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1,4:5,8 - Dimethanonaphthalene, 1,2,3,4,10,10 - hexachloro - 6,7 - epoxy - 1,4,4a,5,6,7,8,8a - octahydro, endo,exo -

RTECS #: IO1750000

CAS #: 60-57-1


UPDATE: May 2009 MW: 380.90 MF: C12H8Cl6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Aldrin epoxide
  2. Alvit 55
  3. Compound 497
  4. Dieldrex
  5. Dieldrin
  6. Dieldrin (ACGIH:OSHA)
  7. Dieldrine (French)
  8. Dielmoth
  9. Dorytox
  10. ENT 16,225
  11. HEOD
  12. Hexachloroepoxyoctahydro - endo,exo - dimethanonaphthalene
  13. Illoxol
  1. Insecticide No. 497
  2. Insectlack
  3. Kombi - Albertan
  4. Latka 497 (Czech)
  5. Moth Snub D
  6. NCI - C00124
  7. Octalox
  8. Panoram D - 31
  9. RCRA waste number P037
  10. Red Shield
  11. SD 3417
  12. Termitox
  13. exo - Dieldrin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis duck lymphocyte 100 ppm 34LXAP -,555,1976
cytogenetic analysis intraperitoneal
mouse
1,200 g/kg SOGEBZ 2,80,1966
DNA damage human mammary gland 2.8 mg/L/24 hour (-enzymatic activation step) MUREAV 588,47,2005
DNA damage mouse fibroblast 25 mol/L/24 hour MOCAT* 18,127,2003
DNA inhibition human lymphocyte 100 mg/L ARTODN 45,101,1980
DNA inhibition human HeLa cell 400 mol/L MUREAV 92,427,1982
DNA inhibition oral
mouse
50 mg/kg MUREAV 46,305,1977
DNA inhibition rat other cell types 10 mg/L ARTODN 45,101,1980
unscheduled DNA synthesis human fibroblast 1 mol/L MUREAV 42,161,1977
mutation in microorganisms Salmonella typhimurium 1 mg/L (+/-enzymatic activation step) JOHEA8 68,184,1977
mutation in mammalian somatic cells hamster lung 10 mol/L CBINA8 19,369,1977
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
morphological transform oral
rat
15 mg/kg CNREA8 40,1157,1980
other mutation test systems mammal (species unspecified) fibroblast 50 mg/L AECTCV 15,581,1986
other mutation test systems oral
mouse
20 mg/kg MUREAV 343,157,1995
other mutation test systems mouse other cell types 1 ppm/4 hour EESADV 3,10,1979
sister chromatid exchange hamster ovary 40 mg/L EMMUEG 10(Suppl 10),1,1987
specific locus test mouse lymphocyte 10 mg/L EMMUEG 17,196,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 219 mg/kg (44 week prior to copulation/1-8 week pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) JAVMA4 123,28,1953
oral
hamster
lowest published toxic dose: 30 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 9,11,1974
oral
hamster
lowest published toxic dose: 30 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 9,11,1974
oral
mouse
lowest published toxic dose: 30,600 g/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
THERAP 25,907,1970
oral
mouse
lowest published toxic dose: 15 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 9,11,1974
oral
mouse
lowest published toxic dose: 2,250 g/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 16,57,1977
oral
mouse
lowest published toxic dose: 12,500 g/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FCTXAV 13,317,1975
oral
mouse
lowest published toxic dose: 4,500 g/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 16,57,1977
oral
mouse
lowest published toxic dose: 6,250 g/kg (5 day male) Reproductive: Other effects on male ENVRAL 9,26,1975
oral
rat
lowest published toxic dose: 14 g/kg (multigenerations) Reproductive: Effects on newborn: Behavioral PCBPBS 13,20,1980
oral
rat
lowest published toxic dose: 21 mg/kg (14-20 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Delayed effects
ENVRAL 18,437,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 546 mg/kg/65 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ATSUDG 2,197,1979
oral
mouse
toxic dose : 11 gm/kg/3 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
FCTXAV 11,415,1973
oral
mouse
toxic dose : 610 mg/kg/73 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
FCTXAV 11,433,1973
oral
mouse
toxic dose : 714 mg/kg/85 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
LAINAW 44,392,1981
oral
mouse
toxic dose : 8 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CRNGDP 3,941,1982
oral
mouse
toxic dose : 4,550 mg/kg/65 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CNREA8 41,3615,1981
oral
rat
lowest published toxic dose: 200 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
FCTXAV 2,551,1964


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lethal dose (50 percent kill): 3 mg/kg Behavioral: Convulsions or effect on seizure threshold TOLED5 60,289,1992
inhalation
cat
lethal concentration (50 percent kill): 80 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
GTPZAB 8(4),30,1964
inhalation
rat
lethal concentration (50 percent kill): 13 mg/m3/4 hour N/R 85GMAT -,73,1982
intraperitoneal
mouse
lowest published lethal dose: 26 mg/kg N/R TXAPA9 23,288,1972
intraperitoneal
rat
lethal dose (50 percent kill): 35 mg/kg N/R CBPCEE 85,437,1986
intraperitoneal
rat
lowest published toxic dose: 20 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other
GEPHDP 18,165,1987
intravenous
mouse
lethal dose (50 percent kill): 10,500 g/kg N/R TXAPA9 23,408,1972
intravenous
pigeon
lethal dose (50 percent kill): 1,200 mg/kg N/R 32ZDAL -,79,1970
intravenous
rat
lethal dose (50 percent kill): 9 mg/kg N/R BJIMAG 21,269,1964
intravenous
rat
lowest published toxic dose: 45 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BCPCA6 67,2141,2004
oral
wild bird
lethal dose (50 percent kill): 13,300 g/kg N/R ASTTA8 (680),157,1979
oral
cat
lowest published lethal dose: 500 mg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes
CVETAA 2,71,1958
oral
chicken
lethal dose (50 percent kill): 20 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Excitement

Behavioral: Food intake (animal)
JEENAI 44,1013,1951
oral
duck
lethal dose (50 percent kill): 381 mg/kg N/R TXAPA9 20,57,1971
oral
dog
lethal dose (50 percent kill): 65 mg/kg N/R GUCHAZ 6,198,1973
oral
guinea pig
lethal dose (50 percent kill): 49 mg/kg N/R PCOC** -,377,1966
oral
hamster
lethal dose (50 percent kill): 60 mg/kg N/R TJADAB 9,11,1974
oral
mammal (species unspecified)
lethal dose (50 percent kill): 94 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
NTIS** PB288-416
oral
man
lowest published lethal dose: 65 mg/kg N/R 34ZIAG -,215,1969
oral
monkey
lethal dose (50 percent kill): 3 mg/kg N/R 32ZDAL -,79,1970
oral
mouse
lethal dose (50 percent kill): 38 mg/kg N/R SPEADM 78-1,13,1978
oral
pigeon
lethal dose (50 percent kill): 23,700 g/kg N/R ASTTA8 (680),157,1979
oral
pig
lethal dose (50 percent kill): 38 mg/kg N/R EJTXAZ 7,159,1974
oral
quail
lethal dose (50 percent kill): 10,780 g/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Irritability
ETOCDK 1,157,1982
oral
rat
lethal dose (50 percent kill): 38,300 g/kg N/R JAFCAU 3,402,1955
oral
rat
lowest published toxic dose: 30 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ENPBBC 5,119,1975
oral
rabbit
lethal dose (50 percent kill): 45 mg/kg N/R PCOC** -,377,1966
subcutaneous
rat
lethal dose (50 percent kill): 49 mg/kg N/R 85GMAT -,73,1982
subcutaneous
rabbit
lowest published lethal dose: 150 mg/kg N/R 85GMAT -,73,1982
skin
cat
lowest published lethal dose: 750 mg/kg Behavioral: Food intake (animal)

Behavioral: Withdrawal

Gastrointestinal: Nausea or vomiting
CVETAA 2,71,1958
skin
rat
lethal dose (50 percent kill): 56 mg/kg N/R RPZHAW 18,161,1967
skin
rabbit
lethal dose (50 percent kill): 250 mg/kg N/R SPEADM 78-1,13,1978
unreported route
dog
lowest published lethal dose: 65 mg/kg N/R AMIHBC 3,64,1951
unreported route
human
lowest published lethal dose: 28 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema
ATXKA8 22,115,1966
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 25 mg/kg N/R 30ZDA9 -,63,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 21 mg/kg/7 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TXAPA9 19,234,1971
oral
domestic bird
lowest published toxic dose: 68 mg/kg/8 week- continuous Autonomic Nervous System: Sympathomimetic

Liver: Changes in liver weight

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TXAPA9 53,75,1980
oral
cat
lowest published toxic dose: 51 mg/kg/17 day- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CVETAA 2,71,1958
oral
dog
lowest published toxic dose: 27,200 g/kg/68 week- intermittent Liver: Changes in liver weight JAFCAU 3,402,1955
oral
mammal (species unspecified)
lowest published toxic dose: 239 mg/kg/30 day- continuous Behavioral: Convulsions or effect on seizure threshold

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB288-416
oral
mouse
lowest published toxic dose: 75,600 g/kg/18 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
EVHPAZ 39,79,1981
oral
mouse
lowest published toxic dose: 840 g/kg/2 week- continuous Immunological Including Allergic: Decrease in humoral immune response EVHPAZ 39,79,1981
oral
mouse
lowest published toxic dose: 25 mg/kg/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Endocrine: Androgenic

Biochemical: Metabolism (intermediary): Other
ENVRAL 13,441,1977
oral
quail
lowest published toxic dose: 14 mg/kg/14 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
POSCAL 53,54,1974
oral
rat
lowest published toxic dose: 75 mg/kg/15 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOLED5 11,131,1982
oral
rat
lowest published toxic dose: 88 mg/kg/88 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JTEHD6 25,461,1988
oral
rat
lowest published toxic dose: 140 mg/kg/8 week- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXAPA9 37,29,1976
oral
rat
lowest published toxic dose: 109 mg/kg/2 year- continuous Liver: Changes in liver weight JAFCAU 3,402,1955
oral
rat
lowest published toxic dose: 410 mg/kg/39 week- continuous Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMPLAO 64,614,1957
oral
rat
lowest published toxic dose: 120 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Behavioral: Aggression
TOXID9 44,432,2005
oral
rat
lowest published toxic dose: 120 mg/kg/30 day- intermittent Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 44,432,2005
oral
rat
lowest published toxic dose: 60 mg/kg/30 day- intermittent Liver: Changes in liver weight TOXID9 44,432,2005
oral
rat
lowest published toxic dose: 30 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 44,432,2005
oral
rat
lowest published toxic dose: 28 mg/kg/7 day- intermittent Behavioral: Food intake (animal) TOXID9 44,432,2005
oral
rat
lowest published toxic dose: 32.5 mg/kg/13 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 90,143,2006
oral
rabbit
lowest published toxic dose: 751 g/kg/13 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Metabolism (intermediary): Other proteins
BECTA6 10,42,1973
unreported route
mouse
lowest published toxic dose: 30 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TOXID9 90,227,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.25 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 5,125,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 5,125,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,196,1987
TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
JSIRAC 34,462,1975
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
ECMAAI 14,141,1973
TOXICOLOGY REVIEW
BNYMAM 54,413,1978
TOXICOLOGY REVIEW
85CVA2 5,250,1970
TOXICOLOGY REVIEW
26UZAB 6,149,1968/1970
TOXICOLOGY REVIEW
EVHPAZ 109(Suppl 1),113,2001
TOXICOLOGY REVIEW
CTOXAO 13,231,1978
TOXICOLOGY REVIEW
EESADV 1,89,1977
TOXICOLOGY REVIEW
TXAPA9 10,613,1967
TOXICOLOGY REVIEW
EVHPAZ 109(Suppl 1),35,2001
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
NETOX* 26,701,2005
TOXICOLOGY REVIEW
NRTXDN 27,579,2006
TOXICOLOGY REVIEW
BPCEM* 16,105,2002
TOXICOLOGY REVIEW
ENTOX* -,15,2005
TOXICOLOGY REVIEW
ENTOX* -,334,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HETOEA 25,413,2006
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
REPTED 23,457,2007
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.25 mg/m3 (skin) DTLVS* 3,84,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.25 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.25 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.25 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.25 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.25 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.25 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.25 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.25 mg/m3, short term exposure limit 0.75 mg/m3, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 0.25 mg/m3, Skin, continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.25 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.25 mg/m3 (resp), short term exposure limit 1 mg/m3 (resp), SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.25 mg/m3, Skin, JAN1993
Occupational Exposure Limit - KOREA time-weighted average 0.25 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.25 mg/m3;
short term exposure limit 0.75 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.25 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.25 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.25 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.25 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.01 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.25 mg/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.25 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.25 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIELDRIN-air Carcinogen time-weighted average 0.25 mg/m3 (Sk) (0.15 mg/m3 LOQ) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2830;
Number of Industries 2;
Total Number of Facilities 56;
Number of Occupations 3;
Total Number of Employees Exposed 760


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182368/AS)
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as an insecticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse NCITR* NCI-TR-21,1978
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-22,1978
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-21,1978


REFERENCES:

CODEN
REFERENCE

26UZAB "Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
32ZDAL "Aldrin Dieldrin Endrin and Telodrin: An Epidemiological and Toxicological Study of Long-Term Occupational Exposure," Jager, K.W., New York, Elsevier Science Pub. Co., 1970
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed., New York, Plenum Pub. Corp., 1976
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
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Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 3039-00-7
Click Here for Additional Information about RTECS

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