Borane, trifluoro-
RTECS #
ED2275000
CAS #
Updated
December 2018
Molecular Weight
67.81
Molecular Formula
BF3
Synonyms
Boron fluoride
Boron trifluoride
Boron trifluoride (ACGIH:OSHA)
Fluorure de bore (French)
Boron trifluoride
Boron trifluoride (ACGIH:OSHA)
Fluorure de bore (French)
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | Lethal concentration: >1000 ppm/3H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Respiratory depression | NTIS** OTS0546539 |
| inhalation/guinea pig | lethal concentration (50 percent kill): 109 mg/m3/4H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Cyanosis Blood: Hemorrhage | FATOAO 35,369,1972 |
| inhalation/guinea pig | Lowest published lethal concentration: 2100 mg/m3/5H | Eye: Lacrimation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea | VCVN1* -,201,1988 |
| inhalation/guinea pig | lethal concentration (50 percent kill): 110 mg/m3 | Eye: Lacrimation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea | VCVN1* -,201,1988 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 8 mg/m3 | Lung, Thorax, or Respiration: Cough | VCVN1* -,201,1988 |
| inhalation/mouse | lethal concentration (50 percent kill): 3460 mg/m3 | Eye: Lacrimation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea | VCVN1* -,201,1988 |
| inhalation/mouse | Lowest published lethal concentration: 2100 mg/m3/5H | Eye: Lacrimation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea | VCVN1* -,201,1988 |
| inhalation/mouse | lethal concentration (50 percent kill): 3460 mg/m3/2H | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Cyanosis Blood: Hemorrhage | FATOAO 35,369,1972 |
| inhalation/rat | lethal concentration (50 percent kill): 1180 mg/m3/4H | 85GMAT -,27,1982 | |
| inhalation/rat | Lowest published lethal concentration: 2100 mg/m3/5H | Eye: Lacrimation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea | VCVN1* -,201,1988 |
| inhalation/rat | lethal concentration (50 percent kill): 1180 mg/m3 | Eye: Lacrimation Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea | VCVN1* -,201,1988 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic concentration: 12800 ppb/7H/65D- intermittent | Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma Nutritional and Gross Metabolic: Changes in: Other metals Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIHAAP 22,263,1961 |
| inhalation/guinea pig | lowest published toxic concentration: 3 mg/m3/4H/17W- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Changes in leukocyte (WBC) count | FATOAO 35(3),369,1972 |
| inhalation/guinea pig | lowest published toxic concentration: 30 mg/m3/15D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN1* -,201,1988 |
| inhalation/guinea pig | lowest published toxic concentration: 10 mg/m3/4H/16W- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Liver function tests impaired Blood: Changes in leukocyte (WBC) count | VCVN1* -,202,1988 |
| inhalation/guinea pig | lowest published toxic concentration: 34 mg/m3/7H/61D- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Liver function tests impaired Blood: Changes in leukocyte (WBC) count | VCVN1* -,202,1988 |
| inhalation/mouse | lowest published toxic concentration: 30 mg/m3/15D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VCVN1* -,201,1988 |
| inhalation/rabbit | lowest published toxic concentration: 10 mg/m3/4H/16W- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Liver function tests impaired Blood: Changes in leukocyte (WBC) count | VCVN1* -,202,1988 |
| inhalation/rabbit | lowest published toxic concentration: 34 mg/m3/7H/61D- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Liver function tests impaired Blood: Changes in leukocyte (WBC) count | VCVN1* -,202,1988 |
| inhalation/rat | lowest published toxic concentration: 34 mg/m3/7H/61D- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Liver function tests impaired Blood: Changes in leukocyte (WBC) count | VCVN1* -,202,1988 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/4H/16W- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Liver function tests impaired Blood: Changes in leukocyte (WBC) count | VCVN1* -,202,1988 |
| inhalation/rat | lowest published toxic concentration: 12800 ppb/7H/65D- intermittent | Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AIHAAP 22,263,1961 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/4H/17W- intermittent | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Changes in leukocyte (WBC) count | FATOAO 35(3),369,1972 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 1 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2.5 mg(F)/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 1 ppm (3 mg/m3) | DTLVS* 3,26,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 1 ppm (3 mg/m3), JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | ceiling concentration 1 ppm (2.8 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2.5 mg(F)/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1 ppm (3 mg/m3);KZW 1 ppm (3 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 1 ppm (3 mg/m3), MAR2002 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 2.5 mg(F)/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 1 ppm (3 mg/m3), MAY2011 | |
| Occupational Exposure Limit-EC | time-weighted average 2.5 mg(F)/m3, JUN2000 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 ppm (2.8 mg/m3), short term exposure limit 3 ppm (8.4 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 2.5 mg(F)/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VLE 1 ppm (3 mg/m3), FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 1 ppm (3 mg/m3), NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.3 ppm (0.83 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | ceiling concentration 1 ppm (3 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | peak 1 ppm (3 mg/m3), 2004 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 2.5 mg(F)/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 1 ppm (2.8 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2.5 mg(F)/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (3 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | short term exposure limit 1 ppm (3 mg/m3), JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 1 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 1 ppm (3 mg/m3), JAN2011 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 1 ppm (3 mg/m3), JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-C 3 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | short term exposure limit 1 ppm (3 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1 ppm (3 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 2.5 mg(F)/m3, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | ceiling concentration 1 ppm (3 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | ceiling concentration 1 ppm (3 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | ceiling concentration 1 ppm (3 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | ceiling concentration 1 ppm (3 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BORON TRIFLUORIDE-air | ceiling concentration 1 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 12980; Number of Industries 6; Total Number of Facilities 79; Number of Occupations 10; Total Number of Employees Exposed 3819; Total Number of Female Employees Exposed 524 | |
| National Occupational Hazard Survey 1974 | Hazard Code 12980; Number of Industries 10; Total Number of Facilities 271; Number of Occupations 13; Total Number of Employees Exposed 4021 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health