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1,2,4 - Benzenetricarboxylic acid 1,2 - anhydride

RTECS #: DC2050000

CAS #: 552-30-7


UPDATE: May 2009 MW: 192.13 MF: C9H4O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,2,4 - Benzenetricarboxylic acid anhydride
  2. 1,2,4 - Benzenetricarboxylic acid, cyclic 1,2 - anhydride
  3. 1,2,4 - Benzenetricarboxylic anhydride
  4. 1,3 - Dihydro - 1,3 - dioxo - 5 - isobenzofurancarboxylic acid
  5. 1,3 - Dioxo - 5 - phthalancarboxylic acid
  6. 4 - Carboxyphthalic anhydride
  7. 5 - Phthalanacarboxylic acid, 1,3 - dioxo -
  8. Anhydrotrimellic acid
  1. Diphenylmethane - 4,4' - diisocyanate - trimellic anhydride - ethomid HT polymer
  2. Epon 9150
  3. NCI - C56633
  4. Trimellic acid 1,2 - anhydride
  5. Trimellic acid anhydride
  6. Trimellitic acid cyclic 1,2 - anhydride
  7. Trimellitic anhydride
  8. Trimellitic anhydride (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 25 pph/4 hour Immunological Including Allergic: Increase in cellular immune response TOXID9 66,160,2002
inhalation
rat
lethal concentration : >7,400 mg/m3/4 hour N/R 85INA8 6,1642,1991
inhalation
rat
lowest published toxic concentration: 15 mg/m3/24 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory obstruction

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
TXAPA9 197,175,2004
intratracheal
guinea pig
lowest published toxic dose: 2 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Immunological Including Allergic: Increase in cellular immune response
TXCYAC 178,89,2002
intratracheal
mouse
lowest published toxic dose: 5 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 60,173,2001
oral
mouse
lethal dose (50 percent kill): 1,900 mg/kg Lung, Thorax, or Respiration: Dyspnea GTPZAB 18(7),57,1974
oral
rabbit
lethal dose (50 percent kill): 5,600 mg/kg N/R 85INA8 6,1642,1991
skin
mouse
lowest published toxic dose: 10 pph Blood: Other changes TOXID9 72,174,2003
skin
mouse
lowest published toxic dose: 25 pph/2 hour Immunological Including Allergic: Increase in cellular immune response TOXID9 44,348,2005
skin
rat
lowest published toxic dose: 600 mg/kg Lung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Anaphylaxis (multiple organ involvement)
ARTODN 76,538,2002
skin
rat
lowest published toxic dose: 100 mg/kg Skin: After topical application: Dermatitis, allergic

Immunological Including Allergic: Increase in humoral response
TOXID9 60,174,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 258 g/m3/6 hour/10 day- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
TXAPA9 87,67,1987
inhalation
rat
lowest published toxic concentration: 5 mg/m3/3 day- intermittent Immunological Including Allergic: Increase in humoral response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 172,157,2002
inhalation
rat
lowest published toxic concentration: 25 mg/m3/5 day- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
TOXID9 72,230,2003
inhalation
rat
lowest published toxic concentration: 25 mg/m3/4 day- intermittent Lung, Thorax, or Respiration: Sputum

Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Anaphylaxis (multiple organ involvement)
ARTODN 76,538,2002
inhalation
rat
lowest published toxic concentration: 120 mg/m3/4 day- intermittent Lung, Thorax, or Respiration: Dyspnea

Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Anaphylaxis (multiple organ involvement)
ARTODN 76,538,2002
subcutaneous
guinea pig
lowest published toxic dose: 180 mg/kg/5 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Immunological Including Allergic: Increase in cellular immune response
TXCYAC 178,89,2002
skin
mouse
lowest published toxic dose: 1,144 mg/kg/13 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
JJATDK 20,221,2000
skin
mouse
lowest published toxic dose: 7.5 mg/kg/3 day- intermittent Immunological Including Allergic: Increase in cellular immune response JJATDK 20,221,2000
skin
mouse
lowest published toxic dose: 1,500 mg/kg/7 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Increase in humoral response
JJATDK 22,397,2002
skin
mouse
lowest published toxic dose: 300 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 184,46,2002
skin
mouse
lowest published toxic dose: 700 mg/kg/8 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response
FCTOD7 40,1881,2002
skin
mouse
lowest published toxic dose: 600 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental) TXCYAC 193,191,2003
skin
mouse
lowest published toxic dose: 600 mg/kg/3 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 188,1,2003
skin
mouse
lowest published toxic dose: 10 pph/3 day- intermittent Immunological Including Allergic: Anaphylaxis (multiple organ involvement) TOLED5 136,121,2002
skin
mouse
lowest published toxic dose: 2 mL/kg/2 day- intermittent Immunological Including Allergic: Increase in humoral response TXCYAC 194,147,2003
skin
mouse
lowest published toxic dose: 600 mg/kg/3 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Increase in humoral response
TXCYAC 206,221,2005
skin
mouse
lowest published toxic concentration: 3 pph/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in humoral response
TOXID9 60,8,2001
skin
mouse
lowest published toxic concentration: 25 pph/3 week- intermittent Immunological Including Allergic: Increase in humoral response TOXID9 60,9,2001
skin
mouse
lowest published toxic dose: 300 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response
TXAPA9 205,259,2005
skin
mouse
lowest published toxic dose: 10 pph/6 day- intermittent Immunological Including Allergic: Uncharacterized (multiple organ involvement) TXAPA9 205,259,2005
skin
mouse
lowest published toxic dose: 90 mg/kg/3 day- continuous Immunological Including Allergic: Increase in cellular immune response TXCYAC 232,132,2007
skin
rat
lowest published toxic dose: 938 mg/kg/7 day- intermittent Skin: After topical application: Primary irritation

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)
TXCYAC 117,229,1997
skin
rat
lowest published toxic dose: 515 mg/kg/8 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Immunological Including Allergic: Increase in cellular immune response
FCTOD7 40,1881,2002
skin
rat
lowest published toxic dose: 4.2 mg/kg/7 day- intermittent Immunological Including Allergic: Increase in humoral response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 172,157,2002
skin
rat
lowest published toxic dose: 468.75 mg/kg/7 day- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
TOXID9 72,230,2003
skin
rat
lowest published toxic dose: 83 mg/kg/7 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Immunological Including Allergic: Increased immune response
TXCYAC 194,1,2003
skin
rat
lowest published toxic concentration: 37.5 pph/7 day- intermittent Blood: Other changes

Immunological Including Allergic: Increase in humoral response
TOXID9 60,9,2001
skin
rat
lowest published toxic dose: 16 mg/kg/21 day- intermittent Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement) TOXID9 66,242,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.04 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
BPCT** -,183,1974
TOXICOLOGY REVIEW
TOLED5 140-141,213,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.005 ppm (0.039 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 0.04 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.04 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.005 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 0.005 ppm (0.04 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.04 mg/m3 (sen), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.04 mg/m3, Occupational Exposure Limit- continuous 0.1 mg/m3, sen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.005 ppm (0.04 mg/m3), 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.005 ppm (0.039 mg/m3), sen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.005 ppm (0.04 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.04 mg/m3, ceiling concentration 0.08 mg/m3, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.04 mg/m3),KZG- week 0.005 ppm (0.04 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.04 mg/m3;
short term exposure limit 0.12 mg/m3 (sen), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.04 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.04 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMELLITIC ANHYDRIDE-air 10 hour time-weighted average 0.005 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83588;
Number of Industries 8;
Total Number of Facilities 196;
Number of Occupations 31;
Total Number of Employees Exposed 11,308
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83588;
Number of Industries 9;
Total Number of Facilities 358;
Number of Occupations 13;
Total Number of Employees Exposed 17,745;
Total Number of Female Employees Exposed 5,236


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to produce trimellitate plasticizers, poly(amide-imide) polymers and in enamels
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 21, 1978
NIOSH Analytical Method, 1994: Trimellitic anhydride, 5036
OSHA ANALYTICAL METHOD #98


REFERENCES:

CODEN
REFERENCE

85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used to produce trimellitate plasticizers, poly(amide-imide) polymers and in enamels

NIOSH PROFILE (ORGANIC ANHYDRIDES), SRC, 2/82

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