CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Benzene, 1,2,4 - trimethyl -

RTECS #: DC3325000

CAS #: 95-63-6


UPDATE: February 2009 MW: 120.21 MF: C9H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2,4 - Trimethylbenzene
  2. Asymmetrical trimethylbenzene
  3. Benzene, 1,2,5 - trimethyl -
  4. Pseudocumene
  1. Pseudocumol
  2. as - Trimethylbenzene
  3. psi - Cumene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sister chromatid exchange intraperitoneal
mouse
900 mg/kg MUREAV 412,299,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 18,000 mg/m3/4 hour N/R VCVGH* -,175,1990
intraperitoneal
guinea pig
lowest published lethal dose: 1,788 mg/kg N/R AMIHBC 9,227,1954
intraperitoneal
guinea pig
lowest published lethal dose: 1.5 mL/kg N/R VCVGH* -,176,1990
intraperitoneal
rat
lowest published lethal dose: 1,752 mg/kg N/R 85KYAH 11,1258,1989
intraperitoneal
rat
lethal dose (30 percent kill): 5 mL/kg Lung, Thorax, or Respiration: Other changes

Vascular: Regional or general arteriolar or venous dilation
VCVGH* -,176,1990
oral
mouse
lethal dose (50 percent kill): 6,900 mg/kg N/R VCVGH* -,175,1990
oral
rat
lethal dose (50 percent kill): 5 gm/kg N/R 85JCAE -,34,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 20 mg/m3/24 hour/17 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 44(5),15,1979
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour/20 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Analgesia

Behavioral: Alteration of operant conditioning
NRTXDN 22,79,2001
inhalation
rat
lowest published toxic concentration: 20 mg/m3/16 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition VCVGH* -,176,1990
oral
rat
lowest published toxic dose: 10 gm/kg/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TIHEEC 1(3),67,1985
oral
rat
lowest published toxic dose: 6,400 mg/kg/8 week- intermittent Peripheral Nerve and Sensation: Recording from afferent nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JJATDK 13,123,1993
oral
rat
lowest published toxic dose: 19,600 mg/kg/4 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGH* -,176,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 20 ppm (100 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 20 ppm (100 mg/m3), FEB 2006
Occupational Exposure Limit - FRANCE VLE 20 ppm (100 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 100 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 100 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 25 ppm (120 mg/m3), APR2007
Occupational Exposure Limit - MEXICO time-weighted average 25 ppm (125 mg/m3);
short term exposure limit 35 ppm (170 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (120 mg/m3);
short term exposure limit 35 ppm (170 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (100 mg/m3),KZG- week 40 ppm (200 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (125 mg/m3), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: B0044;
Number of Industries 2;
Total Number of Facilities 33;
Number of Occupations 13;
Total Number of Employees Exposed 3,186
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: B0044;
Number of Industries 47;
Total Number of Facilities 3,684;
Number of Occupations 42;
Total Number of Employees Exposed 65,953;
Total Number of Female Employees Exposed 9,768


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in production of TRIMELLITIC ANHYDRIDE and as a dye carrier
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8911
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in production of TRIMELLITIC ANHYDRIDE and as a dye carrier

NIOSH PROFILE (ARENES), SRI, 2/77

NIOSH PROFILE (TRIMETHYL BENZENES), SRC, 1/81

RTECS Compound Description:
   Mutagen

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us