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Ethane, 1,1,2 - trichloro -

RTECS #: KJ3150000

CAS #: 79-00-5


UPDATE: May 2009 MW: 133.40 MF: C2H3Cl3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,1,2 - Trichlorethane
  2. 1,1,2 - Trichloroethane
  3. 1,1,2 - Trichloroethane (ACGIH:OSHA)
  4. 1,2,2 - Trichloroethane
  5. Ethane trichloride
  6. NCI - C04579
  1. RCRA waste number U227
  2. RCRA waste number U359
  3. Trojchloroetan (1,1,2) (Polish)
  4. Vinyl trichloride
  5. beta - T
  6. beta - Trichloroethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
162 mg mild EJTXAZ 9,171,1976
eye
rabbit
500 mg/24 hour mild 85JCAE -,95,1986
skin
guinea pig
1,440 mg/15 minute mild APTOA6 41,298,1977
skin
rabbit
500 mg open irritation test mild UCDS** 6/28/1972
skin
rabbit
810 mg/24 hour severe EJTXAZ 9,171,1976
skin
rabbit
500 mg/24 hour mild 85JCAE -,95,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis skin
guinea pig
2,880 g/kg APTOA6 41,298,1977
DNA adduct mammal (species unspecified) lymphocyte 1 mmol/L TOLED5 11,243,1982
DNA damage human lymphocyte 2,500 mol/L MUREAV 371,185,1996
mutation in microorganisms Salmonella typhimurium 10 g/plate (+/-enzymatic activation step) TECSDY 15,101,1987
micronucleus test human lymphocyte 100 mol/L MUREAV 371,185,1996
morphological transform mouse embryo 25 mg/L CALEDQ 28,85,1985
other mutation test systems Escherichia coli 135 mmol/L EMMUEG 19,98,1992
other mutation test systems oral
mouse
100 mg/kg MUREAV 343,157,1995
sex chromosome loss and nondisjunction Aspergillus nidulans 750 ppm MUREAV 201,401,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 76 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Adrenal cortex tumors
NCITR* NCI-TR-74,1978
oral
mouse
toxic dose : 152 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Adrenal cortex tumors
NCITR* NCI-TR-74,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 13,100 mg/m3/4.5 hour Eye: Other eye effects

Behavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands
AHBAAM 116,131,1936
inhalation
mouse
lowest published toxic concentration: 10,000 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,380,1990
inhalation
mouse
lowest published toxic concentration: 20,400 mg/m3/17 minute Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases VCVGH* -,381,1990
inhalation
rat
lowest published lethal concentration: 500 ppm/4 hour N/R UCDS** 6/28/1972
intraperitoneal
dog
lethal dose (50 percent kill): 450 mg/kg Liver: Liver function tests impaired TXAPA9 10,119,1967
intraperitoneal
guinea pig
lowest published lethal dose: 970 mg/kg N/R AOHYA3 19,115,1976
intraperitoneal
mouse
lethal dose (50 percent kill): 494 mg/kg N/R TXAPA9 9,139,1966
intraperitoneal
rat
lethal dose (50 percent kill): 265 mg/kg N/R ENVRAL 40,411,1986
intravenous
dog
lowest published lethal dose: 95 mg/kg N/R QJPPAL 7,205,1934
oral
dog
lowest published lethal dose: 500 mg/kg Behavioral: Sleep

Liver: Hepatitis (hepatocellular necrosis), zonal
AJHYA2 16,325,1932
oral
mouse
lethal dose (50 percent kill): 378 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Ulceration or bleeding from stomach
DCTODJ 8,333,1985
oral
mouse
lethal dose (50 percent kill): 378 mg/kg N/R VCVGH* -,381,1990
oral
rat
lethal dose (50 percent kill): 580 mg/kg N/R ENTOX* -,380,2005
subcutaneous
mouse
lethal dose (50 percent kill): 227 mg/kg N/R JPETAB 123,224,1958
subcutaneous
rabbit
lowest published lethal dose: 500 mg/kg N/R QJPPAL 7,205,1934
skin
guinea pig
lowest published lethal dose: 970 mg/kg N/R AOHYA3 19,115,1976
skin
rabbit
lethal dose (50 percent kill): 3,730 L/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 532 mg/kg/14 day- intermittent Brain and Coverings: Changes in brain weight

Endocrine: Changes in thymus weight

Related to Chronic Data: Changes in testicular weight
DCTODJ 8,333,1985
oral
mouse
lowest published toxic dose: 27 gm/kg/90 day- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
DCTODJ 8,333,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 20,533,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 52,337,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1153,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 20,533,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Available Data IMEMDT 52,337,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1153,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1153,1999
TOXICOLOGY REVIEW
FAZMAE 18,365,1974
TOXICOLOGY REVIEW
AIHAAP 40(3),A46,1979
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,380,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (45 mg/m3) (skin) DTLVS* 3,263,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (45 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (45 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (45 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (45 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 10 ppm (40 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (55 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (56 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (54 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (54 mg/m3), short term exposure limit 20 ppm (110 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 55 mg/m3 (10 mL/m3), 2005
Occupational Exposure Limit - HUNGARY Prohibited in Hungary, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (55 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (55 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (45 mg/m3);
short term exposure limit 20 ppm (30 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 45 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (55 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (54 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 ppm, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (55 mg/m3),KZG- week 20 ppm (110 mg/m3), Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,2-TRICHLOROETHANE-air Carcinogen;
10 hour time-weighted average 10 ppm (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 73770;
Number of Industries 12;
Total Number of Facilities 1,422;
Number of Occupations 18;
Total Number of Employees Exposed 10,453
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 73770;
Number of Industries 4;
Total Number of Facilities 95;
Number of Occupations 12;
Total Number of Employees Exposed 1,038;
Total Number of Female Employees Exposed 16


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/196411/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in the production of VINYLIDINE CHLORIDE, and component of adhesives
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse NCITR* NCI-TR-74,1978
NCI Carcinogenesis Bioassay (gavage);no evidence:rat NCITR* NCI-TR-74,1978
OSHA ANALYTICAL METHOD #11


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For publisher information, see AJEPAS.
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as an intermediate in the production of VINYLIDINE CHLORIDE, and component of adhesives

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Human Data
   Primary Irritant

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