Dimethylamine

RTECS #

IP8750000

CAS #

124-40-3
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

45.10

Molecular Formula

C₂H₇N

Synonyms

Dimethylamine (ACGIH:OSHA)
Methanamine, N-methyl- (9CI)
N-Methylmethanamine
RCRA waste number U092

Skin and Eye Irritation and References

Route/Organism	Dose	Reference
eye /rabbit	50 mg/5M	BJIMAG 23,153,1966
skin /mouse	6%/2H	TPKVAL 1,41,1961
skin /rabbit	3%/5D- intermittent	TPKVAL 1,41,1961
skin /rabbit	6%	TPKVAL 1,41,1961

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	inhalation/rat	50 µg/m³	GISAAA 36(11),9,1971
Cytogenetic Analysis	ovary/hamster	10 mmol/L	MOTOEX 1,217,1987
sister chromatid exchange	ovary/hamster	500 µmol/L	MOTOEX 1,217,1987

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	lowest published toxic concentration: 0.2 gm/m³		TPKVAL 7,56,1965
inhalation/human	lowest published toxic concentration: 0.05 gm/m³	Eye: Conjunctiva irritation	TPKVAL 7,56,1965
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 0.07 gm/m³	Behavioral: Alteration of classical conditioning	TPKVAL 7,56,1965
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 3700 mg/m³		TPKVAL 14,80,1975
inhalation/mammal (species unspecified)	lowest published toxic concentration: 0.05 gm/m³	Eye: Conjunctiva irritation Behavioral: Convulsions or effect on seizure threshold Vascular: Other changes	TPKVAL 7,56,1965
inhalation/mammal (species unspecified)	Lowest published lethal concentration: 2.4 gm/m³	Eye: Conjunctiva irritation	TPKVAL 7,56,1965
inhalation/mouse	Lowest published lethal concentration: 0.35 gm/m³/2H	Behavioral: Alteration of classical conditioning	TPKVAL 1,41,1961
inhalation/mouse	Lowest published lethal concentration: 0.03 gm/m³/2H	Vascular: Structural changes in vessels Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Respiratory obstruction	TPKVAL 1,41,1961
inhalation/mouse	lethal concentration (50 percent kill): 0.07 gm/m³/2H	Behavioral: Alteration of classical conditioning	TPKVAL 1,41,1961
inhalation/mouse	lethal concentration (50 percent kill): 4725 ppm/2H		AIHAAP 43,411,1982
inhalation/mouse	lowest published toxic concentration: 0.005 gm/m³/2H	Behavioral: Alteration of classical conditioning	TPKVAL 7,56,1965
inhalation/mouse	lowest published toxic concentration: 0.005 gm/m³/2H	Behavioral: Somnolence (general depressed activity) Vascular: Structural changes in vessels Lung, Thorax, or Respiration: Respiratory stimulation	TPKVAL 1,41,1961
inhalation/rat	lowest published toxic concentration: 0.005 gm/m³/2H	Liver: Fatty liver degeneration Liver: Other changes Kidney, Ureter, and Bladder: Other changes	TPKVAL 1,41,1961
inhalation/rat	lowest published toxic concentration: 0.005 gm/m³/2H		TPKVAL 7,56,1965
inhalation/rat	lethal concentration (50 percent kill): 4540 ppm/6H	Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Dyspnea	AIHAAP 43,411,1982
inhalation/rat	lethal concentration (50 percent kill): 3 gm/m³/2H	Eye: Conjunctiva irritation Eye: Corneal damage Skin: After systemic exposure: Dermatitis, other	TPKVAL 1,41,1961
intraperitoneal/mouse	lethal dose (50 percent kill): 736 mg/kg		YKKZAJ 97,1117,1977
intravenous/rabbit	lowest published lethal dose: 4 gm/kg		85KYAH 11,509,1989
ocular/mammal (species unspecified)	lowest published toxic dose: 100 pph	Eye: Conjunctiva irritation	TPKVAL 7,56,1965
ocular/rabbit	lowest published toxic dose: 3 pph	Eye: Lacrimation Eye: Conjunctiva irritation Eye: Corneal damage	TPKVAL 1,41,1961
oral/guinea pig	lethal dose (50 percent kill): 240 mg/kg	Behavioral: Excitement Behavioral: Muscle weakness Gastrointestinal: Ulceration or bleeding from stomach	HYSAAV 32(6),329,1967
oral/mouse	lowest published lethal dose: 600 mg/kg		MUREAV 539,65,2003
oral/mouse	lethal dose (50 percent kill): 316 mg/kg	Behavioral: Excitement Behavioral: Muscle weakness Gastrointestinal: Ulceration or bleeding from stomach	HYSAAV 32(6),329,1967
oral/rabbit	lethal dose (50 percent kill): 240 mg/kg	Behavioral: Excitement Behavioral: Muscle weakness Gastrointestinal: Ulceration or bleeding from stomach	HYSAAV 32(6),329,1967
oral/rat	lethal dose (50 percent kill): 698 mg/kg	Behavioral: Excitement Behavioral: Muscle weakness Gastrointestinal: Ulceration or bleeding from stomach	HYSAAV 32(6),329,1967

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 0.005 gm/m³/213D- intermittent	Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Recording from peripheral motor nerve Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	TPKVAL 7,56,1965
inhalation/mouse	lowest published toxic dose: 175 ppm/6H/1Y- intermittent	Olfaction: Other olfaction effects Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FAATDF 5,341,1985
inhalation/mouse	lowest published toxic concentration: 175 ppm/6H/2Y- intermittent	Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 3,24,1983
inhalation/rat	lowest published toxic concentration: 175 ppm/6H/1Y- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases	FAATDF 5,341,1985
inhalation/rat	lowest published toxic concentration: 175 ppm/6H/9D- intermittent	Olfaction: Other olfaction effects	TXAPA9 90,359,1987
inhalation/rat	lowest published toxic concentration: 175 ppm/6H/2Y- intermittent	Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOXID9 3,24,1983
inhalation/rat	lowest published toxic concentration: 0.003 gm/m³/10D- intermittent	Behavioral: Alteration of classical conditioning	TPKVAL 1,41,1961
inhalation/rat	lowest published toxic concentration: 0.003 gm/m³/213D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TPKVAL 1,41,1961
inhalation/rat	lowest published toxic concentration: 0.003 gm/m³/122D- intermittent	Blood: Other changes	TPKVAL 1,41,1961
inhalation/rat	lowest published toxic concentration: 0.003 gm/m³/61D- intermittent	Peripheral Nerve and Sensation: Recording from peripheral motor nerve	TPKVAL 1,41,1961
oral/guinea pig	lowest published toxic dose: 850 mg/kg/35W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Other changes in urine composition Endocrine: Other changes	GISAAA 32(6),12,1967
oral/rat	lowest published toxic dose: 85 mg/kg/35W- intermittent	Behavioral: Alteration of classical conditioning Liver: Changes in liver weight Immunological Including Allergic: Decrease in cellular immune response	GISAAA 32(6),12,1967
oral/rat	lowest published toxic dose: 37128 gm/kg/39W- continuous	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TOLED5 17,125,1983

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 15 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		CHREAY 9,389,1931
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 ppm (18 mg/m³)	DTLVS* 3,88,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 2 ppm (3.8 mg/m³), short term exposure limit 6 ppm (11 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 2 ppm (3.8 mg/m³);KZW 2 ppm (3.8 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 2 ppm (3.8 mg/m³), short term exposure limit 5 ppm (9.4 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (3.7 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 3.8 mg/m³ (2 ppm);short term exposure limit 9.4 mg/m³ (5 ppm), JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 2 ppm (3.7 mg/m³), short term exposure limit 5 ppm (9.4 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 1 ppm (1.9 mg/m³), VLE 2 ppm (3.8 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 2 ppm (3.7 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 3.8 mg/m³, short term exposure limit 9.4 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 2 ppm (3.8 mg/m³), short term exposure limit 5 ppm (9.4 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 10 ppm (18 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (18 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (18 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (18 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 10 ppm (18 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 ppm (9,2 mg/m³); short term exposure limit 15 ppm (27,7 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 9 mg/m³, MAC(short term exposure limit) 18 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 2 ppm (3.5 mg/m³);short term exposure limit 5 ppm (9 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 2 ppm (4 mg/m³), KZG-week 4 ppm (8 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1.8 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 10 ppm (18 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 2 ppm (3.8 mg/m³);short term exposure limit 6 ppm (11 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 10 ppm (18 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 10 ppm (18 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 10 ppm (18 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 10 ppm (18 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLAMINE-air	10H time-weighted average 10 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X1555; Number of Industries 1; Total Number of Facilities 32; Number of Occupations 1; Total Number of Employees Exposed 65; Total Number of Female Employees Exposed 65
National Occupational Exposure Survey 1983	Hazard Code 26130; Number of Industries 22; Total Number of Facilities 1406; Number of Occupations 42; Total Number of Employees Exposed 28879; Total Number of Female Employees Exposed 2001
National Occupational Hazard Survey 1974	Hazard Code 26130; Number of Industries 13; Total Number of Facilities 291; Number of Occupations 16; Total Number of Employees Exposed 3174

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aliphatic, 2010
On EPA IRIS database
OSHA ANALYTICAL METHOD #34

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health