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Decaborane (14)

RTECS #: HD1400000

CAS #: 17702-41-9


UPDATE: May 2009 MW: 122.24 MF: B10H14


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Boron hydride (B10H14)
  2. Decaborane
  3. Decaborane (ACGIH:OSHA)
  1. Decaborane (14) fumes
  2. Tetradecahydrodecaborane
  3. nido - Decaborane (14)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
lowest published toxic dose: 0.1 mg/kg/5 minute Eye: Conjunctiva irritation

Eye: Corneal damage
VCVN1* -,201,1988
inhalation
mouse
lethal concentration (50 percent kill): 12 ppm/4 hour Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
NTIS** AD224-006
inhalation
mouse
lethal concentration (50 percent kill): 30 mg/m3 N/R VCVN1* -,199,1988
inhalation
rat
lethal concentration (50 percent kill): 46 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
AMIHAB 17,362,1958
inhalation
rat
lethal concentration (50 percent kill): 110 mg/m3/4 hour N/R VCVN1* -,199,1988
intraperitoneal
mouse
lethal dose (50 percent kill): 33 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
AMIHAB 11,132,1955
intraperitoneal
mouse
lethal dose (50 percent kill): 33 mg/kg Behavioral: Coma VCVN1* -,199,1988
intraperitoneal
rat
lethal dose (50 percent kill): 23 mg/kg N/R AMIHBC 8,335,1953
intraperitoneal
rat
lethal dose (50 percent kill): 23 mg/kg Behavioral: Coma VCVN1* -,199,1988
intraperitoneal
rabbit
lethal dose (50 percent kill): 28 mg/kg N/R AMIHBC 8,335,1953
intraperitoneal
rabbit
lethal dose (50 percent kill): 28 mg/kg Behavioral: Coma VCVN1* -,199,1988
oral
mouse
lethal dose (50 percent kill): 41 mg/kg Eye: Corneal damage

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
AMIHAB 11,132,1955
oral
rat
lethal dose (50 percent kill): 64 mg/kg N/R MLSR** #8,1951
oral
rat
lethal dose (50 percent kill): 64 mg/kg Behavioral: Coma VCVN1* -,199,1988
skin
cat
lethal dose (50 percent kill): 126 mg/kg Behavioral: Convulsions or effect on seizure threshold

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
STGNBT -,60,1999
skin
cat
lethal dose (50 percent kill): 126 mg/kg/4 hour N/R VCVN1* -,201,1988
skin
guinea pig
lethal dose (50 percent kill): 158 mg/kg Behavioral: Convulsions or effect on seizure threshold

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
STGNBT -,60,1999
skin
guinea pig
lethal dose (50 percent kill): 158 mg/kg/4 hour N/R VCVN1* -,201,1988
skin
mouse
lethal dose (50 percent kill): 317 mg/kg Behavioral: Convulsions or effect on seizure threshold

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
STGNBT -,60,1999
skin
mouse
lethal dose (50 percent kill): 317 mg/kg/4 hour N/R VCVN1* -,201,1988
skin
rat
lethal dose (50 percent kill): 740 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 11,132,1955
skin
rat
lethal dose (50 percent kill): 740 mg/kg/4 hour N/R VCVN1* -,201,1988
skin
rabbit
lethal dose (50 percent kill): 71 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 11,132,1955
skin
rabbit
lethal dose (50 percent kill): 57 mg/kg/4 hour N/R VCVN1* -,201,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 22 mg/m3/5 hour/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
inhalation
rat
lowest published toxic concentration: 22 mg/m3/5 hour/135 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN1* -,199,1988
oral
rat
lowest published toxic dose: 9,100 g/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Blood: Pigmented or nucleated red blood cells
STGNBT -,60,1999
oral
rabbit
lowest published toxic dose: 1,050 g/kg/21 day- intermittent Brain and Coverings: Other degenerative changes

Vascular: Other changes

Lung, Thorax, or Respiration: Other changes
STGNBT -,60,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm;short term exposure limit 0.15 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 ppm (0.3 mg/m3) (skin) DTLVS* 3,68,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 005 ppm (0.25 mg/m3), short term exposure limit 0.15 ppm (0.75 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.25 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.15 ppm (0.76 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 ppm (0.3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.05 ppm (0.25 mg/m3), short term exposure limit 0.15 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.3 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.25 mg/m3 (0.05 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.3 mg/m3, short term exposure limit 0.3 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.05 ppm (0.3 mg/m3), short term exposure limit 0.15 ppm (0.9 mg/m3), skin,2006
Occupational Exposure Limit - MEXICO time-weighted average 0.05 ppm (0.3 mg/m3);
short term exposure limit 0.15 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.3 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 ppm (0.25 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 ppm (0.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.25 mg/m3),KZG- week 0.1 ppm (0.5 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.05 ppm (0.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 ppm;
short term exposure limit 0.15 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 ppm;
short term exposure limit 0.15 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DECABORANE-air 10 hour time-weighted average 0.05 ppm (Sk);
short term exposure limit 0.15 ppm (Sk)
NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a catalyzer in polymers production
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MLSR** U.S. Army, Chemical Corps Medical Laboratories Special Reports. (Army Chemical Center, MD)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as a catalyzer in polymers production

ALT CAS #: 1304-02-5
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