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o - Anisidine

RTECS #: BZ5410000

CAS #: 90-04-0


UPDATE: May 2009 MW: 123.17 MF: C7H9NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 2 - methoxybenzene
  2. 2 - Aminoanisole
  3. 2 - Anisidine
  4. 2 - Methoxy - 1 - aminobenzene
  5. 2 - Methoxyaniline
  6. 2 - Methoxybenzenamine
  7. 2 - Methoxyphenylamine
  1. Benzenamine, 2 - methoxy - (9CI)
  2. o - Aminoanisole
  3. o - Anisidine (ACGIH:OSHA)
  4. o - Anisylamine
  5. o - Methoxyaniline
  6. o - Methoxyphenylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 1,200 mg/L EMMUEG 10(Suppl 10),1,1987
DNA damage mouse lymphocyte 1,250 µmol/L MUREAV 203,155,1988
DNA damage oral
mouse
690 mg/kg MUREAV 412,155,1998
DNA inhibition oral
mouse
200 mg/kg MUREAV 46,305,1977
DNA repair Escherichia coli 31,600 µmol/L MUREAV 272,145,1992
host-mediated assay mouse
Escherichia coli
310 mg/kg MUREAV 272,161,1992
mutation in microorganisms mouse lymphocyte 1 mmol/L (+enzymatic activation step) MUTAEX 3,193,1988
mutation in microorganisms Salmonella typhimurium 333 µg/plate (-enzymatic activation step) IMEMDT 27,63,1982
gene conversion and mitotic recombination Drosophila melanogaster 1 mmol/L MUREAV 514,193,2002
mutation in mammalian somatic cells mouse lymphocyte 2 mmol/L MUTAEX 3,193,1988
sister chromatid exchange hamster ovary 38 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
wild bird
lethal dose (50 percent kill): 422 mg/kg N/R AECTCV 12,355,1983
oral
mouse
lethal dose (50 percent kill): 1,400 mg/kg Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Other changes
IMEMDT 27,63,1982
oral
rat
lethal dose (50 percent kill): 1,150 mg/kg N/R TLSMA6 128,14,1979
oral
rabbit
lethal dose (50 percent kill): 870 mg/kg Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Other changes
IMEMDT 27,63,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,49,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,63,1982
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,49,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 73,49,1999
TOXICOLOGY REVIEW
ENTOX* -,104,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.5 mg/m3) (skin) DTLWS* 3,10,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.5 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA TRK 0.5 mg/m3 (0.1 mL/m3), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.5 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.5 mg/m3), Skin, continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY ceiling concentration 0.5 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.5 mg/m3), skin, 2B carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.5 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.5 mg/m3) (skin), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.5 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.5 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.51 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-ANISIDINE-air Carcinogen;
10 hour time-weighted average 0.5 mg/m3 (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8302;
Number of Industries 1;
Total Number of Facilities 50;
Number of Occupations 3;
Total Number of Employees Exposed 705


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for the production of dyes, pharmaceuticals and textile-processing chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Anisidine, 2514


REFERENCES:

CODEN
REFERENCE

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.

Used for the production of dyes, pharmaceuticals and textile-processing chemicals

RTECS Compound Description:
   Tumorigen
   Mutagen

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