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Chlorine oxide

RTECS #: FO3000000

CAS #: 10049-04-4


UPDATE: May 2009 MW: 67.45 MF: ClO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Alcide
  2. Anthium dioxcide
  3. Chlorine dioxide
  4. Chlorine dioxide (ACGIH:OSHA)
  5. Chlorine peroxide
  1. Chlorine (IV) oxide
  2. Chloroperoxyl
  3. Chloryl radical
  4. Doxcide 50


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild JJATDK 2,160,1982


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human leukocyte 0.2 ppm/1 hour MUTAEX 19,157,2004
DNA damage multiple
other fish
1.63 mg/L/3 hour MUREAV 557,119,2004
DNA damage multiple
other fish
0.1 ppm/72 hour- continuous MUREAV 587,103,2005
DNA inhibition oral
rat
84 mg/kg/12 week- continuous JEPOEC 6(1),105,1985
mutation in microorganisms Salmonella typhimurium 400 g/plate (-enzymatic activation step) FCTOD7 22,623,1984
mutation in microorganisms Saccharomyes cerevisiae 10 ppm/2 hour (+enzymatic activation step) MUTAEX 19,157,2004
micronucleus test intraperitoneal
mouse
3,200 g/kg FCTOD7 26,487,1988
micronucleus test multiple
other fish
1.64 mg/L/20 day- continuous MUREAV 557,119,2004
micronucleus test multiple
other fish
0.1 ppm/72 hour- continuous MUREAV 587,103,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 840 mg/kg (1-21 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) EVHPAZ 46,31,1982
oral
rat
lowest published toxic dose: 960 mg/kg (76 day prior to copulation/1-20 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
JJATDK 3,75,1983
oral
rat
lowest published toxic dose: 570 mg/kg (14 day prior to copulation-21 day after birth) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical
NTIS** PB85-245983
oral
rat
lowest published toxic dose: 1,130 mg/kg (8 week male/2 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Biochemical and metabolic TJADAB 35,43A,1987
oral
rat
lowest published toxic dose: 92 mg/kg (10 week prior to copulation/22 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system VCVN5* -,381,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 100 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,380,1989
inhalation
human
lowest published toxic concentration: 3 mg/m3 Eye: Conjunctiva irritation VCVN5* -,380,1989
inhalation
mammal (species unspecified)
lowest published lethal concentration: 200 mg/m3/15 minute Lung, Thorax, or Respiration: Other changes VCVN5* -,380,1989
inhalation
mouse
lethal concentration (50 percent kill): >547 gm/m3 N/R WDZAEK 9,201,1995
inhalation
mouse
lowest published toxic concentration: 100 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,380,1989
inhalation
rat
lowest published lethal concentration: 260 ppm/2 hour Olfaction: Other olfaction effects

Eye: Other eye effects
AMIHAB 15,101,1957
inhalation
rat
lowest published toxic concentration: 100 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,380,1989
inhalation
rabbit
lowest published toxic concentration: 100 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,380,1989
oral
mouse
lethal dose (50 percent kill): >5 gm/kg N/R WDZAEK 9,201,1995
oral
rat
lethal dose (50 percent kill): 292 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Skin and Appendages: Other: Hair
JJATDK 2,160,1982
oral
rat
lethal dose (50 percent kill): 140 mg/kg N/R VCVN5* -,380,1989
unreported route
rat
lethal dose (50 percent kill): 140 mg/kg N/R GISAAA 36(11),18,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10 ppm/4 hour/14 day- intermittent Olfaction: Other olfaction effects

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 15,101,1957
inhalation
rat
lowest published toxic concentration: 7 mg/m3/7 hour/30 day- intermittent Lung, Thorax, or Respiration: Other changes VCVN5* -,380,1989
inhalation
rat
lowest published toxic concentration: 13 mg/m3/2 hour/30 day- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
VCVN5* -,380,1989
inhalation
rabbit
lowest published toxic concentration: 7 mg/m3/7 hour/30 day- intermittent Lung, Thorax, or Respiration: Other changes VCVN5* -,380,1989
inhalation
rabbit
lowest published toxic concentration: 13 mg/m3/2 hour/30 day- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
VCVN5* -,380,1989
multiple
non-mammalian species
lowest published toxic dose: 0.2 ppm/72 hour- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field MUREAV 587,103,2005
oral
monkey
lowest published toxic dose: 140 mg/kg/4 week- continuous Endocrine: Evidence of thyroid hypofunction VCVN5* -,381,1989
oral
monkey
lowest published toxic dose: 280 mg/kg/8 week- continuous Endocrine: Evidence of thyroid hyperfunction VCVN5* -,381,1989
oral
rat
lowest published toxic dose: 365 mg/kg/1 year- continuous Blood: Pigmented or nucleated red blood cells

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JEPOEC 6(1),105,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm;short term exposure limit 0.3 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 564,179,2004
TOXICOLOGY REVIEW
ENTOX* -,555,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,301,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.3 mg/m3) DTLVS* 3,46,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.3 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.3 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.28 mg/m3), short term exposure limit 0.3 ppm (0.83 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.28 mg/m3), short term exposure limit 0.3 ppm (0.83 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.28 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.3 ppm (0.84 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.3 mg/m3), short term exposure limit 0.3 ppm (0.9 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.3 mg/m3), VLE 0.3 ppm (0.8 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.28 mg/m3 (0.1 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.3 mg/m3), short term exposure limit 0.3 ppm (0.9 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.3 mg/m3);
short term exposure limit 0.3 ppm (0.9 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.28 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.3 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg/m3, MAC(short term exposure limit) 0.9 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 ppm (0.3 mg/m3), ceiling concentration 0.3 ppm (0.8 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.3 mg/m3);
KZG- week 0.1 ppm (0.3 mg/m3),DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 ppm (0.3 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.3 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.28 mg/m3);
short term exposure limit 0.3 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm;
short term exposure limit 0.3 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm;
short term exposure limit 0.3 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORINE DIOXIDE-air 10 hour time-weighted average 0.1 ppm;
short term exposure limit 0.3 ppm
NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 18045;
Number of Industries 7;
Total Number of Facilities 236;
Number of Occupations 12;
Total Number of Employees Exposed 7,892;
Total Number of Female Employees Exposed 4,348


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a liquid sterilizer in an ultrasonic cleaner
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID202


REFERENCES:

CODEN
REFERENCE

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used as a liquid sterilizer in an ultrasonic cleaner

NIOSH PROFILE (PULP AND PAPER MILLS), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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