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Ethane, 1,1,1 - trichloro - 2,2 - bis (p - methoxyphenyl) -

RTECS #: KJ3675000

CAS #: 72-43-5


UPDATE: May 2009 MW: 345.66 MF: C16H15Cl3O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,1' - (2,2,2 - Trichloroethylidene) bis (4 - methoxybenzene)
  2. 1,1,1 - Trichlor - 2,2 - bis (4 - methoxy - phenyl) - aethan (German)
  3. 1,1,1 - Trichloro - 2,2 - bis (4 - methoxyphenyl) ethane
  4. 1,1,1 - Trichloro - 2,2 - bis (p - anisyl) ethane
  5. 1,1,1 - Trichloro - 2,2 - bis (p - methoxyphenyl) ethane
  6. 1,1,1 - Trichloro - 2,2 - di (4 - methoxyphenyl) ethane
  7. 1,1 - Bis (p - methoxyphenyl) - 2,2,2 - trichloroethane
  8. 2,2,2 - Trichloro - 1,1 - bis (4 - methoxyphenyl) ethane
  9. 2,2 - Bis (4 - methoxyphenyl) - 1,1,1 - trichloroethane
  10. 2,2 - Bis (p - anisyl) - 1,1,1 - trichloroethane
  11. 2,2 - Bis (p - methoxyphenyl) - 1,1,1 - trichloroethane
  12. 2,2 - Di - (p - methoxyphenyl) - 1,1,1 - trichloroethane
  13. 2,2 - Di - p - anisyl - 1,1,1 - trichloroethane
  14. 4,4 - (2,2,2 - Trichloroethylidene) dianisole
  15. Benzene, 1,1' - (2,2,2 - trichloroethylidene) bis (4 - methoxy -
  16. DMDT
  17. Di (p - methoxyphenyl) - trichloromethyl methane
  18. Dianisyltrichlorethane
  19. Dimethoxy - DDT
  20. ENT 1,716
  1. Ethane, 2,2 - bis (p - anisyl) - 1,1,1 - trichloro -
  2. Higalmetox
  3. Marlate
  4. Methoxcide
  5. Methoxy - DDT
  6. Methoxychlor
  7. Methoxychlor (ACGIH:OSHA)
  8. Methoxychlor 2 EC
  9. Methoxychlor technical
  10. Metoksychlor (Polish)
  11. Metox
  12. Mezox K
  13. Moxie
  14. NCI - C00497
  15. OMS 466
  16. RCRA waste number U247
  17. p,p' - Dimethoxydiphenyltrichloroethane
  18. p,p' - Dwumetoksydwufenylotrojchloroetan (Polish)
  19. p,p' - Methoxychlor


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis intraperitoneal
hamster
50 mg/kg ARTODN 58,152,1986
cytogenetic analysis oral
mouse
6 mg/kg/50 day- intermittent FOMOAJ 35,361,1976
DNA damage rat liver 150 mol/L EMMUEG 24,181,1994
mutation in microorganisms mouse lymphocyte 10 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
micronucleus test subcutaneous
mouse
49.5 mg/kg/3 day- intermittent REPTED 17,79,2003
morphological transform hamster embryo 10 mg/L MUREAV 356,85,1996
morphological transform mouse fibroblast 2 mg/L JJIND8 67,1303,1981
sperm morphology oral
rat
28 gm/kg/10 week- continuous PSEBAA 176,187,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 800 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 11,703,1997
oral
mammal (species unspecified)
lowest published toxic dose: 100 mg/kg (1 day pregnant-28 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical
NETEEC 28,103,2006
oral
mouse
lowest published toxic dose: 1 gm/kg (20 day pregnant) Reproductive: Maternal effects: Ovaries, fallopian tubes REPTED 5,139,1991
oral
mouse
lowest published toxic dose: 900 mg/kg (6-8 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 6,431,1992
oral
mouse
lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Maternal effects: Parturition REPTED 6,431,1992
oral
mouse
lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death REPTED 6,431,1992
oral
mouse
lowest published toxic dose: 2,000 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system HBPTO* 1,733,2001
oral
mouse
lowest published toxic dose: 140 g/kg (11-17 day pregnant) Reproductive: Maternal effects: Postpartum

Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral
NETEEC 24,55,2002
oral
mouse
lowest published toxic dose: 0.14 mg/kg (11-17 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical
NETEEC 24,55,2002
oral
mouse
lowest published toxic dose: 640 mg/kg (20 day prior to copulation) Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
TOXID9 -,283,2008
oral
rat
lowest published toxic dose: 66 gm/kg (33 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
JPETAB 138,126,1962
oral
rat
lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 45,435,1978
oral
rat
lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 45,435,1978
oral
rat
lowest published toxic dose: 4,250 mg/kg (42 day prior to copulation-21 day after birth) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 10,625 mg/kg (42 day prior to copulation-21 day after birth) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 9,800 mg/kg (multigeneration) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOXID9 15,164,1995
oral
rat
lowest published toxic dose: 50,400 mg/kg (multigeneration) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
TOXID9 15,164,1995
oral
rat
lowest published toxic dose: 12,600 mg/kg (multigeneration) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TOXID9 15,164,1995
oral
rat
lowest published toxic dose: 210 mg/kg (14-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) ENVRAL 18,437,1979
oral
rat
lowest published toxic dose: 1,600 mg/kg (1-8 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) TXAPA9 97,454,1989
oral
rat
lowest published toxic dose: 600 mg/kg (1-3 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
TXAPA9 97,454,1989
oral
rat
lowest published toxic dose: 1,000 mg/kg (4-8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 97,454,1989
oral
rat
lowest published toxic dose: 2,150 mg/kg (0-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system HBPTO* 2,1340,2001
oral
rat
lowest published toxic dose: 18 gm/kg (14 day prior to copulation/0-22 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) HBPTO* 2,1340,2001
oral
rat
lowest published toxic dose: 2,000 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HBPTO* 2,1340,2001
oral
rat
lowest published toxic dose: 400 mg/kg (1-2 day pregnant) Reproductive: Other effects to embryo or fetus TXAPA9 102,110,1990
oral
rat
lowest published toxic dose: 300 mg/kg (1-3 day pregnant) Reproductive: Other effects to embryo or fetus TXAPA9 102,110,1990
oral
rat
lowest published toxic dose: 10.8 gm/kg (43 day male/43 day prior to copulation-1 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 11.2 gm/kg (43 day male/43 day prior to copulation-5 day after birth) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 12.6 gm/kg (6 week prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Physical
JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 23.8 gm/kg (73 day prior to copulation-25 day after birth) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 5.4 gm/kg (43 day male/43 day prior to copulation-1 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 6.6 gm/kg (43 day male/43 day prior to copulation-25 day after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 6.6 gm/kg (43 day male/43 day prior to copulation-25 day after birth) Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 4,250 mg/kg (6 week prior to copulation-21 day after birth) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 50 mg/kg (multigenerations) Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 7,300 mg/kg (73 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 8,000 mg/kg (6 week prior to copulation/22 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)
JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 8,600 mg/kg (43 day male/43 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 8,750 mg/kg (5 week prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 9,500 mg/kg (73 day prior to copulation-1 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 1,720 mg/kg (1-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TXCYAC 172,205,2002
oral
rat
lowest published toxic dose: 216 mg/kg (15-21 day pregnant/10 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 72,77,2003
oral
rat
lowest published toxic dose: 1,080 mg/kg (15-21 day pregnant/10 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 72,77,2003
oral
rat
lowest published toxic dose: 2,458 mg/kg (7-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOLED5 135,199,2002
oral
rat
lowest published toxic dose: 3,072 mg/kg (7-22 day pregnant/4-7 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOLED5 135,199,2002
oral
rat
lowest published toxic dose: 1,760 mg/kg (1-22 day pregnant/22 day after birth) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOSCF2 66,91,2002
oral
rat
lowest published toxic dose: 1,760 mg/kg (1-22 day pregnant/22 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects
ETOPFR 18,161,2004
oral
rat
lowest published toxic dose: 330 mg/kg (7-21 day pregnant/51 day after birth) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system
TXCYAC 207,271,2005
oral
rat
lowest published toxic dose: 280 mg/kg (7 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 1,400 mg/kg (7 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Other effects on male
TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 216 mg/kg (15-22 day pregnant/10 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
ARTODN 78,232,2004
oral
rat
lowest published toxic dose: 46.5 mg/kg (7 day pregnant-77 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,29,2001
oral
rat
lowest published toxic dose: 1,720 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 66,299,2002
oral
rat
lowest published toxic dose: 1 gm/kg (11-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 90,82,2006
oral
rat
lowest published toxic dose: 1,720 mg/kg (1-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 90,238,2006
oral
rat
lowest published toxic dose: 50 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTPTR* NTR-MG96004
oral
rat
lowest published toxic dose: 0.5 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
NTPTR* NTR-MG96004
oral
rat
lowest published toxic dose: 0.55 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) NTPTR* NTR-MG96004
oral
rat
lowest published toxic dose: 5 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Endocrine system NTPTR* NTR-MG96004
oral
rat
lowest published toxic dose: 39 mg/kg (7 day pregnant-64 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TXCYAC 211,207,2005
oral
rat
lowest published toxic dose: 216 mg/kg (15 day pregnant-10 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TXAPA9 208,127,2005
oral
rat
lowest published toxic dose: 40 mg/kg (multigeneration) Reproductive: Effects on newborn: Physical TOSCF2 91,93,2006
oral
rat
lowest published toxic dose: 1.3 gm/kg (3 week male/ 3 week prior to copulation-3 week after birth) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system JTPAE7 17,165,2004
oral
rat
lowest published toxic dose: 638 mg/kg (3 week male/ 3 week prior to copulation-3 week after birth) Reproductive: Specific developmental abnormalities: Urogenital system JTPAE7 18,89,2005
oral
rat
lowest published toxic dose: 1.9 gm/kg (3 week male/ 3 week prior to copulation-3 week after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities
JTPAE7 18,89,2005
oral
rat
lowest published toxic dose: 6.4 gm/kg (3 week male/ 3 week prior to copulation-3 week after birth) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system
JTPAE7 18,89,2005
oral
rat
lowest published toxic dose: 6.4 gm/kg (3 week male/ 3 week prior to copulation-3 week after birth) Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities
JTPAE7 18,89,2005
oral
rat
lowest published toxic dose: 100 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Other effects on female
TOXID9 -,234,2008
oral
rabbit
lowest published toxic dose: 330 mg/kg (6-27 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
CGANE7 39,190,1999
subcutaneous
mouse
lowest published toxic dose: 99 mg/kg (5-7 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
REPTED 13,405,1999
subcutaneous
mouse
lowest published toxic dose: 99 mg/kg (5-7 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral
NETEEC 24,29,2002
subcutaneous
mouse
lowest published toxic dose: 49.5 mg/kg (2-4 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) REPTED 17,79,2003
subcutaneous
mouse
lowest published toxic dose: 99 mg/kg (2-4 day pregnant) Reproductive: Effects on fertility: Other measures of fertility REPTED 17,79,2003
subcutaneous
mouse
lowest published toxic dose: 0.7 g/kg (12-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TXAPA9 183,10,2002
subcutaneous
mouse
lowest published toxic dose: 99 mg/kg (5-7 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral
NETEEC 24,29,2002
subcutaneous
mouse
lowest published toxic dose: 500.1 mg/kg (2-4 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Physical
REPTED 18,103,2004
subcutaneous
mouse
lowest published toxic dose: 500.1 mg/kg (2-4 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Physical
REPTED 18,103,2004
subcutaneous
mouse
lowest published toxic dose: 500.1 mg/kg (2-4 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
REPTED 21,154,2006
unreported route
mammal (species unspecified)
lowest published toxic dose: 1,000 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system HBPTO* 1,733,2001
unreported route
mouse
lowest published toxic dose: 64 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 78,73,2004
unreported route
mouse
lowest published toxic dose: 640 mg/kg (20 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 78,73,2004
unreported route
rat
lowest published toxic dose: 7 gm/kg (70 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) AHEMA5 9,89,1980
unreported route
rat
lowest published toxic dose: 2,100 mg/kg (21 day prior to copulation) Reproductive: Maternal effects: Oogenesis AHEMA5 9,89,1980
unreported route
rat
lowest published toxic dose: 9,100 mg/kg (70 day male/21 day prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) AHEMA5 9,89,1980
unreported route
rat
lowest published toxic dose: 1,600 mg/kg (1-8 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) HBPTO* 1,733,2001
unreported route
rat
lowest published toxic dose: 2,100 mg/kg (7 day pregnant-7 day after birth) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) HBPTO* 1,734,2001
unreported route
rat
lowest published toxic dose: 50 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Physical
HBPTO* 1,734,2001
unreported route
rat
lowest published toxic dose: 5,800 mg/kg (15-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Musculoskeletal system HBPTO* 1,741,2001
unreported route
rat
lowest published toxic dose: 1,450 mg/kg (15-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HBPTO* 1,741,2001
unreported route
rat
lowest published toxic dose: 725 mg/kg (15-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Physical
HBPTO* 1,741,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 383 gm/kg/3 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
EVHPAZ 36,205,1980
oral
mouse
lowest published toxic dose: 56,700 mg/kg/90 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
JCROD7 93,173,1979
oral
mouse
toxic dose : 62,622 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
EVHPAZ 36,205,1980
oral
mouse
lowest published toxic dose: 65.7 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Testicular tumors
HBPTO* 2,1339,2001
oral
rat
lowest published toxic dose: 18,200 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Prostate tumors
EVHPAZ 36,205,1980
oral
rat
toxic dose : 41 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Multiple effects

Lung, Thorax, or Respiration: Other changes
TXAPA9 11,88,1967
oral
rat
toxic dose : 80 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Ovarian tumors
LIFSAK 24,1367,1979
oral
rat
toxic dose : 72,800 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 36,205,1980
oral
rat
toxic dose : 87,360 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 36,205,1980
oral
rat
toxic dose : 10,920 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
AIPTAK 83,491,1950
oral
rat
toxic dose : 45,500 mg/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
AIPTAK 83,491,1950
oral
rat
lowest published toxic dose: 73 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria HBPTO* 2,1339,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lethal dose (50 percent kill): 500 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight
TXAPA9 14,358,1969
oral
duck
lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,574,1991
oral
hamster
lethal dose (50 percent kill): 2,000 mg/kg N/R HBPTO* 2,1337,2001
oral
human
lowest published lethal dose: 6,430 mg/kg N/R PCOC** -,705,1966
oral
mouse
lethal dose (50 percent kill): 510 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Ataxia
GISAAA 58(1),44,1993
oral
mouse
lethal dose (50 percent kill): 1,850 mg/kg N/R HBPTO* 2,1337,2001
oral
mouse
lethal dose (50 percent kill): 5,000 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased
VCVGK* -,297,1994
oral
rat
lethal dose (50 percent kill): 1,855 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: Ataxia
GISAAA 58(1),44,1993
oral
rat
lowest published toxic dose: 4,000 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 6,491,1992
oral
rat
lethal dose (50 percent kill): 5,000 mg/kg N/R HBPTO* 2,1337,2001
oral
rat
lethal dose (50 percent kill): 5,000 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased
VCVGK* -,297,1994
oral
rat
lowest published toxic dose: 100 mg/kg Endocrine: Other changes TOXID9 -,234,2008
oral
rabbit
lethal dose (50 percent kill): >6 gm/kg N/R SPEADM 78-1,16,1978
subcutaneous
rat
lowest published toxic dose: 95 mg/kg Endocrine: Estrogenic JAFCAU 18,1108,1970
skin
human
lowest published toxic dose: 2,414 mg/kg Behavioral: Somnolence (general depressed activity) PCOC** -,705,1966
skin
rat
lethal dose (50 percent kill): >6 gm/kg N/R CMEP** -,1,1956
skin
rabbit
lethal dose (50 percent kill): >6 gm/kg N/R WRPCA2 3,28,1964
unreported route
mammal (species unspecified)
lowest published toxic dose: 4,000 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 353 mg/kg/10 day- intermittent Related to Chronic Data: Changes in ovarian weight BIREBV 42,573,1990
intraperitoneal
mouse
lowest published toxic dose: 1,777 mg/kg/10 day- intermittent Endocrine: Other changes BIREBV 42,573,1990
intraperitoneal
mouse
lowest published toxic dose: 178 mg/kg/10 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina
BIREBV 42,573,1990
intraperitoneal
mouse
lowest published toxic dose: 378 mg/kg/14 day- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Ovaries, fallopian tubes

Related to Chronic Data: Changes in ovarian weight
REPTED 9,379,1995
intraperitoneal
mouse
lowest published toxic dose: 640 mg/kg/20 day- intermittent Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
TOSCF2 68,473,2002
intraperitoneal
mouse
lowest published toxic dose: 80 mg/kg/2 week- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 60,383,2001
intraperitoneal
mouse
lowest published toxic dose: 320 mg/kg/20 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TXAPA9 216,436,2006
intraperitoneal
rat
lowest published toxic dose: 600 mg/kg/3 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 144,93,2003
intraperitoneal
rat
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Liver: Changes in liver weight TOLED5 144,93,2003
intraperitoneal
rat
lowest published toxic dose: 600 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) TOLED5 144,93,2003
oral
dog
lowest published toxic dose: 168 gm/kg/24 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1338,2001
oral
dog
lowest published toxic dose: 84 gm/kg/6 week- continuous Behavioral: Convulsions or effect on seizure threshold HBPTO* 2,1338,2001
oral
dog
lowest published toxic dose: 126 gm/kg/9 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 2,1338,2001
oral
dog
lowest published toxic dose: 365,000 mg/kg/26 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,298,1994
oral
dog
lowest published toxic dose: 112,000 mg/kg/8 week- continuous Eye: Other eye effects

Behavioral: Tetany

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,298,1994
oral
mammal (species unspecified)
lowest published toxic dose: 7,000 mg/kg/70 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001
oral
monkey
lowest published toxic dose: 18,250 mg/kg/1 year- intermittent Behavioral: Alteration of operant conditioning

Behavioral: Change in psychophysiological tests
NETEEC 24,87,2002
oral
monkey
lowest published toxic dose: 18,250 mg/kg/1 year- intermittent Eye: Other eye effects

Behavioral: Change in psychophysiological tests
NETEEC 24,87,2002
oral
monkey
lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of operant conditioning
NETEEC 26,799,2004
oral
monkey
lowest published toxic dose: 6,100 mg/kg/122 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 60,300,2001
oral
mouse
lowest published toxic dose: 2,000 mg/kg/10 day- intermittent Reproductive: Maternal effects: Parturition HBPTO* 1,733,2001
oral
mouse
lowest published toxic dose: 4,000 mg/kg/4 week- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes REPTED 6,93,1992
oral
mouse
lowest published toxic dose: 80 mg/kg/10 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 72,26,2003
oral
mouse
lowest published toxic dose: 975 mg/kg/39 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOLED5 142,61,2003
oral
mouse
lowest published toxic dose: 640 mg/kg/20 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOXID9 44,441,2005
oral
rat
lowest published toxic dose: 266 mg/kg/19 week- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 53(10),82,1988
oral
rat
lowest published toxic dose: 602 mg/kg/43 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 58(1),44,1993
oral
rat
lowest published toxic dose: 20,000 mg/kg/5 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct REPTED 6,491,1992
oral
rat
lowest published toxic dose: 20,000 mg/kg/4 day- intermittent Related to Chronic Data: Changes in prostate weight REPTED 6,491,1992
oral
rat
lowest published toxic dose: 700 mg/kg/14 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TOSCF2 54,154,2000
oral
rat
lowest published toxic dose: 1,250 mg/kg/25 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders TOSCF2 54,154,2000
oral
rat
lowest published toxic dose: 800 mg/kg/8 day- intermittent Endocrine: Other changes TXAPA9 97,454,1989
oral
rat
lowest published toxic dose: 1,600 mg/kg/8 day- intermittent Related to Chronic Data: Changes in uterine weight TXAPA9 97,454,1989
oral
rat
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 97,454,1989
oral
rat
lowest published toxic dose: 1,000 mg/kg/5 day- intermittent Endocrine: Other changes TXAPA9 97,454,1989
oral
rat
lowest published toxic dose: 2,500 mg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight
TXAPA9 97,454,1989
oral
rat
lowest published toxic dose: 600 gm/kg/10 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JPETAB 99,140,1950
oral
rat
lowest published toxic dose: 30 gm/kg/10 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
JPETAB 99,140,1950
oral
rat
lowest published toxic dose: 13,500 mg/kg/45 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JPETAB 99,140,1950
oral
rat
lowest published toxic dose: 405 gm/kg/45 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Liver: Changes in liver weight
JPETAB 99,140,1950
oral
rat
lowest published toxic dose: 405 gm/kg/45 day- continuous Related to Chronic Data: Changes in testicular weight JPETAB 99,140,1950
oral
rat
lowest published toxic dose: 90 gm/kg/30 day- continuous Related to Chronic Data: Changes in testicular weight

Behavioral: Food intake (animal)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JPETAB 99,140,1950
oral
rat
lowest published toxic dose: 5,400 mg/kg/18 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Behavioral: Tremor
JPETAB 99,140,1950
oral
rat
lowest published toxic dose: 101.25 gm/kg/45 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 2,1337,2001
oral
rat
lowest published toxic dose: 87.6 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1338,2001
oral
rat
lowest published toxic dose: 76 gm/kg/760 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
HBPTO* 2,1340,2001
oral
rat
lowest published toxic dose: 1,400 mg/kg/14 day- continuous Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Other effects on female
HBPTO* 2,1340,2001
oral
rat
lowest published toxic dose: 500 mg/kg/10 day- intermittent Reproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1340,2001
oral
rat
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins
JPETAB 294,308,2000
oral
rat
lowest published toxic dose: 14 gm/kg/28 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ARTODN 75,513,2001
oral
rat
lowest published toxic dose: 2.8 gm/kg/28 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 75,513,2001
oral
rat
lowest published toxic dose: 560 mg/kg/28 day- intermittent Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation ARTODN 75,513,2001
oral
rat
lowest published toxic dose: 14 gm/kg/28 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 75,513,2001
oral
rat
lowest published toxic dose: 2.8 gm/kg/28 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
ARTODN 75,513,2001
oral
rat
lowest published toxic dose: 560 mg/kg/28 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) ARTODN 75,513,2001
oral
rat
lowest published toxic dose: 2.8 gm/kg/28 day- intermittent Liver: Other changes

Endocrine: Adrenal cortex hyperplasia
ARTODN 75,513,2001
oral
rat
lowest published toxic dose: 14 gm/kg/28 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ARTODN 75,513,2001
oral
rat
lowest published toxic dose: 2,100 mg/kg/6 week- continuous Related to Chronic Data: Changes in uterine weight

Liver: Changes in liver weight

Liver: Other changes
JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 5,250 mg/kg/6 week- continuous Related to Chronic Data: Changes in ovarian weight JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 8,750 mg/kg/5 week- continuous Endocrine: Effect on menstrual cycle JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 4,200 mg/kg/12 week- continuous Related to Chronic Data: Changes in ovarian weight

Liver: Other changes
JAFCAU 22,969,1974
oral
rat
lowest published toxic dose: 1,600 mg/kg/8 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TXAPA9 90,330,1987
oral
rat
lowest published toxic dose: 1,400 mg/kg/56 day- intermittent Endocrine: Change in gonadotropins TXAPA9 86,474,1986
oral
rat
lowest published toxic dose: 2,800 mg/kg/56 day- intermittent Endocrine: Other changes TXAPA9 86,474,1986
oral
rat
lowest published toxic dose: 1,225 mg/kg/7 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 2,100 mg/kg/6 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 3,500 mg/kg/5 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 700 mg/kg/1 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 125 mg/kg/5 day- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Uterus, cervix, vagina
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 200 mg/kg/4 day- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Uterus, cervix, vagina
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 600 mg/kg/3 day- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Uterus, cervix, vagina
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 6,900 mg/kg/69 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 11,900 mg/kg/119 day- intermittent Endocrine: Changes in pituitary weight

Endocrine: Changes in adrenal weight

Related to Chronic Data: Changes in ovarian weight
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 23,800 mg/kg/119 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 2,300 mg/kg/23 day- intermittent Reproductive: Other effects on male FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 3,100 mg/kg/62 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 1,550 mg/kg/62 day- intermittent Endocrine: Change in gonadotropins

Endocrine: Other changes
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 5,600 mg/kg/56 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 11,200 mg/kg/56 day- intermittent Endocrine: Changes in pituitary weight

Related to Chronic Data: Changes in testicular weight
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 7,500 mg/kg/75 day- intermittent Endocrine: Androgenic

Endocrine: Changes in pituitary weight

Related to Chronic Data: Changes in testicular weight
FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 15,000 mg/kg/75 day- intermittent Blood: Other changes FAATDF 12,92,1989
oral
rat
lowest published toxic dose: 1,720 mg/kg/42 day- intermittent Behavioral: Food intake (animal) TXCYAC 172,205,2002
oral
rat
lowest published toxic dose: 21 gm/kg/7 day- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct TICEL* 13,369,1981
oral
rat
lowest published toxic dose: 27,960 mg/kg/60 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
VCVGK* -,298,1994
oral
rat
lowest published toxic dose: 2,000 mg/kg/10 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 72,132,2003
oral
rat
lowest published toxic dose: 750 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 193,66,2003
oral
rat
lowest published toxic dose: 1,075.2 mg/kg/7 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 135,199,2002
oral
rat
lowest published toxic dose: 1,400 mg/kg/7 day- intermittent Endocrine: Estrogenic

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in testicular weight
TOXID9 44,112,2005
oral
rat
lowest published toxic dose: 280 mg/kg/7 day- intermittent Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 1,400 mg/kg/7 day- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other
TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 32.5 mg/kg/65 day- continuous Blood: Changes in spleen TOXID9 60,29,2001
oral
rat
lowest published toxic dose: 200 mg/kg/4 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 76,692,2002
oral
rat
lowest published toxic dose: 350 mg/kg/7 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in prostate weight
ARTODN 76,692,2002
oral
rat
lowest published toxic dose: 280 mg/kg/7 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct REPTED 21,148,2006
oral
rat
lowest published toxic dose: 1,400 mg/kg/7 day- intermittent Endocrine: Other changes

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
REPTED 21,148,2006
oral
rat
lowest published toxic dose: 250 mg/kg/20 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders
NTPTR* RACB-20103
oral
rat
lowest published toxic dose: 1,000 mg/kg/20 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in pituitary weight

Related to Chronic Data: Changes in ovarian weight
NTPTR* RACB-20103
oral
rat
lowest published toxic dose: 3,600 mg/kg/72 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* MG96004
oral
rat
lowest published toxic dose: 69 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TXAPA9 218,280,2007
oral
rabbit
lowest published toxic dose: 0.8 gm/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Interstitial nephritis
JPETAB 99,140,1950
subcutaneous
mouse
lowest published toxic dose: 150 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight

Endocrine: Estrogenic
EVHPAZ 104,1296,1996
subcutaneous
mouse
lowest published toxic dose: 500.1 mg/kg/3 day- intermittent Reproductive: Effects on fertility: Other measures of fertility REPTED 18,103,2004
subcutaneous
rat
lowest published toxic dose: 750 mg/kg/30 day- intermittent Brain and Coverings: Recordings from specific areas of CNS TXAPA9 197,319,2004
subcutaneous
rat
lowest published toxic dose: 750 mg/kg/30 day- intermittent Endocrine: Change in LH

Endocrine: Androgenic

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
FCTOD7 46,1570,2008
unreported route
mammal (species unspecified)
lowest published toxic dose: 8,000 mg/kg/4 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001
unreported route
mouse
lowest published toxic dose: 640 mg/kg/20 day- intermittent Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 78,73,2004
unreported route
mouse
lowest published toxic dose: 80 mg/kg/10 day- intermittent Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Uterus, cervix, vagina
TOXID9 66,377,2002
unreported route
mouse
lowest published toxic dose: 320 mg/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 66,377,2002
unreported route
mouse
lowest published toxic dose: 1,280 mg/kg/20 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 90,80,2006
unreported route
rat
lowest published toxic dose: 1,600 mg/kg/8 day- continuous Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
HBPTO* 1,733,2001
unreported route
rat
lowest published toxic dose: 60,000 mg/kg/300 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 20,259,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 20,259,1979
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
CTOXAO 13,231,1978
TOXICOLOGY REVIEW
REPTED 22,164,2006
TOXICOLOGY REVIEW
MUREAV 616,7,2007
TOXICOLOGY REVIEW
ENTOX* -,258,2005
TOXICOLOGY REVIEW
ENTOX* -,61,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
REPTED 23,337,2007
TOXICOLOGY REVIEW
REPTED 23,374,2007
TOXICOLOGY REVIEW
REPTED 23,297,2007
TOXICOLOGY REVIEW
REPTED 25,316,2007
TOXICOLOGY REVIEW
MUREAV 543,251,2003
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,132,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 DTLVS* 3,152,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 15 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 15 mg/m3 (inhalable), 2005
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 15 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHOXYCHLOR-air Carcinogen (0.07 mg/m3 LOQ) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 46210;
Number of Industries 2;
Total Number of Facilities 248;
Number of Occupations 2;
Total Number of Employees Exposed 638
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 46210;
Number of Industries 2;
Total Number of Facilities 504;
Number of Occupations 2;
Total Number of Employees Exposed 3,417


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100202/AS)
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
Used as an insecticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-35,1978


REFERENCES:

CODEN
REFERENCE

AHEMA5 Anatomia, Histologia, Embryologia. (Paul Parey Scientific Pub., 35 W. 38th St., Suite 3W, New York, NY 10018) V.2- 1973-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public Health Service, Communicable Disease Center, Atlanta, GA, 1956
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FOMOAJ Folia Morphologica (Warsaw). (Panstwowy Zaklad Wydawnictw Lekarskich, ul. Dluga 38-40, 00 238 Warsaw, Poland) V.1- 1929-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TICEL* Tissue & cell (Edinburgh, Oliver & Boyd) V.1- 1969-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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