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Asphalt

RTECS #: CI9900000

CAS #: 8052-42-4


UPDATE: May 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Asphalt fumes (ACGIH)
  2. Asphalt, petroleum
  3. Asphaltum
  4. Bitumen
  5. Bitumen fumes
  6. Judean pitch
  1. Mineral pitch
  2. Petroleum asphalt
  3. Petroleum bitumen
  4. Petroleum pitch
  5. Petroleum roofing tar
  6. Road asphalt


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct skin
mouse
600 mg/kg CRNGDP 9,1253,1988
DNA damage rat other cell types 641 g/L MUREAV 557,137,2004
micronucleus test rat other cell types 57.8 g/L MUREAV 557,137,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
mouse
lowest published toxic dose: 12 gm/kg/12 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
ARPAAQ 70,372,1960
intramuscular
rat
lowest published toxic dose: 5,400 mg/kg/24 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens
ARPAAQ 70,372,1960
skin
mouse
lowest published toxic dose: 130 gm/kg/81 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
HYSAAV 33(4-6),180,1968
skin
mouse
toxic dose : 69 gm/kg/43 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
HYSAAV 33(4-6),180,1968
skin
mouse
lowest published toxic dose: 905 gm/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
IMSUAI 34,255,1965


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic dose: 10 mg/m3/5.5 year- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands
ARTODN 81,35,2007
inhalation
human
lowest published toxic dose: 10 mg/m3/9 year- intermittent Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
ARTODN 81,35,2007
inhalation
mouse
lowest published toxic concentration: 35 mg/m3/10 day- intermittent Immunological Including Allergic: Decrease in humoral immune response TOXID9 60,27,2001
inhalation
rat
lowest published toxic concentration: 100 mg/m3/6 hour/14 week- intermittent Olfaction: Tumors

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 135,S140,2002
intratracheal
rat
lowest published toxic dose: 1.35 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JJTHEC 65,1247,2002
intratracheal
rat
lowest published toxic dose: 26.64 mg/kg/3 day- intermittent Blood: Changes in bone marrow not included in above JJTHEC 65,1247,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (inhalable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 35,39,1985
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,133,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,101,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 (fume) DTLVS* 3,19,1971
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - AUSTRIA TRK peak 10 mg/m3 (vapor and aerosol), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3 (fume), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, OCT 2002
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3 (fume), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - POLAND time-weighted average 5 mg/m3 (fume), short term exposure limit 15 mg/m3 (fume), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ASPHALT FUMES-air Carcinogen ceiling concentration 5 mg/m3/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 90320;
Number of Industries 175;
Total Number of Facilities 38,326;
Number of Occupations 111;
Total Number of Employees Exposed 573,807
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 90320;
Number of Industries 177;
Total Number of Facilities 26,349;
Number of Occupations 109;
Total Number of Employees Exposed 471,039;
Total Number of Female Employees Exposed 18,959


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for making roads, roofs and for making tanks watertight
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE

ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used for making roads, roofs and for making tanks watertight

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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