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Diphenylamine

RTECS #: JJ7800000

CAS #: 122-39-4


UPDATE: May 2009 MW: 169.24 MF: C12H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Aniline, N - phenyl -
  2. Anilinobenzene
  3. Benzenamine, N - phenyl - (9CI)
  4. Benzene, anilino -
  5. Benzene, (phenylamino) -
  6. Big Dipper
  7. C.I. 10355
  8. DFA
  9. Deccoscald 282
  10. Difenylamin (Czech)
  1. Diphenylamine (ACGIH:OSHA)
  2. N,N - Diphenylamine
  3. N - Fenylanilin (Czech)
  4. N - Phenylaniline
  5. N - Phenylbenzenamine
  6. Naugalube 428L
  7. No - Scald
  8. No - Scald DPA 283
  9. Scaldip
  10. Shield DPA


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 7,500 mg/kg (17-22 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system PEREBL 4,448,1970
unreported route
mammal (species unspecified)
lowest published toxic dose: 131 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FEREAC 64,25845,1999
unreported route
mammal (species unspecified)
lowest published toxic dose: 448 mg/kg (multigenerations) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) FEREAC 64,25845,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
guinea pig
lethal dose (50 percent kill): 300 mg/kg N/R FMCHA2 -,C112,1991
oral
mammal (species unspecified)
lethal dose (50 percent kill): 3,200 mg/kg Lung, Thorax, or Respiration: Cyanosis GISAAA 40(10),114,1975
oral
mouse
lethal dose (50 percent kill): 1,230 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia
STGNBT -,104,1999
oral
rat
lethal dose (50 percent kill): 1,120 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia
STGNBT -,104,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 1,200 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) VTPHAK 27,171,1990
oral
hamster
lowest published toxic dose: 1,200 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VTPHAK 27,171,1990
oral
mouse
lowest published toxic dose: 1,750 mg/kg/10 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
STGNBT -,104,1999
oral
rat
lowest published toxic dose: 25 mg/kg/30 day- intermittent Gastrointestinal: Alteration in gastric secretion

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria
STGNBT -,104,1999
oral
rat
lowest published toxic dose: 309 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes
STGNBT -,104,1999
oral
rat
lowest published toxic dose: 2,400 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Other changes VTPHAK 27,171,1990
skin
rabbit
lowest published toxic dose: 21,000 mg/kg/21 day- intermittent Gastrointestinal: Other changes FEREAC 71,70703,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
EVHPAZ 15,121,1976
TOXICOLOGY REVIEW
CMSHAF 53,809,2003
TOXICOLOGY REVIEW
FEREAC 71,70703,2006
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,177,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 DTLVS* 3,95,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 10 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3;
short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.7 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 4 mg/m3;
short term exposure limit 12 mg/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3;
short term exposure limit 20 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIPHENYLAMINE-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 27615;
Number of Industries 71;
Total Number of Facilities 3,217;
Number of Occupations 55;
Total Number of Employees Exposed 50,967
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 27615;
Number of Industries 97;
Total Number of Facilities 10,880;
Number of Occupations 78;
Total Number of Employees Exposed 155,673;
Total Number of Female Employees Exposed 20,837


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antioxidant for polymers, greases and industrial oils
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #78


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HTOPA*
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
VTPHAK Veterinary Pathology. (Waverly Press, Inc., POB 64025, Baltimore, MD 21264) V.8- 1971-

Used as an antioxidant for polymers, greases and industrial oils

NIOSH PROFILE (AMINES, SECONDARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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