Cyclohexane

RTECS #

GU6300000

CAS #

110-82-7
See: NMAM or OSHA Methods

Updated

March 2018

Molecular Weight

84.18

Molecular Formula

C₆H₁₂

Synonyms

Benzene, hexahydro-
Cicloesano (Italian)
Cyclohexaan (Dutch)
Cyclohexan (German)
Cyclohexane (ACGIH:OSHA)
Cykloheksan (Polish)
Hexahydrobenzene
Hexamethylene
Hexanaphthene
RCRA waste number U056

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	1548 mg/2D- intermittent		JIHTAB 25,199,1943

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA adduct	/Escherichia coli	10 µmol/L	MUREAV 89,95,1981

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	2000 ppm (multigeneration)	Reproductive: Other effects on female	HPV250 -,-,2008
inhalation/rat	7000 ppm (multigeneration)	Reproductive: Other effects on female Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	HPV250 -,-,2008
inhalation/rat	6000 ppm (7-16D pregnant)	Reproductive: Other effects on female	HPV250 -,-,2008

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/iag	Inhibitor Concentration Low: 0.69 mmol/L	In Vitro Toxicity Studies: Other assays	NRTXDN 55,74,2016
inhalation/cat	lowest published toxic concentration: 62500 mg/m³/15M	Behavioral: Convulsions or effect on seizure threshold Vascular: BP lowering not characterized in autonomic section	VCVGH* -,82,1990
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 70 gm/m³		GTPZAB 32(10),25,1988
inhalation/mouse	lethal concentration (50 percent kill): 70000 mg/m³/2H		VCVGH* -,82,1990
inhalation/mouse	Lowest published lethal concentration: 70 gm/m³/2H		85GMAT -,41,1982
inhalation/rabbit	Lowest published lethal concentration: 89600 mg/m³/1H	Behavioral: General anesthetic Behavioral: Tremor Behavioral: Muscle contraction or spasticity	JIHTAB 25,323,1943
inhalation/rabbit	Lowest published lethal concentration: 89500 mg/m³/1H	Behavioral: General anesthetic	VCVGH* -,82,1990
inhalation/rat	lethal concentration (50 percent kill): >9500 ppm/4H	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression	HPV250 -,-,2008
oral/mouse	lethal dose (50 percent kill): 813 mg/kg		ENTOX* -,705,2005
oral/rabbit	lethal dose (50 percent kill): 5.5 mg/kg		ENTOX* -,705,2005
oral/rabbit	lowest published lethal dose: 5500 mg/kg	Gastrointestinal: Hypermotility, diarrhea	JIHTAB 25,199,1943
oral/rat	lethal dose (50 percent kill): >5000 mg/kg		HPV250 -,-,2008
oral/rat	lethal dose (50 percent kill): 6240 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Hypermotility, diarrhea	HPV250 -,-,2008
skin/rabbit	lethal dose (50 percent kill): >2000 mg/kg		HPV250 -,-,2008
skin/rabbit	Lethal dose: >180 gm/kg		JIHTAB 25,199,1943

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 2000 ppm/90D- intermittent	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay)	TOXID9 42,255,1998
inhalation/mouse	lowest published toxic concentration: 2000 ppm/13W- intermittent	Behavioral: Somnolence (general depressed activity)	HPV250 -,-,2008
inhalation/mouse	lowest published toxic concentration: 7000 ppm/13W- intermittent	Behavioral: Somnolence (general depressed activity) Liver: Changes in liver weight	HPV250 -,-,2008
inhalation/rabbit	lowest published toxic concentration: 7444 ppm/6H/2W- intermittent	Autonomic Nervous System: Other (direct) parasympathomimetic Gastrointestinal: Hypermotility, diarrhea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JIHTAB 25,323,1943
inhalation/rabbit	lowest published toxic concentration: 9220 ppm/6H/5W- intermittent	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Tremor Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JIHTAB 25,323,1943
inhalation/rat	lowest published toxic concentration: 6000 ppm/9D- intermittent	Behavioral: Somnolence (general depressed activity) Liver: Other changes	HPV250 -,-,2008
inhalation/rat	lowest published toxic concentration: 9000 ppm/9D- intermittent	Behavioral: Somnolence (general depressed activity) Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV250 -,-,2008
inhalation/rat	lowest published toxic concentration: 500 ppm/13W- intermittent	Behavioral: Somnolence (general depressed activity)	HPV250 -,-,2008
inhalation/rat	lowest published toxic concentration: 2000 ppm/13W- intermittent	Behavioral: Somnolence (general depressed activity) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	HPV250 -,-,2008
inhalation/rat	lowest published toxic concentration: 7000 ppm/13W- intermittent	Behavioral: Somnolence (general depressed activity) Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	HPV250 -,-,2008
inhalation/rat	lowest published toxic concentration: 300 ppm/6H/2W- intermittent	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	TOLED5 7,17,1980
intraperitoneal/rat	lowest published toxic dose: 15 gm/kg/2W- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition	TOLED5 45,271,1989

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 100 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		ENTOX* -,705,2005
TOXICOLOGY REVIEW		NCLNA* 16,503,1998
TOXICOLOGY REVIEW		NEUCL* 18,215,2000

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 300 ppm (1050 mg/m³)	DTLVS* 3,65,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 100 ppm (350 mg/m³), short term exposure limit 300 ppm (1050 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 200 ppm (700 mg/m³);KZW 800 ppm (2800 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 200 ppm (700 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 50 ppm (172 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 700 mg/m³ (200 ppm), FEB2006
Occupational Exposure Limit-FINLAND	time-weighted average 100 ppm (350 mg/m³), short term exposure limit 250 ppm (875 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 300 ppm (1050 mg/m³), VLE 375 ppm (1300 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 200 ppm (700 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 700 mg/m³, short term exposure limit 2800 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 50 ppm (175 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 150 ppm (520 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 300 ppm (1050 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 300 ppm (1050 mg/m³);short term exposure limit 375 ppm (1300 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 100 ppm (350 mg/m³); short term exposure limit 300 ppm (1500 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 150 ppm (525 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 100 ppm (344 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 300 mg/m³, MAC(short term exposure limit) 1000 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 80 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 300 ppm (1000 mg/m³);short term exposure limit 370 ppm (1300 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 200 ppm (700 mg/m³), KZG-week 800 ppm (2800 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 875 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 300 ppm (1050 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 100 ppm (350 mg/m³);short term exposure limit 300 ppm (1050 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 300 ppm (1050 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 300 ppm (1050 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 300 ppm (1050 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 300 ppm (1050 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLOHEXANE-air	10H time-weighted average 300 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 21190; Number of Industries 37; Total Number of Facilities 2260; Number of Occupations 54; Total Number of Employees Exposed 55077; Total Number of Female Employees Exposed 14873
National Occupational Hazard Survey 1974	Hazard Code 21190; Number of Industries 117; Total Number of Facilities 14841; Number of Occupations 74; Total Number of Employees Exposed 125761

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health