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Carbon monoxide

RTECS #: FG3500000

CAS #: 630-08-0


UPDATE: May 2009 MW: 28.01 MF: CO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. CO
  2. Carbon monoxide (ACGIH:OSHA)
  3. Carbon oxide (CO)
  4. Carbone (oxyde de) (French)
  5. Carbonic oxide
  6. Carbonio (ossido di) (Italian)
  7. Exhaust gas
  1. Flue gas
  2. Kohlenmonoxid (German)
  3. Kohlenoxyd (German)
  4. Koolmonoxyde (Dutch)
  5. Oxyde de carbone (French)
  6. Wegla tlenek (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
micronucleus test inhalation
mouse
1,500 ppm/10 minute YOMJA9 27,205,1986
sister chromatid exchange inhalation
mouse
2,500 ppm/10 minute YOMJA9 27,205,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 200 ppm/10 hour (23-61 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Hepatobiliary system
JNENAD 59,218,2000
inhalation
guinea pig
lowest published toxic concentration: 550 mg/m3 (20-40 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
VCVN1* -,318,1988
inhalation
guinea pig
lowest published toxic concentration: 480 mg/m3 (20-50 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
VCVN1* -,318,1988
inhalation
guinea pig
lowest published toxic concentration: 100 mg/m3 (10 week prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVN1* -,318,1988
inhalation
guinea pig
lowest published toxic concentration: 100 mg/m3 (10 week prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) VCVN1* -,318,1988
inhalation
mouse
lowest published toxic concentration: 65 ppm/24 hour (7-18 day pregnant) Reproductive: Effects on newborn: Behavioral TJADAB 29(2),8B,1984
inhalation
mouse
lowest published toxic concentration: 250 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 19,385,1979
inhalation
mouse
lowest published toxic concentration: 125 ppm/24 hour (7-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 30,253,1984
inhalation
mouse
lowest published toxic concentration: 8 pph/1 hour (8 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
FPNJAG 11,301,1958
inhalation
mouse
lowest published toxic concentration: 8 pph/1 hour (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system FPNJAG 11,301,1958
inhalation
mouse
lowest published toxic concentration: 103 mg/m3 (1-21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVN1* -,318,1988
inhalation
mouse
lowest published toxic concentration: 500 ppm (7-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 20,453,2005
inhalation
mouse
lowest published toxic concentration: 125 ppm (1-7 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
REPTED 22,263,2006
inhalation
mouse
lowest published toxic concentration: 500 ppm (8-18 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TERP2* -,304,2004
inhalation
mouse
lowest published toxic concentration: 125 ppm (1-14 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Stillbirth
BDERB* 77,216,2006
inhalation
mouse
lowest published toxic concentration: 65 ppm (1-14 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) BDERB* 77,216,2006
inhalation
mouse
lowest published toxic concentration: 500 ppm (8-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Gastrointestinal system
BDERB* 68,355,2003
inhalation
mouse
lowest published toxic concentration: 500 ppm (8-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TSPSA* -,255,2003
inhalation
rat
lowest published toxic concentration: 75 ppm/24 hour (0-20 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral
BRREAP 844,201,1999
inhalation
rat
lowest published toxic concentration: 150 ppm/24 hour (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system TXAPA9 56,370,1980
inhalation
rat
lowest published toxic concentration: 150 ppm/24 hour (1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NETOD7 2,7,1980
inhalation
rat
lowest published toxic concentration: 1 mg/m3/24 hour (72 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
HYSAAV 35(4-6),277,1970
inhalation
rat
lowest published toxic concentration: 150 ppm/24 hour (0-20 day pregnant) Reproductive: Effects on newborn: Behavioral LIFSAK 59,1553,1996
inhalation
rat
lowest published toxic concentration: 75 ppm/24 hour (0-20 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system PHTOEH 73,274,1993
inhalation
rat
lowest published toxic concentration: 150 ppm (0-20 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical
JPETAB 294,728,2000
inhalation
rat
lowest published toxic concentration: 103 mg/m3 (1-22 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVN1* -,318,1988
inhalation
rat
lowest published toxic concentration: 150 ppm (1-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TOLED5 135,S82,2002
inhalation
rat
lowest published toxic concentration: 150 ppm (0-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NSAPCC 369(Suppl 1),R163,2004
inhalation
rabbit
lowest published toxic concentration: 180 ppm/24 hour (1-30 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
LANCAO 2,1220,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
wild bird
lethal concentration (50 percent kill): 1,334 ppm N/R AECTCV 12,355,1983
inhalation
cat
lowest published toxic concentration: 50 mg/m3/60 minute Behavioral: Alteration of classical conditioning VCVN1* -,308,1988
inhalation
cat
lowest published toxic concentration: 2,000 mg/m3/20 minute Behavioral: Alteration of classical conditioning VCVN1* -,308,1988
inhalation
cat
lowest published lethal concentration: 500 mg/m3/30 minute N/R VCVN1* -,308,1988
inhalation
cat
lowest published lethal concentration: 34,400 mg/m3/3 minute N/R VCVN1* -,308,1988
inhalation
dog
lowest published lethal concentration: 4,000 ppm/46 minute N/R HBAMAK 4,1360,1935
inhalation
dog
lowest published toxic concentration: 2,000 mg/m3/30 minute Behavioral: Alteration of classical conditioning VCVN1* -,308,1988
inhalation
dog
lowest published lethal concentration: 23,000 mg/m3/20 minute N/R VCVN1* -,308,1988
inhalation
domestic animal
lowest published toxic concentration: 1%/45 minute Cardiac: Pulse rate increased without fall in BP TXCYAC 165,97,2001
inhalation
domestic animal
lowest published toxic concentration: 1%/65 minute Nutritional and Gross Metabolic: Changes in: Metabolic acidosis

Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)
TXCYAC 165,97,2001
inhalation
domestic animal
lowest published toxic concentration: 1%/95 minute Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease
TXCYAC 165,97,2001
inhalation
domestic animal
lowest published toxic concentration: 1%/100 minute Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease
TXCYAC 165,97,2001
inhalation
domestic animal
lowest published toxic concentration: 1%/120 minute Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease
TXCYAC 165,97,2001
inhalation
domestic animal
lowest published toxic concentration: 1%/150 minute Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease
TXCYAC 165,97,2001
inhalation
domestic animal
lowest published toxic concentration: 1 pph Brain and Coverings: Changes in surface EEG

Behavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 179,79,2002
inhalation
domestic animal
lowest published toxic concentration: 1 pph/120 minute Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 186,143,2003
inhalation
domestic animal
lowest published lethal concentration: 1 pph/2 hour Brain and Coverings: Changes in surface EEG

Brain and Coverings: Other degenerative changes

Behavioral: General anesthetic
TXCYAC 209,237,2005
inhalation
guinea pig
lethal concentration (50 percent kill): 5,718 ppm/4 hour N/R TXAPA9 17,752,1970
inhalation
guinea pig
lowest published toxic concentration: 2,000 mg/m3/30 minute Behavioral: Alteration of classical conditioning VCVN1* -,309,1988
inhalation
guinea pig
lowest published lethal concentration: 4,600 mg/m3/2 hour N/R VCVN1* -,309,1988
inhalation
guinea pig
lowest published lethal concentration: 10,300 mg/m3/60 minute N/R VCVN1* -,309,1988
inhalation
human
lowest published lethal concentration: 4 mg/m3/12 hour Behavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOVEFN (4),26,1999
inhalation
human
lowest published toxic concentration: 600 mg/m3/10 minute Behavioral: Headache GTPZAB 31(4),34,1987
inhalation
human
lowest published lethal concentration: 5,000 ppm/5 minute N/R TABIA2 3,231,1933
inhalation
human
lowest published toxic concentration: 6 mg/m3/25 minute Eye: Other eye effects VCVN1* -,313,1988
inhalation
human
lowest published toxic concentration: 11 mg/m3/5 hour Behavioral: Alteration of classical conditioning VCVN1* -,313,1988
inhalation
human
lowest published toxic concentration: 31 mg/m3/3 hour Eye: Visual field changes VCVN1* -,313,1988
inhalation
human
lowest published toxic concentration: 33 mg/m3/6 hour Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVN1* -,313,1988
inhalation
human
lowest published toxic concentration: 50 mg/m3/2 hour Ear: Change in acuity

Brain and Coverings: Changes in surface EEG
VCVN1* -,313,1988
inhalation
human
lowest published toxic concentration: 50 mg/m3/5 hour Behavioral: Change in psychophysiological tests VCVN1* -,313,1988
inhalation
human
lowest published toxic concentration: 55 mg/m3/8 hour Eye: Other eye effects VCVN1* -,313,1988
inhalation
human
lowest published toxic concentration: 60 mg/m3/6 hour Cardiac: Pulse rate decreased with fall in BP

Brain and Coverings: Changes in surface EEG
VCVN1* -,313,1988
inhalation
human
lowest published toxic concentration: 80 mg/m3/3 hour Eye: Other eye effects

Behavioral: Change in psychophysiological tests

Behavioral: Ataxia
VCVN1* -,313,1988
inhalation
human
lowest published toxic concentration: 220 mg/m3/1 hour Behavioral: Headache VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 220 mg/m3/3 hour Behavioral: Somnolence (general depressed activity) VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 230 mg/m3/6 hour Brain and Coverings: Increased intracranial pressure

Behavioral: Somnolence (general depressed activity)
VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 440 mg/m3/4 hour Behavioral: Headache

Gastrointestinal: Nausea or vomiting
VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 440 mg/m3/1 hour Behavioral: Headache

Cardiac: Pulse rate increased without fall in BP
VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 460 mg/m3/4 hour Behavioral: Headache

Behavioral: Somnolence (general depressed activity)

Vascular: BP lowering not characterized in autonomic section
VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 660 mg/m3/2 hour Gastrointestinal: Nausea or vomiting VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 660 mg/m3/4 hour Behavioral: General anesthetic VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 800 mg/m3/5 minute Behavioral: Headache

Behavioral: Somnolence (general depressed activity)
VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 800 mg/m3/20 minute Gastrointestinal: Nausea or vomiting

Behavioral: Muscle weakness
VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 800 mg/m3/3 hour Cardiac: Pulse rate increased without fall in BP

Vascular: BP lowering not characterized in autonomic section
VCVN1* -,314,1988
inhalation
human
lowest published toxic concentration: 880 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: General anesthetic

Vascular: BP lowering not characterized in autonomic section
VCVN1* -,315,1988
inhalation
human
lowest published lethal concentration: 880 mg/m3/4 hour Behavioral: Tetany

Behavioral: Coma
VCVN1* -,315,1988
inhalation
human
lowest published toxic concentration: 1,260 mg/m3/90 minute Cardiac: Pulse rate increased without fall in BP

Behavioral: Coma

Behavioral: Tetany
VCVN1* -,315,1988
inhalation
human
lowest published toxic concentration: 1,300 mg/m3/2 hour Gastrointestinal: Nausea or vomiting

Cardiac: Pulse rate increased without fall in BP

Behavioral: Headache
VCVN1* -,315,1988
inhalation
human
lowest published toxic concentration: 1,350 mg/m3/33 minute Cardiac: Pulse rate increased without fall in BP

Eye: Other eye effects

Behavioral: Alteration of classical conditioning
VCVN1* -,315,1988
inhalation
human
lowest published toxic concentration: 1,760 mg/m3/20 minute Behavioral: Headache

Gastrointestinal: Nausea or vomiting
VCVN1* -,315,1988
inhalation
human
lowest published toxic concentration: 1,760 mg/m3/2 hour Behavioral: General anesthetic

Vascular: BP lowering not characterized in autonomic section
VCVN1* -,315,1988
inhalation
human
lowest published lethal concentration: 1,800 mg/m3/1 hour Lung, Thorax, or Respiration: Respiratory depression

Cardiac: Change in force of contraction
VCVN1* -,315,1988
inhalation
human
lowest published toxic concentration: 2,000 mg/m3/12 minute Behavioral: Tetany

Behavioral: Coma
VCVN1* -,315,1988
inhalation
human
lowest published lethal concentration: 3,000 mg/m3/1 hour N/R VCVN1* -,315,1988
inhalation
human
lowest published lethal concentration: 2,300 mg/m3/30 minute Behavioral: General anesthetic

Vascular: BP lowering not characterized in autonomic section
VCVN1* -,315,1988
inhalation
human
lowest published toxic concentration: 3,520 mg/m3/5 minute Behavioral: Headache VCVN1* -,315,1988
inhalation
human
lowest published toxic concentration: 3,520 mg/m3/30 minute Behavioral: General anesthetic

Gastrointestinal: Nausea or vomiting
VCVN1* -,315,1988
inhalation
human
lowest published lethal concentration: 3,400 mg/m3/20 minute Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression
VCVN1* -,315,1988
inhalation
human
lowest published toxic concentration: 5,000 mg/m3/17 minute Behavioral: General anesthetic

Behavioral: Tetany
VCVN1* -,315,1988
inhalation
human
lowest published lethal concentration: 5,700 mg/m3/2 minute N/R VCVN1* -,315,1988
inhalation
human
lowest published lethal concentration: 14,080 mg/m3/1 minute Gastrointestinal: Nausea or vomiting

Behavioral: General anesthetic
VCVN1* -,315,1988
inhalation
mammal (species unspecified)
lowest published lethal concentration: 5,000 ppm/5 minute N/R AEPPAE 138,65,1928
inhalation
man
lowest published lethal concentration: 4,000 ppm/30 minute N/R 29ZWAE -,207,1968
inhalation
man
lowest published toxic concentration: 650 ppm/45 minute Blood: Methemoglobinemia- Carboxhemoglobinemia

Behavioral: Change in psychophysiological tests
AIHAAP 34,212,1973
inhalation
monkey
lowest published toxic concentration: 1,145 mg/m3/30 minute Cardiac: Other changes

Liver: Multiple effects

Lung, Thorax, or Respiration: Other changes
VCVN1* -,309,1988
inhalation
mouse
lethal concentration (50 percent kill): 2,444 ppm/4 hour N/R TXAPA9 17,752,1970
inhalation
mouse
lethal concentration (50 percent kill): 2,230 mg/m3/2 hour N/R VCVN1* -,308,1988
inhalation
mouse
lethal concentration : 1,900 mg/m3/2 hour N/R VCVN1* -,308,1988
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/40 minute Brain and Coverings: Changes in circulation

Vascular: Measurement of regional blood flow

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXAPA9 194,280,2004
inhalation
rat
lethal concentration (50 percent kill): 1,807 ppm/4 hour N/R TXAPA9 17,752,1970
inhalation
rat
lethal concentration : 5,200 mg/m3/1 hour N/R VCVN1* -,308,1988
inhalation
rat
lowest published toxic concentration: 40 mg/m3/4 hour Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVN1* -,308,1988
inhalation
rat
lowest published toxic concentration: 88 mg/m3/20 minute Nutritional and Gross Metabolic: Changes in: P VCVN1* -,308,1988
inhalation
rat
lowest published toxic concentration: 176 mg/m3/20 minute Brain and Coverings: Other degenerative changes VCVN1* -,308,1988
inhalation
rat
lowest published toxic concentration: 800 mg/m3/4 hour Behavioral: Altered sleep time (including change in righting reflex) VCVN1* -,308,1988
inhalation
rat
lethal concentration (50 percent kill): 1,900 mg/m3/4 hour N/R VCVN1* -,308,1988
inhalation
rat
lowest published toxic concentration: 2,000 mg/m3/11 minute Behavioral: Alteration of classical conditioning VCVN1* -,308,1988
inhalation
rat
lethal concentration (50 percent kill): 13,500 mg/m3/15 minute N/R VCVN1* -,308,1988
inhalation
rat
lowest published toxic concentration: 1,000 ppm/5 minute Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
TOXID9 72,297,2003
inhalation
rat
lowest published toxic concentration: 1,005 ppm/90 minute Brain and Coverings: Recordings from specific areas of CNS TOLED5 145,101,2003
inhalation
rat
lowest published toxic concentration: 50 ppm/2 hour Blood: Methemoglobinemia- Carboxhemoglobinemia TXCYAC 194,51,2003
inhalation
rat
lowest published toxic concentration: 4,000 ppm/15 minute Brain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Blood: Methemoglobinemia- Carboxhemoglobinemia
TXCYAC 194,51,2003
inhalation
rat
lowest published toxic concentration: 1,000 ppm/40 minute Brain and Coverings: Changes in circulation

Vascular: Measurement of regional blood flow

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
TXAPA9 194,280,2004
inhalation
rat
lowest published toxic concentration: 0.3 pph/40 minute Behavioral: Somnolence (general depressed activity)

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
ARTODN 76,596,2002
inhalation
rat
lowest published toxic concentration: 1,000 ppm Blood: Other changes TOXID9 66,345,2002
inhalation
rat
lowest published lethal concentration: 12,000 ppm N/R TOXID9 66,345,2002
inhalation
rat
lethal concentration (50 percent kill): 6,600 ppm/30 minute N/R ENTOX* -,639,2005
inhalation
rat
lowest published toxic dose: 3,000 ppm/60 minute Brain and Coverings: Other degenerative changes TXCYAC 225,138,2006
inhalation
rat
lowest published toxic dose: 24,000 ppm/4 minute Lung, Thorax, or Respiration: Respiratory depression INHTE5 17,755,2005
inhalation
rat
lethal dose (30 percent kill): 24,000 ppm/5 minute Lung, Thorax, or Respiration: Respiratory obstruction

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
INHTE5 17,755,2005
inhalation
rat
lowest published toxic dose: 500 ppm/5 minute Blood: Methemoglobinemia- Carboxhemoglobinemia INHTE5 17,755,2005
inhalation
rat
lowest published toxic concentration: 3,000 ppm/40 minute Brain and Coverings: Other degenerative changes TXCYAC 239,136,2007
inhalation
rat
lowest published toxic concentration: 24,000 ppm/4 minute Lung, Thorax, or Respiration: Respiratory depression INHTE5 17,755,2005
inhalation
rat
lethal concentration (30 percent kill): 24,000 ppm/5 minute Lung, Thorax, or Respiration: Respiratory obstruction

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
INHTE5 17,755,2005
inhalation
rat
lowest published toxic concentration: 500 ppm/5 minute Blood: Methemoglobinemia- Carboxhemoglobinemia INHTE5 17,755,2005
inhalation
rat
lowest published toxic concentration: 2,000 ppm/60 minute Behavioral: General anesthetic TOLED5 170,111,2007
inhalation
rat
lowest published toxic concentration: 2,000 ppm/120 minute Behavioral: Alteration of operant conditioning TOLED5 170,111,2007
inhalation
rabbit
lowest published lethal concentration: 4,000 ppm N/R HBAMAK 4,1360,1935
inhalation
rabbit
lowest published toxic concentration: 100 mg/m3/2 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve VCVN1* -,309,1988
inhalation
rabbit
lowest published toxic concentration: 6,600 mg/m3/10 minute Lung, Thorax, or Respiration: Acute pulmonary edema VCVN1* -,309,1988
inhalation
rabbit
lowest published lethal concentration: 17,200 mg/m3/40 minute N/R VCVN1* -,309,1988
inhalation
rabbit
lowest published lethal concentration: 20,000 mg/m3/60 minute N/R VCVN1* -,309,1988
intraperitoneal
mouse
lowest published toxic dose: 2,240.8 g/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation JPETAB 319,1265,2006
intraperitoneal
rat
lowest published toxic dose: 35 mL/kg Ear: Change in cochlear structure or function NETEEC 23,157,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 200 mg/m3/5 hour/4 week- intermittent Endocrine: Hyperglycemia GISAAA 30(5),30,1965
inhalation
guinea pig
lowest published toxic concentration: 200 mg/m3/5 hour/30 week- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP
GISAAA 31(3),102,1966
inhalation
guinea pig
lowest published toxic concentration: 200 ppm/24 hour/90 day- continuous Blood: Pigmented or nucleated red blood cells

Blood: Other changes
TXAPA9 19,46,1971
inhalation
guinea pig
lowest published toxic concentration: 100 mg/m3/10 week- continuous Endocrine: Effect on menstrual cycle VCVN1* -,318,1988
inhalation
guinea pig
lowest published toxic concentration: 16 pph/48 hour- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN1* -,329,1988
inhalation
man
lowest published toxic concentration: 2 pph/30 day- intermittent Behavioral: Somnolence (general depressed activity) VCVN1* -,329,1988
inhalation
monkey
lowest published toxic concentration: 200 ppm/24 hour/90 day- continuous Blood: Pigmented or nucleated red blood cells

Blood: Other changes
TXAPA9 19,46,1971
inhalation
monkey
lowest published toxic concentration: 110 mg/m3/90 day- intermittent Cardiac: Other changes VCVN1* -,316,1988
inhalation
mouse
lowest published toxic concentration: 50 ppm/30 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi NKYZA2 10,16,1972
inhalation
mouse
lowest published toxic concentration: 10 mg/m3/4 hour/10 week- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Endocrine: Other changes
VCVN1* -,316,1988
inhalation
rat
lowest published toxic concentration: 1,800 ppm/1 hour/14 day- intermittent Cardiac: Other changes TOPADD 15,366,1987
inhalation
rat
lowest published toxic concentration: 30 mg/m3/8 hour/10 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Muscle contraction or spasticity
GISAAA 26(3),3,1961
inhalation
rat
lowest published toxic concentration: 96 ppm/24 hour/90 day- continuous Blood: Pigmented or nucleated red blood cells

Blood: Other changes
TXAPA9 19,46,1971
inhalation
rat
lowest published toxic concentration: 250 ppm/5 hour/20 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
BECTA6 13,537,1975
inhalation
rat
lowest published toxic concentration: 375 mg/m3/5 hour/20 week- intermittent Vascular: Structural changes in vessels

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes
WDZAEK 6,133,1992
inhalation
rat
lowest published toxic concentration: 105 ppm/7 day- continuous Cardiac: Cardiomegaly

Blood: Other changes

Cardiac: Change in force of contraction
ETOPFR 8,23,1999
inhalation
rat
lowest published toxic concentration: 315 ppm/21 day- continuous Cardiac: Changes in coronary arteries

Cardiac: Arrythmias (indlucing changes in conduction)
ETOPFR 8,23,1999
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/10 week- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Endocrine: Other changes
VCVN1* -,316,1988
inhalation
rat
lowest published toxic concentration: 53 mg/m3/30 day- continuous Liver: Other changes

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN1* -,316,1988
inhalation
rat
lowest published toxic concentration: 100 mg/m3/1 week- continuous Liver: Other changes

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN1* -,316,1988
inhalation
rabbit
lowest published toxic concentration: 200 mg/m3/3 hour/13 week- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Blood: Hemorrhage
GISAAA 24(6),22,1959
inhalation
rabbit
lowest published toxic concentration: 50 ppm/24 hour/8 week- continuous Blood: Changes in platelet count JEPTDQ 4(1),351,1980
inhalation
rabbit
lowest published toxic concentration: 110 mg/m3/1 year- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVN1* -,316,1988
inhalation
rabbit
lowest published toxic concentration: 170 mg/m3/45 day- intermittent Vascular: Structural changes in vessels VCVN1* -,316,1988
inhalation
rabbit
lowest published toxic concentration: 4.5 pph/13 day- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN1* -,329,1988
intraperitoneal
mouse
lowest published toxic dose: 700 mL/kg/7 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Change in psychophysiological tests

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CYLPDN 21,360,2000
intraperitoneal
mouse
lowest published toxic dose: 700 mL/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CYLPDN 22,423,2001
subcutaneous
rat
lowest published toxic dose: 5,983 mg/kg/18 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 1,275,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TXCYAC 187,25,2003
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
CTOXAO 39,35,2001
TOXICOLOGY REVIEW
CMAJAX 166,1685,2002
TOXICOLOGY REVIEW
TXCYAC 180,139,2002
TOXICOLOGY REVIEW
AOHYA3 17,159,1974
TOXICOLOGY REVIEW
NTIS** CONF-691001
TOXICOLOGY REVIEW
TOLED5 140-141,183,2003
TOXICOLOGY REVIEW
ARPTDI 45,147,2005
TOXICOLOGY REVIEW
CRTXB2 32,259,2002
TOXICOLOGY REVIEW
BPAAAG 135,350,1967
TOXICOLOGY REVIEW
JTCTDW 39,1,2001
TOXICOLOGY REVIEW
TOLED5 134,3,2002
TOXICOLOGY REVIEW
DIMON* 46,551,2000
TOXICOLOGY REVIEW
ENTOX* -,639,2005
TOXICOLOGY REVIEW
PAREAQ 57,585,2005
TOXICOLOGY REVIEW
PAREAQ 57,585,2005
TOXICOLOGY REVIEW
FSINDR 161,41,2006
TOXICOLOGY REVIEW
FSINDR 164,164,2006
TOXICOLOGY REVIEW
ITODC* -,327,2004
TOXICOLOGY REVIEW
HUTOX* -,247,1996
TOXICOLOGY REVIEW
HUTOX* -,661,1996
TOXICOLOGY REVIEW
MCLNA* 89,1161,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (55 mg/m3) DTLVS* 3,41,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (55 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (55 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (55 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (55 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 50 ppm (55 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 30 ppm (34 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (29 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (29 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 30 ppm (34 mg/m3), short term exposure limit 75 ppm (86 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (55 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 35 mg/m3 (30 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 33 mg/m3, short term exposure limit 132 mg/m3, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 50 ppm (55 mg/m3), short term exposure limit 400 ppm (440 mg/m3), JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (57 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (55 mg/m3), short term exposure limit 400 ppm (440 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (55 mg/m3);
short term exposure limit 400 ppm (400 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 29 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND short term exposure limit 200 ppm (15 min), JAN2002
Occupational Exposure Limit - NEW ZEALAND short term exposure limit 100 ppm (30 min), JAN2002
Occupational Exposure Limit - NEW ZEALAND short term exposure limit 50 ppm (60 min), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 35 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (55 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 30 mg/m3, MAC(short term exposure limit) 180 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 200 mg/m3 (15 minute), JUN2003
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3 (30 minute), JUN2003
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3 (1 hour), JUN2003
Occupational Exposure Limit - RUSSIA short term exposure limit 20 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 35 ppm (40 mg/m3);
short term exposure limit 100 ppm (120 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 30 ppm (35 mg/m3),KZG- week 30 ppm (35 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 50 ppm (55 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (55 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 30 ppm (35 mg/m3);
short term exposure limit 200 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBON MONOXIDE-air 8 hour time-weighted average 35 ppm;
ceiling concentration 200 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 17460;
Number of Industries 43;
Total Number of Facilities 2,593;
Number of Occupations 68;
Total Number of Employees Exposed 32,958
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 17460;
Number of Industries 24;
Total Number of Facilities 1,950;
Number of Occupations 52;
Total Number of Employees Exposed 68,434;
Total Number of Female Employees Exposed 7,860


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1996: Carbon monoxide, 6604
OSHA ANALYTICAL METHOD #ID209
OSHA ANALYTICAL METHOD #ID210


REFERENCES:

CODEN
REFERENCE

29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BDERB*
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BPAAAG Beitraege zur Pathologischen Anatomie und Allgemeinen Pathologie. (Stuttgart, Fed. Rep. Ger.) V.3-140, 1888-1970. For publisher information, see PARPDS.
BRREAP Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FPNJAG Folia Psychiatrica et Neurologica Japonica. (Folia Pub. Soc., Todai YMCA Bldg., 1-20-6 Mukogaoka, Bunkyo-Ku, Tokyo 113, Japan) V.1- 1933-
FSINDR Forensic Science International. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.12- 1978-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HUTOX*
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
ITODC*
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JNENAD Journal of Neuropathology and Experimental Neurology. (American Association of Neuropathologists, Inc., 1041 New Hapshire St., Lawrence, KS 66044) V.1- 1942-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MCLNA*
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80. For publisher information, see NTOTDY.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NKYZA2 Japanaese Journal of Thoracic Diseases. (Nihon Kyobu Shikkan Gakkai Zasshi, c/o Toyo Bunko, No. 28-21, 2-Chome, Kamagome, Bunkyo-ku, Tokyo 112 Japan) V.10- 1972-
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63. Discontinued.
TERP2*
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TSPSA*
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
YOMJA9 Yonsei Medical Journal. (Yonsei Univ. College of Medicine, P.O. Box 71, Seoul, S. Korea) V.1- 1960-

NIOSH PROFILE (ALUMINUM REDUCTION PLANTS), FIRL, 4/78

NIOSH PROFILE (DIESEL EMISSIONS), SRI, 2/77

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

NIOSH PROFILE (INCINERATION), FIRL, 4/78

NIOSH PROFILE (IRON AND STEEL FOUNDRIES), SRC, 14/77

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

NIOSH PROFILE (SLAUGHTERING AND RENDERING PLANTS), SRC, 10/77

NIOSH PROFILE (WELDING AND BRAZING), SRC, 10/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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