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Aniline, p - nitro -

RTECS #: BY7000000

CAS #: 100-01-6


UPDATE: May 2009 MW: 138.14 MF: C6H6N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 4 - nitrobenzene
  2. 4 - Nitraniline
  3. 4 - Nitroaniline
  4. 4 - Nitrobenzenamine
  5. Aniline, 4 - nitro -
  6. Azoamine Red ZH
  7. Azoic Diazo Component 37
  8. Benzenamine, 4 - nitro - (9CI)
  9. C.I. 37035
  10. C.I. Azoic Diazo Component 37
  11. C.I. Developer 17
  12. Developer P
  13. Devol Red GG
  14. Diazo Fast Red GG
  15. Fast Red 2G Base
  16. Fast Red Base 2J
  17. Fast Red Base GG
  1. Fast Red GG Base
  2. Fast Red MP Base
  3. Fast Red P Base
  4. NCI - C60786
  5. Naphtoelan Red GG Base
  6. Nitrazol CF Extra
  7. PNA
  8. RCRA waste number P077
  9. Red 2G Base
  10. Shinnippon Fast Red GG Base
  11. p - Aminonitrobenzene
  12. p - Nitraniline
  13. p - Nitroanilina (Polish)
  14. p - Nitroaniline
  15. p - Nitroaniline (ACGIH:OSHA)
  16. p - Nitrophenylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 173 mg/L EMMUEG 27,67,1996
DNA repair Bacillus subtilis 5 mg/disc MUREAV 170,11,1986
mutation in microorganisms other microorganisms 1,500 g/L (-enzymatic activation step) MUREAV 173,233,1986
mutation in microorganisms Salmonella typhimurium 333 g/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 50 g/plate (-enzymatic activation step) MUREAV 44,9,1977
phage inhibition capacity Escherichia coli 100 mmol/L MDMIAZ 31,11,1979
sister chromatid exchange hamster ovary 1,600 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 9,600 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,29,1987
oral
rat
lowest published toxic dose: 1,764 mg/kg (14 week male/14 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) FAATDF 15,607,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 51,500 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Vascular: Tumors
NTPTR* NTP-TR-418,1993
oral
mouse
lowest published toxic dose: 51,500 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Angiosarcoma

Blood: Normocytic anemia
NTIS** PB94-104528


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
mouse
lethal dose (50 percent kill): 800 mg/kg N/R IGIBA5 15,151,1966
intraperitoneal
mouse
lethal dose (50 percent kill): 250 mg/kg N/R NTIS** AD691-490
intraperitoneal
rat
lowest published lethal dose: 600 mg/kg N/R 85GMAT -,92,1982
intravenous
mammal (species unspecified)
lowest published lethal dose: 40 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia XPHBAO 271,34,1941
oral
wild bird
lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
guinea pig
lethal dose (50 percent kill): 450 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
VKMGA7 6,89,1966
oral
mouse
lethal dose (50 percent kill): 810 mg/kg N/R TXAPA9 42,417,1977
oral
mouse
lethal dose : 500 mg/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory obstruction

Liver: Multiple effects
TPKVAL 7,138,1965
oral
mouse
lethal dose : 5,000 mg/kg Kidney, Ureter, and Bladder: Other changes

Blood: Hemorrhage

Blood: Methemoglobinemia- Carboxhemoglobinemia
TPKVAL 7,138,1965
oral
mouse
lethal dose : 3,000 mg/kg Cardiac: EKG changes not diagnostic of above

Blood: Changes in spleen

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 7,138,1965
oral
mouse
lethal dose (50 percent kill): 1,000 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Somnolence (general depressed activity)

Cardiac: EKG changes not diagnostic of above
TPKVAL 7,138,1965
oral
quail
lethal dose (50 percent kill): 1 gm/kg N/R AECTCV 12,355,1983
oral
rat
lethal dose (50 percent kill): 750 mg/kg N/R CEHYAN 23,168,1978
skin
guinea pig
lethal dose (50 percent kill): >500 mg/kg N/R NTIS** OTS0572389


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 80 mg/m3/6 hour/4 week- intermittent Endocrine: Changes in spleen weight

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in leukocyte (WBC) count
FAATDF 6,618,1986
inhalation
rat
lowest published toxic concentration: 510 mg/m3/6 hour/2 week- intermittent Blood: Other hemolysis with or without anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0546534
oral
mouse
lowest published toxic dose: 300 mg/kg/14 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count
NTPTR* NTP-TR-418,1993
oral
mouse
lowest published toxic dose: 650 mg/kg/13 week- intermittent Liver: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in spleen
NTPTR* NTP-TR-418,1993
oral
rat
lowest published toxic dose: 6,750 mg/kg/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0533716
oral
rat
lowest published toxic dose: 2,700 mg/kg/90 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in spleen

Blood: Changes in other cell count (unspecified)
TOXID9 3,128,1983
oral
rat
lowest published toxic dose: 120 mg/kg/30 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 50(4),82,1985
oral
rat
lowest published toxic dose: 180 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count
GISAAA 50(4),82,1985
oral
rat
lowest published toxic dose: 6,552 mg/kg/2 year- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Endocrine: Changes in spleen weight
FAATDF 15,607,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (6 mg/m3) (skin) DTLVS* 3,182,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (6 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (6 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (6 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (6 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 ppm (6 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 3 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (6 mg/m3), short term exposure limit 3 ppm (18 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 3 mg/m3, Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 6 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 3 mg/m3, skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 3 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 ppm (6 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 3 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (6 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 3 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (3 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (6 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-NITROANILINE-air 10 hour time-weighted average 3 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3131;
Number of Industries 4;
Total Number of Facilities 281;
Number of Occupations 10;
Total Number of Employees Exposed 2,814
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3131;
Number of Industries 2;
Total Number of Facilities 48;
Number of Occupations 7;
Total Number of Employees Exposed 1,448;
Total Number of Female Employees Exposed 262


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in the preparation of dyes and in the manufacture of antioxidants
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: p-Nitroaniline, 5033
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
CEHYAN Ceskoslovenska Hygiena. Czechoslovak Hygiene. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1956-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IGIBA5 Igiena. (Bucharest, Romania) V.5-23, 1956-74(?). For publisher information, see RABIDH.
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VKMGA7 Voprosy Kommunal'noi Gigieny. Problems of Communal Hygiene. (Kiev, USSR) V.6, 1966. For publisher information, see GNAMAP.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used in the preparation of dyes and in the manufacture of antioxidants

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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