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Cyanamide

RTECS #: GS5950000

CAS #: 420-04-2


UPDATE: May 2009 MW: 42.05 MF: CH2N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Alzogur
  2. Amidocyanogen
  3. Carbamonitrile
  4. Carbimide
  5. Carbodiimide
  6. Cyanamide (ACGIH)
  7. Cyanoamine
  1. Cyanogenamide
  2. Cyanogen nitride
  3. Hydrogen cyanamide
  4. N - Cyanoamine
  5. TsAKS
  6. USAF EK - 1995


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 2,450 mg/kg (70 day male/2 week prior to copulation-2 week pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Other measures of fertility
PHTOEH 61,20,1987
oral
rat
lowest published toxic dose: 1,750 mg/kg (70 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
PHTOEH 61,20,1987
oral
rat
lowest published toxic dose: 2,600 mg/kg (70 day male/2 week prior to copulation-3 week pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
PHTOEH 61,20,1987
oral
rat
lowest published toxic dose: 208 mg/kg (70 day male/2 week prior to copulation-3 week pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
PHTOEH 61,20,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 86 mg/m3/4 hour N/R 85GMAT -,40,1982
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat
lowest published lethal dose: 200 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Coma

Gastrointestinal: Changes in structure or function of salivary glands
PSEBAA 54,254,1943
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
EKFAE9 59,38,1996
intraperitoneal
rat
lowest published toxic dose: 25 gm/kg Taste: Change in function PSCHDL 167,130,2003
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Nutritional and Gross Metabolic: Body temperature decrease PSCHDL 189,459,2007
intravenous
rat
lethal dose (50 percent kill): 56 mg/kg N/R ENTOX* -,695,2005
oral
cat
lethal dose (50 percent kill): 100 mg/kg N/R 85GMAT -,40,1982
oral
mouse
lethal dose (50 percent kill): 388 mg/kg N/R 85GMAT -,40,1982
oral
rat
lethal dose (50 percent kill): 125 mg/kg N/R ENTOX* -,695,2005
oral
rabbit
lethal dose (50 percent kill): 150 mg/kg N/R 85GMAT -,40,1982
skin
rat
lethal dose (50 percent kill): 84 mg/kg N/R ENTOX* -,695,2005
skin
rabbit
lethal dose (50 percent kill): 590 mg/kg N/R ENTOX* -,695,2005
unreported route
rat
lethal dose (50 percent kill): 280 mg/kg N/R 34ZIAG -,190,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
unreported route
human
lowest published toxic dose: 312 mg/kg/182 day- intermittent Blood: Aplastic anemia EJCPAS 61,467,2005
unreported route
woman
lowest published toxic dose: 61 mg/kg/61 day- intermittent Blood: Aplastic anemia SANGR* 35,412,1990
unreported route
woman
lowest published toxic dose: 20 mg/kg/20 day- intermittent Blood: Aplastic anemia EJHAEC 48,179,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,695,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,373,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (11 mg/m3) (skin) DTLVS* 3,130,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.58 ppm (1 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 mg/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 1 mg/m3 (0.58 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 2 mg/m3, short term exposure limit 4 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 mg/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg/m3 (inhalable, skin, sen), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2 mg/m3 (resp), short term exposure limit 8 mg/m3 (resp), SEP2000
Occupational Exposure Limit - KOREA time-weighted average 2 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 2 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 mg/m3;
short term exposure limit 4 mg/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.58 ppm (1 mg/m3);
KZG- week 1.16 ppm (2 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYANAMIDE-air 10 hour time-weighted average 2 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 20930;
Number of Industries 2;
Total Number of Facilities 76;
Number of Occupations 2;
Total Number of Employees Exposed 962
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 20930;
Number of Industries 2;
Total Number of Facilities 19;
Number of Occupations 2;
Total Number of Employees Exposed 2,564;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970-
EJHAEC European Journal of Haematology. (Munksgaard International Publishers, POB 2148, DK-1016 Copenhagen K, Denmark) V.38- 1987-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SANGR* Sangre (Barcelona C Elosegui Y J Guasch). V.1-44, 1956-1999. Discontinued

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Reproductive Effector
   Human Data

ALT CAS #: 65931-45-5
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