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Coal - tar pitch

RTECS #: GF8655000

CAS #: 65996-93-2


UPDATE: May 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Coal tar pitch volatiles (ACGIH:OSHA)
  2. Pitch
  1. Pitch, coal tar


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratracheal
rat
lowest published toxic dose: 1 gm/kg/10 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CRNGDP 13,233,1992
skin
mouse
lowest published toxic dose: 36 gm/kg/18 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
AJIMD8 2,59,1981
skin
mouse
toxic dose : 4,200 mg/kg/31 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
TXAPA9 18,41,1971
skin
mouse
toxic dose : 82 gm/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
HYSAAV 33(4-6),180,1968


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 880 mg/m3/7 day- continuous Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVPS* -,146,1998
inhalation
mouse
lowest published toxic concentration: 50 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVPS* -,146,1998
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/8 week- intermittent Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
VCVPS* -,131,1998
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/17 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Normocytic anemia

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
VCVPS* -,131,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 3,22,1973
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,174,1987
TOXICOLOGY REVIEW
JIDHAN 5,462,1924
TOXICOLOGY REVIEW
PAASAH 54,171,1959


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 DTLVS* 3,57,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, FEB2006
Occupational Exposure Limit - MEXICO time-weighted average 0.02 mg/m3;
short term exposure limit 0.015 ppm (0.03 mg/m3), 2004
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COAL TAR PRODUCTS-air 10 hour time-weighted average 0.1 mg/m3 CHE fraction MMWR** 37(S-7),9,1988
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0535;
Number of Industries 4;
Total Number of Facilities 190;
Number of Occupations 6;
Total Number of Employees Exposed 1,354
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0535;
Number of Industries 20;
Total Number of Facilities 1,235;
Number of Occupations 22;
Total Number of Employees Exposed 19,021;
Total Number of Female Employees Exposed 98


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-58


REFERENCES:

CODEN
REFERENCE

AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
MMWR** MMWR. Morbidity and Mortality Weekly Report. (Centers for Disease Control, Atlanta, GA 30333) V.25(10)- 1976- for RTECS citation, only V.34(Suppl 1S), 1985 is used.
PAASAH Publication of the American Association for the Advancement of Science. (Washington, DC) No.1-94, 1934-73. Discontinued.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

NIOSH PROFILE (ALUMINUM REDUCTION PLANTS), FIRL, 4/78

RTECS Compound Description:
   Tumorigen

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