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Ethanol, 2 - butoxy - , acetate

RTECS #: KJ8925000

CAS #: 112-07-2


UPDATE: May 2009 MW: 160.24 MF: C8H16O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Butoxyethanol acetate
  2. 2 - Butoxyethyl acetate
  3. 2 - Butoxyethylester kyseliny octove (Czech)
  4. Acetic acid, 2 - butoxyethyl ester
  5. Butyl cellosolve acetate
  1. Butylcelosolvacetat (Czech)
  2. Butylglycol acetate
  3. Ektasolve EB acetate
  4. Ethylene glycol monobutyl ether acetate
  5. Glycol monobutyl ether acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,713,1986
skin
rabbit
500 mg open irritation test mild UCDS** 1/31/1966


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 3,200 mg/kg N/R KODAK* 21MAY1971
oral
rat
lethal dose (50 percent kill): 2,400 mg/kg Kidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Other changes in urine composition
TXAPA9 51,117,1979
skin
guinea pig
lowest published lethal dose: 5 mL/kg N/R KODAK* 21MAY1971
skin
rabbit
lethal dose (50 percent kill): 1,500 mg/kg Kidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Normocytic anemia
TXAPA9 51,117,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 4,060 mg/kg/2 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
ARTODN 73,229,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 20 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 20 ppm (133 mg/m3), short term exposure limit 50 ppm (333 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 20 ppm (133 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 50 ppm (333 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 20 ppm (130 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 133 mg/m3 (20 ppm);
short term exposure limit 333 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FRANCE VME 2 ppm (13.3 mg/m3), VLE 30 ppm (199.8 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 130 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 133 mg/m3, short term exposure limit 333 mg/m3, Skin, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 135 mg/m3, Skin, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (70 mg/m3);
short term exposure limit 20 ppm (140 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (135 mg/m3);
KZG- week 80 ppm (540 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 20 ppm;
short term exposure limit 50 ppm (skin), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGBEA-air 10 hour time-weighted average 5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81350;
Number of Industries 50;
Total Number of Facilities 4,676;
Number of Occupations 41;
Total Number of Employees Exposed 36,527
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81350;
Number of Industries 116;
Total Number of Facilities 15,329;
Number of Occupations 70;
Total Number of Employees Exposed 150,893;
Total Number of Female Employees Exposed 38,379


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102527/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #83


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

RTECS Compound Description:
   Primary Irritant

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