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Diesel exhaust

RTECS #: HZ1755000

CAS #: N/R


UPDATE: May 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. MUTATION DATA:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

N/R N/R


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct inhalation
mouse
6,200 g/m3/16 hour/12 week- intermittent EMMUEG 16,64,1990
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+/-enzymatic activation step) MUREAV 415,13,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 4,900 g/m3/8 hour/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
DTESD7 13,349,1986
inhalation
rat
toxic concentration (other than lowest) : 7 mg/m3/7 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
FAATDF 9,208,1987
inhalation
rat
toxic concentration (other than lowest) : 4 mg/m3/18 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
DTESD7 13,459,1986
inhalation
rat
toxic concentration (other than lowest) : 2,500 g/m3/18 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
INHTE5 7,533,1995
inhalation
rat
lowest published toxic concentration: 274 mg/m3/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
INHTE5 12,97,2000
intratracheal
rat
lowest published toxic dose: 36,400 mg/kg/2.5 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
ARDSBL 141(Suppl),A3-A937,1990


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 350 g/m3/4 hour Vascular: Regional or general arteriolar constriction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 -,258,2008
inhalation
mouse
lowest published toxic concentration: 350 g/m3/4 hour Vascular: Contraction (isolated tissue) TXAPA9 230,346,2008
inhalation
rat
lowest published toxic concentration: 300 g/m3/5 hour Cardiac: Other changes

Vascular: Regional or general arteriolar constriction

Biochemical: Metabolism (intermediary): Other
TOXID9 -,150,2008
inhalation
rat
lowest published toxic concentration: 300 g/m3/5 hour Autonomic Nervous System: Sympathomimetic

Cardiac: Changes in coronary arteries

Vascular: BP elevation not characterized in autonomic section
TOXID9 -,258,2008


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 6,300 g/m3/20 hour/8 week- intermittent Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
ENVRAL 22,285,1980
inhalation
guinea pig
lowest published toxic concentration: 300 g/m3/5 week- intermittent Olfaction: Other olfaction effects AJCMED 162,352,2000
inhalation
mouse
lowest published toxic concentration: 3 mg/m3/12 hour/34 week- intermittent Lung, Thorax, or Respiration: Other changes TOSCF2 44,70,1998
inhalation
mouse
lowest published toxic concentration: 3,500 g/m3/7 hour/78 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FAATDF 11,546,1988
inhalation
mouse
lowest published toxic concentration: 6 mg/m3/12 hour/3 week- intermittent Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Increase in humoral response
TXCYAC 116,227,1997
inhalation
mouse
lowest published toxic concentration: 30 g/m3/24 week- intermittent Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
TXAPA9 196,337,2004
inhalation
mouse
lowest published toxic dose: 2 mg/m3/4 week- intermittent Cardiac: Other changes

Vascular: Structural changes in vessels
TOXID9 -,148,2008
inhalation
mouse
lowest published toxic dose: 400 g/m3/3 day- intermittent Blood: Changes in spleen TOXID9 -,35,2008
inhalation
rat
lowest published toxic concentration: 3,500 g/m3/7 hour/2 year- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FAATDF 11,546,1988
inhalation
rat
lowest published toxic concentration: 300 g/m3/0.5 year- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other
TOXID9 78,284,2004
inhalation
rat
lowest published toxic concentration: 669.3 g/m3/4 hour/3 week- intermittent Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 78,284,2004
inhalation
rat
lowest published toxic dose: 2 mg/m3/16 week- intermittent Vascular: Other changes

Blood: Hemorrhage

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,151,2008
inhalation
rat
lowest published toxic concentration: 2 mg/m3/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other changes
TOXID9 -,220,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 46,41,1989
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 46,41,1989
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 46,41,1989
TOXICOLOGY REVIEW
ENTOX* -,17,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Carcinogen, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

On EPA IRIS database
NIOSH Analytical Method, 1996: Element carbon (diesel exhaust), 5040


REFERENCES:

CODEN
REFERENCE

AJCMED American Journal of Respiratory and Critical Care Medicine. (American Lung Association, 1740 Broadway, New Youk, NY 10019) V. 149- 1994-
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: N/R
Click Here for Additional Information about RTECS

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