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Benzene, 2,4 - diisocyanato - 1 - methyl -

RTECS #: CZ6300000

CAS #: 584-84-9


UPDATE: May 2009 MW: 174.17 MF: C9H6N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,4 - Diisocyanato - 1 - methylbenzene (9CI)
  2. 2,4 - Diisocyanatotoluene
  3. 2,4 - TDI
  4. 2,4 - Toluenediisocyanate
  5. 2,4 - Tolylenediisocyanate
  6. 4 - Methyl - phenylene diisocyanate
  7. 4 - Methyl - phenylene isocyanate
  8. Cresorcinol diisocyanate
  9. Desmodur T80
  10. Di - iso - cyanatoluene
  11. Di - isocyanate de toluylene (French)
  12. Diisocyanat - toluol (German)
  13. Hylene T
  14. Isocyanic acid, 4 - methyl - m - phenylene ester
  15. Mondur TD
  16. Mondur TD - 80
  17. Mondur TDS
  1. NCI - C50533
  2. Nacconate IOO
  3. RCRA waste number U223
  4. TDI
  5. TDI (OSHA)
  6. TDI - 80
  7. Tolueen - diisocyanaat (Dutch)
  8. Toluen - disocianato (Italian)
  9. Toluene 2,4 - diisocyanate
  10. Toluene diisocyanate
  11. Toluene - 2,4 - diisocyanate
  12. Toluene - 2,4 - diisocyanate (ACGIH:OSHA)
  13. Toluilenodwuizocyjanian (Polish)
  14. Toluylene - 2,4 - diisocyanate
  15. Tolyene 2,4 - diisocyanate
  16. Tolylene - 2,4 - diisocyanate
  17. Tuluylendiisocyanat (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg severe EJTXAZ 9,41,1976
skin
rabbit
500 mg open irritation test severe UCDS** 3/8/1973
skin
rabbit
500 mg/24 hour moderate EJTXAZ 9,41,1976


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 g/plate (-enzymatic activation step) ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms Salmonella typhimurium 0.33 mg/plate (+enzymatic activation step) CRTXB2 31,737,2001
micronucleus test inhalation
rat
0.5 ppm/6 hour/4 week CRTXB2 31,737,2001
morphological transform mouse fibroblast 0.2 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster ovary 300 mg/L EMMUEG 13,133,1989
specific locus test mouse lymphocyte 75 mg/L EMMUEG 17,196,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lethal concentration (50 percent kill): 13 ppm/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Pleural effusion
AIHAAP 23,447,1962
inhalation
human
lowest published toxic concentration: 20 ppb/2 year Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Sputum
PRSMA4 63,372,1970
inhalation
human
lowest published toxic concentration: 500 ppb Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes
JOCMA7 1,448,1959
inhalation
human
lowest published toxic concentration: 80 ppb Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes
ATXKA8 19,364,1962
inhalation
mouse
lethal concentration (50 percent kill): 10 ppm/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
AIHAAP 23,447,1962
inhalation
mouse
lethal concentration (50 percent kill): 10 ppm/4 hour N/R ENTOX* -,204,2005
inhalation
rat
lethal concentration (50 percent kill): 14 ppm/4 hour Eye: Lacrimation

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 23,447,1962
inhalation
rat
lethal concentration (50 percent kill): 14 ppm/4 hour N/R ENTOX* -,204,2005
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/4 hour Liver: Hepatitis (hepatocellular necrosis), zonal TPKVAL 9,37,1967
inhalation
rabbit
lethal concentration (50 percent kill): 11 ppm/4 hour Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
AIHAAP 23,447,1962
inhalation
woman
lowest published toxic concentration: 300 ppt/8 hour/5 day Lung, Thorax, or Respiration: Respiratory obstruction LANCAO 1,756,1980
intravenous
mouse
lethal dose (50 percent kill): 56 mg/kg N/R CSLNX* NX#07807
oral
wild bird
lethal dose (50 percent kill): 100 mg/kg N/R AECTCV 12,355,1983
oral
rat
lethal dose (50 percent kill): 5,800 mg/kg Gastrointestinal: Other changes AMIHAB 15,324,1957
oral
rat
lethal dose (30 percent kill): 6.17 gm/kg N/R ENTOX* -,204,2005
skin
rabbit
lethal dose (50 percent kill): >16 mL/kg N/R UCDS** 3/8/1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intradermal
mouse
lowest published toxic dose: 500 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental) EXPDE* 15,322,2006
inhalation
guinea pig
lowest published toxic concentration: 3,100 ppb/4 hour/5 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count
EXLRDA 11,145,1986
inhalation
mouse
lowest published toxic concentration: 990 ppb/6 hour/14 day- intermittent Olfaction: Other olfaction effects JJATDK 15,207,1995
inhalation
rat
lowest published toxic concentration: 204 g/m3/24 hour/84 day- continuous Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Lipids including transport
GISAAA 28(6),8,1963
inhalation
rat
lowest published toxic concentration: 102 ppb/24 hour/7 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi JJATDK 14,369,1994
inhalation
rat
lowest published toxic concentration: 26 ppm/6 hour/5 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0570993
inhalation
rabbit
lowest published toxic dose: 1,500 ppb/71 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 15,324,1957
inhalation
rabbit
lowest published toxic concentration: 1,500 ppb/6 hour/79 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi AMIHAB 15,324,1957
multiple
mouse
lowest published toxic dose: 0.3 pph/3 day- intermittent Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight
TOXID9 72,43,2003
oral
guinea pig
lowest published toxic dose: 70 mg/kg/7 day- intermittent Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)

Biochemical: Metabolism (intermediary): Histamines (including liberation not immunochemical in origin)
ACPSI* 24,251,2003
oral
rat
lowest published toxic dose: 15 gm/kg/10 day- intermittent Gastrointestinal: Other changes

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 15,324,1957
skin
mouse
lowest published toxic dose: 800 mg/kg/4 day- intermittent Immunological Including Allergic: Increased immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
EJPHAZ 446,195,2002
skin
mouse
lowest published toxic dose: 15 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 184,46,2002
skin
mouse
lowest published toxic dose: 240 mg/kg/28 day- intermittent Immunological Including Allergic: Increase in humoral response TOSCF2 94,108,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm;short term exposure limit 0.02 ppm (sen) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 39,287,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,865,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,287,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,865,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,865,1999
TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
AOHYA3 17,143,1974
TOXICOLOGY REVIEW
JJOMDZ 15,808,1973
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
DIMON* 46,551,2000
TOXICOLOGY REVIEW
ENTOX* -,204,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 681,93,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 0.02 ppm (0.14 mg/m3) DTLVS* 3,260,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.02 ppm (0.14 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.02 ppm (0.14 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.02 ppm (0.14 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.02 ppm (0.14 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.02 ppm (0.14 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, JUL2008
Occupational Exposure Limit - AUSTRIA MAK 0.035 mg/m3 (0.005 ppm), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.005 ppm (0.037 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.02 ppm (0.14 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.035 mg/m3), OCT 2002
Occupational Exposure Limit - HUNGARY ceiling concentration 0.035 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.005 ppm (0.035 mg/m3), 2B carcinogen, sen, APR2007
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 0.02 ppm (0.14 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.005 ppm (0.04 mg/m3), short term exposure limit 0.02 ppm (0.15 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.02 ppm (0.14 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.04 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.02 mg(NCO)/m3;
short term exposure limit 0.07 mg(NCO)/m3, sen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.005 ppm (0.035 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.02 ppm (0.14 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.035 mg/m3, MAC(short term exposure limit) 0.070 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.002 ppm (0.014 mg/m3), Carcinogen, Sen, JUN2005
Occupational Exposure Limit - SWEDEN ceiling concentration 0.005 ppm (0.04 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.02 mg/m3),KZG- week 0.005 ppm (0.02 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.02 ppm (0.14 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.02 ppm (0.14 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TOLUENE DIISOCYANATE-air Carcinogen lowest feasible conc NIOSH* DHHS#92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 73390;
Number of Industries 47;
Total Number of Facilities 2,310;
Number of Occupations 54;
Total Number of Employees Exposed 26,654
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 73390;
Number of Industries 19;
Total Number of Facilities 838;
Number of Occupations 30;
Total Number of Employees Exposed 10,921;
Total Number of Female Employees Exposed 545


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of POLYURETHANE flexible foams, coatings, and elastomers
Used in production of plastics and adhesives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isocyanates, monomeric, 5521
NIOSH Analytical Method, 1994: Toluene-2,4-diisocyanate, 2535
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #18, SUPERSEDED BY #42
OSHA ANALYTICAL METHOD #33


REFERENCES:

CODEN
REFERENCE

ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EXLRDA Experimental Lung Research. (Hemisphere Publishing, c/o Taylor & Francis 1900 Frost Road, Suite 101, Bristol, PA 19007) V.1- 1980-
EXPDE* Experimental dermatology (Copenhagen : Munksgaard) V.1- 1992-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67. For publisher information, see:JJOMDZ
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PRSMA4 Proceedings of the Royal Society of Medicine. (New York, NY) V.1-70, 1907-77. For publisher information, see JRSMD9.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in the production of POLYURETHANE flexible foams, coatings, and elastomers

Used in production of plastics and adhesives

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

NIOSH PROFILE (ISOCYANATES, ORGANIC), SRC, 10/77

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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