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Ethanol, 2,2' - iminodi -

RTECS #: KL2975000

CAS #: 111-42-2


UPDATE: May 2009 MW: 105.16 MF: C4H11NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,2' - Dihydroxydiethylamine
  2. 2,2' - Iminobisethanol
  3. 2,2' - Iminodiethanol
  4. 2 - (2 - Hydroxyethylamino) ethanol
  5. Bis (2 - hydroxyethyl) amine
  6. DEA
  7. Di (2 - hydroxyethyl) amine
  8. Diaethanolamin (German)
  1. Diethanolamin (Czech)
  2. Diethanolamine
  3. Diethanolamine (ACGIH)
  4. Diethylamine, 2,2' - dihydroxy -
  5. Diethylolamine
  6. Diolamine
  7. NCI - C55174


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
5,500 mg severe AJOPAA 29,1363,1946
eye
rabbit
750 g/24 hour severe 85JCAE -,685,1986
skin
rabbit
50 mg open irritation test mild UCDS** 12/29/1971
skin
rabbit
500 mg/24 hour mild 85JCAE -,685,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
unscheduled DNA synthesis mouse liver 10 mg/L/24 hour TOXID9 72,238,2003
unscheduled DNA synthesis rat liver 10 mg/L/24 hour TOXID9 72,238,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 200 mg/m3/6 hour (6-15 day pregnant) Reproductive: Other effects on female NTIS** OTS0538412
oral
rat
lowest published toxic dose: 18,382 mg/kg (14 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTPTR* NIH-92-3343
oral
rat
lowest published toxic dose: 2,800 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
BDERB* 74,243,2005
oral
rat
lowest published toxic dose: 1,750 mg/kg (6-19 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Other postnatal measures or effects
BDERB* 74,243,2005
skin
rat
lowest published toxic dose: 15 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Other postnatal measures or effects
RTOPDW 30,169,1999
skin
rat
lowest published toxic dose: 15,000 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system RTOPDW 30,169,1999
skin
rabbit
lowest published toxic dose: 4,550 mg/kg (6-18 day pregnant) Reproductive: Other effects on female RTOPDW 30,169,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 21 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-478,1999
skin
mouse
lowest published toxic dose: 57,680 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB99-167553
skin
mouse
lowest published toxic dose: 28,840 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB99-167553
skin
mouse
lowest published toxic dose: 20,857 mg/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
CBINA8 146,251,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lethal dose (50 percent kill): 1,500 mg/kg N/R EVSSAV 2,289,1968
intraperitoneal
mouse
lethal dose (50 percent kill): 210 mg/kg N/R NTIS** OTS0516742
intraperitoneal
rat
lethal dose (50 percent kill): 120 mg/kg N/R EVSSAV 2,289,1968
intravenous
rat
lethal dose (50 percent kill): 778 mg/kg N/R EVSSAV 2,289,1968
oral
guinea pig
lethal dose (50 percent kill): 2 gm/kg N/R 85INA8 5,197,1986
oral
mammal (species unspecified)
lowest published lethal dose: 3 gm/kg N/R NTIS** OTS0520710
oral
mouse
lethal dose (50 percent kill): 3,300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GISAAA 29(11),25,1964
oral
rat
lethal dose (50 percent kill): 620 L/kg Eye: Lacrimation

Behavioral: Tremor

Skin and Appendages: Other: Hair
NTIS** OTS0516797
oral
rabbit
lethal dose (50 percent kill): 2,200 mg/kg N/R EVSSAV 2,289,1968
subcutaneous
rat
lethal dose (50 percent kill): 2,200 mg/kg N/R EVSSAV 2,289,1968
skin
guinea pig
lethal dose (50 percent kill): 11,900 L/kg N/R NTIS** OTS0516742
skin
rabbit
lethal dose (50 percent kill): 7,640 L/kg Behavioral: Ataxia

Musculoskeletal: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0516797


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 400 mg/m3/6 hour/98 day- intermittent Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 46,2173,2008
inhalation
rat
lowest published toxic concentration: 400 mg/m3/6 hour/98 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in erythrocyte (RBC) count
FCTOD7 46,2173,2008
inhalation
rat
lowest published toxic concentration: 150 mg/m3/6 hour/98 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
FCTOD7 46,2173,2008
inhalation
rat
lowest published toxic concentration: 150 mg/m3/6 hour/98 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 46,2173,2008
inhalation
rat
lowest published toxic concentration: 150 mg/m3/6 hour/98 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 46,2173,2008
inhalation
rat
lowest published toxic concentration: 15 mg/m3/6 hour/98 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 46,2173,2008
inhalation
rat
lowest published toxic concentration: 8 mg/m3/6 hour/103 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 46,2173,2008
inhalation
rat
lowest published toxic concentration: 8 mg/m3/6 hour/103 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 46,2173,2008
oral
mouse
lowest published toxic dose: 30,366 mg/kg/14 day- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-92-3343
oral
mouse
lowest published toxic dose: 38,402 mg/kg/13 week- continuous Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NIH-92-3343
oral
mouse
lowest published toxic dose: 4,800 mg/kg/8 day- intermittent Liver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* IMM-9801
oral
mouse
lowest published toxic dose: 8,400 mg/kg/14 day- intermittent Blood: Normocytic anemia

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
NTPTR* IMM-9801
oral
mouse
lowest published toxic dose: 8,400 mg/kg/14 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-9801
oral
mouse
lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Immunological Including Allergic: Decreased immune response NTPTR* IMM-9801
oral
rat
lowest published toxic dose: 52 gm/kg/14 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-92-3343
oral
rat
lowest published toxic dose: 8,827 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia

Related to Chronic Data: Changes in testicular weight
NTPTR* NIH-92-3343
oral
rat
lowest published toxic dose: 49 gm/kg/7 week- continuous Liver: Other changes

Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 17,308,1970
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB2001-103718
oral
rat
lowest published toxic dose: 2,100 mg/kg/7 day- intermittent Behavioral: Sleep

Behavioral: Tremor

Skin and Appendages: Other: Hair
NTIS** #PB2001-103718
oral
rat
lowest published toxic dose: 500 mg/kg/4 day- intermittent Behavioral: Fluid intake NTIS** #PB2001-103718
oral
rat
lowest published toxic dose: 1,750 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #PB2001-103718
oral
rat
lowest published toxic dose: 1,600 mg/kg/8 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* IMM-20303
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Blood: Normocytic anemia

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
NTPTR* IMM-20303
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Blood: Changes in cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-20303
oral
rat
lowest published toxic dose: 1,400 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 74,243,2005
oral
rat
lowest published toxic dose: 800 mg/kg/4 day- intermittent Behavioral: Food intake (animal) BDERB* 74,243,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 74,243,2005
oral
rat
lowest published toxic dose: 875 mg/kg/7 day- intermittent Behavioral: Fluid intake BDERB* 74,243,2005
skin
mouse
lowest published toxic dose: 30 gm/kg/16 day- intermittent Liver: Changes in liver weight

Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NIH-92-3343
skin
mouse
lowest published toxic dose: 40,950 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NIH-92-3343
skin
mouse
lowest published toxic dose: 70 mg/kg/1 week- intermittent Liver: Changes in liver weight FCTOD7 42,127,2004
skin
mouse
lowest published toxic dose: 910 mg/kg/13 week- intermittent Tumorigenic: Cells (cultured) transformed FCTOD7 42,127,2004
skin
mouse
lowest published toxic dose: 280 mg/kg/1 week- intermittent Liver: Other changes FCTOD7 42,127,2004
skin
mouse
lowest published toxic dose: 1,120 mg/kg/1 week- intermittent Liver: Changes in liver weight

Tumorigenic: Cells (cultured) transformed
FCTOD7 42,127,2004
skin
mouse
lowest published toxic dose: 4,410 mg/kg/1 week- intermittent Skin: After topical application: Corrosive FCTOD7 42,127,2004
skin
mouse
lowest published toxic dose: 1,120 mg/kg/1 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 60,287,2001
skin
rat
lowest published toxic dose: 1,008 mg/kg/16 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
NTPTR* NIH-92-3343
skin
rat
lowest published toxic dose: 8,125 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia
NTPTR* NIH-92-3343


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3 (skin) DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 77,564,2000
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
ENTOX* -,266,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
TOPADD 33,517,2005
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 566,49,2004
TOXICOLOGY REVIEW
MUREAV 672,10,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 3 ppm (13 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.46 ppm (2 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.46 ppm (2 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 3 ppm (15 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 3 ppm (15 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 3 ppm (13 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 3 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 3 ppm (15 mg/m3);
short term exposure limit 6 ppm (30 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3,KZG- week 1 mg/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg/m3 (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHANOLAMINE-air 10 hour time-weighted average 3 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0517;
Number of Industries 3;
Total Number of Facilities 315;
Number of Occupations 2;
Total Number of Employees Exposed 857
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24615;
Number of Industries 147;
Total Number of Facilities 18,443;
Number of Occupations 118;
Total Number of Employees Exposed 186,455
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24615;
Number of Industries 249;
Total Number of Facilities 46,466;
Number of Occupations 171;
Total Number of Employees Exposed 828,471;
Total Number of Female Employees Exposed 218,923


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as absorbent and to make fatty alkanolamides, MORPHOLINE, plasticizers and resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8736;8EHQ-0293-8746
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aminoethanol compounds II, 3509
NCI Carcinogenesis Studies (derm);clear evidence:mouse
NCI Carcinogenesis Studies (derm);no evidence:rat
NTP Toxicity studies, RPT# TOX-20, October 2000


REFERENCES:

CODEN
REFERENCE

85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
BDERB*
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVSSAV Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as absorbent and to make fatty alkanolamides, MORPHOLINE, plasticizers and resins

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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