation/mouse | lethal concentration (50 percent kill): >60000 ppm/1H | Behavioral: Ataxia | HPV112 -,-,2008 |
| inhalation/mouse | lowest published toxic concentration: 13300 ppm/1.33H | Behavioral: Ataxia | HPV112 -,-,2008 |
| inhalation/mouse | lowest published toxic concentration: 23940 ppm/1.25H | Behavioral: General anesthetic | HPV112 -,-,2008 |
| inhalation/mouse | Lowest published lethal concentration: 29300 ppm/7H | Behavioral: General anesthetic | HPV112 -,-,2008 |
| inhalation/mouse | lowest published toxic concentration: 31900 ppm/0.33H | Behavioral: Ataxia | HPV112 -,-,2008 |
| inhalation/mouse | lethal concentration (50 percent kill): >40000 ppm/10M | Behavioral: Ataxia | HPV228 -,-,2001 |
| inhalation/mouse | Lowest published lethal concentration: 117000 mg/m3/2H | VCVGK* -,93,1984 | |
| inhalation/mouse | lowest published toxic concentration: 50000 mg/m3/2H | Behavioral: Alteration of classical conditioning | VCVGK* -,93,1984 |
| inhalation/mouse | lowest published toxic concentration: 2500 mg/m3/40M | Brain and Coverings: Other degenerative changes | VCVGK* -,93,1984 |
| inhalation/rabbit | lowest published toxic concentration: 2500 mg/m3/40M | Brain and Coverings: Other degenerative changes | VCVGK* -,93,1984 |
| inhalation/rat | lowest published toxic concentration: 12000 mg/m3/8H | Behavioral: General anesthetic | VCVGK* -,93,1984 |
| inhalation/rat | lethal concentration (50 percent kill): 20000 ppm/10H | NPIRI* 1,44,1974 | |
| inhalation/rat | lethal concentration (50 percent kill): 5900 mg/m3/6H | HPV112 -,-,2008 | |
| inhalation/rat | lethal concentration (50 percent kill): 124700 mg/m3/4H | HPV112 -,-,2008 | |
| inhalation/rat | lowest published toxic concentration: 4930 mg/m3 | TPKVAL 15,76,1979 | |
| inhalation/rat | lowest published toxic concentration: 1110 mg/m3/4H | TPKVAL 15,76,1979 | |
| inhalation/rat | Lethal concentration: >29430 mg/m3/7H | HPV112 -,-,2008 | |
| intraarterial/man | lowest published toxic dose: 0.071 mL/kg | Vascular: Acute arterial occulsion | JKMSEH 18,585,2003 |
| intraarterial/rat | lethal dose (50 percent kill): 11 mg/kg | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Lung, Thorax, or Respiration: Dyspnea | TXAPA9 18,60,1971 |
| intracerebral/rat | lowest published toxic dose: 363.6 µg/kg | Behavioral: Alteration of operant conditioning | PSCHDL 170,51,2003 |
| intracerebral/rat | lowest published toxic dose: 106 µg/kg | Behavioral: Change in motor activity (specific assay) | PSCHDL 170,368,2003 |
| intramuscular/non-mammalian species | lowest published toxic dose: 0.1 gm/kg | Cardiac: Other changes Musculoskeletal: Other changes | MUREAV 542,1,2003 |
| intraperitoneal/Dog | lowest published lethal dose: 3 gm/kg | BJIMAG 1,207,1944 | |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 3414 mg/kg | EVHPAZ 61,321,1985 | |
| intraperitoneal/hamster | lethal dose (50 percent kill): 5068 mg/kg | EVHPAZ 61,321,1985 | |
| intraperitoneal/mammal (species unspecified) | lethal dose (50 percent kill): 4300 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) | TXAPA9 13,358,1968 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 528 mg/kg | STRAAA 127,245,1965 | |
| intraperitoneal/mouse | lowest published toxic dose: 4.2 gm/kg | Nutritional and Gross Metabolic: Body temperature decrease | JPETAB 293,188,2000 |
| intraperitoneal/mouse | lowest published lethal dose: 4000 mg/kg | Behavioral: Alteration of classical conditioning Nutritional and Gross Metabolic: Body temperature decrease | EJPHAZ 499,285,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 1.75 gm/kg | Behavioral: Ataxia | PSCHDL 153,415,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 0.5 gm/kg | Behavioral: Change in motor activity (specific assay) | NNAPBA 367,414,2003 |
| intraperitoneal/mouse | lowest published toxic dose: 4.25 gm/kg | Behavioral: Sleep | PSCHDL 174,283,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 2 mg/kg | Brain and Coverings: Recordings from specific areas of CNS | TOLED5 145,69,2003 |
| intraperitoneal/mouse | lowest published toxic dose: 1.5 mg/kg | Behavioral: Antianxiety | PSCHDL 177,84,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 2 gm/kg | Behavioral: Alteration of operant conditioning Behavioral: Change in psychophysiological tests | PSCHDL 176,166,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 2.5 gm/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Alteration of operant conditioning Behavioral: Change in psychophysiological tests | PSCHDL 176,166,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 2 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning | PSCHDL 174,291,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 1 gm/kg | Behavioral: Antianxiety Behavioral: Change in psychophysiological tests | HOBEAO 49,123,2006 |
| intraperitoneal/mouse | lowest published toxic dose: 1000 mg/kg | Liver: Other changes | MUREAV 577S,1,2005 |
| intraperitoneal/mouse | lowest published toxic dose: 0.25 gm/kg | Behavioral: Analgesia | JPETAB 309,86,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 2 gm/kg | Behavioral: Change in psychophysiological tests | JPETAB 314,675,2005 |
| intraperitoneal/mouse | lowest published toxic dose: 4 gm/kg | Behavioral: Somnolence (general depressed activity) | PSCHDL 174,358,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 2.0 gm/kg | Behavioral: Ataxia Nutritional and Gross Metabolic: Body temperature decrease | JPETAB 319,219,2006 |
| intraperitoneal/mouse | lowest published toxic dose: 4 gm/kg | Behavioral: Withdrawal | NETEEC 34,177,2012 |
| intraperitoneal/mouse | lowest published toxic dose: 1.5 gm/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Antianxiety | PSCHDL 191,311,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 2 gm/kg | Behavioral: Ataxia Behavioral: Alteration of classical conditioning | PSCHDL 191,311,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 3.5 gm/kg | Behavioral: Altered sleep time (including change in righting reflex) | PSCHDL 191,311,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 0.3 mg/kg | Behavioral: Alteration of operant conditioning | PSCHDL 192,39,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 1.2 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Antianxiety Behavioral: Alteration of operant conditioning | PSCHDL 192,39,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 1.8 mg/kg | Behavioral: Alteration of classical conditioning Behavioral: Antianxiety Behavioral: Alteration of operant conditioning | PSCHDL 192,39,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 1.5 gm/kg | Behavioral: Alteration of classical conditioning | PYTOEY 15,587,2008 |
| intraperitoneal/mouse | lowest published toxic dose: 4.4 gm/kg | Brain and Coverings: Other degenerative changes | NRTXDN 30,459,2009 |
| intraperitoneal/mouse | lowest published toxic dose: 1.5 mg/kg | Behavioral: Alteration of classical conditioning Behavioral: Alteration of operant conditioning | PSCHDL 200,105,2008 |
| intraperitoneal/mouse | lowest published toxic dose: 3 gm/kg | Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | JPETAB 322,1003,2007 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 4 mL/kg | HPV228 -,-,2001 | |
| intraperitoneal/mouse | lowest published toxic dose: 3 gm/kg | Endocrine: Hyperglycemia Endocrine: Other changes | TXCYAC 326,44,2014 |
| intraperitoneal/rabbit | lethal dose (50 percent kill): 963 mg/kg | EVHPAZ 61,321,1985 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 3600 µg/kg | PHMGBN 2,27,1969 | |
| intraperitoneal/rat | lowest published toxic dose: 2.45 gm/kg | Behavioral: Altered sleep time (including change in righting reflex) | JPETAB 299,698,2001 |
| intraperitoneal/rat | lowest published toxic dose: 3500 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | FATOAO 51,92,1988 |
| intraperitoneal/rat | lowest published toxic dose: 0.5 gm/kg | Behavioral: Change in psychophysiological tests | EJPHAZ 462,115,2003 |
| intraperitoneal/rat | lowest published toxic dose: 1000 mg/kg | Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | EKFAE9 59,38,1996 |
| intraperitoneal/rat | lowest published toxic dose: 2 gm/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase | JPETAB 319,1366,2006 |
| intraperitoneal/rat | lowest published toxic dose: 2000 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other | EJPHAZ 520,51,2005 |
| intraperitoneal/rat | lowest published toxic dose: 1000 mg/kg | Behavioral: Food intake (animal) | EJPHAZ 519,96,2005 |
| intraperitoneal/rat | lowest published toxic dose: 0.25 gm/kg | Behavioral: Alteration of operant conditioning | JOPSEQ 17,293,2003 |
| intraperitoneal/rat | lowest published toxic dose: 0.5 gm/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of operant conditioning | JOPSEQ 17,293,2003 |
| intraperitoneal/rat | lowest published toxic dose: 1.5 gm/kg | Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | NEROEW 28,939,2003 |
| intraperitoneal/rat | lowest published toxic dose: 1.25 mg/kg | Behavioral: Change in motor activity (specific assay) | NEROEW 28,2124,2003 |
| intraperitoneal/rat | lowest published toxic dose: 2.4 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | PSCHDL 169,60,2003 |
| intraperitoneal/rat | lowest published toxic dose: 1 gm/kg | Taste: Change in function | PSCHDL 167,130,2003 |
| intraperitoneal/rat | lowest published toxic dose: 3000 mg/kg | Behavioral: Sleep | TOSCF2 73,270,2003 |
| intraperitoneal/rat | lowest published toxic dose: 2 gm/kg | Brain and Coverings: Other degenerative changes Endocrine: Differential effect of sex or castration on observed toxicity Biochemical: Metabolism (intermediary): Other | EJPHAZ 484,241,2004 |
| intraperitoneal/rat | lowest published toxic dose: 500 mg/kg | Behavioral: Analgesia | PSCHDL 171,204,2004 |
| intraperitoneal/rat | lowest published toxic dose: 2700 mg/kg | Behavioral: Ataxia | PSCHDL 194,139,2007 |
| intraperitoneal/rat | lowest published toxic dose: 1000 mg/kg | Nutritional and Gross Metabolic: Body temperature decrease | PSCHDL 197,409,2008 |
| intraperitoneal/rat | lowest published toxic dose: 1500 mg/kg | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature decrease | PSCHDL 197,67,2008 |
| intraperitoneal/rat | lowest published toxic dose: 2800 mg/kg | Brain and Coverings: Other degenerative changes | PSCHDL 201,261,2008 |
| intraperitoneal/rat | lowest published toxic dose: 2500 mg/kg | Endocrine: Change in LH Endocrine: Androgenic Reproductive: Paternal effects: Testes, epididymis, sperm duct | HPV112 -,-,2008 |
| intraperitoneal/rat | lowest published toxic dose: 1000 mg/kg | Behavioral: Muscle weakness | NRTXDN 27,1064,2006 |
| intraperitoneal/rat | lowest published toxic dose: 2000 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia Behavioral: Alteration of operant conditioning | NRTXDN 27,1064,2006 |
| intraperitoneal/rat | lowest published toxic dose: 500 mg/kg | Behavioral: Alteration of classical conditioning | NETEEC 29,23,2007 |
| intraperitoneal/rat | lowest published toxic dose: 3000 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) | TOLED5 169,253,2007 |
| intraperitoneal/rat | lowest published toxic dose: 2 gm/kg | Brain and Coverings: Recordings from specific areas of CNS Behavioral: Anticonvulsant | JPHPH* 58,641,2007 |
| intraperitoneal/rat | lowest published toxic dose: 2 gm/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | FCTOD7 46,1739,2008 |
| intraperitoneal/rat | lowest published toxic dose: 0.4 mL/kg | Gastrointestinal: Peritonitis | TOXRE* 1,31,2014 |
| intraspinal/rat | lowest published toxic dose: 0.436 mL/kg | Spinal Cord: Demyelination Behavioral: Alteration of classical conditioning Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NRTXDN 32,864,2011 |
| intravenous/cat | lowest published toxic dose: 2 gm/kg | Brain and Coverings: Recordings from specific areas of CNS Eye: Other eye effects | TXAPA9 243,348,2010 |
| intravenous/cat | lowest published lethal dose: 3945 mg/kg | HBTXAC 1,130,1955 | |
| intravenous/chicken | lowest published lethal dose: 8216 mg/kg | Vascular: Other changes | JPETAB 60,312,1937 |
| intravenous/Dog | lowest published lethal dose: 1600 mg/kg | Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea | TXAPA9 18,60,1971 |
| intravenous/human | lowest published toxic dose: 1.6 gm/kg/6H | Biochemical: Metabolism (intermediary): Other | CLPTAT 67,591,2000 |
| intravenous/human | lowest published toxic dose: 0.89 mL/kg | Vascular: Regional or general arteriolar constriction Vascular: Measurement of regional blood flow | JKMSEH 19,51,2004 |
| intravenous/man | lowest published toxic dose: 0.57 gm/kg | Behavioral: Change in psychophysiological tests | NEROEW 29,1527,2004 |
| intravenous/man | lowest published toxic dose: 0.571 gm/kg | Brain and Coverings: Other degenerative changes | PSCHDL 191,975,2007 |
| intravenous/mouse | lethal dose (50 percent kill): 1973 mg/kg | ENTOX* ,706,2005 | |
| intravenous/mouse | lethal dose (50 percent kill): 2.8 mL/kg | HPV228 -,-,2001 | |
| intravenous/mouse | lowest published toxic dose: 3 gm/kg | Behavioral: Sleep | JPETAB 302,257,2002 |
| intravenous/mouse | lowest published toxic dose: 3 gm/kg | Behavioral: Sleep Behavioral: Tolerance | JPETAB 302,257,2002 |
| intravenous/rabbit | lethal dose (50 percent kill): 2374 mg/kg | EVHPAZ 61,321,1985 | |
| intravenous/rabbit | lowest published toxic dose: 0.8 gm/kg | Brain and Coverings: Changes in surface EEG Behavioral: Ataxia | PHREP* 58,890,2006 |
| intravenous/rabbit | lowest published toxic dose: 0.8 gm/kg | Brain and Coverings: Changes in surface EEG | PHREP* 57,61,2005 |
| intravenous/rat | lowest published toxic dose: 0.72 gm/kg/10M | Spinal Cord: Other degenerative changes Vascular: BP lowering not characterized in autonomic section | BJPCBM 158,806,2009 |
| intravenous/rat | lowest published toxic dose: 1.03 gm/kg/40M | Spinal Cord: Other degenerative changes Behavioral: Tolerance | BJPCBM 158,806,2009 |
| intravenous/rat | lowest published toxic dose: 1 gm/kg | Cardiac: Change in rate Vascular: BP elevation not characterized in autonomic section Vascular: BP lowering not characterized in autonomic section | FCTOD7 50,2622,2012 |
| intravenous/rat | lethal dose (50 percent kill): 1440 mg/kg | Lung, Thorax, or Respiration: Dyspnea | TXAPA9 18,60,1971 |
| intravenous/rat | lowest published toxic dose: 0.5 gm/kg | Brain and Coverings: Recordings from specific areas of CNS | NEROEW 29,530,2004 |
| multiple/man | lowest published toxic dose: 3660 mg/kg | Endocrine: Evidence of thyroid hypofunction | PSCHDL 170,213,2003 |
| multiple/non-mammalian species | lowest published toxic concentration: 1 pph/30M | Behavioral: Change in motor activity (specific assay) | NETEEC 32,84,2010 |
| oral/cat | lowest published lethal dose: 6000 mg/kg | HPV112 -,-,2008 | |
| oral/cat | lowest published lethal dose: 6 gm/kg | Gastrointestinal: Gastritis Liver: Hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, and Bladder: Interstitial nephritis | JPETAB 56,117,1936 |
| oral/child | lowest published lethal dose: 2 gm/kg | Lung, Thorax, or Respiration: Other changes Liver: Fatty liver degeneration Blood: Other changes | ATXKA8 17,183,1958 |
| oral/child | lowest published toxic dose: 14400 mg/kg/30M- intermittent | Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Nausea or vomiting | APSVAM 74,977,1985 |
| oral/Dog | lowest published toxic dose: 2 gm/kg | Behavioral: Change in psychophysiological tests | TOXID9 66,263,2002 |
| oral/Dog | lowest published lethal dose: 5500 mg/kg | HPV112 -,-,2008 | |
| oral/guinea pig | lethal dose (50 percent kill): 5560 mg/kg | HPV112 -,-,2008 | |
| oral/human | lowest published toxic dose: 600 mg/kg | Cardiac: Change in rate Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Other changes | JTCTDW 42,761,2004 |
| oral/human | lowest published toxic dose: 0.1 gm/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | NSAPCC 369(Suppl 1),R106,2004 |
| oral/human | lowest published toxic dose: 0.5 mg/kg | Behavioral: Change in psychophysiological tests | JOPSEQ 17,379,2003 |
| oral/human | lowest published toxic dose: 0.7 gm/kg/10M | Behavioral: Change in psychophysiological tests | JOPSEQ 19,627,2005 |
| oral/human | lowest published toxic dose: 400 mg/kg | Behavioral: Alteration of operant conditioning | PSCHDL 172,68,2004 |
| oral/human | lowest published toxic dose: 0.5 gm/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Change in psychophysiological tests | NEROEW 28,371,2003 |
| oral/human | lowest published toxic dose: 1.4 gm/kg | Behavioral: Euphoria Behavioral: Change in psychophysiological tests Gastrointestinal: Nausea or vomiting | NEROEW 28,740,2003 |
| oral/human | lowest published lethal dose: 1400 mg/kg | Behavioral: Sleep Behavioral: Headache Gastrointestinal: Nausea or vomiting | NPIRI* 1,44,1974 |
| oral/infant | lowest published toxic dose: 11712 µL/kg | Behavioral: General anesthetic Cardiac: Arrythmias (indlucing changes in conduction) Lung, Thorax, or Respiration: Dyspnea | JOUOD4 9,53,1987 |
| oral/mammal (species unspecified) | lowest published toxic dose: 4000 mg/kg | Endocrine: Other changes Immunological Including Allergic: Decrease in humoral immune response | TOXID9 44,184,2005 |
| oral/man | lowest published toxic dose: 625 mg/kg | Cardiac: Pulse rate decreased with fall in BP Cardiac: Change in rate Nutritional and Gross Metabolic: Body temperature increase | ECPPH* 2,53,1994 |
| oral/man | lowest published toxic dose: 0.8 gm/kg | Brain and Coverings: Changes in surface EEG Behavioral: Change in psychophysiological tests | NEROEW 28,747,2003 |
| oral/man | lowest published toxic dose: 0.5 gm/kg | Cardiac: Pulse rate increased without fall in BP Vascular: BP elevation not characterized in autonomic section Endocrine: Other changes | NEROEW 25,537,2001 |
| oral/man | lowest published toxic dose: 1.14 mL/kg | Behavioral: Change in psychophysiological tests | NEROEW 28,1366,2003 |
| oral/man | lowest published toxic dose: 0.8 gm/kg | Behavioral: Euphoria Behavioral: Somnolence (general depressed activity) Behavioral: Change in psychophysiological tests | JPETAB 300,236,2002 |
| oral/man | lowest published toxic dose: 0.6 gm/kg | Behavioral: Change in psychophysiological tests Endocrine: Other changes | NEROEW 29,1156,2004 |
| oral/man | lowest published toxic dose: 22500 mg/kg/4W- intermittent | Endocrine: Other changes Blood: Other changes | CLECAP 25,143,1986 |
| oral/man | lowest published toxic dose: 3371 µL/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Excitement Behavioral: Coma | VHTODE 21,272,1979 |
| oral/man | lowest published toxic dose: 50 mg/kg | Gastrointestinal: Alteration in gastric secretion Gastrointestinal: Other changes | JPETAB 56,117,1936 |
| oral/man | lowest published toxic dose: 1430 µg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia Behavioral: Antipsychotic | JPETAB 197,488,1976 |
| oral/man | lowest published toxic dose: 650 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia Behavioral: Alteration of operant conditioning | NRTXDN 27,1064,2006 |
| oral/man | lowest published toxic dose: 0.45 gm/kg | Behavioral: Change in psychophysiological tests | ALCOH* 4,293,1987 |
| oral/monkey | lowest published toxic dose: 4.8 mg/kg | Behavioral: Abuse | JPETAB 301,993,2002 |
| oral/monkey | lowest published toxic dose: 102 mg/kg | Behavioral: Alteration of operant conditioning | PSCHDL 170,1,2003 |
| oral/mouse | lowest published toxic dose: 5000 mg/kg | Liver: Other changes | TOXID9 44,213,2005 |
| oral/mouse | lowest published toxic dose: 6000 mg/kg | Immunological Including Allergic: Decrease in cellular immune response | TOXID9 60,28,2001 |
| oral/mouse | lowest published toxic dose: 1.5 mg/kg | Behavioral: Alteration of classical conditioning | ACPSI* 24,1137,2003 |
| oral/mouse | lowest published toxic dose: 1000 mg/kg | Behavioral: Aggression | PSCHDL 172,255,2004 |
| oral/mouse | lowest published toxic dose: 5000 mg/kg | Endocrine: Other changes Blood: Changes in other cell count (unspecified) | TOXID9 44,184,2005 |
| oral/mouse | lowest published toxic dose: 6000 mg/kg | Blood: Changes in spleen | TOXID9 44,184,2005 |
| oral/mouse | lowest published toxic dose: 1 gm/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Aggression | PSCHDL 157,131,2001 |
| oral/mouse | lowest published toxic dose: 6 gm/kg | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOXID9 72,202,2003 |
| oral/mouse | lowest published toxic dose: 5 gm/kg | Blood: Other changes | TOXID9 72,99,2003 |
| oral/mouse | lowest published toxic dose: 4 gm/kg | Endocrine: Other changes Blood: Changes in spleen Immunological Including Allergic: Decrease in cellular immune response | TOXID9 72,172,2003 |
| oral/mouse | lowest published toxic dose: 5 gm/kg | Brain and Coverings: Other degenerative changes Vascular: Other changes Liver: Other changes | JPETAB 298,737,2001 |
| oral/mouse | lethal dose (50 percent kill): 3450 mg/kg | GISAAA 32(3),31,1967 | |
| oral/mouse | lowest published toxic dose: 500 mg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Other | TXAPA9 223,225,2007 |
| oral/mouse | lowest published toxic dose: 6.45 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach Gastrointestinal: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | BPBLEO 31,1351,2008 |
| oral/mouse | lowest published toxic dose: 4.8 gm/kg | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TXCYAC 252,86,2008 |
| oral/mouse | lowest published toxic dose: 3 gm/kg | Behavioral: Sleep | JPHSC* 106,361,2008 |
| oral/mouse | lowest published toxic dose: 4 gm/kg | Immunological Including Allergic: Decreased immune response Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOXID9 -,276,2008 |
| oral/mouse | lowest published toxic dose: 3.08 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach | PYTOEY 9,125,2002 |
| oral/mouse | lethal dose (50 percent kill): 10.5 mL/kg | HPV228 -,-,2001 | |
| oral/mouse | lowest published toxic dose: 6000 mg/kg | Liver: Other changes Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TOXID9 -,237,2009 |
| oral/mouse | lowest published toxic dose: 3 mL/kg | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 50,363,2012 |
| oral/mouse | lowest published toxic dose: 4000 mg/kg | Behavioral: Anticonvulsant | TOXIA6 138,59,2017 |
| oral/mouse | lowest published toxic dose: 5 gm/kg | Gastrointestinal: Other changes | TOLED5 237,79,2015 |
| oral/mouse | lowest published toxic dose: 5 gm/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Liver: Fatty liver degeneration | TXCYAC 314,193,2013 |
| oral/mouse | lowest published lethal dose: 8 gm/kg | Brain and Coverings: Other degenerative changes Behavioral: Altered sleep time (including change in righting reflex) Liver: Other changes | JOETD7 192,67,2016 |
| oral/mouse | lowest published toxic dose: 5 gm/kg | Liver: Liver function tests impaired Liver: Fatty liver degeneration Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TXCYAC 309,100,2013 |
| oral/mouse | lowest published toxic dose: 4444 µL/kg | Liver: Other changes Immunological Including Allergic: Decrease in cellular immune response Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 53,286,2013 |
| oral/mouse | lowest published toxic dose: 1111 µL/kg | Blood: Changes in spleen Immunological Including Allergic: Decrease in cellular immune response | FCTOD7 53,286,2013 |
| oral/mouse | lowest published toxic dose: 16 mL/kg | Immunological Including Allergic: Decrease in cellular immune response | FCTOD7 53,286,2013 |
| oral/mouse | lowest published toxic dose: 5 gm/kg | Liver: Changes in liver weight | TXCYAC 296,56,2012 |
| oral/mouse | lowest published toxic dose: 2.5 gm/kg | Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other | TXCYAC 296,56,2012 |
| oral/pigeon | lowest published toxic dose: 1 gm/kg | Behavioral: Change in psychophysiological tests | JPETAB 293,551,2000 |
| oral/rabbit | lethal dose (50 percent kill): 6300 mg/kg | HPV112 -,-,2008 | |
| oral/rat | lowest published toxic dose: 1 gm/kg | Cardiac: Change in rate Cardiac: Cardiac output Vascular: BP lowering not characterized in autonomic section | JPETAB 324,368,2008 |
| oral/rat | lowest published toxic dose: 3.9 gm/kg | Gastrointestinal: Gastritis Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | MUREAV 579,214,2005 |
| oral/rat | lowest published toxic dose: 4.8 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Effect on active transport | PYTOEY 12,264,2005 |
| oral/rat | lowest published toxic dose: 4.57 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach Biochemical: Metabolism (intermediary): Other | PYTOEY 9,515,2002 |
| oral/rat | lowest published toxic dose: 1000 mg/kg | Behavioral: Alteration of operant conditioning | PBBHAU 89,179,2008 |
| oral/rat | lowest published toxic dose: 4.44 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach Gastrointestinal: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | PHREP* 57,481,2005 |
| oral/rat | lowest published toxic dose: 2 gm/kg | Behavioral: Altered sleep time (including change in righting reflex) | BJMRDK 41,782,2008 |
| oral/rat | lowest published toxic dose: 12800 mg/kg | Gastrointestinal: Ulceration or bleeding from stomach Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | FCTOD7 47,134,2009 |
| oral/rat | lethal dose (50 percent kill): 15010 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Gastritis | HPV112 -,-,2008 |
| oral/rat | lowest published lethal dose: 7000 mg/kg | Lung, Thorax, or Respiration: Respiratory depression | HPV112 -,-,2008 |
| oral/rat | lowest published toxic dose: 0.4 gm/kg | Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | PSCHDL 191,679,2007 |
| oral/rat | lowest published toxic dose: 2 gm/kg | Gastrointestinal: Other changes | JOETD7 135,603,2011 |
| oral/rat | lowest published toxic dose: 6 gm/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 33,444,2011 |
| oral/rat | lowest published toxic dose: 2.375 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach | JOETD7 134,904,2011 |
| oral/rat | lowest published toxic dose: 5 mL/kg | Gastrointestinal: Alteration in gastric secretion Gastrointestinal: Ulceration or bleeding from stomach | FCLPH* 16,311,2002 |
| oral/rat | lowest published toxic dose: 1600 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 41,1551,2003 |
| oral/rat | lowest published toxic dose: 10 mL/kg | Gastrointestinal: Gastritis | JPETAB 303,1301,2002 |
| oral/rat | lowest published toxic dose: 5.25 gm/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | TOXID9 72,128,2003 |
| oral/rat | lowest published toxic dose: 8000 mg/kg | Brain and Coverings: Other degenerative changes Cardiac: Cardiomyopathy including infarction Liver: Multiple effects | FATOAO 50,52,1987 |
| oral/rat | lowest published toxic dose: 3 gm/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | FATOAO 44,319,1981 |
| oral/rat | lowest published toxic dose: 5 gm/kg | Behavioral: Change in motor activity (specific assay) | FATOAO 44,319,1981 |
| oral/rat | lowest published toxic dose: 4800 mg/kg | Gastrointestinal: Ulceration or bleeding from stomach | FATOAO 51,82,1988 |
| oral/rat | lowest published toxic dose: 6000 mg/kg | Biochemical: Metabolism (intermediary): Effect on mitochondrial function | FATOAO 55,18,1992 |
| oral/rat | lowest published toxic dose: 1500 mg/kg | Behavioral: Ataxia | VCVGK* -,93,1984 |
| oral/rat | lethal dose (50 percent kill): 7060 mg/kg | Lung, Thorax, or Respiration: Other changes | TXAPA9 16,718,1970 |
| oral/rat | lowest published toxic dose: 6.4 gm/kg | Gastrointestinal: Alteration in gastric secretion Gastrointestinal: Ulceration or bleeding from stomach | LIFSAK 70,17,2001 |
| oral/rat | lowest published toxic dose: 5000 mg/kg | Immunological Including Allergic: Decrease in cellular immune response | TOXID9 44,184,2005 |
| oral/rat | lowest published toxic dose: 3 gm/kg | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | TXAPA9 197,206,2004 |
| oral/rat | lowest published toxic dose: 5000 mg/kg | Endocrine: Other changes Blood: Changes in other cell count (unspecified) | TOXID9 44,184,2005 |
| oral/rat | lethal dose (50 percent kill): 7 gm/kg | USXXAM #6696575 | |
| oral/rat | lowest published toxic dose: 5250 mg/kg | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 26,451,2004 |
| oral/rat | lowest published toxic dose: 0.5 gm/kg | Brain and Coverings: Other degenerative changes | TOLED5 133,255,2002 |
| oral/rat | lowest published toxic dose: 5000 mg/kg | Behavioral: General anesthetic | TOVEFN (5),13,2002 |
| oral/rat | lowest published toxic dose: 6000 mg/kg | Behavioral: Change in psychophysiological tests | TOVEFN (5),13,2002 |
| oral/rat | lowest published toxic dose: 6 gm/kg | Behavioral: Alteration of classical conditioning Nutritional and Gross Metabolic: Weight loss or decreased weight gain | PSCHDL 175,189,2004 |
| oral/rat | lowest published toxic dose: 4 mL/kg | Gastrointestinal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | BPBLEO 29,1973,2006 |
| oral/rat | lowest published toxic dose: 10 mL/kg | Gastrointestinal: Other changes | BPBLEO 29,2206,2006 |
| oral/rat | lowest published toxic dose: 4300 mg/kg | Vascular: Measurement of regional blood flow | TXCYAC 235,141,2007 |
| oral/rat | lowest published toxic dose: 6000 mg/kg | Biochemical: Metabolism (intermediary): Other | TXCYAC 235,141,2007 |
| oral/rat | lowest published toxic dose: 1500 mg/kg | Behavioral: Alteration of classical conditioning | TOXID9 44,224,2005 |
| oral/rat | lowest published toxic dose: 5 gm/kg | Behavioral: Anticonvulsant | ARTODN 79,610,2005 |
| oral/rat | lowest published toxic dose: 0.72 gm/kg | Behavioral: Abuse Endocrine: Differential effect of sex or castration on observed toxicity | BJMRDK 37,1511,2004 |
| oral/rat | lowest published toxic dose: 10.5 gm/kg/2H | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other | TOXID9 78,380,2004 |
| oral/rat | lowest published toxic dose: 7.5 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach Gastrointestinal: Other changes | JOETD7 144,497,2012 |
| oral/rat | lowest published toxic dose: 4.75 mL/kg | Gastrointestinal: Alteration in gastric secretion Gastrointestinal: Ulceration or bleeding from stomach Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | JOETD7 148,277,2013 |
| oral/rat | lowest published toxic dose: 5.3 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | JOETD7 158,358,2014 |
| oral/rat | lowest published toxic dose: 5 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | JOETD7 146,505,2013 |
| oral/rat | lowest published toxic dose: 1 gm/kg | Vascular: BP lowering not characterized in autonomic section Vascular: Other changes | TXAPA9 264,470,2012 |
| oral/rat | lowest published toxic dose: 5 mL/kg | Gastrointestinal: Ulceration or bleeding from stomach Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | JOETD7 197,294,2017 |
| oral/rat | lowest published toxic dose: 0.4736 gm/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct | FCTOD7 105,44,2017 |
| oral/woman | lowest published toxic dose: 256 gm/kg/12W | Behavioral: Hallucinations, distorted perceptions Endocrine: Effect on menstrual cycle | JAMAAP 238,2143,1977 |
| oral/woman | lowest published toxic dose: 1200 mg/kg/3H | Endocrine: Change in gonadotropins Endocrine: Other changes Blood: Other changes | ACRSDM 7,289,1983 |
| oral/woman | lowest published toxic dose: 0.7 gm/kg | Behavioral: Change in psychophysiological tests | JOPSEQ 16,379,2002 |
| parenteral/frog | lowest published lethal dose: 36 gm/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity) | AIPTAK 50,296,1935 |
| skin/rabbit | lowest published lethal dose: 20000 mg/kg | HPV112 -,-,2008 | |
| subcutaneous/chicken | lowest published lethal dose: 5 gm/kg | FDWU** -,-,1931 | |
| subcutaneous/Dog | lowest published lethal dose: 6 gm/kg | HBTXAC 1,130,1955 | |
| subcutaneous/frog | lowest published lethal dose: 7100 mg/kg | HBTXAC 1,128,1955 | |
| subcutaneous/infant | lowest published lethal dose: 19440 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Coma Nutritional and Gross Metabolic: Body temperature decrease | AJCPAI 5,466,1935 |
| subcutaneous/mouse | lethal dose (50 percent kill): 8285 mg/kg | FAONAU 48A,99,1970 | |
| subcutaneous/mouse | lowest published toxic dose: 5 gm/kg | Liver: Hepatitis (hepatocellular necrosis), zonal | TOXID9 66,119,2002 |
| subcutaneous/pigeon | lowest published lethal dose: 5 gm/kg | FDWU** -,-,1931 | |
| subcutaneous/rabbit | lowest published lethal dose: 20 gm/kg | YAKUD5 22,651,1980 | |
| subcutaneous/rat | lowest published toxic dose: 7900 mg/kg | Reproductive: Maternal effects: Menstrual cycle changes or disorders | HPV112 -,-,2008 |
| Tank with water/Other invertebrate | lowest published toxic concentration: 1 pph/1D | Behavioral: Change in psychophysiological tests | NETEEC 48,28,2015 |
| Tank with water/Other invertebrate | lethal concentration (50 percent kill): 2.8 pph/8D | NETEEC 48,28,2015 | |
| Tank with water/Zebrafish | lowest published toxic concentration: 6048 mg/L/24H | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear | NETEEC 38,92,2013 |
| Tank with water/Zebrafish | lowest published toxic concentration: 12096 mg/L/24H | Reproductive: Effects on embryo or fetus: Fetal death | NETEEC 38,92,2013 |
| Tank with water/Zebrafish | lowest published toxic concentration: 4608 mg/L/5H | Reproductive: Other developmental abnormalities Reproductive: Effects on newborn: Behavioral | NETEEC 48,18,2015 |
| Tank with water/Zebrafish | lowest published toxic concentration: 4608 mg/L/5H | Reproductive: Specific developmental abnormalities: Central nervous system | NETEEC 48,18,2015 |
| Tank with water/Zebrafish | lowest published toxic concentration: 3 pph/3H | Reproductive: Specific developmental abnormalities: Eye, ear | NETEEC 44,70,2014 |
| Tank with water/Zebrafish | lowest published toxic concentration: 1 pph/3H | Reproductive: Effects on newborn: Behavioral | NETEEC 48,1,2015 |
| Tank with water/Zebrafish | lowest published toxic concentration: 3 pph/3H | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | NETEEC 48,1,2015 |
| Tank with water/Zebrafish | Inhibitor Concentration: 150 mmol/L/5H | Behavioral: Change in psychophysiological tests Cardiac: Other changes Musculoskeletal: Other changes | NRTXDN 62,100,2017 |
| Tank with water/Zebrafish | lowest published toxic concentration: 1 pph/3H | Behavioral: Alteration of classical conditioning | NETEEC 61,66,2017 |
| Tank with water/Zebrafish | Lowest published lethal concentration: 1 gm/L/144H | TIVIEQ 102,162,2011 | |
| Tank with water/Zebrafish | lowest published toxic concentration: 0.01 gm/L/144H | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning | TIVIEQ 102,162,2011 |
| Tank with water/Zebrafish | lowest published toxic concentration: 1.5 pph/20H | Reproductive: Specific developmental abnormalities: Eye, ear | NETEEC 33,686,2011 |
| Tank with water/Zebrafish | lowest published toxic concentration: 0.25 pph/2H | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | NETEEC 33,698,2011 |
| Tank with water/Zebrafish | lowest published toxic concentration: 0.5 pph/7D | NRTXDN 32,871,2011 | |
| unreported route/mouse | lowest published toxic dose: 4.8 gm/kg | Liver: Fatty liver degeneration Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Effect on mitochondrial function | FCTOD7 50,485,2012 |
| unreported route/mouse | lowest published lethal dose: 2 gm/kg | JTSCDR 32,421,2007 | |
| unreported route/rat | lowest published toxic dose: 3 gm/kg | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | TOLED5 150,325,2004 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 8000 mg/m3/4H/17W- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Other changes Immunological Including Allergic: Decreased immune response | VCVGK* -,93,1994 |
| inhalation/mouse | lowest published toxic concentration: 22000 mg/m3/20D- intermittent | Blood: Thrombocytopenia | HPV112 -,-,2008 |
| inhalation/rabbit | lowest published toxic concentration: 8000 mg/m3/4H/17W- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Other changes Immunological Including Allergic: Decreased immune response | VCVGK* -,93,1994 |
| inhalation/rat | lowest published toxic concentration: 8000 mg/m3/4H/17W- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Other changes Immunological Including Allergic: Decreased immune response | VCVGK* -,93,1994 |
| inhalation/rat | lowest published toxic concentration: 6130 ppm/4W- intermittent | Endocrine: Changes in thymus weight | JAPTO* 25,193,2005 |
| inhalation/rat | lowest published toxic concentration: 6130 ppm/4W- intermittent | Brain and Coverings: Other degenerative changes Cardiac: Changes in heart weight Endocrine: Hyperglycemia | JAPTO* 25,193,2005 |
| inhalation/rat | lowest published toxic concentration: 6130 ppm/4W- intermittent | Biochemical: Metabolism (intermediary): Other | JAPTO* 25,193,2005 |
| inhalation/rat | lowest published toxic concentration: 4930 mg/m3/4D- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Lung, Thorax, or Respiration: Other changes | TPKVAL 15,76,1979 |
| inhalation/rat | lowest published toxic concentration: 4930 mg/m3/8D- intermittent | Behavioral: Alteration of classical conditioning | TPKVAL 15,76,1979 |
| inhalation/rat | lowest published toxic concentration: 4930 mg/m3/14D- intermittent | Behavioral: Change in motor activity (specific assay) | TPKVAL 15,76,1979 |
| inhalation/rat | lowest published toxic concentration: 1110 mg/m3/14D- intermittent | Vascular: Other changes | TPKVAL 15,76,1979 |
| inhalation/rat | lowest published toxic concentration: 22.4 gm/m3/5D- intermittent | Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | PSCHDL 193,495,2007 |
| inhalation/rat | lowest published toxic concentration: 25000 mg/m3/14D- intermittent | Blood: Changes in bone marrow not included in above Blood: Changes in spleen Blood: Other changes | HPV112 -,-,2008 |
| intramuscular/mouse | lowest published toxic dose: 42 gm/kg/14D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Liver: Other changes | FATOAO 46,103,1983 |
| intramuscular/mouse | lowest published toxic dose: 63 gm/kg/21D- intermittent | Liver: Fatty liver degeneration Liver: Liver function tests impaired | FATOAO 46,103,1983 |
| intramuscular/rat | lowest published toxic dose: 420 gm/kg/6W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Fatty liver degeneration Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | JPETAB 299,832,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 12 mg/kg/3D- intermittent | Behavioral: Alteration of classical conditioning | BJPCBM 138,9,2003 |
| intraperitoneal/mouse | lowest published toxic dose: 4 gm/kg/8D- intermittent | Behavioral: Alteration of classical conditioning Behavioral: Change in psychophysiological tests | PSCHDL 176,50,2004 |
| intraperitoneal/mouse | lowest published toxic dose: 37.8 mg/kg/21D- intermittent | Behavioral: Change in motor activity (specific assay) Behavioral: Tolerance Behavioral: Alteration of classical conditioning | PSCHDL 192,39,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 12.6 mg/kg/21D- intermittent | Behavioral: Tolerance | PSCHDL 192,39,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 3 gm/kg/3D- intermittent | Cardiac: Change in force of contraction Nutritional and Gross Metabolic: Changes in: Ca Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TOLED5 233,267,2015 |
| intraperitoneal/mouse | lowest published toxic dose: 6.125 gm/kg/7D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | JOETD7 141,831,2012 |
| intraperitoneal/mouse | lowest published toxic dose: 14000 mg/kg/7D- intermittent | Behavioral: Change in motor activity (specific assay) | PSCHDL 197,361,2008 |
| intraperitoneal/mouse | lowest published toxic dose: 8000 mg/kg/4D- intermittent | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning | PSCHDL 195,103,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 13.2 gm/kg/6D- intermittent | Brain and Coverings: Other degenerative changes | NRTXDN 30,459,2009 |
| intraperitoneal/mouse | lowest published toxic dose: 26.4 gm/kg/6D- intermittent | Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NRTXDN 30,459,2009 |
| intraperitoneal/mouse | lowest published toxic dose: 16000 mg/kg/8D- intermittent | Behavioral: Change in motor activity (specific assay) | PSCHDL 201,249,2008 |
| intraperitoneal/mouse | lowest published toxic dose: 48000 mg/kg/8D- intermittent | Behavioral: Somnolence (general depressed activity) | PSCHDL 201,249,2008 |
| intraperitoneal/rat | lowest published toxic dose: 5400 mg/kg/2D- intermittent | Behavioral: Tolerance | PSCHDL 194,139,2007 |
| intraperitoneal/rat | lowest published toxic dose: 5 gm/kg/7D- intermittent | Behavioral: Alteration of classical conditioning | NETEEC 34,108,2012 |
| intraperitoneal/rat | lowest published toxic dose: 14 gm/kg/19D- intermittent | Behavioral: Tolerance Nutritional and Gross Metabolic: Body temperature decrease | BJMRDK 40,1517,2007 |
| intraperitoneal/rat | lowest published toxic dose: 16 gm/kg/19D- intermittent | Nutritional and Gross Metabolic: Body temperature decrease | BJMRDK 40,1517,2007 |
| intraperitoneal/rat | lowest published toxic dose: 3 gm/kg/3D- intermittent | Behavioral: Alteration of classical conditioning | PSCHDL 191,909,2007 |
| intraperitoneal/rat | lowest published toxic dose: 7000 mg/kg/7D- intermittent | Behavioral: Change in psychophysiological tests Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 29,23,2007 |
| intraperitoneal/rat | lowest published toxic dose: 7000 mg/kg/7D- intermittent | Behavioral: Change in psychophysiological tests | NETEEC 29,23,2007 |
| intraperitoneal/rat | lowest published toxic dose: 7000 mg/kg/7D- intermittent | Behavioral: Tolerance Behavioral: Change in psychophysiological tests | NETEEC 29,23,2007 |
| intraperitoneal/rat | lowest published toxic dose: 4.8 mg/kg/4D- intermittent | Behavioral: Change in motor activity (specific assay) | PSCHDL 160,48,2002 |
| oral/Dog | lowest published toxic dose: 560 mL/kg/10W- continuous | Brain and Coverings: Other degenerative changes Cardiac: Other changes Liver: Other changes | PSEBAA 128,1021,1968 |
| oral/guinea pig | lowest published toxic dose: 204 gm/kg/68D- continuous | Reproductive: Other effects on female | JPETAB 308,644,2004 |
| oral/guinea pig | lowest published toxic dose: 180 gm/kg/45D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | NETEEC 32,164,2010 |
| oral/hamster | lowest published toxic dose: 512 mg/kg/30D- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | CBCPAI 129,285,2001 |
| oral/hamster | lowest published toxic dose: 559 mg/kg/30D- continuous | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | CBCPAI 129,285,2001 |
| oral/human | lowest published toxic dose: 149 units/kg/4Y- intermittent | Skin: After systemic exposure: Dermatitis, other | BJDEAZ 155,195,2006 |
| oral/mammal (species unspecified) | lowest published toxic dose: 112000 mg/kg/28D- intermittent | Immunological Including Allergic: Decrease in cellular immune response | TOXID9 44,184,2005 |
| oral/man | lowest published toxic dose: 4623 gm/kg/12Y- intermittent | Brain and Coverings: Other degenerative changes | DADEDV 65,159,2002 |
| oral/monkey | lowest published toxic dose: 210 gm/kg/5W- intermittent | Liver: Fatty liver degeneration | JTSCDR 8,243,1983 |
| oral/monkey | lowest published toxic dose: 260 gm/kg/2Y- intermittent | Behavioral: Alteration of classical conditioning Behavioral: Aggression | PSCHDL 165,1,2002 |
| oral/monkey | lowest published toxic dose: 32.5 gm/kg/90D- intermittent | Cardiac: Change in rate | PSCHDL 192,183,2007 |
| oral/monkey | lowest published toxic dose: 13500 gm/kg/72W- intermittent | Liver: Fatty liver degeneration | HPV112 -,-,2008 |
| oral/mouse | lowest published toxic dose: 657000 mg/kg/90D- intermittent | Cardiac: Changes in heart weight Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | HPV112 -,-,2008 |
| oral/mouse | lowest published toxic dose: 25200 mg/kg/7D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV112 -,-,2008 |
| oral/mouse | lowest published toxic dose: 284.4 gm/kg/45D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Effect on Na-K pump | SIMEJ* 47,864,2006 |
| oral/mouse | lowest published toxic dose: 1344 gm/kg/8W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Lipids including transport | TXCYAC 252,64,2008 |
| oral/mouse | lowest published toxic dose: 84 gm/kg/5W- continuous | Cardiac: Cardiomyopathy including infarction Cardiac: Other changes Cardiac: Changes in heart weight | NSAPCC 375(Suppl 1),60,2007 |
| oral/mouse | lowest published toxic dose: 84 gm/kg/5W- continuous | Vascular: Relaxation (isolated tissue) | NSAPCC 375(Suppl 1),60,2007 |
| oral/mouse | lowest published toxic dose: 470220 mg/kg/51D- continuous | Musculoskeletal: Osteoporosis | TXAPA9 220,302,2007 |
| oral/mouse | lowest published toxic dose: 284.4 gm/kg/45D- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Endocrine: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | FCLPH* 20,129,2006 |
| oral/mouse | lowest published toxic dose: 72 mL/kg/4W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 46,1503,2008 |
| oral/mouse | lowest published toxic dose: 284.4 gm/kg/45D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Lipids including transport | HETOEA 22,149,2003 |
| oral/mouse | lowest published toxic dose: 95200 mg/kg/4W- intermittent | Behavioral: Food intake (animal) Behavioral: Fluid intake | NTPTR* TR-510 |
| oral/mouse | lowest published toxic dose: 78400 mg/kg/4W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | NTPTR* TR-510 |
| oral/mouse | lowest published toxic dose: 496000 mg/kg/80W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTPTR* TR-510 |
| oral/mouse | lowest published toxic dose: 2920000 mg/kg/2Y- intermittent | Liver: Other changes Liver: Tumors Liver: Changes in liver weight | NTPTR* TR-510 |
| oral/mouse | lowest published toxic dose: 5256000 mg/kg/2Y- intermittent | Liver: Tumors | NTPTR* TR-510 |
| oral/mouse | lowest published toxic dose: 35 gm/kg/5W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other proteins | TXCYAC 215,234,2005 |
| oral/mouse | lowest published toxic dose: 15000 mg/kg/2D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Other | TOXID9 60,41,2001 |
| oral/mouse | lowest published toxic dose: 24000 mL/kg/120D- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition | TOXID9 72,195,2003 |
| oral/mouse | lowest published toxic dose: 36000 mL/kg/180D- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOXID9 72,195,2003 |
| oral/mouse | lowest published toxic dose: 36000 mL/kg/180D- continuous | Liver: Other changes Nutritional and Gross Metabolic: Changes in: Fe Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOXID9 72,195,2003 |
| oral/mouse | lowest published toxic dose: 3500 gm/kg/10W- continuous | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | JPETAB 225,479,1983 |
| oral/mouse | lowest published toxic dose: 2100 gm/kg/5W- continuous | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | JPETAB 225,479,1983 |
| oral/mouse | lowest published toxic dose: 1750 gm/kg/5W- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | JPETAB 225,479,1983 |
| oral/mouse | lowest published toxic dose: 448 gm/kg/4W- continuous | Behavioral: Fluid intake | NTIS** #PB85118651 |
| oral/mouse | lowest published toxic dose: 1120 gm/kg/4W- intermittent | Blood: Changes in spleen Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOSCF2 73,72,2003 |
| oral/mouse | lowest published toxic dose: 98800 mg/kg/13D- continuous | Behavioral: Withdrawal Behavioral: Alteration of classical conditioning | EJPHAZ 499,285,2004 |
| oral/mouse | lowest published toxic dose: 480000 mg/kg/60D- continuous | Gastrointestinal: Changes in structure or function of exocrine pancreas | TOXID9 44,318,2005 |
| oral/mouse | lowest published toxic dose: 396 gm/kg/198D- continuous | Liver: Other changes Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | TOXID9 78,14,2004 |
| oral/mouse | lowest published toxic dose: 396 gm/kg/198D- continuous | Liver: Other changes Nutritional and Gross Metabolic: Changes in: Fe Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOXID9 78,14,2004 |
| oral/mouse | lowest published toxic dose: 295.2 gm/kg/10W- intermittent | Cardiac: Cardiomyopathy including infarction Cardiac: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase | TOXID9 78,167,2004 |
| oral/mouse | lowest published toxic dose: 40 gm/kg/8D- intermittent | Liver: Liver function tests impaired Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FCTOD7 48,1632,2010 |
| oral/mouse | lowest published toxic dose: 194 gm/kg/6W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JPETAB 331,23,2009 |
| oral/mouse | lowest published toxic dose: 298 gm/kg/8W- continuous | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JPETAB 331,23,2009 |
| oral/mouse | lowest published toxic dose: 298 gm/kg/8W- continuous | Behavioral: Food intake (animal) | JPETAB 331,23,2009 |
| oral/mouse | lowest published toxic dose: 2070 gm/kg/0.5Y- continuous | Liver: Other changes Endocrine: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | JPETAB 331,23,2009 |
| oral/mouse | lowest published toxic dose: 2070 gm/kg/0.5Y- continuous | Liver: Other changes Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase | JPETAB 331,23,2009 |
| oral/mouse | lowest published toxic dose: 672000 mg/kg/12W- continuous | Brain and Coverings: Other degenerative changes Cardiac: Changes in heart weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOLED5 187,149,2009 |
| oral/mouse | lowest published toxic dose: 1440 gm/kg/90D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | HPV228 -,-,2001 |
| oral/mouse | lowest published toxic dose: 28000 mg/kg/7D- continuous | Liver: Other changes | TOXID9 -,339,2009 |
| oral/mouse | lowest published toxic dose: 56000 mg/kg/7D- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TOXID9 -,339,2009 |
| oral/mouse | lowest published toxic dose: 25200 mg/kg/7D- intermittent | Behavioral: Food intake (animal) Lung, Thorax, or Respiration: Respiratory depression Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV228 -,-,2001 |
| oral/mouse | lowest published toxic dose: 16665 µL/kg/30D- intermittent | Liver: Other changes Immunological Including Allergic: Decrease in cellular immune response Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 53,286,2013 |
| oral/mouse | lowest published toxic dose: 33330 µL/kg/30D- intermittent | Liver: Other changes Blood: Changes in spleen Immunological Including Allergic: Decrease in cellular immune response | FCTOD7 53,286,2013 |
| oral/mouse | lowest published toxic dose: 15 gm/kg/2D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Liver: Fatty liver degeneration Liver: Hepatitis (hepatocellular necrosis), zonal | TXCYAC 314,193,2013 |
| oral/mouse | lowest published toxic dose: 15 gm/kg/2D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Liver: Fatty liver degeneration Biochemical: Metabolism (intermediary): Other | TXCYAC 314,193,2013 |
| oral/mouse | lowest published toxic dose: 18 gm/kg/24D- intermittent | Liver: Other changes Liver: Changes in liver weight | TXCYAC 390,53,2017 |
| oral/mouse | lowest published toxic dose: 1041.6 mL/kg/21D- continuous | Liver: Fatty liver degeneration Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TXCYAC 379,12,2017 |
| oral/mouse | lowest published toxic dose: 1041.6 mL/kg/21D- continuous | Liver: Fatty liver degeneration | TXCYAC 379,12,2017 |
| oral/mouse | lowest published toxic dose: 20 gm/kg/2D- intermittent | Liver: Liver function tests impaired Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | FCTOD7 98,119,2016 |
| oral/mouse | lowest published toxic dose: 12 gm/kg/2D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JOETD7 173,231,2015 |
| oral/mouse | lowest published toxic dose: 54 gm/kg/9D- intermittent | Liver: Liver function tests impaired Liver: Hepatitis (hepatocellular necrosis), zonal Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | JOETD7 173,231,2015 |
| oral/mouse | lowest published toxic dose: 3040 mL/kg/152D- continuous | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation Endocrine: Differential effect of sex or castration on observed toxicity | TXCYAC 311,27,2013 |
| oral/mouse | lowest published toxic dose: 1022.4 mL/kg/213D- continuous | Liver: Fatty liver degeneration | TXCYAC 311,87,2013 |
| oral/mouse | lowest published toxic dose: 1022.4 mL/kg/213D- continuous | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 311,87,2013 |
| oral/mouse | lowest published toxic dose: 585.6 mL/kg/122D- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TXCYAC 311,87,2013 |
| oral/mouse | lowest published toxic dose: 585.6 mL/kg/122D- continuous | Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TXCYAC 311,87,2013 |
| oral/mouse | lowest published toxic dose: 480 gm/kg/12W- continuous | Immunological Including Allergic: Increased immune response | TXAPA9 282,139,2015 |
| oral/mouse | lowest published toxic dose: 15 gm/kg/2D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | JOETD7 136,168,2011 |
| oral/mouse | lowest published toxic dose: 15 gm/kg/2D- intermittent | Liver: Fatty liver degeneration Liver: Other changes Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TXCYAC 276,64,2010 |
| oral/mouse | lowest published toxic dose: 44 gm/kg/11D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FCTOD7 50,1986,2012 |
| oral/mouse | lowest published toxic dose: 56 gm/kg/14D- intermittent | Liver: Fatty liver degeneration Liver: Liver function tests impaired Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FCTOD7 50,1986,2012 |
| oral/mouse | lowest published toxic dose: 25 ml/kg/2D- intermittent | Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | PYTOEY 27,23,2017 |
| oral/mouse | lowest published toxic dose: 18 gm/kg/2D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | FCTOD7 50,2964,2012 |
| oral/rat | lowest published toxic dose: 300 gm/kg/60D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Effect on Na-K pump | NETEEC 63,60,2017 |
| oral/rat | lowest published toxic dose: 1386 gm/kg/24W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FCTOD7 50,1992,2012 |
| oral/rat | lowest published toxic dose: 168 gm/kg/4W- intermittent | Liver: Fatty liver degeneration Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 50,2149,2012 |
| oral/rat | lowest published toxic dose: 126 gm/kg/3W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTOD7 50,2149,2012 |
| oral/rat | lowest published toxic dose: 112 gm/kg/4W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 50,2149,2012 |
| oral/rat | lowest published toxic dose: 15 gm/kg/2D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TXCYAC 279,108,2011 |
| oral/rat | lowest published toxic dose: 369.6 gm/kg/28D- continuous | Cardiac: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Metabolism (intermediary): Lipids including transport | TIHEEC 25,385,2009 |
| oral/rat | lowest published toxic dose: 114 gm/kg/4W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | FCTOD7 50,135,2012 |
| oral/rat | lowest published toxic dose: 360 gm/kg/90D- intermittent | Liver: Liver function tests impaired Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Effect on mitochondrial function | FCTOD7 50,1194,2012 |
| oral/rat | lowest published toxic dose: 217 gm/kg/4W- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Liver function tests impaired Liver: Changes in liver weight | FCTOD7 50,1377,2012 |
| oral/rat | lowest published toxic dose: 152 gm/kg/4W- intermittent | JOETD7 146,250,2013 | |
| oral/rat | lowest published toxic dose: 68 gm/kg/2W- intermittent | JOETD7 146,250,2013 | |
| oral/rat | lowest published toxic dose: 31.5 gm/kg/63D- intermittent | TXCYAC 330,1,2015 | |
| oral/rat | lowest published toxic dose: 1224 gm/kg/26W- continuous | Brain and Coverings: Other degenerative changes | NRTXDN 54,153,2016 |
| oral/rat | lowest published toxic dose: 1.42 gm/kg/3D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | FCTOD7 105,44,2017 |
| oral/rat | lowest published toxic dose: 106.56 mL/kg/28D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Behavioral: Withdrawal | PYTOEY 22,1000,2015 |
| oral/rat | lowest published toxic dose: 16 gm/kg/5D- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Lipids including transport | CTOXAO 47,730,2009 |
| oral/rat | lowest published toxic dose: 1386 mg/kg/24W- intermittent | Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOLED5 217,102,2013 |
| oral/rat | lowest published toxic dose: 522 gm/kg/90D- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | HPV228 -,-,2001 |
| oral/rat | lowest published toxic dose: 360 gm/kg/90D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | HPV228 -,-,2001 |
| oral/rat | lowest published toxic dose: 540000 mg/kg/45D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,237,2009 |
| oral/rat | lowest published toxic dose: 112000 mg/kg/4W- continuous | Endocrine: Other changes | TOXID9 -,281,2009 |
| oral/rat | lowest published toxic dose: 963.2 gm/kg/16W- continuous | Behavioral: Food intake (animal) Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTPAE7 22,65,2009 |
| oral/rat | lowest published toxic dose: 300 gm/kg/12W- continuous | Liver: Other changes Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation Biochemical: Metabolism (intermediary): Other proteins | CBINA8 180,31,2009 |
| oral/rat | lowest published toxic dose: 336 gm/kg/12W- continuous | Vascular: BP elevation not characterized in autonomic section Vascular: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | HETOEA 26,427,2007 |
| oral/rat | lowest published toxic dose: 56.25 gm/kg/90D- continuous | Gastrointestinal: Gastritis Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other proteins | JAPTO* 28,591,2008 |
| oral/rat | lowest published toxic dose: 175 mL/kg/10W- intermittent | Brain and Coverings: Other degenerative changes Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Changes in testicular weight | BCLPT* 101,320,2007 |
| oral/rat | lowest published toxic dose: 213.15 gm/kg/15D- continuous | Behavioral: Tremor Behavioral: Change in motor activity (specific assay) Behavioral: Withdrawal | FCLPH* -,1,2006 |
| oral/rat | lowest published toxic dose: 355.5 gm/kg/45D- intermittent | Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Renal function tests depressed | FCLPH* 21,355,2007 |
| oral/rat | lowest published toxic dose: 300 gm/kg/60D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases Biochemical: Metabolism (intermediary): Other proteins | FCLPH* 21,507,2007 |
| oral/rat | lowest published toxic dose: 300 gm/kg/60D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Effect on Na-K pump | FCTOD7 47,1958,2009 |
| oral/rat | lowest published toxic dose: 1512 gm/kg/90D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 47,2666,2009 |
| oral/rat | lowest published toxic dose: 96 gm/kg/16D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 31,303,2009 |
| oral/rat | lowest published toxic dose: 42 gm/kg/7D- intermittent | Behavioral: Alteration of classical conditioning Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 32,158,2010 |
| oral/rat | lowest published toxic dose: 355.5 gm/kg/9W- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on mitochondrial function | FTRPAE 81,1239,2010 |
| oral/rat | lowest published toxic dose: 70 gm/kg/10W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | PAINDB 145,129,2009 |
| oral/rat | lowest published toxic dose: 355.5 gm/kg/45D- intermittent | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other | FCLPH* 21,621,2007 |
| oral/rat | lowest published toxic dose: 469 gm/kg/12W- intermittent | Gastrointestinal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Other proteins | JPETAB 329,952,2009 |
| oral/rat | lowest published toxic dose: 168 gm/kg/12W- intermittent | Cardiac: Other changes Vascular: BP elevation not characterized in autonomic section Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOXID9 78,168,2004 |
| oral/rat | lowest published toxic dose: 270 gm/kg/90D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Other proteins | ARTODN 78,276,2004 |
| oral/rat | lowest published toxic dose: 54 gm/kg/9D- intermittent | Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal: Other changes | TOXID9 78,280,2004 |
| oral/rat | lowest published toxic dose: 54 gm/kg/9D- intermittent | Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal: Osteoporosis | TOXID9 78,280,2004 |
| oral/rat | lowest published toxic dose: 273000 mg/kg/21D- continuous | Musculoskeletal: Osteoporosis | TOXID9 44,354,2005 |
| oral/rat | lowest published toxic dose: 1428000 mg/kg/14D- continuous | Behavioral: Fluid intake Liver: Other changes Nutritional and Gross Metabolic: Conditioned vitamin deficiency | DCTODJ 26,191,2003 |
| oral/rat | lowest published toxic dose: 875 gm/kg/35D- continuous | Liver: Liver function tests impaired | TXAPA9 197,206,2004 |
| oral/rat | lowest published toxic dose: 42 gm/kg/7D- intermittent | Behavioral: Change in psychophysiological tests | NETEEC 27,55,2005 |
| oral/rat | lowest published toxic dose: 25000 mg/kg/5D- intermittent | Behavioral: Alteration of operant conditioning | PSCHDL 171,204,2004 |
| oral/rat | lowest published toxic dose: 420 gm/kg/10W- intermittent | Brain and Coverings: Other degenerative changes Musculoskeletal: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | TXCYAC 199,161,2004 |
| oral/rat | lowest published toxic dose: 48000 mg/kg/12W- intermittent | Cardiac: Other changes Vascular: BP elevation not characterized in autonomic section Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOXID9 44,46,2005 |
| oral/rat | lowest published toxic dose: 41.6 gm/kg/4D- continuous | Behavioral: Analgesia | LIFSAK 73,3351,2003 |
| oral/rat | lowest published toxic dose: 130 gm/kg/10D- continuous | Behavioral: Tolerance Behavioral: Withdrawal | LIFSAK 73,3351,2003 |
| oral/rat | lowest published toxic dose: 36000 mg/kg/6D- continuous | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning Behavioral: Alteration of operant conditioning | NETEEC 26,35,2004 |
| oral/rat | lowest published toxic dose: 8 gm/kg/10D- intermittent | Behavioral: Abuse | PSCHDL 168,208,2003 |
| oral/rat | lowest published toxic dose: 300 gm/kg/12W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FCTOD7 42,429,2004 |
| oral/rat | lowest published toxic dose: 27000 mg/kg/6D- intermittent | Brain and Coverings: Other degenerative changes | NETEEC 26,353,2004 |
| oral/rat | lowest published toxic dose: 31500 mg/kg/6D- intermittent | Cardiac: Change in rate | NETEEC 26,451,2004 |
| oral/rat | lowest published toxic dose: 108 gm/kg/4W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Liver: Other changes | FCTOD7 42,2045,2004 |
| oral/rat | lowest published toxic dose: 10400 mg/kg/13D- intermittent | Endocrine: Estrogenic | BJCAAI 90,2225,2004 |
| oral/rat | lowest published toxic dose: 875 mg/kg/10W- intermittent | Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Effect on Na-K pump | LIFSAK 71,2881,2002 |
| oral/rat | lowest published toxic dose: 21000 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | BJPCBM 138,1376,2003 |
| oral/rat | lowest published toxic dose: 15 gm/kg/15D- intermittent | Endocrine: Androgenic | REPTED 17,641,2003 |
| oral/rat | lowest published toxic dose: 30 gm/kg/15D- intermittent | Endocrine: Estrogenic | REPTED 17,641,2003 |
| oral/rat | lowest published toxic dose: 90 gm/kg/15D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | REPTED 17,641,2003 |
| oral/rat | lowest published toxic dose: 65 gm/kg/13D- continuous | Endocrine: Other changes | ENDOAO 138,389,1997 |
| oral/rat | lowest published toxic dose: 900 mL/kg/62D- continuous | Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 24,275,2002 |
| oral/rat | lowest published toxic dose: 240000 mg/kg/30D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | FATOAO 47,82,1984 |
| oral/rat | lowest published toxic dose: 62.5 gm/kg/5D- continuous | Brain and Coverings: Other degenerative changes Endocrine: Effect on menstrual cycle Endocrine: Change in gonadotropins | BIREBV 37,1089,1987 |
| oral/rat | lowest published toxic dose: 62.5 gm/kg/6D- continuous | Endocrine: Effect on menstrual cycle | BIREBV 37,1089,1987 |
| oral/rat | lowest published toxic dose: 45 gm/kg/30D- intermittent | Behavioral: Change in psychophysiological tests | GISAAA -,64,1993 |
| oral/rat | lowest published toxic dose: 1825 gm/kg/1Y- continuous | Liver: Fatty liver degeneration Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | DDSCDJ 25,587,1980 |
| oral/rat | lowest published toxic dose: 19 gm/kg/21D- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOLED5 12,265,1982 |
| oral/rat | lowest published toxic dose: 280 gm/kg/5W- intermittent | Cardiac: Changes in heart weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data: Changes in testicular weight | JTSCDR 8,243,1983 |
| oral/rat | lowest published toxic dose: 851 gm/kg/10W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | APTOA6 38,260,1976 |
| oral/rat | lowest published toxic dose: 7 mL/kg/7D- intermittent | Liver: Other changes Biochemical: Effect on specific coenzyme: B vitamins including folate | JDGRAX 10(1-2),25,1978 |
| oral/rat | lowest published toxic dose: 6300 mg/kg/9W- intermittent | Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | GISAAA 64(1),46,1999 |
| oral/rat | lowest published toxic dose: 8 mg/kg/4D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 72,127,2003 |
| oral/rat | lowest published toxic dose: 9660 gm/kg/56W- intermittent | Cardiac: Change in resting or action potential Endocrine: Differential effect of sex or castration on observed toxicity Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 189,196,2003 |
| oral/rat | lowest published toxic dose: 240 gm/kg/60D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | TOXIA6 42,367,2003 |
| oral/rat | lowest published toxic dose: 12 gm/kg/20D- continuous | Behavioral: Tolerance Behavioral: Alteration of operant conditioning | EJPHAZ 477,129,2003 |
| oral/rat | lowest published toxic dose: 210 gm/kg/10W- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 41,1551,2003 |
| oral/rat | lowest published toxic dose: 4500 gm/kg/24W- intermittent | Behavioral: Food intake (animal) Cardiac: Change in force of contraction Endocrine: Differential effect of sex or castration on observed toxicity | TXAPA9 179,111,2002 |
| oral/rat | lowest published toxic dose: 84 gm/kg/4W- intermittent | Behavioral: Food intake (animal) Endocrine: Other changes Nutritional and Gross Metabolic: Other changes | BJMRDK 36,125,2003 |
| oral/rat | lowest published toxic dose: 14 gm/kg/7D- intermittent | Brain and Coverings: Other degenerative changes | BJMRDK 36,503,2003 |
| oral/rat | lowest published toxic dose: 28 gm/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | BJMRDK 36,503,2003 |
| oral/rat | lowest published toxic dose: 35000 mg/kg/7D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | EKFAE9 59,44,1996 |
| oral/rat | lowest published toxic dose: 115000 mg/kg/23D- intermittent | Behavioral: Alteration of classical conditioning | EKFAE9 59,44,1996 |
| oral/rat | lowest published toxic dose: 67.5 mg/kg/15D- continuous | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Xanthine, purine or nucleotides including urate Biochemical: Metabolism (intermediary): Other proteins | JPETAB 296,857,2001 |
| oral/rat | lowest published toxic dose: 93.8 mL/kg/2W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport | JJATDK 22,207,2002 |
| oral/rat | lowest published toxic dose: 882 gm/kg/75D- intermittent | Musculoskeletal: Other changes | JPETAB 301,1132,2002 |
| oral/rat | lowest published toxic dose: 72 gm/kg/7D- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | TOXID9 72,315,2003 |
| oral/rat | lowest published toxic dose: 908 mg/kg/4W- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | JAPTO* 22,207,2002 |
| oral/rat | lowest published toxic dose: 1372 gm/kg/20W- continuous | Behavioral: Food intake (animal) Vascular: Regional or general arteriolar constriction Vascular: Other changes | CEXPB9 29,707,2002 |
| oral/rat | lowest published toxic dose: 60 gm/kg/30D- intermittent | Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | BJMRDK 37,1839,2004 |
| oral/rat | lowest published toxic dose: 50 gm/kg/10D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Other | PSCHDL 182,58,2005 |
| oral/rat | lowest published toxic dose: 600000 mg/kg/75D- intermittent | Musculoskeletal: Other changes Nutritional and Gross Metabolic: Changes in: Ca | TOXID9 60,388,2001 |
| oral/rat | lowest published toxic dose: 354000 mg/kg/30D- intermittent | Musculoskeletal: Other changes Nutritional and Gross Metabolic: Changes in: Ca | TOXID9 60,388,2001 |
| oral/rat | lowest published toxic dose: 462000 mg/kg/6W- intermittent | Musculoskeletal: Other changes | TOXID9 60,388,2001 |
| oral/rat | lowest published toxic dose: 31.5 gm/kg/6D- intermittent | Behavioral: Change in psychophysiological tests Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 27,815,2005 |
| oral/rat | lowest published toxic dose: 126 gm/kg/12W- continuous | Vascular: BP lowering not characterized in autonomic section | JPETAB 306,271,2003 |
| oral/rat | lowest published toxic dose: 400 gm/kg/8W- intermittent | Brain and Coverings: Recordings from specific areas of CNS Behavioral: Withdrawal | JPETAB 307,566,2003 |
| oral/rat | lowest published toxic dose: 6650 mL/kg/10W- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | CBCPAI 131,161,2002 |
| oral/rat | lowest published toxic dose: 52800 mg/kg/6D- intermittent | Behavioral: Convulsions or effect on seizure threshold Behavioral: Withdrawal Gastrointestinal: Other changes | TOVEFN (5),13,2002 |
| oral/rat | lowest published toxic dose: 52800 mg/kg/6D- intermittent | Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TOVEFN (5),13,2002 |
| oral/rat | lowest published toxic dose: 52800 mg/kg/6D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOVEFN (5),13,2002 |
| oral/rat | lowest published toxic dose: 30 gm/kg/3D- continuous | Biochemical: Effect on specific coenzyme: Proportion of isoenzymes Liver: Other changes | ACPSI* 24,831,2003 |
| oral/rat | lowest published toxic dose: 195 gm/kg/30D- continuous | Brain and Coverings: Other degenerative changes | ACPSI* 24,930,2003 |
| oral/rat | lowest published toxic dose: 420000 mg/kg/12W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Other changes | TXCYAC 219,11,2006 |
| oral/rat | lowest published toxic dose: 210 gm/kg/6W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | BPBLEO 27,1636,2004 |
| oral/rat | lowest published toxic dose: 315 gm/kg/9W- intermittent | Vascular: BP elevation not characterized in autonomic section Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | CEXPB9 33,183,2006 |
| oral/rat | lowest published toxic dose: 151.2 gm/kg/21D- intermittent | Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) Behavioral: Abuse | FCLPH* 18,693,2004 |
| oral/rat | lowest published toxic dose: 50.4 gm/kg/7D- continuous | Brain and Coverings: Other degenerative changes Behavioral: Abuse | BJPCBM 143,455,2004 |
| oral/rat | lowest published toxic dose: 300000 mg/kg/12W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Conditioned vitamin deficiency | FCTOD7 45,1478,2007 |
| oral/rat | lowest published toxic dose: 216000 mg/kg/90D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 45,1333,2007 |
| oral/rat | lowest published toxic dose: 355.5 gm/kg/45D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FCTOD7 46,1627,2008 |
| oral/rat | lowest published toxic dose: 1814.4 gm/kg/12W- continuous | Vascular: Measurement of regional blood flow Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 46,1940,2008 |
| oral/rat | lowest published toxic dose: 980 gm/kg/8W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | FCTOD7 46,1378,2008 |
| oral/rat | lowest published toxic dose: 140 mL/kg/2W- continuous | Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | PHREP* 58,876,2006 |
| oral/rat | lowest published toxic dose: 980 gm/kg/14W- intermittent | Behavioral: Food intake (animal) Cardiac: Cardiac output Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney | JTEHF8 68,797,2005 |
| oral/rat | lowest published toxic dose: 1050 gm/kg/70D- intermittent | Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins | ALCOH* 41,591,2007 |
| oral/rat | lowest published toxic dose: 188 gm/kg/25D- intermittent | Liver: Fatty liver degeneration Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport | INJPD2 39,43,2007 |
| oral/rat | lowest published toxic dose: 665 mL/kg/6W- continuous | Vascular: Contraction (isolated tissue) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BJPCBM 153,468,2008 |
| oral/rat | lowest published toxic dose: 665 mL/kg/6W- continuous | Vascular: Contraction (isolated tissue) Vascular: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | BJPCBM 153,468,2008 |
| oral/rat | lowest published toxic dose: 324000 mg/kg/90D- intermittent | Liver: Fatty liver degeneration Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | HPV112 -,-,2008 |
| oral/rat | lowest published toxic dose: 355.5 gm/kg/45D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport | SIMEJ* 48,311,2007 |
| oral/rat | lowest published toxic dose: 13920 mg/kg/3D- intermittent | Behavioral: Alteration of classical conditioning | NETEEC 30,256,2008 |
| oral/rat | lowest published toxic dose: 15000 mg/kg/3D- intermittent | Brain and Coverings: Changes in brain weight | NETEEC 30,228,2008 |
| oral/rat | lowest published toxic dose: 21 gm/kg/3W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | FCTOD7 46,2658,2008 |
| oral/rat | lowest published toxic dose: 252000 mg/kg/90D- intermittent | Endocrine: Changes in thymus weight | HPV112 -,-,2008 |
| oral/rat | lowest published toxic dose: 2016 gm/kg/36W- intermittent | Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV112 -,-,2008 |
| oral/rat | lowest published toxic dose: 35 gm/kg/1W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | HPV112 -,-,2008 |
| parenteral/rat | lowest published toxic dose: 336000 mg/kg/4W- intermittent | Musculoskeletal: Osteoporosis Musculoskeletal: Other changes | TOXID9 -,193,2009 |
| parenteral/rat | lowest published toxic dose: 50000 mg/kg/50D- intermittent | Liver: Hepatitis (hepatocellular necrosis), zonal Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | TOXID9 44,15,2005 |
| subcutaneous/mouse | lowest published toxic dose: 5000 mg/kg/20D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | FCTOD7 44,588,2006 |
| unreported route/monkey | lowest published toxic dose: 261000 mg/kg/90D- intermittent | Endocrine: Change in LH Related to Chronic Data: Changes in ovarian weight Related to Chronic Data: Changes in uterine weight | HPV112 -,-,2008 |
| unreported route/mouse | lowest published toxic dose: 8 gm/kg/4D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTSCDR 32,421,2007 |
| unreported route/mouse | lowest published toxic dose: 16 gm/kg/8D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTSCDR 32,421,2007 |
| unreported route/mouse | lowest published toxic dose: 16 gm/kg/8D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTSCDR 32,421,2007 |
| unreported route/rat | lowest published toxic dose: 20 gm/kg/10D- intermittent | Behavioral: Alteration of classical conditioning | NETEEC 32,503,2010 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-short term exposure limit 1000 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 44,35,1988 |
| TOXICOLOGY REVIEW | IRXPAT 11,177,1972 | |
| TOXICOLOGY REVIEW | AEMBAP 56,291,1975 | |
| TOXICOLOGY REVIEW | AICMA2 44,874,1974 | |
| TOXICOLOGY REVIEW | MAEPBU 6,81,1972 | |
| TOXICOLOGY REVIEW | FCTXAV 8,433,1970 | |
| TOXICOLOGY REVIEW | CLCHAU 19,361,1973 | |
| TOXICOLOGY REVIEW | PAREAQ 4,1,1952 | |
| TOXICOLOGY REVIEW | FNSCA6 2,67,1973 | |
| TOXICOLOGY REVIEW | SCIEAS 209,353,1980 | |
| TOXICOLOGY REVIEW | JAMAAP 235,1458,1976 | |
| TOXICOLOGY REVIEW | TJADAB 21,157,1980 | |
| TOXICOLOGY REVIEW | TJADAB 16,53,1977 | |
| TOXICOLOGY REVIEW | NEJMAG 342,186,2000 | |
| TOXICOLOGY REVIEW | JFSCAS 45,7,2000 | |
| TOXICOLOGY REVIEW | TOLED5 127,197,2002 | |
| TOXICOLOGY REVIEW | TOLED5 134,3,2002 | |
| TOXICOLOGY REVIEW | TOLED5 140-141,155,2003 | |
| TOXICOLOGY REVIEW | TOLED5 140-141,161,2003 | |
| TOXICOLOGY REVIEW | PSCHDL 174,539,2004 | |
| TOXICOLOGY REVIEW | ARPTDI 44,27,2004 | |
| TOXICOLOGY REVIEW | ARPTDI 44,87,2004 | |
| TOXICOLOGY REVIEW | REPTED 19,421,2005 | |
| TOXICOLOGY REVIEW | JKMSEH 17,236,2002 | |
| TOXICOLOGY REVIEW | TPHSDY 23,519,2002 | |
| TOXICOLOGY REVIEW | CRTXB2 33,407,2003 | |
| TOXICOLOGY REVIEW | PSCHDL 172,352,2004 | |
| TOXICOLOGY REVIEW | PBBHAU 55,501,1996 | |
| TOXICOLOGY REVIEW | TPHSDY 24,55,2003 | |
| TOXICOLOGY REVIEW | TPHSDY 24,41,2003 | |
| TOXICOLOGY REVIEW | TPHSDY 24,266,2003 | |
| TOXICOLOGY REVIEW | TPHSDY 24,151,2003 | |
| TOXICOLOGY REVIEW | TPHSDY 24,456,2003 | |
| TOXICOLOGY REVIEW | EMMUEG 45,271,2005 | |
| TOXICOLOGY REVIEW | JAPTO* 23,289,2003 | |
| TOXICOLOGY REVIEW | REPTED 22,196,2006 | |
| TOXICOLOGY REVIEW | MUREAV 613,17,2006 | |
| TOXICOLOGY REVIEW | NETOX* 26,521,2005 | |
| TOXICOLOGY REVIEW | EJCCER 41,956,2005 | |
| TOXICOLOGY REVIEW | JPETAB 312,875,2005 | |
| TOXICOLOGY REVIEW | MUTAEX 19,251,2004 | |
| TOXICOLOGY REVIEW | EJPHAZ 526,113,2005 | |
| TOXICOLOGY REVIEW | EJPHAZ 526,163,2005 | |
| TOXICOLOGY REVIEW | JOPSEQ 20,143,2006 | |
| TOXICOLOGY REVIEW | AINCM* 7,63,2006 | |
| TOXICOLOGY REVIEW | BIPHEX 58,84,2004 | |
| TOXICOLOGY REVIEW | CHHSA* 9,6,2002 | |
| TOXICOLOGY REVIEW | ENTOX* -,62,2005 | |
| TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
| TOXICOLOGY REVIEW | MUREAV 628,67,2007 | |
| TOXICOLOGY REVIEW | JPETAB 318,1,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,742,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,263,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,387,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | NETEEC 29,425,2007 | |
| TOXICOLOGY REVIEW | ALCOH* 41,399,2007 | |
| TOXICOLOGY REVIEW | ALCOH* 41,479,2007 | |
| TOXICOLOGY REVIEW | MUREAV 654,114,2008 | |
| TOXICOLOGY REVIEW | PHREP* 57,23,2005 | |
| TOXICOLOGY REVIEW | PSBUL* 35,89,2001 | |
| TOXICOLOGY REVIEW | PSBUL* 35,66,2001 | |
| TOXICOLOGY REVIEW | PSBUL* 37,64,2003 | |
| TOXICOLOGY REVIEW | JTPAE7 19,111,2006 | |
| TOXICOLOGY REVIEW | REPTED 23,125,2007 | |
| TOXICOLOGY REVIEW | ITODC* -,327,2004 | |
| TOXICOLOGY REVIEW | HUTOX* -,493,1996 | |
| TOXICOLOGY REVIEW | HUTOX* -,577,1996 | |
| TOXICOLOGY REVIEW | HUTOX* -,623,1996 | |
| TOXICOLOGY REVIEW | TPHSDY 29,109,2008 | |
| TOXICOLOGY REVIEW | PTPAD4 113,229,2007 | |
| TOXICOLOGY REVIEW | PTPAD4 116,306,2007 | |
| TOXICOLOGY REVIEW | AGVBE* 8,155,2003 | |
| TOXICOLOGY REVIEW | BPRCR* 17,877,2003 | |
| TOXICOLOGY REVIEW | AEMED3 53,439,2009 | |
| TOXICOLOGY REVIEW | BLREV* 3,71,1989 | |
| TOXICOLOGY REVIEW | BLREV* 4,226,1990 | |
| TOXICOLOGY REVIEW | COCPH* -,701,2008 | |
| TOXICOLOGY REVIEW | HETOEA 26,251,2007 | |
| TOXICOLOGY REVIEW | DERCL* 27,289,2009 | |
| TOXICOLOGY REVIEW | MUREAV 682,94,2009 | |
| TOXICOLOGY REVIEW | ARTODN 83,519,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 22,91,2007 | |
| TOXICOLOGY REVIEW | PYTOEY 16,638,2009 | |
| TOXICOLOGY REVIEW | NEUCL* 15,711,1997 | |
| TOXICOLOGY REVIEW | NCLNA* 16,503,1998 | |
| TOXICOLOGY REVIEW | NEUCL* 18,215,2000 | |
| TOXICOLOGY REVIEW | NEUCL* 18,695,2000 | |
| TOXICOLOGY REVIEW | NCLNA* 16,107,1998 | |
| TOXICOLOGY REVIEW | NEUCL* 23,321,2005 | |
| TOXICOLOGY REVIEW | NEUCL* 23,377,2005 | |
| TOXICOLOGY REVIEW | NEUCL* 23,397,2005 | |
| TOXICOLOGY REVIEW | NBREV* 5,1,1981 | |
| TOXICOLOGY REVIEW | OSMPR* 103,e20,2007 | |
| TOXICOLOGY REVIEW | NETEEC 32,4,2010 | |
| TOXICOLOGY REVIEW | NTAPM* -,265,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,617,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,641,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,711,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,727,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,753,1995 | |
| TOXICOLOGY REVIEW | FCLPH* 22(Suppl 1),82,2008 | |
| TOXICOLOGY REVIEW | TOVEFN -,6,2010 | |
| TOXICOLOGY REVIEW | NBREV* 11,107,1987 | |
| TOXICOLOGY REVIEW | MUTAEX 26,231,2011 | |
| TOXICOLOGY REVIEW | REPTED 31,319,2011 | |
| TOXICOLOGY REVIEW | FCLPH* 23(Suppl 1),51,2009 | |
| TOXICOLOGY REVIEW | MUREAV 727,55,2011 | |
| TOXICOLOGY REVIEW | MUREAV 723,77,2011 | |
| TOXICOLOGY REVIEW | REPTED 32,235,2011 | |
| TOXICOLOGY REVIEW | NRTXDN 31,562,2010 | |
| TOXICOLOGY REVIEW | MUREAV 728,88,2011 | |
| TOXICOLOGY REVIEW | MUREAV 728,118,2011 | |
| TOXICOLOGY REVIEW | MUREAV 717,67,2011 | |
| TOXICOLOGY REVIEW | REPTED 35,165,2013 | |
| TOXICOLOGY REVIEW | NRTXDN 32,563,2011 | |
| TOXICOLOGY REVIEW | NRTXDN 33,605,2012 | |
| TOXICOLOGY REVIEW | NRTXDN 33,530,2012 | |
| TOXICOLOGY REVIEW | MUTAEX 27,275,2012 | |
| TOXICOLOGY REVIEW | MUREAV 741-742,44,2013 | |
| TOXICOLOGY REVIEW | MUREAV 744,8,2012 | |
| TOXICOLOGY REVIEW | EMMUEG 55,77,2014 | |
| TOXICOLOGY REVIEW | TOLED5 198,100,2010 | |
| TOXICOLOGY REVIEW | MUREAV 764-765,46,2014 | |
| TOXICOLOGY REVIEW | NETEEC 33,608,2011 | |
| TOXICOLOGY REVIEW | MUREAV 762,37,2014 | |
| TOXICOLOGY REVIEW | MUREAV 762,76,2014 | |
| TOXICOLOGY REVIEW | MUREAV 733,61,2012 | |
| TOXICOLOGY REVIEW | TOLED5 222,171,2013 | |
| TOXICOLOGY REVIEW | MUREAV 786-788,14,2015 | |
| TOXICOLOGY REVIEW | MUREAV 777,91,2015 | |
| TOXICOLOGY REVIEW | REPTED 58,252,2015 | |
| TOXICOLOGY REVIEW | MUREAV 767,23,2016 | |
| TOXICOLOGY REVIEW | NETEEC 44,30,2014 | |
| TOXICOLOGY REVIEW | MUREAV 768,53,2016 | |
| TOXICOLOGY REVIEW | FCTOD7 86,298,2015 | |
| TOXICOLOGY REVIEW | FCTOD7 86,309,2015 | |
| TOXICOLOGY REVIEW | TXCYAC 325,74,2014 | |
| TOXICOLOGY REVIEW | NETEEC 52,25,2015 | |
| TOXICOLOGY REVIEW | NETEEC 52,68,2015 | |
| TOXICOLOGY REVIEW | NETEEC 52,78,2015 | |
| TOXICOLOGY REVIEW | NETEEC 52,109,2015 | |
| TOXICOLOGY REVIEW | REPTED 69,174,2017 | |
| TOXICOLOGY REVIEW | TIVIEQ 30,569,2015 | |
| TOXICOLOGY REVIEW | REPTED 54,148,2015 | |
| TOXICOLOGY REVIEW | REPTED 61,120,2016 | |
| TOXICOLOGY REVIEW | FCTOD7 108,365,2017 | |
| TOXICOLOGY REVIEW | MUREAV 776,32,2018 | |
| TOXICOLOGY REVIEW | COTOX* 2,443,2018 | |
| TOXICOLOGY REVIEW | NETEEC 60,2,2017 | |
| TOXICOLOGY REVIEW | RTOPDW 55,52,2009 | |
| TOXICOLOGY REVIEW | RTOPDW 58,395,2010 | |
| TOXICOLOGY REVIEW | RTOPDW 59,364,2011 | |
| TOXICOLOGY REVIEW | RTOPDW 60,93,2011 | |
| TOXICOLOGY REVIEW | FCTOD7 111,467,2018 | |
| TOXICOLOGY REVIEW | FCTOD7 114,190,2018 | |
| TOXICOLOGY REVIEW | MAANU* ,337,2016 | |
| TOXICOLOGY REVIEW | MUREAV 777,19,2018 | |
| TOXICOLOGY REVIEW | VETODR ,197,2018 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,290,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1000 ppm (1900 mg/m3) | DTLVS* 3,103,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 1000 ppm (1880 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1000 ppm (1900 mg/m3);KZW 2000 ppm (3800 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1000 ppm (1907 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1000 ppm (1900 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1000 ppm (1900 mg/m3), short term exposure limit 1300 ppm (2500 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 1000 ppm (1900 mg/m3), VLE 5000 ppm (9500), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 500 ppm (960 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 1900 mg/m3, short term exposure limit 7600 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1000 ppm (1900 mg/m3), NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 1000 ppm (1900 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 1000 ppm (1900 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1000 ppm (1880 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 500 ppm (950 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 1000 ppm (1884 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 3000 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 1000 mg/m3, short term exposure limit 2000 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 500 ppm (1000 mg/m3);short term exposure limit 1000 ppm (1900 mg/m3), JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 500 ppm (960 mg/m3), KZG-week 1000 ppm (1920 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 1000 ppm (1900 mg/m3), JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1000 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1000 ppm (1900 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1000 ppm (1900 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 1000 ppm (1920 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1000 ppm (1900 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1000 ppm (1900 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1000 ppm (1900 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1000 ppm (1900 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ALCOHOL-air | 10H time-weighted average 1000 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 31500; Number of Industries 334; Total Number of Facilities 86077; Number of Occupations 222; Total Number of Employees Exposed 2069125; Total Number of Female Employees Exposed 1014002 | |
| National Occupational Hazard Survey 1974 | Hazard Code 31500; Number of Industries 430; Total Number of Facilities 157709; Number of Occupations 242; Total Number of Employees Exposed 2088926 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health