1,3-Benzenedicarbonitrile

RTECS #

CZ1900000

CAS #

626-17-5
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

128.14

Molecular Formula

C₈H₄N₂

Synonyms

1,3-Benzendikarbonitril (Czech)
1,3-Dicyanobenzene
Dinitrile of isophthalic acid
IPN
Isoftalodinitril (Czech)
Isoftalonitril (Czech)
Isophthalodinitrile
Isophthalonitrile
m-Dicyanobenzene
m-Phthalodinitrile
m-Phthalodinitrile (ACGIH)
Nitril kyseliny isoftalove (Czech)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg/24H	mild	85JCAE -,905,1986

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lethal concentration (50 percent kill): >8970 mg/m³/1H		NTIS** OTS0533488
inhalation/rat	lethal concentration (50 percent kill): >8970 mg/m³/1H	Lung, Thorax, or Respiration: Other changes Blood: Hemorrhage Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV271 -,-,2005
intraperitoneal/mouse	lethal dose (50 percent kill): 450 mg/kg	Behavioral: Convulsions or effect on seizure threshold	ZAARAM 19,225,1969
intraperitoneal/rat	lethal dose (50 percent kill): 520 mg/kg	Eye: Ptosis Behavioral: Muscle weakness Lung, Thorax, or Respiration: Acute pulmonary edema	APFRAD 48,23,1990
oral/cat	lethal dose (50 percent kill): 500 mg/kg		ZAARAM 19,225,1969
oral/mouse	lethal dose (50 percent kill): 369 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression	HPV271 -,-,2005
oral/mouse	lethal dose (50 percent kill): 178 mg/kg		JMCMAR 21,906,1978
oral/rabbit	lethal dose (50 percent kill): 250 mg/kg		ZAARAM 19,225,1969
oral/rat	lethal dose (50 percent kill): 1790 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes	HPV271 -,-,2005
oral/rat	lethal dose (50 percent kill): 860 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Body temperature decrease	NTIS** OTS0533488
skin/rabbit	lethal dose (50 percent kill): >2000 mg/kg		HPV271 -,-,2005
skin/rat	lethal dose (50 percent kill): >5 gm/kg		NTIS** OTS0533488
unreported route/guinea pig	lethal dose (50 percent kill): 370 mg/kg		GISAAA 39(11),17,1974
unreported route/mouse	lethal dose (50 percent kill): 548 mg/kg		GISAAA 39(11),17,1974
unreported route/rabbit	lethal dose (50 percent kill): 350 mg/kg		GISAAA 39(11),17,1974
unreported route/rat	lethal dose (50 percent kill): 1708 mg/kg		GISAAA 39(11),17,1974

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 1250 mg/m³/6H/2W- intermittent	Gastrointestinal: Hypermotility, diarrhea Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0533488
inhalation/rat	lowest published toxic concentration: 1500 mg/m³/2W- intermittent	Behavioral: Food intake (animal) Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV271 -,-,2005
oral/mouse	lowest published toxic dose: 13500 mg/kg/90D- intermittent	Brain and Coverings: Changes in brain weight Liver: Changes in liver weight Related to Chronic Data: Changes in ovarian weight	NTIS** OTS0572435
oral/mouse	lowest published toxic dose: 5250 mg/kg/35D- continuous	Liver: Other changes Liver: Changes in liver weight	NTIS** OTS0538085
oral/mouse	lowest published toxic dose: 6300 mg/kg/35D- intermittent	Liver: Other changes Liver: Changes in liver weight	HPV271 -,-,2005
oral/mouse	lowest published toxic dose: 12600 mg/kg/35D- intermittent	Liver: Other changes Liver: Changes in liver weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV271 -,-,2005
oral/rabbit	lowest published toxic dose: 4550 mg/kg/26W- intermittent	Liver: Liver function tests impaired Liver: Other changes Blood: Pigmented or nucleated red blood cells	GISAAA 39(11),17,1974
oral/rat	lowest published toxic dose: 495 mg/kg/99D- intermittent	Kidney, Ureter, and Bladder: Other changes Biochemical: Metabolism (intermediary): Other proteins	HPV271 -,-,2005
oral/rat	lowest published toxic dose: 2475 mg/kg/99D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Metabolism (intermediary): Other proteins	HPV271 -,-,2005
oral/rat	lowest published toxic dose: 2475 mg/kg/99D- intermittent	Liver: Other changes Liver: Changes in liver weight Kidney, Ureter, and Bladder: Urine volume increased	NTIS** OTS0537740
oral/rat	lowest published toxic dose: 5250 mg/kg/1W- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0533488
oral/rat	lowest published toxic dose: 4050 mg/kg/30D- intermittent	Behavioral: Food intake (animal) Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0533488
skin/rabbit	lowest published toxic dose: 15000 mg/kg/21D- intermittent	Endocrine: Evidence of thyroid hypofunction Related to Chronic Data: Changes in ovarian weight	HPV271 -,-,2005
skin/rabbit	lowest published toxic dose: 30000 mg/kg/21D- intermittent	Endocrine: Evidence of thyroid hypofunction Endocrine: Changes in spleen weight Related to Chronic Data: Changes in ovarian weight	HPV271 -,-,2005

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³ (inhal, vapor)	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 mg/m³;KZW 10 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 5 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 5 mg/m³, short term exposure limit 20 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 5 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 5 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-PHTHALODINITRILE-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X3037; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 5; Total Number of Employees Exposed 208; Total Number of Female Employees Exposed 44

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health