RTECS:EL6475000 The Registry of Toxic Effects of Chemical Substances

2 - Butanone

RTECS #: EL6475000

CAS #: 78-93-3

UPDATE: May 2009 MW: 72.12 MF: C₄H₈O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2 - Butanone (OSHA)

3 - Butanone

Acetone, methyl -

Aethylmethylketon (German)

Butanone

Butanone 2 (French)

Ethyl methyl cetone (French)

Ethylmethylketon (Dutch)

Ketone, ethyl methyl

MEK (OSHA)

Meetco

Methyl acetone

Methyl ethyl ketone

Methyl ethyl ketone (ACGIH:OSHA)

Metiletilchetone (Italian)

Metyloetyloketon (Polish)

RCRA waste number U159

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
human 350 ppm N/R JIHTAB 25,282,1943
eye
rabbit 80 mg N/R TXAPA9 19,276,1971
skin
rabbit 500 mg/24 hour moderate JIHTAB 25,282,1943
skin
rabbit 402 mg/24 hour mild TXAPA9 19,276,1971
skin
rabbit 14 mg/24 hour open irritation test mild AIHAAP 23,95,1962

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 33,800 ppm MUREAV 149,339,1985

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lowest published toxic concentration: 3,000 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 16,742,1991
inhalation
mouse lowest published toxic concentration: 3,000 ppm (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** #DE89-009563
inhalation
rat lowest published toxic concentration: 3,000 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Homeostasis TXAPA9 28,452,1974
inhalation
rat lowest published toxic concentration: 1,000 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 28,452,1974
inhalation
rat lowest published toxic concentration: 2,900 mg/m³ (6-10 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system VCVGK* -,418,1994
inhalation
rat lowest published toxic concentration: 2,000 ppm (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FCTOD7 44,1287,2006

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
cat lowest published toxic concentration: 25,000 mg/m³ Gastrointestinal: Changes in structure or function of salivary glands VCVGK* -,417,1984
inhalation
cat lowest published toxic concentration: 50,000 mg/m³ Eye: Conjunctiva irritation VCVGK* -,417,1984
inhalation
guinea pig lowest published toxic concentration: 30,000 mg/m³/2 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVGK* -,417,1984
inhalation
guinea pig lowest published toxic concentration: 30,000 mg/m³/4 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Emphysema

Liver: Other changes VCVGK* -,417,1984
inhalation
guinea pig lowest published toxic concentration: 97,300 mg/m³/30 minute Behavioral: Ataxia VCVGK* -,417,1984
inhalation
guinea pig lowest published lethal concentration: 97,300 mg/m³/1 hour Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVGK* -,417,1984
inhalation
human lowest published toxic concentration: 100 ppm/5 minute Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes JIHTAB 25,282,1943
inhalation
human lowest published toxic concentration: 1,000 mg/m³ Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVGK* -,417,1994
inhalation
human lowest published toxic concentration: 10 ppm/4 hour Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes NRTXDN 24,179,2003
inhalation
mammal (species unspecified) lethal concentration (50 percent kill): 38 gm/m³ N/R GISAAA 51(5),61,1986
inhalation
mouse lethal concentration (50 percent kill): 32 gm/m³/4 hour N/R CUTOEX 1,47,1993
inhalation
mouse lowest published toxic concentration: 25,000 mg/m³/2 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Emphysema

Liver: Other changes VCVGK* -,417,1984
inhalation
mouse lowest published lethal concentration: 40,000 mg/m³ Lung, Thorax, or Respiration: Emphysema

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes VCVGK* -,417,1984
inhalation
mouse lowest published toxic concentration: 4,000 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
mouse lethal concentration (50 percent kill): 32 mg/m³ N/R ENTOX* -,77,2005
inhalation
rat lethal concentration (50 percent kill): 23,500 mg/m³/8 hour N/R AIHAAP 20,364,1959
inhalation
rat lethal concentration (50 percent kill): 23,500 mg/m³ N/R ENTOX* -,77,2005
inhalation
rabbit lowest published toxic concentration: 1,250 mg/m³ Peripheral Nerve and Sensation: Recording from peripheral motor nerve VCVGK* -,417,1984
intraperitoneal
guinea pig lowest published lethal dose: 2 gm/kg Liver: Other changes

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)

Biochemical: Metabolism (intermediary): Lipids including transport FCTXAV 15,627,1977
intraperitoneal
guinea pig lethal dose (50 percent kill): 2 gm/kg N/R ENTOX* -,77,2005
intraperitoneal
mouse lethal dose (50 percent kill): 616 mg/kg N/R ENTOX* -,77,2005
intraperitoneal
rat lethal dose (50 percent kill): 607 mg/kg N/R ENTOX* -,77,2005
oral
human lowest published lethal dose: 714.3 mg/kg N/R VCVGK* -,417,1994
oral
mouse lethal dose (50 percent kill): 3,000 mg/kg N/R VCVGK* -,417,1984
oral
rat lethal dose (50 percent kill): 2,737 mg/kg N/R ENTOX* -,77,2005
skin
rabbit lethal dose (50 percent kill): 6,480 mg/kg N/R SHELL* MSDS-5390-4

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified) lowest published toxic concentration: 588 mg/m³/12 hour/24 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve VCVGK* -,418,1994
inhalation
rat lowest published toxic concentration: 5,000 ppm/6 hour/90 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Urine volume increased

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases FAATDF 3,264,1983
inhalation
rat lowest published toxic concentration: 750 ppm/7 hour/7 day- intermittent Liver: Liver function tests impaired TXAPA9 41,285,1977
inhalation
rat : 4,000 ppm/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 44,1287,2006
inhalation
rat : 3,000 ppm/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 44,1287,2006
inhalation
rat : 3,000 ppm/15 day- intermittent Liver: Changes in liver weight FCTOD7 44,1287,2006
inhalation
woman lowest published toxic concentration: 61 mg/m³/169 week- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve VCVGK* -,418,1994
oral
mouse lowest published toxic dose: 3,000 ppm/10 day- intermittent Liver: Changes in liver weight NTIS #DE89-009563
subcutaneous
cat lowest published toxic dose: 55,500 mg/kg/37 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 37,301,1976

REVIEWS:
ORGANIZATION STANDARD
REFERENCE**

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm;short term exposure limit 300 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
NTIS** DE89-563
TOXICOLOGY REVIEW
TOLED5 128,99,2002
TOXICOLOGY REVIEW
TOLED5 140-141,261,2003
TOXICOLOGY REVIEW
ENTOX* -,77,2005
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
MUREAV 659,93,2008
TOXICOLOGY REVIEW
HUTOX* -,577,1996
TOXICOLOGY REVIEW
HUTOX* -,649,1996

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,263,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (590 mg/m³) DTLVS* 3,29,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (590 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (590 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (590 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (590 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 150 ppm (445 mg/m³), short term exposure limit 300 ppm (890 mg/m³), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm(600 mg/m³), short term exposure limit 300 ppm(900 mg/m³), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (145 mg/m³), OCT 2002
Occupational Exposure Limit - EC time-weighted average 600 mg/m³ (200 ppm);
short term exposure limit 900 mg/m³ (300 ppm), FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 100 ppm, JAN1993
Occupational Exposure Limit - FRANCE VME 200 ppm (600 mg/m³), VLE 300 ppm (900 mg/m³), FEB2006
Occupational Exposure Limit - GERMANY MAK 600 mg/m³ (200 mL/m³), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 600 mg/m³, short term exposure limit 900 mg/m³, Skin, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 200 ppm (590 mg/m³), short term exposure limit 300 ppm (885 mg/m³), JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (590 mg/m³), APR2007
Occupational Exposure Limit - KOREA time-weighted average 200 ppm (590 mg/m³), short term exposure limit 300 ppm (885 mg/m³), 2006
Occupational Exposure Limit - MEXICO time-weighted average 200 ppm (590 mg/m³);
short term exposure limit 300 ppm (885 mg/m³), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 590 mg/m³, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 150 ppm (445 mg/m³);
short term exposure limit 300 ppm (890 mg/m³), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 75 ppm (220 mg/m³), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (590 mg/m³), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 200 mg/m³, MAC(short term exposure limit) 850 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 200 mg/m³, short term exposure limit 400 mg/m³, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (150 mg/m³);
short term exposure limit 100 ppm (300 mg/m³), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (590 mg/m³);
KZG- week 200 ppm (590 mg/m³),DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (590 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (600 mg/m³);
short term exposure limit 300 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm;
short term exposure limit 300 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm;
short term exposure limit 300 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ETHYL KETONE-air 10 hour time-weighted average 200 ppm;
short term exposure limit 300 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 13980;
Number of Industries 319;
Total Number of Facilities 64,013;
Number of Occupations 177;
Total Number of Employees Exposed 801,382
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 13980;
Number of Industries 318;
Total Number of Facilities 87,227;
Number of Occupations 208;
Total Number of Employees Exposed 1,447,456;
Total Number of Female Employees Exposed 245,372

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS PB/93/110708/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an industrial chemical, solvent, emulsifier, in manufacture of plastics, resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl ethyl ketone, 2500; in blood, 8002
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
OSHA ANALYTICAL METHOD #84
OSHA ANALYTICAL METHOD #1004

REFERENCES:
CODEN
REFERENCE**

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*

JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SHELL* Shell Chemical Company. (P.O. Box 4320, Houston, TX 77210)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as an industrial chemical, solvent, emulsifier, in manufacture of plastics, resins

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

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SYNONYMS:
2 - Butanone (OSHA) 3 - Butanone Acetone, methyl - Aethylmethylketon (German) Butanone Butanone 2 (French) Ethyl methyl cetone (French) Ethylmethylketon (Dutch) Ketone, ethyl methyl	MEK (OSHA) Meetco Methyl acetone Methyl ethyl ketone Methyl ethyl ketone (ACGIH:OSHA) Metiletilchetone (Italian) Metyloetyloketon (Polish) RCRA waste number U159

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye human	350 ppm	N/R	JIHTAB 25,282,1943
eye rabbit	80 mg	N/R	TXAPA9 19,276,1971
skin rabbit	500 mg/24 hour	moderate	JIHTAB 25,282,1943
skin rabbit	402 mg/24 hour	mild	TXAPA9 19,276,1971
skin rabbit	14 mg/24 hour open irritation test	mild	AIHAAP 23,95,1962

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
sex chromosome loss and nondisjunction	Saccharomyes cerevisiae	33,800 ppm	MUREAV 149,339,1985

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lowest published toxic concentration: 3,000 ppm/7 hour (6-15 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	FAATDF 16,742,1991
inhalation mouse	lowest published toxic concentration: 3,000 ppm (6-15 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system	NTIS** #DE89-009563
inhalation rat	lowest published toxic concentration: 3,000 ppm/7 hour (6-15 day pregnant)	Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Specific developmental abnormalities: Homeostasis	TXAPA9 28,452,1974
inhalation rat	lowest published toxic concentration: 1,000 ppm/7 hour (6-15 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 28,452,1974
inhalation rat	lowest published toxic concentration: 2,900 mg/m³ (6-10 day pregnant)	Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Gastrointestinal system	VCVGK* -,418,1994
inhalation rat	lowest published toxic concentration: 2,000 ppm (6-20 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	FCTOD7 44,1287,2006

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation cat	lowest published toxic concentration: 25,000 mg/m³	Gastrointestinal: Changes in structure or function of salivary glands	VCVGK* -,417,1984
inhalation cat	lowest published toxic concentration: 50,000 mg/m³	Eye: Conjunctiva irritation	VCVGK* -,417,1984
inhalation guinea pig	lowest published toxic concentration: 30,000 mg/m³/2 minute	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,417,1984
inhalation guinea pig	lowest published toxic concentration: 30,000 mg/m³/4 hour	Behavioral: General anesthetic Lung, Thorax, or Respiration: Emphysema Liver: Other changes	VCVGK* -,417,1984
inhalation guinea pig	lowest published toxic concentration: 97,300 mg/m³/30 minute	Behavioral: Ataxia	VCVGK* -,417,1984
inhalation guinea pig	lowest published lethal concentration: 97,300 mg/m³/1 hour	Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,417,1984
inhalation human	lowest published toxic concentration: 100 ppm/5 minute	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes	JIHTAB 25,282,1943
inhalation human	lowest published toxic concentration: 1,000 mg/m³	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,417,1994
inhalation human	lowest published toxic concentration: 10 ppm/4 hour	Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Other changes	NRTXDN 24,179,2003
inhalation mammal (species unspecified)	lethal concentration (50 percent kill): 38 gm/m³	N/R	GISAAA 51(5),61,1986
inhalation mouse	lethal concentration (50 percent kill): 32 gm/m³/4 hour	N/R	CUTOEX 1,47,1993
inhalation mouse	lowest published toxic concentration: 25,000 mg/m³/2 hour	Behavioral: General anesthetic Lung, Thorax, or Respiration: Emphysema Liver: Other changes	VCVGK* -,417,1984
inhalation mouse	lowest published lethal concentration: 40,000 mg/m³	Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,417,1984
inhalation mouse	lowest published toxic concentration: 4,000 ppm/6 minute	Lung, Thorax, or Respiration: Respiratory depression	TOLED5 9,137,1981
inhalation mouse	lethal concentration (50 percent kill): 32 mg/m³	N/R	ENTOX* -,77,2005
inhalation rat	lethal concentration (50 percent kill): 23,500 mg/m³/8 hour	N/R	AIHAAP 20,364,1959
inhalation rat	lethal concentration (50 percent kill): 23,500 mg/m³	N/R	ENTOX* -,77,2005
inhalation rabbit	lowest published toxic concentration: 1,250 mg/m³	Peripheral Nerve and Sensation: Recording from peripheral motor nerve	VCVGK* -,417,1984
intraperitoneal guinea pig	lowest published lethal dose: 2 gm/kg	Liver: Other changes Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) Biochemical: Metabolism (intermediary): Lipids including transport	FCTXAV 15,627,1977
intraperitoneal guinea pig	lethal dose (50 percent kill): 2 gm/kg	N/R	ENTOX* -,77,2005
intraperitoneal mouse	lethal dose (50 percent kill): 616 mg/kg	N/R	ENTOX* -,77,2005
intraperitoneal rat	lethal dose (50 percent kill): 607 mg/kg	N/R	ENTOX* -,77,2005
oral human	lowest published lethal dose: 714.3 mg/kg	N/R	VCVGK* -,417,1994
oral mouse	lethal dose (50 percent kill): 3,000 mg/kg	N/R	VCVGK* -,417,1984
oral rat	lethal dose (50 percent kill): 2,737 mg/kg	N/R	ENTOX* -,77,2005
skin rabbit	lethal dose (50 percent kill): 6,480 mg/kg	N/R	SHELL* MSDS-5390-4

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mammal (species unspecified)	lowest published toxic concentration: 588 mg/m³/12 hour/24 week- intermittent	Peripheral Nerve and Sensation: Recording from peripheral motor nerve	VCVGK* -,418,1994
inhalation rat	lowest published toxic concentration: 5,000 ppm/6 hour/90 day- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Urine volume increased Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	FAATDF 3,264,1983
inhalation rat	lowest published toxic concentration: 750 ppm/7 hour/7 day- intermittent	Liver: Liver function tests impaired	TXAPA9 41,285,1977
inhalation rat	: 4,000 ppm/8 day- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 44,1287,2006
inhalation rat	: 3,000 ppm/15 day- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTOD7 44,1287,2006
inhalation rat	: 3,000 ppm/15 day- intermittent	Liver: Changes in liver weight	FCTOD7 44,1287,2006
inhalation woman	lowest published toxic concentration: 61 mg/m³/169 week- intermittent	Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Peripheral Nerve and Sensation: Recording from peripheral motor nerve	VCVGK* -,418,1994
oral mouse	lowest published toxic dose: 3,000 ppm/10 day- intermittent	Liver: Changes in liver weight	NTIS** #DE89-009563
subcutaneous cat	lowest published toxic dose: 55,500 mg/kg/37 week- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 37,301,1976

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 200 ppm;short term exposure limit 300 ppm	DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW		TOLED5 127,111,2002
TOXICOLOGY REVIEW		NTIS** DE89-563
TOXICOLOGY REVIEW		TOLED5 128,99,2002
TOXICOLOGY REVIEW		TOLED5 140-141,261,2003
TOXICOLOGY REVIEW		ENTOX* -,77,2005
TOXICOLOGY REVIEW		REPTED 25,192,2008
TOXICOLOGY REVIEW		MUREAV 659,93,2008
TOXICOLOGY REVIEW		HUTOX* -,577,1996
TOXICOLOGY REVIEW		HUTOX* -,649,1996

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988	PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION	FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF	PESTICIDES: Cancelled	RBREV* -,263,1998
Mine Safety and Health Administration (MSHA) STANDARD - air	time-weighted average 200 ppm (590 mg/m³)	DTLVS* 3,29,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8 hour time-weighted average 200 ppm (590 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8 hour time-weighted average 200 ppm (590 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8 hour time-weighted average 200 ppm (590 mg/m³)	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8 hour time-weighted average 200 ppm (590 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA	time-weighted average 150 ppm (445 mg/m³), short term exposure limit 300 ppm (890 mg/m³), JUL2008
Occupational Exposure Limit - BELGIUM	time-weighted average 200 ppm(600 mg/m³), short term exposure limit 300 ppm(900 mg/m³), MAR2002
Occupational Exposure Limit - DENMARK	time-weighted average 50 ppm (145 mg/m³), OCT 2002
Occupational Exposure Limit - EC	time-weighted average 600 mg/m³ (200 ppm); short term exposure limit 900 mg/m³ (300 ppm), FEB 2006
Occupational Exposure Limit - FINLAND	short term exposure limit 100 ppm, JAN1993
Occupational Exposure Limit - FRANCE	VME 200 ppm (600 mg/m³), VLE 300 ppm (900 mg/m³), FEB2006
Occupational Exposure Limit - GERMANY	MAK 600 mg/m³ (200 mL/m³), 2005
Occupational Exposure Limit - HUNGARY	time-weighted average 600 mg/m³, short term exposure limit 900 mg/m³, Skin, SEP2000
Occupational Exposure Limit - INDIA	time-weighted average 200 ppm (590 mg/m³), short term exposure limit 300 ppm (885 mg/m³), JAN1993
Occupational Exposure Limit - JAPAN	Occupational Exposure Limit 200 ppm (590 mg/m³), APR2007
Occupational Exposure Limit - KOREA	time-weighted average 200 ppm (590 mg/m³), short term exposure limit 300 ppm (885 mg/m³), 2006
Occupational Exposure Limit - MEXICO	time-weighted average 200 ppm (590 mg/m³); short term exposure limit 300 ppm (885 mg/m³), 2004
Occupational Exposure Limit - THE NETHERLANDS	MAC-TGG 590 mg/m³, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND	time-weighted average 150 ppm (445 mg/m³); short term exposure limit 300 ppm (890 mg/m³), JAN2002
Occupational Exposure Limit - NORWAY	time-weighted average 75 ppm (220 mg/m³), JAN1999
Occupational Exposure Limit - THE PHILIPPINES	time-weighted average 200 ppm (590 mg/m³), JAN1993
Occupational Exposure Limit - POLAND	MAC(time-weighted average) 200 mg/m³, MAC(short term exposure limit) 850 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA	time-weighted average 200 mg/m³, short term exposure limit 400 mg/m³, JUN2003
Occupational Exposure Limit - SWEDEN	time-weighted average 50 ppm (150 mg/m³); short term exposure limit 100 ppm (300 mg/m³), JUN2005
Occupational Exposure Limit - SWITZERLAND	MAK- week 200 ppm (590 mg/m³); KZG- week 200 ppm (590 mg/m³),DEC2006
Occupational Exposure Limit - TURKEY	time-weighted average 200 ppm (590 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM	time-weighted average 200 ppm (600 mg/m³); short term exposure limit 300 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 200 ppm; short term exposure limit 300 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm; short term exposure limit 300 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ETHYL KETONE-air	10 hour time-weighted average 200 ppm; short term exposure limit 300 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 13980; Number of Industries 319; Total Number of Facilities 64,013; Number of Occupations 177; Total Number of Employees Exposed 801,382
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 13980; Number of Industries 318; Total Number of Facilities 87,227; Number of Occupations 208; Total Number of Employees Exposed 1,447,456; Total Number of Female Employees Exposed 245,372

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110708/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
Used as an industrial chemical, solvent, emulsifier, in manufacture of plastics, resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl ethyl ketone, 2500; in blood, 8002
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
OSHA ANALYTICAL METHOD #84
OSHA ANALYTICAL METHOD #1004

REFERENCES:
CODEN	REFERENCE
AIHAAP	American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR	Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CUTOEX	Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993-
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF	Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7	Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA	Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
JIHTAB	Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN	Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV*	Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED	Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SHELL*	Shell Chemical Company. (P.O. Box 4320, Houston, TX 77210)
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.