CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Ethanol, 2 - chloro -

RTECS #: KK0875000

CAS #: 107-07-3


UPDATE: May 2009 MW: 80.52 MF: C2H5ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - Chloorethanol (Dutch)
  2. 2 - Chloraethanol (German)
  3. 2 - Chlorethanol (German)
  4. 2 - Chloroethanol
  5. 2 - Chloroethanol (OSHA)
  6. 2 - Chloroethyl alcohol
  7. 2 - Cloroetanolo (Italian)
  8. 2 - Monochloroethanol
  9. Aethylenechlorhydrin (German)
  10. Chloroethanol
  11. Chloroethylowy alkohol (Polish)
  12. Ethyleen - chloorhydrine (Dutch)
  13. Ethylene chlorhydrin
  1. Ethylene chlorohydrin
  2. Ethylene chlorohydrin (ACGIH:OSHA)
  3. Ethylene glycol, chlorohydrin
  4. Glicol monocloridrina (Italian)
  5. Glycol chlorohydrin
  6. Glycol monochlorohydrin
  7. Glycolmonochloorhydrine (Dutch)
  8. Glycomonochlorhydrin
  9. Monochlorhydrine du glycol (French)
  10. NCI - C50135
  11. beta - Chloroethyl alcohol
  12. delta - Chloroethanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
2 mg severe AJOPAA 29,1363,1946
eye
rabbit
33 mg moderate TXAPA9 16,382,1970
eye
rabbit
9 mg/6 hour moderate BUYRAI 31,25,1977
skin
rabbit
200 mg/2 hour mild TXAPA9 16,382,1970


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 980 mg/L EMMUEG 14,165,1989
cytogenetic analysis oral
mouse
500 µg/kg GISAAA 43(8),13,1978
cytogenetic analysis inhalation
rat
1 mg/m3 GISAAA 36(11),9,1971
DNA repair Escherichia coli 10 µmol/plate MUREAV 26,367,1974
mutation in microorganisms Aspergillus nidulans 40 gm/L (-enzymatic activation step) CBINA8 30,9,1980
mutation in microorganisms Klebsiella pneumoniae 15 mmol/L (-enzymatic activation step) EXPEAM 25,85,1969
mutation in microorganisms mouse lymphocyte 80 mg/L (+enzymatic activation step) EMMUEG 12,85,1988
mutation in microorganisms Salmonella typhimurium 20 µmol/plate (+enzymatic activation step) MUREAV 26,367,1974
mutation in microorganisms Salmonella typhimurium 3,333 µg/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
other mutation test systems Escherichia coli 2,914 µmol/L EMMUEG 19,98,1992
other mutation test systems oral
rat
20 mg/L JACTDZ 1(3),37,1982
other mutation test systems rat liver 12 gm/L JACTDZ 1(3),37,1982
other mutation test systems inhalation
rat
1 mg/m3 GISAAA 36(11),9,1971
sister chromatid exchange hamster ovary 1,200 mg/L SCIEAS 236,933,1987
sex chromosome loss and nondisjunction Aspergillus nidulans 74,500 µmol/L MUREAV 138,33,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
mouse
lowest published toxic dose: 180 mg/kg (8-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB85-172104/AS
intravenous
mouse
lowest published toxic dose: 360 mg/kg (4-6 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** #PB85-172104/AS
intravenous
mouse
lowest published toxic dose: 360 mg/kg (8-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus
NTIS** #PB85-172104/AS
intravenous
mouse
lowest published toxic dose: 360 mg/kg (10-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** #PB85-172104/AS
oral
mouse
lowest published toxic dose: 1,100 mg/kg (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
JPFCD2 17,381,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 156,000 mg/kg/104 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB86-145513/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lethal concentration (50 percent kill): 870 mg/m3 N/R GTPZAB 15(2),54,1971
inhalation
guinea pig
lethal concentration (50 percent kill): 870 mg/m3 Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,182,1994
inhalation
human
lowest published lethal concentration: 1,000 mg/m3 Behavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,183,1994
inhalation
man
lowest published lethal concentration: 305 ppm/2 hour Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 26,277,1944
inhalation
mouse
lethal concentration (50 percent kill): 385 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 36(4-6),376,1971
inhalation
mouse
lethal concentration (50 percent kill): 385 mg/m3 Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,182,1994
inhalation
rat
lethal concentration (50 percent kill): 290 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 36(4-6),376,1971
inhalation
rat
lethal concentration (50 percent kill): 290 mg/m3 Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,182,1994
inhalation
rat
lowest published toxic concentration: 40 mg/m3/4 hour Brain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGK* -,183,1994
inhalation
rat
lowest published toxic concentration: 100 mg/m3 Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVGK* -,183,1994
inhalation
rat
lowest published toxic concentration: 1 mg/m3 Blood: Changes in bone marrow not included in above VCVGK* -,183,1994
intraperitoneal
guinea pig
lethal dose (50 percent kill): 85 mg/kg N/R JPMSAE 61,19,1972
intraperitoneal
guinea pig
lethal dose (50 percent kill): 110 mg/kg Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,182,1994
intraperitoneal
mouse
lethal dose (50 percent kill): 97 mg/kg N/R JPMSAE 61,19,1972
intraperitoneal
rat
lethal dose (50 percent kill): 95 mg/kg Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,182,1994
intraperitoneal
rat
lowest published lethal dose: 58 mg/kg Lung, Thorax, or Respiration: Respiratory depression TOXID9 90,249,2006
intraperitoneal
rabbit
lethal dose (50 percent kill): 80 mg/kg N/R JPMSAE 61,19,1972
intravenous
rabbit
lowest published lethal dose: 100 mg/kg Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
BJIMAG 1,207,1944
oral
child
lowest published lethal dose: 396 mg/kg N/R JTCTDW 39,587,2001
oral
guinea pig
lethal dose (50 percent kill): 110 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
guinea pig
lethal dose (50 percent kill): 75 mg/kg Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,182,1994
oral
man
lowest published lethal dose: 330 mg/kg N/R JTCTDW 39,587,2001
oral
man
lowest published toxic dose: 88 mg/kg Cardiac: Change in rate

Gastrointestinal: Nausea or vomiting

Vascular: BP lowering not characterized in autonomic section
CTOXAO 39,587,2001
oral
mouse
lethal dose (50 percent kill): 81 mg/kg N/R JPMSAE 60,568,1971
oral
mouse
lethal dose (50 percent kill): 91 mg/kg Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,182,1994
oral
rat
lethal dose (50 percent kill): 71 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 36(4-6),376,1971
oral
rat
lethal dose (50 percent kill): 71 mg/kg Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,182,1994
oral
rabbit
lethal dose (50 percent kill): 100 mg/kg Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,183,1994
oral
woman
lowest published toxic dose: 99 mg/kg Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting
JTCTDW 39,587,2001
oral
woman
lowest published lethal dose: 800 mg/kg N/R CTOXAO 39,587,2001
oral
woman
lowest published toxic dose: 99 mg/kg Cardiac: Change in rate

Gastrointestinal: Nausea or vomiting

Vascular: BP lowering not characterized in autonomic section
CTOXAO 39,587,2001
subcutaneous
frog
lowest published lethal dose: 250 mg/kg N/R BJIMAG 1,207,1944
subcutaneous
guinea pig
lethal dose (50 percent kill): 75 mg/kg N/R GTPZAB 15(2),54,1971
subcutaneous
mouse
lethal dose (50 percent kill): 98 mg/kg N/R GTPZAB 15(2),54,1971
subcutaneous
rat
lethal dose (50 percent kill): 84 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 36(4-6),376,1971
subcutaneous
rat
lethal dose (50 percent kill): 84 mg/kg Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,182,1994
subcutaneous
rabbit
lethal dose (50 percent kill): 100 mg/kg N/R GTPZAB 15(2),54,1971
skin
guinea pig
lowest published lethal dose: 70 mg/kg N/R JIHTAB 27,93,1945
skin
guinea pig
lethal dose (50 percent kill): 20 mg/kg N/R VCVGK* -,183,1994
skin
mammal (species unspecified)
lowest published lethal dose: 0.7 mg/kg N/R TPKVAL 2,41,1961
skin
mouse
lethal dose (50 percent kill): 18 mg/kg N/R 85GMAT -,66,1982
skin
rat
lethal dose (50 percent kill): 293 mg/kg N/R NTPTR* NTP-TR-275,1985
skin
rabbit
lethal dose (50 percent kill): 67 mg/kg N/R JPMSAE 61,19,1972
skin
rabbit
lethal dose (50 percent kill): 700 mg/kg Brain and Coverings: Increased intracranial pressure

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)
VCVGK* -,183,1994
unreported route
mouse
lethal dose (50 percent kill): 91 mg/kg Brain and Coverings: Recordings from specific areas of CNS GISAAA 43(8),13,1978
unreported route
rat
lethal dose (50 percent kill): 71 mg/kg Brain and Coverings: Recordings from specific areas of CNS GISAAA 43(8),13,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 3,400 mg/m3/15 minute/11 day- intermittent Liver: Fatty liver degeneration

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 1,207,1944
inhalation
rat
lowest published toxic concentration: 1 mg/m3/4 hour/17 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 36(6),37,1971
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/28 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Change in clotting factors

Blood: Changes in bone marrow not included in above
VCVGK* -,183,1994
inhalation
rat
lowest published toxic concentration: 1 mg/m3/4 hour/28 day- intermittent Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGK* -,183,1994
inhalation
rat
lowest published toxic concentration: 10 mg/m3/122 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,183,1994
intraperitoneal
rat
lowest published toxic dose: 384 mg/kg/30 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPMSAE 60,1163,1971
intraperitoneal
rat
lowest published toxic dose: 1,152 mg/kg/12 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JPMSAE 60,1163,1971
intravenous
mouse
lowest published toxic dose: 360 mg/kg/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** #PB85-172104/AS
intravenous
rabbit
lowest published toxic dose: 81 mg/kg/9 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB85-170959/AS
oral
dog
lowest published toxic dose: 1,932 mg/kg/15 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTXAV 13,313,1975
oral
rat
lowest published toxic dose: 5,670 mg/kg/12 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in pituitary weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTXAV 13,313,1975
oral
rat
lowest published toxic dose: 91 mg/kg/26 week- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas GISAAA 41(7),102,1976
oral
rat
lowest published toxic dose: 91 mg/kg/26 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Other changes
VCVGK* -,183,1994
skin
mouse
lowest published toxic dose: 1,411 gm/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-275,1985
skin
mouse
lowest published toxic dose: 1,154 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-275,1985
skin
rat
lowest published toxic dose: 6,188 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-275,1985
skin
rat
lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-275,1985
unreported route
rat
lowest published toxic dose: 910 mg/kg/26 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA 43(8),13,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 1 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
REPTED 25,192,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (16 mg/m3) DTLVS* 3,108,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (16 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (16 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (16 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (16 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA ceiling concentration 1 ppm (3.3 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 1 ppm (3.3 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 1 ppm (3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 1 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 1 ppm (3 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 3.3 mg/m3 (1 mL/m3), 2005
Occupational Exposure Limit - KOREA ceiling concentration 1 ppm (3 mg/m3), 2006
Occupational Exposure Limit - MEXICO peak 1 ppm (3 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 3 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 1 ppm (3.3 mg/m3), skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (16 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN ceiling concentration 1 ppm (3.5 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (3 mg/m3);
KZG- week 1 ppm (3 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (16 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 1 ppm (3.4 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE CHLOROHYDRIN-air ceiling concentration 1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4018;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 476;
Total Number of Female Employees Exposed 68


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: S pombe-forward mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent and emulsifier
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethylene chlorohydrin, 2513
NCI Carcinogenesis Studies (derm);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
BUYRAI Bulletin of Parenteral Drug Association. (Philadelphia, PA) V.1-31, 1946-77.
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent and emulsifier

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us