Diesel exhaust
RTECS #
HZ1755000
CAS #
Updated
March 2018
Molecular Weight
N/R
Molecular Formula
N/R
Synonyms
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA adduct | inhalation/mouse | 6200 µg/m3/16H/12W- intermittent | EMMUEG 16,64,1990 |
| mutation in microorganisms | /Salmonella typhimurium | 1 mg/plate (+/-enzymatic activation step) | MUREAV 415,13,1998 |
| other mutation test systems | inhalation/mouse | 3 gm/L/12H/4W- intermittent | EMMUEG 48,682,2007 |
| other mutation test systems | inhalation/mouse | 1 gm/L/12H/12W- intermittent | EMMUEG 48,682,2007 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | toxic concentration: 7 mg/m3/7H/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | FAATDF 9,208,1987 |
| inhalation/rat | toxic concentration: 4 mg/m3/18H/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | DTESD7 13,459,1986 |
| inhalation/rat | toxic concentration: 2500 µg/m3/18H/2Y- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | INHTE5 7,533,1995 |
| inhalation/rat | lowest published toxic concentration: 274 mg/m3/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | INHTE5 12,97,2000 |
| inhalation/rat | lowest published toxic concentration: 4900 µg/m3/8H/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Blood: Lymphoma including Hodgkin's disease | DTESD7 13,349,1986 |
| intratracheal/rat | lowest published toxic dose: 36400 mg/kg/2.5Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors | ARDSBL 141(Suppl),A3-A937,1990 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 350 µg/m3/4H | Vascular: Regional or general arteriolar constriction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOXID9 -,258,2008 |
| inhalation/mouse | lowest published toxic concentration: 350 µg/m3/4H | Vascular: Contraction (isolated tissue) | TXAPA9 230,346,2008 |
| inhalation/rat | lowest published toxic concentration: 300 µg/m3/5H | Cardiac: Other changes Vascular: Regional or general arteriolar constriction Biochemical: Metabolism (intermediary): Other | TOXID9 -,150,2008 |
| inhalation/rat | lowest published toxic concentration: 300 µg/m3/5H | Autonomic Nervous System: Sympathomimetic Cardiac: Changes in coronary arteries Vascular: BP elevation not characterized in autonomic section | TOXID9 -,258,2008 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic concentration: 6300 µg/m3/20H/8W- intermittent | Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Other changes Lung, Thorax, or Respiration: Changes in lung weight | ENVRAL 22,285,1980 |
| inhalation/guinea pig | lowest published toxic concentration: 300 µg/m3/5W- intermittent | Olfaction: Other olfaction effects | AJCMED 162,352,2000 |
| inhalation/mouse | lowest published toxic concentration: 30 µg/m3/24W- intermittent | Blood: Changes in spleen Immunological Including Allergic: Decrease in cellular immune response | TXAPA9 196,337,2004 |
| inhalation/mouse | lowest published toxic concentration: 3 mg/m3/12H/34W- intermittent | Lung, Thorax, or Respiration: Other changes | TOSCF2 44,70,1998 |
| inhalation/mouse | lowest published toxic concentration: 3500 µg/m3/7H/78W- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FAATDF 11,546,1988 |
| inhalation/mouse | lowest published toxic concentration: 6 mg/m3/12H/3W- intermittent | Endocrine: Changes in spleen weight Immunological Including Allergic: Decrease in cellular immune response Immunological Including Allergic: Increase in humoral response | TXCYAC 116,227,1997 |
| inhalation/mouse | lowest published toxic dose: 2 mg/m3/4W- intermittent | Cardiac: Other changes Vascular: Structural changes in vessels | TOXID9 -,148,2008 |
| inhalation/mouse | lowest published toxic dose: 400 µg/m3/3D- intermittent | Blood: Changes in spleen | TOXID9 -,35,2008 |
| inhalation/mouse | lowest published toxic concentration: 200 µg/m3/6H/7W- intermittent | Cardiac: Other changes Vascular: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | TXAPA9 255,184,2011 |
| inhalation/mouse | lowest published toxic concentration: 0.69 µg/m3/5H/8W- intermittent | Endocrine: Adrenal cortex hypoplasia | TOLED5 209,277,2012 |
| inhalation/rat | lowest published toxic concentration: 2 mg/m3/16W- intermittent | Lung, Thorax, or Respiration: Other changes Blood: Other changes | TOXID9 -,220,2008 |
| inhalation/rat | lowest published toxic concentration: 3500 µg/m3/7H/2Y- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | FAATDF 11,546,1988 |
| inhalation/rat | lowest published toxic dose: 2 mg/m3/16W- intermittent | Vascular: Other changes Blood: Hemorrhage Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 -,151,2008 |
| inhalation/rat | lowest published toxic concentration: 300 µg/m3/0.5Y- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Other | TOXID9 78,284,2004 |
| inhalation/rat | lowest published toxic concentration: 669.3 µg/m3/4H/3W- intermittent | Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TOXID9 78,284,2004 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 46,41,1989 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Limited Evidence | IMEMDT 46,41,1989 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 46,41,1989 |
| TOXICOLOGY REVIEW | ENTOX* -,17,2005 | |
| TOXICOLOGY REVIEW | TXAPA9 244,66,2010 | |
| TOXICOLOGY REVIEW | TIVIEQ 32,92,2016 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 mg/m3, carc 2, resp, JAN2011 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| NIOSH Analytical Method, 1996: Element carbon (diesel exhaust), 5040 | |
| NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health