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Borane, trifluoro -

RTECS #: ED2275000

CAS #: 7637-07-2


UPDATE: May 2009 MW: 67.81 MF: BF3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Boron fluoride
  2. Boron trifluoride
  1. Boron trifluoride (ACGIH:OSHA)
  2. Fluorure de bore (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lethal concentration : >1,000 ppm/3 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression
NTIS** OTS0546539
inhalation
guinea pig
lethal concentration (50 percent kill): 109 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Blood: Hemorrhage
FATOAO 35,369,1972
inhalation
guinea pig
lowest published lethal concentration: 2,100 mg/m3/5 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation
guinea pig
lethal concentration (50 percent kill): 110 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation
mammal (species unspecified)
lowest published toxic concentration: 8 mg/m3 Lung, Thorax, or Respiration: Cough VCVN1* -,201,1988
inhalation
mouse
lethal concentration (50 percent kill): 3,460 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Blood: Hemorrhage
FATOAO 35,369,1972
inhalation
mouse
lowest published lethal concentration: 2,100 mg/m3/5 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation
mouse
lethal concentration (50 percent kill): 3,460 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation
rat
lethal concentration (50 percent kill): 1,180 mg/m3/4 hour N/R 85GMAT -,27,1982
inhalation
rat
lowest published lethal concentration: 2,100 mg/m3/5 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988
inhalation
rat
lethal concentration (50 percent kill): 1,180 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
VCVN1* -,201,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 12,800 ppb/7 hour/65 day- intermittent Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Nutritional and Gross Metabolic: Changes in: Other metals

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 22,263,1961
inhalation
guinea pig
lowest published toxic concentration: 3 mg/m3/4 hour/17 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count
FATOAO 35(3),369,1972
inhalation
guinea pig
lowest published toxic concentration: 30 mg/m3/15 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,201,1988
inhalation
guinea pig
lowest published toxic concentration: 10 mg/m3/4 hour/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation
guinea pig
lowest published toxic concentration: 34 mg/m3/7 hour/61 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation
mouse
lowest published toxic concentration: 30 mg/m3/15 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN1* -,201,1988
inhalation
rat
lowest published toxic concentration: 12,800 ppb/7 hour/65 day- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 22,263,1961
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/17 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count
FATOAO 35(3),369,1972
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation
rat
lowest published toxic concentration: 34 mg/m3/7 hour/61 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation
rabbit
lowest published toxic concentration: 10 mg/m3/4 hour/16 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988
inhalation
rabbit
lowest published toxic concentration: 34 mg/m3/7 hour/61 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Blood: Changes in leukocyte (WBC) count
VCVN1* -,202,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 1 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg(F)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 1 ppm (3 mg/m3) DTLVS* 3,26,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA ceiling concentration 1 ppm (2.8 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 1 ppm (3 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 1 ppm (3 mg/m3), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2.5 mg(F)/m3, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (3 mg/m3), short term exposure limit 3 ppm (8.3 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VLE 1 ppm (3 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg(F)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 ppm (0.83 mg/m3), APR2007
Occupational Exposure Limit - KOREA ceiling concentration 1 ppm (3 mg/m3), 2006
Occupational Exposure Limit - MEXICO peak 1 ppm (3 mg/m3), 2004
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 3 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 1 ppm (2.8 mg/m3), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES short term exposure limit 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (3 mg/m3);
KZG- week 1 ppm (3 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BORON TRIFLUORIDE-air ceiling concentration 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 12980;
Number of Industries 10;
Total Number of Facilities 271;
Number of Occupations 13;
Total Number of Employees Exposed 4,021
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 12980;
Number of Industries 6;
Total Number of Facilities 79;
Number of Occupations 10;
Total Number of Employees Exposed 3,819;
Total Number of Female Employees Exposed 524


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

NIOSH PROFILE (BORON and ITS COMPOUNDS), SRC, 10/77

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