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Ethane, 1,2 - difluoro - 1,1,2,2 - tetrachloro -

RTECS #: KI1420000

CAS #: 76-12-0


UPDATE: May 2009 MW: 203.82 MF: C2Cl4F2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,1,2,2 - Tetrachloro - 1,2 - difluoroethane
  2. 1,1,2,2 - Tetrachloro - 1,2 - difluoroethane (ACGIH:OSHA)
  3. 1,2 - Difluoro - 1,1,2,2 - tetrachloroethane
  4. CFC - 112
  5. Daiflon 112
  6. Daiflon S2
  7. Ethane, 1,1,2,2 - tetrachloro - 1,2 - difluoro -
  1. F - 112
  2. Freon 112
  3. Genetron 112
  4. Halocarbon 112
  5. R 112
  6. Refrigerant 112
  7. Ucon 112


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
guinea pig
100 mg/20S rinse mild AIHAAP 27,332,1966
skin
guinea pig
1,00%/24 hour open irritation test mild AIHAAP 27,332,1966


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 50 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
TLSMA6 75,241,1963
inhalation
mouse
lowest published lethal concentration: 40,000 mg/m3/2 hour N/R VCVGH* -,634,1990
inhalation
mouse
lethal concentration (50 percent kill): 123,000 mg/m3/2 hour N/R VCVGH* -,634,1990
inhalation
rat
lethal concentration (50 percent kill): 2 pph/15 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
HUTODJ 1,239,1982
inhalation
rat
lowest published toxic concentration: 84,000 mg/m3 Behavioral: General anesthetic VCVGH* -,634,1990
inhalation
rat
lethal concentration (50 percent kill): 125,000 mg/m3/4 hour N/R VCVGH* -,634,1990
inhalation
rat
lowest published lethal concentration: 258,000 mg/m3/40 minute N/R VCVGH* -,634,1990
oral
guinea pig
lowest published lethal dose: >10 gm/kg N/R NTIS** OTS0520705
oral
mouse
lethal dose (50 percent kill): 800 mg/kg N/R 85GMAT -,54,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,000 ppm/6 hour/31 day- intermittent Liver: Other changes

Blood: Luekopenia
AIHAAP 27,332,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (4170 mg/m3) DTLVS* 3,249,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 500 ppm (4170 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 500 ppm (4231 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (1665 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 500 ppm (4170 mg/m3), short term exposure limit 625 ppm (5215 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 500 ppm (4170 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1700 mg/m3 (200 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 500 ppm (4170 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 500 ppm (4170 mg/m3);
short term exposure limit 625 ppm (5210 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 850 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 500 ppm (4170 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 500 ppm (4170 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 1000 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (1690 mg/m3),KZG- week 400 ppm (3380 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 500 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 500 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE-air time-weighted average 500 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71447;
Number of Industries 8;
Total Number of Facilities 451;
Number of Occupations 7;
Total Number of Employees Exposed 7,803
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71447;
Number of Industries 5;
Total Number of Facilities 95;
Number of Occupations 5;
Total Number of Employees Exposed 1,434;
Total Number of Female Employees Exposed 191


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a refrigerant, a solvent extractant, and in dry cleaning industry
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,2,2-Tetrachloro-1,2-difluoroethane, 1016
NTP Toxicity studies, RPT# TOX-45, October 2000


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a refrigerant, a solvent extractant, and in dry cleaning industry

RTECS Compound Description:
   Tumorigen
   Primary Irritant

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