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Ethanol, 2 - methoxy -

RTECS #: KL5775000

CAS #: 109-86-4


UPDATE: May 2009 MW: 76.11 MF: C3H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Methoxy - aethanol (German)
  2. 2 - Methoxyethanol
  3. 2 - Methoxyethanol (ACGIH:OSHA)
  4. 2 - Metossietanolo (Italian)
  5. Aethylenglykol - monomethylaether (German)
  6. Dowanol 7
  7. Dowanol EM
  8. EGME
  9. Ether monomethylique de l'ethylene - glycol (French)
  10. Ethylene glycol methyl ether
  11. Ethylene glycol monomethyl ether
  12. Glycol ether EM
  13. Glycol monomethyl ether
  14. Glycolmethyl ether
  15. Jeffersol EM
  1. Methoxyethanol
  2. Methoxyhydroxyethane
  3. Methyl cellosolve
  4. Methyl cellosolve (OSHA)
  5. Methyl cellosolve methyl glycol
  6. Methyl ethoxol
  7. Methyl glycol
  8. Methyl oxitol
  9. Methylcelosolv (Czech)
  10. Methylglykol (German)
  11. Metil cellosolve (Italian)
  12. Metoksyetylowy alkohol (Polish)
  13. Monomethyl ether of ethylene glycol
  14. Poly - Solv EM
  15. Prist


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
guinea pig
10 g mild JPPMAB 11,150,1959
eye
rabbit
97 mg mild TXAPA9 19,276,1971
eye
rabbit
500 mg/24 hour mild 85JCAE -,623,1986
skin
rabbit
483 mg/24 hour mild TXAPA9 19,276,1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 150 mmol/L MUREAV 320,125,1994
dominant lethal test oral
rat
500 mg/kg ENMUDM 6,390,1984
DNA damage oral
rat
800 mg/kg/4 day- intermittent TOXID9 44,114,2005
sperm morphology oral
mouse
500 mg/kg ENMUDM 6,390,1984
sperm morphology oral
rat
500 mg/kg ENMUDM 6,390,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/6 hour (11 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 61,368,1981
inhalation
mouse
lowest published toxic concentration: 500 ppm/7 hour (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 70,303,1983
inhalation
mouse
lowest published toxic concentration: 50 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 75,409,1984
inhalation
mouse
lowest published toxic concentration: 50 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
EVHPAZ 57,7,1984
inhalation
rat
lowest published toxic concentration: 68 mg/kg/4 hour (1-19 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
FAVUAI 21,30,1989
inhalation
rat
lowest published toxic concentration: 30 ppm/6 hour (65 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FAATDF 3,49,1983
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour (6-17 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TXAPA9 69,43,1983
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour (6-17 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 69,43,1983
inhalation
rat
lowest published toxic concentration: 30 ppm/6 hour (13 week male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 3,80,1983
inhalation
rat
lowest published toxic concentration: 933 mg/m3 (6-17 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
VCVGK* -,160,1994
inhalation
rabbit
lowest published toxic concentration: 300 ppm/6 hour (65 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FAATDF 3,49,1983
inhalation
rabbit
lowest published toxic concentration: 50 ppm/6 hour (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 75,409,1984
inhalation
rabbit
lowest published toxic concentration: 50 ppm/6 hour (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 57,7,1984
inhalation
rabbit
lowest published toxic concentration: 10 ppm/6 hour (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 75,409,1984
intraperitoneal
rat
lowest published toxic dose: 330 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TJADAB 29(2),54A,1984
intraperitoneal
rat
lowest published toxic dose: 190 mg/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system
JJATDK 4,35,1984
intraperitoneal
rat
lowest published toxic dose: 190 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JJATDK 4,35,1984
intraperitoneal
rat
lowest published toxic dose: 190 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JJATDK 4,35,1984
intravenous
mouse
lowest published toxic dose: 250 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 12,101,1992
oral
guinea pig
lowest published toxic dose: 6,250 mg/kg (25 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EVHPAZ 57,75,1984
oral
hamster
lowest published toxic dose: 1,562 mg/kg (25 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EVHPAZ 57,75,1984
oral
monkey
lowest published toxic dose: 930 mg/kg (20-45 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 35,66A,1987
oral
monkey
lowest published toxic dose: 633 mg/kg (20-45 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 35,66A,1987
oral
mouse
lowest published toxic dose: 175 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 31,48A,1985
oral
mouse
lowest published toxic dose: 2 gm/kg (7-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
TXCYAC 20,335,1981
oral
mouse
lowest published toxic dose: 500 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 80,108,1985
oral
mouse
lowest published toxic dose: 250 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 80,108,1985
oral
mouse
lowest published toxic dose: 6,250 mg/kg (25 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct SAIGBL 21,29,1979
oral
mouse
lowest published toxic dose: 11,200 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 1,000 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,160,1994
oral
mouse
lowest published toxic dose: 2 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB89152565
oral
mouse
lowest published toxic dose: 4.45 gm/kg (7 day prior to copulation/21 day pregnant) Reproductive: Maternal effects: Postpartum NTIS** #PB86163136
oral
mouse
lowest published toxic dose: 5.6 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) NTIS** #PB86163136
oral
mouse
lowest published toxic dose: 7.2 gm/kg (7 day male/7 day prior to copulation-1 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB88192240
oral
mouse
lowest published toxic dose: 8.4 gm/kg (7 day male/7 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility NTIS** #PB88192240
oral
mouse
lowest published toxic dose: 11.8 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB86163136
oral
mouse
lowest published toxic dose: 14 gm/kg (14 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) NTIS** #PB86163136
oral
mouse
lowest published toxic dose: 14 gm/kg (14 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) NTIS** #PB86163136
oral
mouse
lowest published toxic dose: 17.5 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB89152565
oral
mouse
lowest published toxic dose: 35.28 gm/kg (15 week prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB86163136
oral
mouse
lowest published toxic dose: 43 gm/kg (15 week male/15 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB89152565
oral
mouse
lowest published toxic dose: 50 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB89152565
oral
mouse
lowest published toxic dose: 159 mg/kg (multigenerations) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB86163136
oral
mouse
lowest published toxic dose: 159 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system NTIS** #PB86163136
oral
mouse
lowest published toxic dose: 170 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) NTIS** #PB89152565
oral
mouse
lowest published toxic dose: 19 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility NTIS** #PB88211446
oral
mouse
lowest published toxic dose: 200 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB88211446
oral
mouse
lowest published toxic dose: 60 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB88211446
oral
rat
lowest published toxic dose: 175 mg/kg (7-13 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system TJADAB 32,33,1985
oral
rat
lowest published toxic dose: 175 mg/kg (7-13 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Biochemical and metabolic
DCTODJ 9,1,1986
oral
rat
lowest published toxic dose: 15,015 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTPTR* NIH-93-3349
oral
rat
lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 69,385,1983
oral
rat
lowest published toxic dose: 350 mg/kg (9-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TXAPA9 86,197,1986
oral
rat
lowest published toxic dose: 250 mg/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 145,415,1997
oral
rat
lowest published toxic dose: 1,000 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,160,1994
oral
rat
lowest published toxic dose: 350 mg/kg (9-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 82,197,1986
oral
rat
lowest published toxic dose: 350 mg/kg (9-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TXAPA9 82,197,1986
oral
rat
lowest published toxic dose: 5.5 gm/kg (21 week male) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) NTIS** #PB90252321/AS
oral
rat
lowest published toxic dose: 36.75 gm/kg (21 week male/21 week prior to copulation) Reproductive: Effects on fertility: Other measures of fertility NTIS** #PB90252321/AS
oral
rat
lowest published toxic dose: 30 mg/kg (multigenerations) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Sex ratio
NTIS** #PB90252321
oral
rat
lowest published toxic dose: 37.5 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) NTIS** #PB90252321/AS
oral
rat
lowest published toxic dose: 1,050 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Sex ratio
NTIS** #PB90252321
oral
rat
lowest published toxic dose: 3,570 mg/kg (17 week male) Reproductive: Effects on newborn: Sex ratio NTIS** #PB90252321
oral
rat
lowest published toxic dose: 15 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB90252321
oral
rat
lowest published toxic dose: 262 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) NTIS** #PB90252321
oral
rabbit
lowest published toxic dose: 1,000 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,160,1994
subcutaneous
mouse
lowest published toxic dose: 1,200 mg/kg (7-13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOLED5 50,263,1990
subcutaneous
mouse
lowest published toxic dose: 3,200 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TOLED5 50,263,1990
subcutaneous
mouse
lowest published toxic dose: 250 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 54,219,1996
subcutaneous
rat
lowest published toxic dose: 600 mg/kg (6-20 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
EVHPAZ 57,199,1984
subcutaneous
rat
lowest published toxic dose: 440 mg/kg (7-17 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TCMUD8 7,73,1987
skin
guinea pig
lowest published toxic dose: 65 gm/kg (65 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FAATDF 6,339,1986
skin
rat
lowest published toxic dose: 11,592 mg/kg (6-17 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on embryo or fetus: Fetal death
JJATDK 6,165,1986
skin
rat
lowest published toxic dose: 4,375 mg/kg (7 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
TXAPA9 100,145,1989
skin
rat
lowest published toxic dose: 2 gm/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 15,448,1990
skin
rat
lowest published toxic dose: 1 gm/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Gastrointestinal system
FAATDF 15,448,1990
skin
rat
lowest published toxic dose: 2.5 mg/kg (7-16 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,159,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 25 ppm Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
JIHTAB 20,134,1938
inhalation
mouse
lethal concentration (50 percent kill): 1,480 ppm/7 hour Behavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria
JIHTAB 25,157,1943
inhalation
mouse
lethal concentration (50 percent kill): 4,600 ppm N/R ENTOX* -,63,2005
inhalation
rat
lethal concentration (50 percent kill): 1,500 ppm/7 hour N/R NPIRI* 1,57,1974
inhalation
rat
lowest published toxic concentration: 625 ppm/4 hour Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) ATSUDG 7,167,1984
inhalation
rat
lowest published toxic concentration: 1,000 ppm/4 hour Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
ATSUDG 7,167,1984
intraperitoneal
mouse
lethal dose (50 percent kill): 2,147 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen

Blood: Other changes
FEPRA7 6,342,1947
intraperitoneal
rat
lethal dose (50 percent kill): 2,500 mg/kg N/R NPIRI* 1,57,1974
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Reproductive: Effects on fertility: Other measures of fertility REPTED 14,45,2000
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,159,1984
intravenous
rat
lethal dose (50 percent kill): 2,068 mg/kg Blood: Other hemolysis with or without anemia AMIHAB 14,114,1956
oral
guinea pig
lethal dose (50 percent kill): 950 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
guinea pig
lowest published toxic dose: 200 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct EXMPA6 61,119,1994
oral
guinea pig
lowest published toxic dose: 300 mg/kg Blood: Other changes EXMPA6 61,119,1994
oral
human
lowest published lethal dose: 3,380 mg/kg Gastrointestinal: Gastritis

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 28,267,1946
oral
human
lowest published lethal dose: 143 mg/kg N/R VCVGK* -,159,1984
oral
mouse
lethal dose (50 percent kill): 2,560 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Cardiac: Other changes
GTPZAB 32(3),48,1988
oral
mouse
lethal dose (50 percent kill): 2,800 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,159,1984
oral
rat
lethal dose (50 percent kill): 2,370 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Other changes
VHTODE 29,361,1987
oral
rat
lowest published toxic dose: 250 mg/kg Related to Chronic Data: Changes in prostate weight REPTED 6,491,1992
oral
rat
lowest published toxic dose: 200 mg/kg Blood: Normocytic anemia

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
EXMPA6 61,119,1994
oral
rat
lethal dose (50 percent kill): 2,460 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,159,1984
oral
rat
lowest published toxic dose: 150 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JOAND3 5,369,1984
oral
rat
lowest published toxic dose: 200 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOXID9 44,114,2005
oral
rat
lowest published toxic dose: 2,000 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTSCDR 32,515,2007
oral
rat
lowest published toxic dose: 50 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JTSCDR 32,515,2007
oral
rabbit
lethal dose (50 percent kill): 890 mg/kg Behavioral: General anesthetic

Blood: Other hemolysis with or without anemia
AMIHAB 14,114,1956
oral
rabbit
lethal dose (50 percent kill): 890 mg/kg Behavioral: Somnolence (general depressed activity)

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,159,1984
skin
rabbit
lethal dose (50 percent kill): 1,280 mg/kg N/R NPIRI* 1,57,1974
skin
rabbit
lethal dose (50 percent kill): 2,000 mg/kg Kidney, Ureter, and Bladder: Urine volume decreased or anuria VCVGK* -,159,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 750 ppm/7 hour/12 week- intermittent Blood: Microcytosis with or without anemia

Blood: Other changes
JIHTAB 25,409,1943
inhalation
dog
lowest published toxic concentration: 2,500 mg/m3/7 hour/60 day- intermittent Blood: Changes in spleen

Blood: Microcytosis with or without anemia
VCVGK* -,160,1994
inhalation
mammal (species unspecified)
lowest published toxic concentration: 1,240 mg/m3/6 hour/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Brain and Coverings: Other degenerative changes
VCVGK* -,159,1994
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/6 hour/11 day- intermittent Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight
TXAPA9 61,368,1981
inhalation
mouse
lowest published toxic concentration: 3,680 mg/m3/6 hour/9 day- intermittent Spinal Cord: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,159,1994
inhalation
mouse
lowest published toxic concentration: 3,680 mg/m3/6 hour/9 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,159,1994
inhalation
rat
lowest published toxic concentration: 400 ppm/6 hour/2 week- intermittent Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ENVRAL 22,423,1980
inhalation
rat
lowest published toxic concentration: 300 ppm/6 hour/13 week- intermittent Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
FAATDF 3,49,1983
inhalation
rat
lowest published toxic concentration: 970 mg/m3/7 hour/5 week- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in spleen
JIHTAB 25,374,1943
inhalation
rat
lowest published toxic concentration: 1,000 ppm/6 hour/11 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count
TXAPA9 61,368,1981
inhalation
rat
lowest published toxic concentration: 3,680 mg/m3/6 hour/9 day- intermittent Spinal Cord: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,159,1994
inhalation
rat
lowest published toxic concentration: 3,680 mg/m3/6 hour/9 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,159,1994
inhalation
rat
lowest published toxic concentration: 1,100 mg/m3/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
VCVGK* -,160,1994
inhalation
rabbit
lowest published toxic concentration: 300 ppm/6 hour/13 week- intermittent Endocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Changes in testicular weight
FAATDF 3,49,1983
intraperitoneal
rat
lowest published toxic dose: 450 mg/kg/16 day- intermittent Blood: Changes in other cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TIHEEC 9,617,1993
oral
guinea pig
lowest published toxic dose: 600 mg/kg/3 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) EXMPA6 61,119,1994
oral
mouse
lowest published toxic dose: 12,110 mg/kg/2 week- continuous Endocrine: Changes in thymus weight

Related to Chronic Data: Changes in testicular weight
NTPTR* NIH-93-3349
oral
mouse
lowest published toxic dose: 82 gm/kg/13 week- continuous Endocrine: Effect on menstrual cycle

Endocrine: Other changes

Blood: Changes in spleen
NTPTR* NIH-93-3349
oral
mouse
lowest published toxic dose: 11,200 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 8,820 mg/kg/21 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #PB88211446
oral
mouse
lowest published toxic dose: 29,400 mg/kg/21 week- continuous Liver: Changes in liver weight NTIS** #PB88211446
oral
mouse
lowest published toxic dose: 80,850 mg/kg/21 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTIS** #PB88211446
oral
mouse
lowest published toxic dose: 8,820 mg/kg/21 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB88211446
oral
mouse
lowest published toxic dose: 126,000 mg/kg/15 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB89152565
oral
mouse
lowest published toxic dose: 17,850 mg/kg/15 week- continuous Liver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTIS** #PB89152565
oral
mouse
lowest published toxic dose: 6,300 mg/kg/15 week- continuous Liver: Changes in liver weight NTIS** #PB88192240
oral
mouse
lowest published toxic dose: 4,200 mg/kg/7 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB88192240
oral
mouse
lowest published toxic dose: 4,200 mg/kg/7 day- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
NTIS** #PB88192240
oral
mouse
lowest published toxic dose: 9,800 mg/kg/49 day- continuous Liver: Changes in liver weight

Reproductive: Maternal effects: Ovaries, fallopian tubes
NTIS** #PB88192240
oral
mouse
lowest published toxic dose: 21,665 mg/kg/28 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB86163136
oral
mouse
lowest published toxic dose: 35,280 mg/kg/15 week- continuous Reproductive: Maternal effects: Menstrual cycle changes or disorders NTIS** #PB86163136
oral
rat
lowest published toxic dose: 10,206 mg/kg/21 day- continuous Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
FAATDF 16,830,1991
oral
rat
lowest published toxic dose: 500 mg/kg/10 day- intermittent Endocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response
TXAPA9 109,494,1991
oral
rat
lowest published toxic dose: 29,484 mg/kg/13 week- continuous Endocrine: Changes in thymus weight

Blood: Changes in platelet count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NIH-93-3349
oral
rat
lowest published toxic dose: 900 mg/kg/3 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders TXAPA9 142,328,1997
oral
rat
lowest published toxic dose: 4,500 mg/kg/15 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight TXAPA9 142,328,1997
oral
rat
lowest published toxic dose: 1,050 mg/kg/2 week- continuous Reproductive: Maternal effects: Oogenesis

Reproductive: Effects on fertility: Other measures of fertility
REPTED 14,45,2000
oral
rat
lowest published toxic dose: 600 mg/kg/3 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) EXMPA6 61,119,1994
oral
rat
lowest published toxic dose: 500 mg/kg/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
VCVGK* -,160,1994
oral
rat
lowest published toxic dose: 700 mg/kg/7 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Changes in: Ca

Related to Chronic Data: Changes in uterine weight
TXAPA9 82,197,1986
oral
rat
lowest published toxic dose: 1,200 mg/kg/8 day- intermittent Related to Chronic Data: Changes in testicular weight JOAND3 5,369,1984
oral
rat
lowest published toxic dose: 1,400 mg/kg/1 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 25,259,2000
oral
rat
lowest published toxic dose: 2,800 mg/kg/2 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
JTSCDR 25,259,2000
oral
rat
lowest published toxic dose: 200 mg/kg/2 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) EXMPA6 40,169,1984
skin
guinea pig
lowest published toxic dose: 65 gm/kg/13 week- intermittent Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
FAATDF 6,339,1986
skin
rat
lowest published toxic dose: 20 gm/kg/4 week- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight
TXCYAC 57,209,1989
skin
rat
lowest published toxic dose: 3,200 mg/kg/4 day- intermittent Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
TXCYAC 98,215,1995
unreported route
rat
lowest published toxic dose: 150 mg/kg/3 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Other
TOXID9 90,219,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
CRTXB2 30,307,2000
TOXICOLOGY REVIEW
JTSCDR 25,1,2000
TOXICOLOGY REVIEW
CRTXB2 33,137,2003
TOXICOLOGY REVIEW
ENTOX* -,451,2005
TOXICOLOGY REVIEW
ENTOX* -,63,2005
TOXICOLOGY REVIEW
HUTOX* -,623,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,241,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (80 mg/m3) (skin) DTLVS* 3,158,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (80 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (80 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (80 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (80 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (16 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (16 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (16 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (80 mg/m3), short term exposure limit 40 ppm (120 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (16 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 16 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 15 mg/m3, short term exposure limit 60 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 ppm (16 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (16 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 25 ppm (80 mg/m3);
short term exposure limit 35 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (16 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (16 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (80 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 15 mg/m3, MAC(short term exposure limit) 60 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 5 ppm, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (15 mg/m3),KZG- week 40 ppm (120 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (80 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (16 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEGLYCOL MONOMETHYL ETHER-air 10 hour time-weighted average 0.1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 46240;
Number of Industries 128;
Total Number of Facilities 11,165;
Number of Occupations 102;
Total Number of Employees Exposed 103,424
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 46240;
Number of Industries 89;
Total Number of Facilities 8,042;
Number of Occupations 86;
Total Number of Employees Exposed 168,180;
Total Number of Female Employees Exposed 53,403


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as jet fuel additive, solvent for protective coating and in chemical synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9101
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN, #39
NIOSH Analytical Method, 1994: Alcohols IV, 1403
NTP Toxicity studies, RPT# TOX-26, October 2000
OSHA ANALYTICAL METHOD #53
OSHA ANALYTICAL METHOD #79


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAVUAI Fiziologicheski Aktivnye Veshchestva. Physiologically Active Substances. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1966-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used as jet fuel additive, solvent for protective coating and in chemical synthesis

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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