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p - Cresol, 2,6 - di - tert - butyl -

RTECS #: GO7875000

CAS #: 128-37-0


UPDATE: May 2009 MW: 220.39 MF: C15H24O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2,6 - Bis (1,1 - dimethylethyl) - 4 - methylphenol
  2. 2,6 - Di - terc.butyl - p - kresol (Czech)
  3. 2,6 - Di - tert - butyl - 1 - hydroxy - 4 - methylbenzene
  4. 2,6 - Di - tert - butyl - 4 - methylphenol
  5. 2,6 - Di - tert - butyl - p - cresol
  6. 2,6 - Di - tert - butyl - p - cresol (ACGIH)
  7. 2,6 - Di - tert - butyl - p - methylphenol
  8. 3,5 - Di - tert - butyl - 4 - hydroxytoluene
  9. 4 - Hydroxy - 3,5 - di - tert - butyltoluene
  10. 4 - Methyl - 2,6 - di - terc. butylfenol (Czech)
  11. 4 - Methyl - 2,6 - di - tert - butylphenol
  12. AO 29
  13. AO 4K
  14. Advastab 401
  15. Agidol
  16. Agidol 1
  17. Alkofen BP
  18. Antioxidant 29
  19. Antioxidant 30
  20. Antioxidant 4
  21. Antioxidant 4K
  22. Antioxidant DBPC
  23. Antioxidant KB
  24. Antrancine 8
  25. BHT
  26. BHT (food grade)
  27. BUKS
  28. Butylated hydroxytoluene
  29. Butylhydroxytoluene
  30. Butylohydroksytoluenu (Polish)
  31. CAO 1
  32. CAO 3
  33. Catalin cao - 3
  34. Chemanox 11
  35. DBMP
  1. DBPC
  2. DBPC (technical grade)
  3. Dalpac
  4. Deenax
  5. Dibunol
  6. Dibutylated hydroxytoluene
  7. Impruvol
  8. Ionol
  9. Ionol (antioxidant)
  10. Ionol 1
  11. Ionol CP
  12. Ionole
  13. Kerabit
  14. Methyldi - tert - butylphenol
  15. NCI - C03598
  16. Nocrac 200
  17. Nonox TBC
  18. P 21
  19. Parabar 441
  20. Paranox 441
  21. Phenol, 2,6 - bis (1,1 - dimethylethyl) - 4 - methyl - (9CI)
  22. Stavox
  23. Sumilizer BHT
  24. Sustane BHT
  25. Swanox BHT
  26. Tenamene 3
  27. Tenox BHT
  28. Topanol
  29. Topanol O
  30. Topanol OC
  31. Toxolan P
  32. Vanlube PC
  33. Vanlube PCX
  34. Vianol
  35. Vulkanox KB


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 85JCAE -,229,1986
skin
human
500 mg/48 hour mild AMIHBC 5,311,1952
skin
rabbit
500 mg/48 hour moderate AMIHBC 5,311,1952


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 100 µg/L MUREAV 345,73,1995
dominant lethal test oral
mouse
12 gm/kg/10 week- continuous NTIS** PB278-026
dominant lethal test oral
rat
5,460 mg/kg/10 week- continuous ENMUDM 8,357,1986
DNA damage oral
mouse
100 mg/kg MUREAV 519,103,2002
DNA damage oral
rat
1,400 mg/kg FCTOD7 25,603,1987
DNA inhibition human HeLa cell 500 µmol/L CRNGDP 13,2389,1992
DNA inhibition human lymphocyte 20 µmol/L BBRCA9 80,963,1978
DNA inhibition intraperitoneal
mouse
250 mg/kg CBINA8 19,279,1977
unscheduled DNA synthesis oral
rat
16,800 mg/kg/4 week- continuous TXAPA9 99,37,1989
unscheduled DNA synthesis rat liver 100 pmol/L CRNGDP 5,1547,1984
unscheduled DNA synthesis intraperitoneal
rat
1,200 mg/kg/3 day- continuous DANKAS 287,371,1986
mutation in microorganisms mouse lymphocyte 6 mg/L (+enzymatic activation step) EMMUEG 11,91,1988
mutation in mammalian somatic cells mouse lymphocyte 6 mg/L EMMUEG 11,91,1988
other mutation test systems oral
mouse
500 mg/kg MUREAV 343,157,1995
specific locus test mouse other cell types 45 µmol/L MUREAV 608,29,2006
sperm morphology intraperitoneal
mouse
350 mg/kg/5 day- intermittent CMMUAO 5,257,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 43,800 mg/kg (52 day prior to copulation/1-21 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FCTXAV 3,371,1965
oral
mouse
lowest published toxic dose: 12,600 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Behavioral FEPRA7 31,596,1972
oral
mouse
lowest published toxic dose: 1,200 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TRENAF 28(2),45,1977
oral
rat
lowest published toxic dose: 6 gm/kg (13 week male/13 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FCTOD7 24,1,1986
oral
rat
lowest published toxic dose: 18 gm/kg (2 week male/2 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
FCTXAV 19,153,1981
oral
rat
lowest published toxic dose: 9 gm/kg (2 week male/2 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) FCTXAV 19,153,1981
oral
rat
lowest published toxic dose: 35 gm/kg (10 week male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) ENMUDM 8,357,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 435 mg/kg/69 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
FCTXAV 12,367,1974
oral
mouse
toxic dose : 1,423 mg/kg/43 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
TXCYAC 38,151,1986
oral
mouse
lowest published toxic dose: 1,200 mg/kg/3 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously
CALEDQ 145,101,1999
oral
rat
lowest published toxic dose: 134 gm/kg/32 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Cells (cultured) transformed
CRNGDP 4,895,1983
oral
rat
toxic dose : 247 gm/kg/3 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Liver: Tumors
FCTOD7 24,1,1986
oral
rat
toxic dose : 247 gm/kg/3 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors
FCTOD7 24,1,1986
oral
rat
toxic dose : 247 gm/kg Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
FCTOD7 24,1121,1986
oral
rat
toxic dose : 963 gm/kg Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
FCTOD7 24,1071,1986


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 138 mg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
TXAPA9 61,475,1981
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,212,1994
intraperitoneal
mouse
lethal dose (50 percent kill): 138 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
IJTOFN 21,19,2002
intraperitoneal
mouse
lethal dose (50 percent kill): 138 mg/kg N/R ENTOX* -,365,2005
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
FATOAO 55,34,1992
intraperitoneal
rat
lethal dose (50 percent kill): 8 gm/kg N/R IJTOFN 21,19,2002
intraperitoneal
rat
lowest published toxic dose: 1 mg/kg Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) TXAPA9 223,164,2007
intravenous
mouse
lethal dose (50 percent kill): 180 mg/kg Behavioral: Sleep JMCMAR 23,1350,1980
oral
cat
lowest published lethal dose: 940 mg/kg Gastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHAB 11,93,1955
oral
cat
lowest published lethal dose: 940 mg/kg N/R VCVGK* -,212,1994
oral
guinea pig
lethal dose (50 percent kill): 10,700 mg/kg Gastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHAB 11,93,1955
oral
guinea pig
lethal dose (50 percent kill): 10,700 mg/kg N/R ENTOX* -,365,2005
oral
mouse
lethal dose (50 percent kill): 650 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
SRTCAC 36(1-4),10,1989
oral
mouse
lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation EKFAE9 62,56,1999
oral
mouse
lethal dose (50 percent kill): 650 mg/kg Behavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes
IJTOFN 21,19,2002
oral
mouse
lethal dose (50 percent kill): 1,040 mg/kg N/R ENTOX* -,365,2005
oral
rat
lowest published toxic dose: 25 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
EKFAE9 62,56,1999
oral
rat
lethal dose (50 percent kill): 890 mg/kg N/R ENTOX* -,365,2005
oral
rabbit
lowest published lethal dose: 2,100 mg/kg Gastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHAB 11,93,1955
oral
rabbit
lethal dose (50 percent kill): 2,100 mg/kg N/R VCVGK* -,212,1994
oral
rabbit
lowest published lethal dose: 2,000 mg/kg N/R VCVGK* -,212,1994
oral
woman
lowest published toxic dose: 80 mg/kg Behavioral: Coma

Gastrointestinal: Gastritis

Gastrointestinal: Nausea or vomiting
NEJMAG 314,648,1986
rectal
mouse
lowest published toxic dose: 50 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation EKFAE9 62,56,1999
rectal
rat
lowest published toxic dose: 25 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
EKFAE9 62,56,1999
subcutaneous
mouse
lethal dose (50 percent kill): 650 mg/kg N/R ENTOX* -,365,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
guinea pig
lowest published toxic dose: 570 mg/kg/3 day- intermittent Blood: Change in clotting factors VCVGK* -,212,1994
intraperitoneal
hamster
lowest published toxic dose: 1,140 mg/kg/3 day- intermittent Brain and Coverings: Changes in circulation

Behavioral: Tremor
VCVGK* -,212,1994
intraperitoneal
mouse
lowest published toxic dose: 750 mg/kg/3 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 169,1,2001
intraperitoneal
mouse
lowest published toxic dose: 750 mg/kg/3 week- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TXCYAC 169,1,2001
intraperitoneal
mouse
lowest published toxic dose: 1,750 mg/kg/1 week- intermittent Gastrointestinal: Tumors

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
VCVGK* -,213,1994
intraperitoneal
mouse
lowest published toxic dose: 735 mg/kg/4 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JNCIEQ 97,1778,2005
intraperitoneal
rabbit
lowest published toxic dose: 480 mg/kg/4 day- intermittent Cardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FATOAO 55,19,1992
oral
hamster
lowest published toxic dose: 1,596 mg/kg/14 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 34,595,1996
oral
monkey
lowest published toxic dose: 14 gm/kg/4 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases FCTXAV 10,769,1972
oral
mouse
lowest published toxic dose: 13,500 mg/kg/18 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
FCTXAV 3,417,1965
oral
mouse
lowest published toxic dose: 48,600 mg/kg/30 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
FCTOD7 30,89,1992
oral
mouse
lowest published toxic dose: 2,000 mg/kg/4 day- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral
mouse
lowest published toxic dose: 10.08 mg/kg/1 week- continuous Brain and Coverings: Changes in circulation

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral
rat
lowest published toxic dose: 5,185 mg/kg/4 week- continuous Liver: Other changes

Liver: Changes in liver weight
TOLED5 87,103,1996
oral
rat
lowest published toxic dose: 109 gm/kg/2 year- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
FCTXAV 19,147,1981
oral
rat
lowest published toxic dose: 27 gm/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Endocrine: Changes in thyroid weight
TOLED5 10,239,1982
oral
rat
lowest published toxic dose: 37,800 mg/kg/6 week- continuous Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AJEBAK 39,353,1961
oral
rat
lowest published toxic dose: 5,600 mg/kg/16 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition
FCTXAV 3,433,1965
oral
rat
lowest published toxic dose: 275 mg/kg/26 week- continuous Liver: Changes in liver weight

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AJEBAK 37,533,1959
oral
rat
lowest published toxic dose: 112 gm/kg/80 week- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 7,289,1977
oral
rat
lowest published toxic dose: 5,040 mg/kg/7 day- continuous Liver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
APTOA6 49,14,1981
oral
rat
lowest published toxic dose: 1,200 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases FATOAO 50,81,1987
oral
rat
lowest published toxic dose: 840 mg/kg/14 day- intermittent Cardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
EKFAE9 56,47,1993
oral
rat
lowest published toxic dose: 350 mg/kg/7 day- intermittent Gastrointestinal: Other changes

Liver: Other changes
FATOAO 47,87,1984
oral
rat
lowest published toxic dose: 350 mg/kg/7 day- intermittent Gastrointestinal: Other changes FATOAO 47,87,1984
oral
rat
lowest published toxic dose: 500 mg/kg/5 day- intermittent Gastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
EKFAE9 61,21,1998
oral
rat
lowest published toxic dose: 39.7 mg/kg/3 day- intermittent Blood: Change in clotting factors EKFAE9 62,38,1999
oral
rat
lowest published toxic dose: 6,300 mg/kg/6 week- continuous Liver: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent
CALEDQ 143,173,1999
oral
rat
lowest published toxic dose: 2.625 mg/kg/1 week- continuous Liver: Other changes

Blood: Change in clotting factors

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVGK* -,212,1994
oral
rat
lowest published toxic dose: 2,000 mg/kg/4 day- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral
rat
lowest published toxic dose: 6.3 mg/kg/1 week- continuous Brain and Coverings: Changes in circulation

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral
rat
lowest published toxic dose: 547.5 mg/kg/2 year- continuous Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,213,1994
oral
rat
lowest published toxic dose: 4,200 mg/kg/14 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
BIJOAK 300,117,1994
oral
turkey
lowest published toxic dose: 4,000 ppm/10 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) FCTOD7 41,671,2003
skin
mouse
lowest published toxic dose: 5 gm/kg/4 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 34,99,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3 (inhalable, vapor) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 40,161,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 40,161,1986
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
IJTOFN 21,19,2002
TOXICOLOGY REVIEW
ENTOX* -,365,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 659,15,2008
TOXICOLOGY REVIEW
HUTOX* -,259,1996
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 20 mg/m3 (inhalable), 2005
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3;
short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,6-DI-t-BUTYL-p-CRESOL-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83383;
Number of Industries 32;
Total Number of Facilities 1,526;
Number of Occupations 39;
Total Number of Employees Exposed 28,860
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83383;
Number of Industries 210;
Total Number of Facilities 27,242;
Number of Occupations 154;
Total Number of Employees Exposed 591,238;
Total Number of Female Employees Exposed 163,774


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Mouse specific locus
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a food and feed additive, flavor and packaging material
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9076
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-150,1979


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86.
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CMMUAO Chemical Mutagens. Principles and Methods for Their Detection. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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Used as a food and feed additive, flavor and packaging material

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 58500-82-6
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