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Ethanol, 2 - methoxy - , acetate

RTECS #: KL5950000

CAS #: 110-49-6


UPDATE: May 2009 MW: 118.15 MF: C5H10O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Methoxy - ethyl acetaat (Dutch)
  2. 2 - Methoxyaethylacetat (German)
  3. 2 - Methoxyethanol acetate
  4. 2 - Methoxyethanol, acetate
  5. 2 - Methoxyethyl acetate
  6. 2 - Methoxyethyl acetate (ACGIH:OSHA)
  7. 2 - Methoxyethyle, acetate de (French)
  8. 2 - Methoxyethylester kyseliny octove (Czech)
  9. 2 - Metossietilacetato (Italian)
  10. Acetate de l'ether monomethylique de l'ethylene - glycol (French)
  11. Acetate de methyle glycol (French)
  12. Acetato di metil cellosolve (Italian)
  13. Acetic acid 2 - methoxyethyl ester
  14. Aethylenglykolmethylaetheracetat (German)
  1. EGMEA
  2. Ethylene glycol methyl acetate (OSHA)
  3. Ethylene glycol methyl ether acetate
  4. Ethylene glycol monomethyl ether acetate
  5. Glycol ether EM acetate
  6. Glycol monomethyl ether acetate
  7. MeCsac
  8. Methyl cellosolve acetate
  9. Methyl cellosolve acetate (OSHA)
  10. Methyl cellosolye acetaat (Dutch)
  11. Methyl glycol acetate
  12. Methyl glycol monoacetate
  13. Methylcelosolvacetat (Czech)
  14. Methylglykolacetat (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
218 mg mild UCDS** 3/20/1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
32,000 ppm MUREAV 259,147,1991
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 56,600 ppm MUREAV 149,339,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 12,500 mg/kg (25 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct SAIGBL 21,29,1979
oral
mouse
lowest published toxic dose: 50 gm/kg (25 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands SAIGBL 21,29,1979
oral
mouse
lowest published toxic dose: 9,800 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** PB86-197605
oral
mouse
lowest published toxic dose: 9,800 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TCMUD8 7,29,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 6 gm/m3/7 hour Eye: Lacrimation

Behavioral: Food intake (animal)

Gastrointestinal: Changes in structure or function of salivary glands
AGGHAR 5,1,1933
inhalation
human
lowest published toxic concentration: 1,000 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
AGGHAR 5,1,1933
inhalation
mammal (species unspecified)
lowest published toxic concentration: 1,014 mg/m3/4 hour Behavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Other changes in urine composition
TOVEFN (1),28,1996
inhalation
rat
lowest published lethal concentration: 7,000 ppm/4 hour N/R JIHTAB 30,63,1948
intraperitoneal
rat
lowest published lethal dose: 1,200 mg/kg Behavioral: General anesthetic

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Renal function tests depressed
JPPMAB 11,150,1959
oral
guinea pig
lethal dose (50 percent kill): 1,250 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
mouse
lethal dose (50 percent kill): 3,100 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),27,1996
oral
mouse
lethal dose (50 percent kill): 3,100 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),28,1996
oral
rat
lethal dose (50 percent kill): 2,900 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),27,1996
oral
rat
lethal dose (50 percent kill): 2,900 mg/kg N/R TOVEFN (1),28,1996
oral
rat
lethal dose (16 percent kill): 2,600 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
TOVEFN (1),28,1996
oral
rat
lethal dose : 3,200 mg/kg N/R TOVEFN (1),28,1996
subcutaneous
cat
lowest published lethal dose: 3 gm/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
AGGHAR 5,1,1933
subcutaneous
guinea pig
lowest published lethal dose: 5 gm/kg Behavioral: Somnolence (general depressed activity) AGGHAR 5,1,1933
skin
rabbit
lethal dose (50 percent kill): 5,250 ÁL/kg N/R UCDS** 3/20/1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CRTXB2 30,307,2000


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (120 mg/m3) (skin) DTLVS* 3,159,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (120 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (120 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (120 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (120 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (24 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (24 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (24 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (120 mg/m3), short term exposure limit 40 ppm (180 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (24 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 25 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 25 mg/m3, short term exposure limit 100 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 ppm (24 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (24 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (16 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1.5 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (24 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (120 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 25 mg/m3, MAC(short term exposure limit) 100 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (25 mg/m3),KZG- week 40 ppm (200 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (120 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (25 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGMEA-air 10 hour time-weighted average 0.1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 46935;
Number of Industries 45;
Total Number of Facilities 2,907;
Number of Occupations 49;
Total Number of Employees Exposed 20,492
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 46935;
Number of Industries 20;
Total Number of Facilities 658;
Number of Occupations 27;
Total Number of Employees Exposed 9,892;
Total Number of Female Employees Exposed 2,801


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl cellosolve acetate, 1451
OSHA ANALYTICAL METHOD #53
OSHA ANALYTICAL METHOD #79


REFERENCES:

CODEN
REFERENCE

AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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