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Carbamic acid, methyl - , 1 - naphthyl ester

RTECS #: FC5950000

CAS #: 63-25-2


UPDATE: May 2009 MW: 201.24 MF: C12H11NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Naftylester kyseliny methylkarbaminove (Czech)
  2. 1 - Naphthalenol, methylcarbamate (9CI)
  3. 1 - Naphthalenyl methylcarbamate
  4. 1 - Naphthol N - methylcarbamate
  5. 1 - Naphthyl N - methylcarbamate
  6. 1 - Naphthyl methylcarbamate
  7. 1 - Naphthyl - N - methyl - karbamat (German)
  8. Arilat
  9. Arilate
  10. Arylam
  11. Atoxan
  12. Bug master
  13. Carbaril
  14. Carbaryl
  15. Carbaryl (ACGIH:OSHA)
  16. Carbatox
  17. Carbatox - 60
  18. Carbatox - 75
  19. Carbavur
  20. Carbomate
  21. Carylderm
  22. Cekubaryl
  23. Compound 7744
  24. Crunch
  25. Denapon
  26. Dicarbam
  27. Dyna - carbyl
  28. ENT 23,969
  29. Experimental Insecticide 7744
  30. Germain's
  31. Hexavin
  32. Karbaryl (Polish)
  33. Karbatox
  34. Karbatox 75
  35. Karbatox zawiesinowy
  36. Karbosep
  37. Latka 7744 (Czech)
  1. Menaphtam
  2. Methylcarbamic acid, 1 - naphthyl ester
  3. Monsur
  4. Mugan
  5. Murvin
  6. N - Methyl - 1 - naftyl - carbamaat (Dutch)
  7. N - Methyl - 1 - naphthyl carbamate
  8. N - Methyl - 1 - naphthyl - carbamat (German)
  9. N - Methyl - alpha - naphthylcarbamate
  10. N - Methyl - alpha - naphthylurethan
  11. N - Methylcarbamate de 1 - naphtyle (French)
  12. N - Metil - 1 - naftil - carbammato (Italian)
  13. NAC (insecticide)
  14. NMC 50
  15. OMS - 29
  16. Oltitox
  17. Panam
  18. Pomex
  19. Prosevor 85
  20. Ravyon
  21. Savit
  22. Seffein
  23. Sevimol
  24. Sevin
  25. Sevin (OSHA)
  26. Sevin 4
  27. Tercyl
  28. Toxan
  29. Tricarnam
  30. UC 7744
  31. Union carbide 7,744
  32. Vetox
  33. Vioxan
  34. alpha - Naftyl - N - methylkarbamat (Czech)
  35. alpha - Naphthalenyl methylcarbamate
  36. alpha - Naphthyl N - methylcarbamate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,955,1986
skin
rabbit
12 mg/24 hour severe JAFCAU 9,30,1961


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis parenteral
grasshopper
100 pph CUSCAM 43,187,1974
cytogenetic analysis hamster fibroblast 30 mg/L/48 hour MUREAV 48,337,1977
cytogenetic analysis hamster lung 100 µmol/L MUREAV 119,319,1983
cytogenetic analysis human embryo 40 mg/L ZDVKAP 20(4),14,1977
DNA inhibition human lung 1 mmol/L NNGADV 8,353,1983
DNA inhibition human lymphocyte 50 mg/L ARTODN 45,101,1980
DNA inhibition mouse Ascites tumor 100 µmol/L BECTA6 14,441,1975
DNA inhibition rat other cell types 1 mg/L ARTODN 45,101,1980
unscheduled DNA synthesis human fibroblast 1 µmol/L MUREAV 42,161,1977
host-mediated assay mouse
Ascites tumor
60 mg/kg/5 day- intermittent BECTA6 14,441,1975
mutation in microorganisms other microorganisms 5 mg/L (-enzymatic activation step) JASIAB 104,571,1985
mutation in microorganisms Salmonella typhimurium 250 µg/plate (+enzymatic activation step) RPZHAW 30,81,1979
mutation in microorganisms Salmonella typhimurium 100 µmol/L (-enzymatic activation step) ARTODN 39,159,1977
mutation in microorganisms Saccharomyes cerevisiae 100 ppm (-enzymatic activation step) RSTUDV 6,161,1976
micronucleus test multiple
non-mammalian species
5 ppm/8 day- continuous MUREAV 125,275,1984
mutation in mammalian somatic cells hamster lung 10 µmol/L CBINA8 19,369,1977
other mutation test systems human lung 1 mmol/L NNGADV 8,353,1983
other mutation test systems human fibroblast 100 mg/kg GTPZAB 17(3),32,1973
other mutation test systems mouse Ascites tumor 400 µmol/L BECTA6 14,441,1975
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
1 pph/24 hour SOGEBZ 8,798,1972
sex chromosome loss and nondisjunction hamster lung 50 µmol/L MUREAV 119,319,1983
sperm morphology intraperitoneal
mouse
1 mmol/L BSRSA6 45,46,1976
sperm morphology oral
mouse
1 mmol/L BSRSA6 45,46,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 375 mg/kg (3-62 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
TXAPA9 13,392,1968
oral
dog
lowest published toxic dose: 750 mg/kg (3-62 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TXAPA9 13,392,1968
oral
dog
lowest published toxic dose: 197 mg/kg (1-63 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Stillbirth
32OAAP -,253,1973
oral
dog
lowest published toxic dose: 394 mg/kg (1-63 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system
32OAAP -,253,1973
oral
guinea pig
lowest published toxic dose: 300 mg/kg (12-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 15,152,1969
oral
gerbil
lowest published toxic dose: 12,500 mg/kg (multigenerations) Reproductive: Effects on fertility: Other measures of fertility TXAPA9 17,273,1970
oral
gerbil
lowest published toxic dose: 20,300 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TXAPA9 19,202,1971
oral
gerbil
lowest published toxic dose: 20,300 mg/kg (multigenerations) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) TXAPA9 19,202,1971
oral
gerbil
lowest published toxic dose: 40,600 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXAPA9 19,202,1971
oral
hamster
lowest published toxic dose: 250 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TXAPA9 15,152,1969
oral
mouse
lowest published toxic dose: 11,660 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXAPA9 51,81,1979
oral
mouse
lowest published toxic dose: 100 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
FCTOD7 29,629,1991
oral
mouse
lowest published toxic dose: 200 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
FCTOD7 29,629,1991
oral
mouse
lowest published toxic dose: 150 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
FCTOD7 29,629,1991
oral
pig
lowest published toxic dose: 912 mg/kg (1-16 week pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 32OAAP -,253,1973
oral
rat
lowest published toxic dose: 1,370 mg/kg (39 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders VPITAR 27(6),49,1968
oral
rat
lowest published toxic dose: 5,500 mg/kg (multigenerations) Reproductive: Effects on fertility: Other measures of fertility TXAPA9 17,273,1970
oral
rat
lowest published toxic dose: 27,500 µg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 21,390,1972
oral
rat
lowest published toxic dose: 220 mg/kg (5-15 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TXAPA9 21,390,1972
oral
rat
lowest published toxic dose: 1,370 mg/kg (39 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) VPITAR 27(6),49,1968
oral
rat
lowest published toxic dose: 5,475 mg/kg (52 week prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
VPITAR 27(6),49,1968
oral
rat
lowest published toxic dose: 3,250 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) VHTODE 37,421,1995
oral
rat
lowest published toxic dose: 375 mg/kg (14-22 day pregnant/7 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) TOXID9 36,344,1997
oral
rabbit
lowest published toxic dose: 1,950 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 51,81,1979
oral
rabbit
lowest published toxic dose: 2,600 mg/kg (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Body wall TXAPA9 51,81,1979
subcutaneous
mouse
lowest published toxic dose: 900 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 900 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 418 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 4,176 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
implant
rat
lowest published toxic dose: 80 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
VPITAR 29,71,1970
oral
rat
lowest published toxic dose: 5,640 mg/kg/94 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
VPITAR 29,71,1970


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 40 mg/m3 Behavioral: Change in motor activity (specific assay) HBPTO* 2,1099,2001
inhalation
guinea pig
lethal concentration : >390 mg/m3/4 hour N/R UCDS** 11/21/1973
inhalation
rat
lethal concentration (50 percent kill): 5 mg/m3 N/R HBPTO* 2,1094,2001
intramuscular
monkey
lowest published toxic dose: 3 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Peripheral Nerve and Sensation: Structural change in nerve or sheath
HBPTO* 2,1100,2001
intramuscular
rat
lowest published toxic dose: 3 mg/kg Behavioral: Alteration of operant conditioning HBPTO* 2,1095,2001
intraperitoneal
hamster
lethal dose (50 percent kill): 640 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse
lethal dose (50 percent kill): 25 mg/kg N/R TXAPA9 6,402,1964
intraperitoneal
rat
lethal dose (50 percent kill): 64 mg/kg N/R PSEBAA 114,509,1963
intraperitoneal
rat
lowest published toxic dose: 7.3 mg/kg Behavioral: Change in psychophysiological tests HBPTO* 2,1099,2001
intraperitoneal
rabbit
lethal dose (50 percent kill): 223 mg/kg N/R JAFCAU 9,30,1961
intravenous
rat
lethal dose (50 percent kill): 18 mg/kg N/R JAFCAU 9,30,1961
oral
wild bird
lethal dose (50 percent kill): 56 mg/kg N/R TXAPA9 21,315,1972
oral
cat
lethal dose (50 percent kill): 150 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands
GISAAA 32(4),29,1967
oral
cat
lethal dose (50 percent kill): 125 mg/kg N/R HBPTO* 2,1094,2001
oral
dog
lethal dose (50 percent kill): 250 mg/kg N/R HBPTO* 2,1094,2001
oral
guinea pig
lethal dose (50 percent kill): 250 mg/kg N/R PCBPBS 21,199,1984
oral
gerbil
lethal dose (50 percent kill): 491 mg/kg N/R PCBPBS 21,199,1984
oral
hamster
lowest published lethal dose: 250 mg/kg N/R TXAPA9 15,152,1969
oral
human
lowest published toxic dose: 2.8 mg/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
HBPTO* 2,1096,2001
oral
mammal (species unspecified)
lethal dose (50 percent kill): 510 mg/kg N/R HPBIA9 21,53,1975
oral
man
lowest published toxic dose: 500 mg/kg Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Muscle weakness
NEURAI 37,1229,1987
oral
monkey
lethal dose (50 percent kill): 1,000 mg/kg N/R HBPTO* 2,1094,2001
oral
mouse
lethal dose (50 percent kill): 108 mg/kg N/R HBPTO* 2,1094,2001
oral
pig
lowest published toxic dose: 20 mg/kg Behavioral: Change in psychophysiological tests HBPTO* 2,1098,2001
oral
pig
lethal dose (50 percent kill): 1,500 mg/kg N/R HBPTO* 2,1094,2001
oral
quail
lethal dose (50 percent kill): 829 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
OYYAA2 51,137,1996
oral
rat
lethal dose (50 percent kill): 230 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 11,546,1967
oral
rat
lowest published toxic dose: 0.56 mg/kg Behavioral: Change in psychophysiological tests HBPTO* 2,1100,2001
oral
rat
lethal dose (50 percent kill): 233 mg/kg N/R HBPTO* 2,1094,2001
oral
rat
lowest published toxic dose: 50 mg/kg Behavioral: Tremor

Behavioral: Alteration of classical conditioning

Gastrointestinal: Changes in structure or function of salivary glands
TOXID9 44,224,2005
oral
rat
lowest published toxic dose: 15 mg/kg Behavioral: Change in motor activity (specific assay)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,321,2002
oral
rat
lowest published toxic dose: 10 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases TXCYAC 217,1,2006
oral
rat
lowest published toxic dose: 50 mg/kg Behavioral: Tremor

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 217,1,2006
oral
rat
lowest published lethal dose: 75 mg/kg Behavioral: Tremor

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 217,1,2006
oral
rat
lowest published toxic dose: 3 mg/kg Behavioral: Change in motor activity (specific assay) TOXID9 90,302,2006
oral
rat
lowest published toxic dose: 3 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NRTXDN 29,87,2008
oral
rat
lowest published toxic dose: 75 mg/kg Brain and Coverings: Recordings from specific areas of CNS NRTXDN 29,87,2008
oral
rat
lowest published toxic dose: 30 mg/kg Nutritional and Gross Metabolic: Body temperature decrease NRTXDN 29,87,2008
oral
rat
lowest published toxic dose: 30 mg/kg Peripheral Nerve and Sensation: Fasciculations

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
TOXID9 12,478,2008
oral
rabbit
lethal dose (50 percent kill): 710 mg/kg N/R HBPTO* 2,1094,2001
oral
woman
lowest published lethal dose: 5 gm/kg Autonomic Nervous System: Parasympatholytic

Cardiac: Change in rate

Nutritional and Gross Metabolic: Other changes
HETOEA 11,373,1992
subcutaneous
chicken
lowest published lethal dose: 2 gm/kg N/R JAFCAU 9,30,1961
subcutaneous
mouse
lethal dose (50 percent kill): 860 mg/kg N/R AHRTAN 29,251,1978
subcutaneous
rat
lethal dose (50 percent kill): 1,400 mg/kg N/R 34ZIAG -,528,1969
subcutaneous
rabbit
lethal dose : >2 gm/kg N/R JAFCAU 9,30,1961
skin
rat
lethal dose (50 percent kill): 4 gm/kg N/R 85DPAN -,-,1971/1976
skin
rabbit
lethal dose (50 percent kill): 2 gm/kg N/R 85DPAN -,-,1971/1976
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 310 mg/kg N/R GISAAA 53(7),72,1988
unreported route
mouse
lethal dose (50 percent kill): 370 mg/kg N/R GISAAA 49(10),23,1984
unreported route
rat
lethal dose (50 percent kill): 500 mg/kg N/R 30ZDA9 -,188,1971
unreported route
rat
lowest published toxic dose: 80 mg/kg Behavioral: Change in motor activity (specific assay) TOXID9 72,128,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 63 mg/kg/4 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 32(4),29,1967
inhalation
rat
lowest published toxic concentration: 214 µg/m3/24 hour/13 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 53(7),72,1988
inhalation
rat
lowest published toxic concentration: 23 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
GISAAA 43(11),33,1978
inhalation
rat
lowest published toxic concentration: 12 mg/m3/6 hour/16 week- intermittent Behavioral: Change in psychophysiological tests HBPTO* 2,1100,2001
oral
mouse
lowest published toxic dose: 11.4 gm/kg/16 day- continuous Behavioral: Food intake (animal) FCTOD7 41,99,2003
oral
mouse
lowest published toxic dose: 15.2 gm/kg/20 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 41,99,2003
oral
mouse
lowest published toxic dose: 32.22 gm/kg/180 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight
FCTOD7 41,99,2003
oral
mouse
lowest published toxic dose: 3,222 mg/kg/180 day- continuous Kidney, Ureter, and Bladder: Other changes FCTOD7 41,99,2003
oral
mouse
lowest published toxic dose: 16.8 gm/kg/7 day- intermittent Behavioral: Fluid intake

Behavioral: Change in motor activity (specific assay)

Behavioral: Aggression
BECTA6 71,37,2003
oral
pig
lowest published toxic dose: 8,157 mg/kg/72 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Musculoskeletal: Other changes
TXAPA9 14,409,1969
oral
pig
lowest published toxic dose: 9.6 gm/kg/46 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity
HBPTO* 2,1098,2001
oral
quail
lowest published toxic dose: 13,230 mg/kg/14 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BECTA6 17,360,1977
oral
rat
lowest published toxic dose: 30 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
BECTA6 23,438,1979
oral
rat
lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
AECTCV 14,459,1985
oral
rat
lowest published toxic dose: 10,800 mg/kg/96 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JAFCAU 9,30,1961
oral
rat
lowest published toxic dose: 25,480 mg/kg/1 year- intermittent Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
FCTXAV 6,461,1968
oral
rat
lowest published toxic dose: 1,109 mg/kg/22 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
GISAAA 35(7),97,1970
oral
rat
lowest published toxic dose: 720 mg/kg/10 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
GISAAA 49(5),80,1984
oral
rat
lowest published toxic dose: 300 mg/kg/50 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 27,465,1974
oral
rat
lowest published toxic dose: 500 mg/kg/50 day- continuous Behavioral: Change in psychophysiological tests HBPTO* 2,1100,2001
oral
rabbit
lowest published toxic dose: 7.59 mg/kg/33 day- continuous Immunological Including Allergic: Decrease in humoral immune response TXAPA9 32,587,1975
oral
rabbit
lowest published toxic dose: 131.1 mg/kg/57 day- continuous Endocrine: Other changes TXAPA9 32,587,1975
unreported route
quail
lowest published toxic dose: 50 µg/kg/5 day- intermittent Immunological Including Allergic: Decreased immune response HBPTO* 1,775,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,37,1976
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 12,37,1976
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
85ALAU -,106,1977
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,588,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
FEREAC 73,29456,2008
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
MUREAV 681,3,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,94,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,37,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 5 mg/m3, continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - GERMANY MAK 5 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 mg/m3, skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 8 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBARYL-air 10 hour time-weighted average 5 mg/m3;
min expos during pregnancy
NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 47800;
Number of Industries 5;
Total Number of Facilities 678;
Number of Occupations 16;
Total Number of Employees Exposed 14,120
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 47800;
Number of Industries 5;
Total Number of Facilities 2,381;
Number of Occupations 4;
Total Number of Employees Exposed 16,544;
Total Number of Female Employees Exposed 3,228


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a broad spectrum insecticide and as acaricide and molluscicide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Carbaryl, 5006
OSHA ANALYTICAL METHOD #63


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
32OAAP "Pesticide and the Environment: a Continuing Controversy, Selected Papers Presented and Papers Reviewed at the 8th Inter-American Conference on Toxicology and Occupational Medicine, Miami, FL, 1973," Deichmann, W.B., ed., New York, Stratton Intercontinental Medical Book Corp., 1973
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85ALAU "Carbamate Insecticides: Chemistry, Biochemistry, and Toxicology," Kuhr, R.J., and H.W. Dorough, Cleveland, OH, CRC Press, 1976
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AHRTAN Arhiv za Higijenu Rada i Toksikologiju. Archives of Industrial Hygiene and Toxicology. (Jugoslovenska Knjiga, POB 36, YU-11001 Belgrade, Yugoslavia) V.7- 1956-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BSRSA6 Bulletin de la Societe Royale des Sciences de Liege. (Societe Royale des Sciences de Liege, Universite de Liege, 15, Ave des Tilleuls, B-4000 Liege, Belgium) V.1- 1932-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11- 1965-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JASIAB Journal of Agricultural Science. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1905-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
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RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966-
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TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
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ZDVKAP Zdravookhranenie. Public Health. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1958-

Used as a broad spectrum insecticide and as acaricide and molluscicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 11095-11-7
ALT CAS #: 52001-89-5
Click Here for Additional Information about RTECS

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