CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






2 - Butanone, peroxide

RTECS #: EL9450000

CAS #: 1338-23-4


UPDATE: May 2009 MW: 176.24 MF: C8H16O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Butanox LPT
  2. Butanox M 105
  3. Butanox M 50
  4. Chaloxyd MEKP - HA 1
  5. Chaloxyd MEKP - LA 1
  6. Esperfoam FR
  7. Ethyl methyl ketone peroxide
  8. FR 222
  9. HI - Point 180
  10. HI - Point 90
  11. HI - Point PD - 1
  12. Kayamek A
  13. Kayamek M
  14. Ketonox
  15. Lucidol DDM 9
  16. Lucidol Delta X
  17. Lupersol DDA 30
  18. Lupersol DDM
  19. Lupersol DNF
  1. Lupersol DSW
  2. Lupersol Delta X
  3. MEK peroxide
  4. MEKPO
  5. Mepox
  6. Methyl ethyl ketone hydroperoxide
  7. Methyl ethyl ketone peroxide
  8. Methyl ethyl ketone peroxide (ACGIH)
  9. Methylethylketonhydroperoxide
  10. NCI - C55447
  11. Permek G
  12. Permek N
  13. Quickset Extra
  14. Quickset super
  15. RCRA waste number U160
  16. Sprayset MEKP
  17. Superox 46 - 710
  18. Thermacure


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
3 mg N/R AIHAAP 19,205,1958
eye
rabbit
40 % VCVGK* -,529,1994
skin
rabbit
500 mg % AIHAAP 19,205,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 104 g/plate/72 hour (-enzymatic activation step) MUTAEX 15,495,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
unreported route
mouse
lowest published toxic dose: 282 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 170 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
inhalation
mouse
lethal concentration (50 percent kill): 2,500 mg/m3/4 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,528,1994
inhalation
rat
lethal concentration (50 percent kill): 200 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
inhalation
rat
lethal concentration (50 percent kill): 3,600 mg/m3/4 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,528,1994
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R VCVGK* -,528,1994
intraperitoneal
rat
lethal dose (50 percent kill): 65 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia
AIHAAP 19,205,1958
intraperitoneal
rat
lowest published toxic dose: 90 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
VCVGK* -,528,1994
oral
human
lowest published toxic dose: 480 mg/kg Gastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
NCPBBY Jan/Feb,1969
oral
mouse
lethal dose (50 percent kill): 250 mg/kg N/R VCVGK* -,528,1994
oral
rat
lethal dose (50 percent kill): 470 mg/kg N/R VCVGK* -,528,1994
skin
rabbit
lowest published toxic dose: 2,000 mg/kg Skin: After topical application: Primary irritation VCVGK* -,528,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 273 mg/kg/7 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 19,205,1958
oral
rat
lowest published toxic dose: 2,033 mg/kg/7 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 19,205,1958
skin
mouse
lowest published toxic dose: 141 mg/kg/4 week- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation CRNGDP 25,431,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.2 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA ceiling concentration 0.2 ppm (1.5 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 ppm (1.5 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 1 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.2 ppm (1.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 0.2 ppm (1.5 mg/m3), FEB2006
Occupational Exposure Limit - KOREA ceiling concentration 0.2 ppm (1.5 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 1.5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 0.2 ppm (1.5 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN ceiling concentration 0.2 ppm (1.5 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 ppm (1.5 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.2 ppm (1.5 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.2 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ETHYL KETONE PEROXIDE-air ceiling concentration 0.2 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80105;
Number of Industries 29;
Total Number of Facilities 2,226;
Number of Occupations 31;
Total Number of Employees Exposed 20,053
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80105;
Number of Industries 23;
Total Number of Facilities 1,879;
Number of Occupations 31;
Total Number of Employees Exposed 25,827;
Total Number of Female Employees Exposed 6,514


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization catalyst, curing agent and cross-linking agent
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl ethyl ketone peroxide, 3508
NTP Toxicity studies, RPT# TOX-18, October 2000
OSHA ANALYTICAL METHOD #77


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
HUTOX*
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCPBBY National Clearinghouse for Poison Control Centers, Bulletin. (U.S. Department of Health, Education, and Welfare, Washington, DC)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as polymerization catalyst, curing agent and cross-linking agent

NIOSH PROFILE (METHYL ETHYL KETONE PEROXIDE), SRC, 10/77

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us