o-Cresol
RTECS #
GO6300000
CAS #
Updated
June 2017
Molecular Weight
108.15
Molecular Formula
C7H8O
Synonyms
1-Hydroxy-2-methylbenzene
2-Cresol
2-Hydroxytoluene
2-Methylphenol
m-Cresol
o-Cresol (ACGIH:OSHA)
o-Cresylic acid
o-Hydroxytoluene
o-Kresol (German)
o-Methylphenol
o-Methylphenylol
o-Oxytoluene
Orthocresol
o-Toluol
Phenol, 2-methyl- (9CI)
RCRA waste number U052
2-Cresol
2-Hydroxytoluene
2-Methylphenol
m-Cresol
o-Cresol (ACGIH:OSHA)
o-Cresylic acid
o-Hydroxytoluene
o-Kresol (German)
o-Methylphenol
o-Methylphenylol
o-Oxytoluene
Orthocresol
o-Toluol
Phenol, 2-methyl- (9CI)
RCRA waste number U052
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| sister chromatid exchange | fibroblast/human | 8 mmol/L | MUREAV 137,51,1984 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | 2.31 gm/kg (7D prior to copulation/21D pregnant) | Reproductive: Maternal effects: Parturition | NTIS** #PB92-176890 |
| oral/mouse | 660 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB92-176890 |
| oral/rat | 19775 mg/kg (multigeneration) | Reproductive: Other effects on female | HPV299 -,-,2002 |
| oral/rat | 50850 mg/kg (multigeneration) | Reproductive: Other effects on female Reproductive: Effects on newborn: Stillbirth | HPV299 -,-,2002 |
| oral/rat | 4500 mg/kg (6-15D pregnant) | Reproductive: Other effects on female | HPV299 -,-,2002 |
| oral/rabbit | 650 mg/kg (6-18D pregnant) | Reproductive: Other effects on female | HPV299 -,-,2002 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin/mouse | lowest published toxic dose: 4800 mg/kg/12W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Skin and Appendages: Tumors | CNREA8 19,413,1959 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lethal concentration (50 percent kill): 179 mg/m3/2H | 85GMAT -,40,1982 | |
| inhalation/mouse | lethal concentration (50 percent kill): 179 mg/m3 | Behavioral: Tetany Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Hematuria | VCVGK* -,207,1994 |
| inhalation/rat | lethal concentration (50 percent kill): 29 mg/m3 | Behavioral: Tetany Lung, Thorax, or Respiration: Acute pulmonary edema Kidney, Ureter, and Bladder: Hematuria | VCVGK* -,207,1994 |
| intraperitoneal/guinea pig | lowest published lethal dose: 360 mg/kg | VCVGK* -,207,1994 | |
| intraperitoneal/mouse | lowest published lethal dose: 200 mg/kg | RBPMAZ 22,1,1952 | |
| intraperitoneal/rabbit | lowest published lethal dose: 180 mg/kg | VCVGK* -,207,1994 | |
| intravenous/Dog | lowest published lethal dose: 80 mg/kg | VCVGK* -,207,1994 | |
| intravenous/rabbit | lowest published lethal dose: 180 mg/kg | JPETAB 80,233,1944 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 100 mg/kg | Cardiac: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,207,1994 |
| oral/mouse | lethal dose (50 percent kill): 344 mg/kg | GTPZAB 18(2),58,1974 | |
| oral/mouse | lethal dose (50 percent kill): 344 mg/kg | Cardiac: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,207,1994 |
| oral/rabbit | lethal dose (50 percent kill): 940 mg/kg | Cardiac: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,207,1994 |
| oral/rabbit | lowest published lethal dose: 940 mg/kg | JPETAB 80,233,1944 | |
| oral/rat | lethal dose (50 percent kill): 1350 mg/kg | Cardiac: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,207,1994 |
| skin/rabbit | lethal dose (50 percent kill): 890 mg/kg | TXAPA9 42,417,1977 | |
| skin/rabbit | lethal dose (50 percent kill): 890 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tetany | VCVGK* -,207,1994 |
| skin/rat | lethal dose (50 percent kill): 620 mg/kg | GTPZAB 18(2),58,1974 | |
| skin/rat | lethal dose (50 percent kill): 620 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tetany | VCVGK* -,207,1994 |
| subcutaneous/cat | lowest published lethal dose: 55 mg/kg | VCVGK* -,207,1994 | |
| subcutaneous/frog | lowest published lethal dose: 200 mg/kg | HBAMAK 4,1361,1935 | |
| subcutaneous/guinea pig | lowest published lethal dose: 35 mg/kg | Eye: Miosis (pupilliary constriction) Behavioral: Excitement Lung, Thorax, or Respiration: Acute pulmonary edema | RMSRA6 15,561,1895 |
| subcutaneous/mouse | lowest published lethal dose: 410 mg/kg | VCVGK* -,207,1994 | |
| subcutaneous/rabbit | lowest published lethal dose: 450 mg/kg | HBAMAK 4,1361,1935 | |
| subcutaneous/rat | lowest published lethal dose: 65 mg/kg | Eye: Miosis (pupilliary constriction) Behavioral: Excitement Lung, Thorax, or Respiration: Acute pulmonary edema | RMSRA6 15,561,1895 |
| subcutaneous/rat | lowest published lethal dose: 65 mg/kg | VCVGK* -,207,1994 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic concentration: 9 mg/m3/4H/122D- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,208,1994 |
| inhalation/mouse | lowest published toxic concentration: 50 mg/m3/2H/24D- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,208,1994 |
| inhalation/rabbit | lowest published toxic concentration: 9 mg/m3/4H/122D- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,208,1994 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/4H/40D- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,208,1994 |
| inhalation/rat | lowest published toxic concentration: 9 mg/m3/4H/122D- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,208,1994 |
| oral/mammal (species unspecified) | lowest published toxic dose: 1169 mg/kg/28D- continuous | Liver: Changes in liver weight | ETOCDK 5,713,1986 |
| oral/mouse | lowest published toxic dose: 18480 mg/kg/28D- continuous | Kidney, Ureter, and Bladder: Changes in kidney weight | NTIS** #PB92-176890 |
| oral/mouse | lowest published toxic dose: 101 gm/kg/28D- continuous | Brain and Coverings: Changes in brain weight Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** PB92-174242 |
| oral/mouse | lowest published toxic dose: 218 gm/kg/13W- continuous | Brain and Coverings: Changes in brain weight Endocrine: Changes in thymus weight Related to Chronic Data: Changes in testicular weight | NTIS** PB92-174242 |
| oral/mouse | lowest published toxic dose: 54000 mg/kg/90D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV299 -,-,2002 |
| oral/mouse | lowest published toxic dose: 1680 mg/kg/28D- intermittent | Behavioral: Food intake (animal) Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | HPV299 -,-,2002 |
| oral/rat | lowest published toxic dose: 4550 mg/kg/13W- intermittent | Behavioral: Somnolence (general depressed activity) | HPV299 -,-,2002 |
| oral/rat | lowest published toxic dose: 54600 mg/kg/13W- intermittent | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV299 -,-,2002 |
| oral/rat | lowest published toxic dose: 33750 mg/kg/90D- intermittent | Liver: Changes in liver weight | HPV299 -,-,2002 |
| oral/rat | lowest published toxic dose: 6776 mg/kg/28D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV299 -,-,2002 |
| oral/rat | lowest published toxic dose: 21 gm/kg/28D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight | NTIS** PB92-174242 |
| oral/rat | lowest published toxic dose: 82 gm/kg/13W- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Endocrine: Changes in thymus weight | NTIS** PB92-174242 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 20 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | MUREAV 47,75,1978 | |
| TOXICOLOGY REVIEW | ENTOX* -,678,2005 | |
| TOXICOLOGY REVIEW | FCTOD7 94,93,2016 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 ppm (22 mg/m3) | DTLVS* 3,61,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (22 mg/m3), JUL2008 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (22 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (22 mg/m3), skin, EC-limit, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (22 mg/m3), short term exposure limit 10 ppm (45 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (22 mg/m3), FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (22 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 5 ppm (22 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (22 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (22 mg/m3), JAN1999 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 1 ppm (4.5 mg/m3);short term exposure limit 2 ppm (9 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 5 ppm (22 5 mg/m3), skin, JAN2011 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-CRESOL-air | 10H time-weighted average 2.3 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 84364; Number of Industries 16; Total Number of Facilities 1707; Number of Occupations 24; Total Number of Employees Exposed 10985; Total Number of Female Employees Exposed 483 | |
| National Occupational Hazard Survey 1974 | Hazard Code 84364; Number of Industries 26; Total Number of Facilities 1724; Number of Occupations 28; Total Number of Employees Exposed 14550 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Cresol (all isomers) and phenol, 2546 | |
| NIOSH Analytical Method, 1996: Volatile organic compound, 2549 | |
| NTP Toxicity studies, RPT# TOX-09, October 2000 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health