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Benzene, p - dinitro -

RTECS #: CZ7525000

CAS #: 100-25-4


UPDATE: May 2009 MW: 168.12 MF: C6H4N2O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,4 - Dinitrobenzene
  2. Benzene, 1,4 - dinitro - (9CI)
  3. Dithane A - 4
  1. p - Dinitrobenzene
  2. p - Dinitrobenzene (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 5 g/plate (+enzymatic activation step) CRNGDP 6,727,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): 56 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia JPETAB 80,31,1944
oral
cat
lowest published lethal dose: 29 mg/kg N/R 85KYAH 11,516,1989
oral
rat
lowest published lethal dose: 50 mg/kg Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0546024
oral
rat
lowest published toxic dose: 5 mg/kg Lung, Thorax, or Respiration: Cyanosis

Blood: Changes in spleen
TXAPA9 92,54,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.15 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.15 ppm (1 mg/m3) (skin) DTLVS* 3,92,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.15 ppm (1 mg/m3), JUL2008
Occupational Exposure Limit - FRANCE VME 0.15 ppm (1 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.15 ppm (1 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.15 ppm (1 mg/m3), skin, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.15 ppm (1 mg/m3), skin, JAN2002
Occupational Exposure Limit - SWEDEN time-weighted average 0.15 ppm (1 mg/m3);
short term exposure limit 0.3 ppm (2 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.15 ppm (1 mg/m3),KZG- week 0.3 ppm (2 mg/m3), Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-DINITROBENZENE-air 10 hour time-weighted average 1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Mutagen

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