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Cyclohexanone, 2 - methyl -

RTECS #: GW1750000

CAS #: 583-60-8


UPDATE: May 2009 MW: 112.19 MF: C7H12O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - cyclohexanon (German, Dutch)
  2. alpha - Methylcyclohexanone
  1. o - Methylcyclohexanone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 2,800 ppm/4 hour N/R AIHAAP 30,470,1969
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R NTIS** AD691-490
intravenous
mouse
lowest published lethal dose: 270 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section
COREAF 236,633,1953
oral
rat
lethal dose (50 percent kill): 2,140 ÁL/kg N/R AIHAAP 30,470,1969
skin
rabbit
lethal dose (50 percent kill): 1,770 ÁL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm;short term exposure limit 75 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (230 mg/m3) (skin) DTLWS* 3,23,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (460 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (460 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (460 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (460 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (229 mg/m3), short term exposure limit 75 ppm (344 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (232 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 75 ppm (349 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (230 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (345 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (230 mg/m3), Skin, FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (230 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (345 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (230 mg/m3);
short term exposure limit 75 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 230 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (229 mg/m3);
short term exposure limit 75 ppm (344 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (460 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 340 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 50 ppm, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (230 mg/m3),KZG- week 100 ppm (460 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (460 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (233 mg/m3);
short term exposure limit 75 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm;
short term exposure limit 75 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm;
short term exposure limit 75 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 50 ppm (Sk);
short term exposure limit 75 ppm (Sk)
NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Methylcyclohexanone, 2521


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

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