CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Aniline

RTECS #: BW6650000

CAS #: 62-53-3


UPDATE: May 2009 MW: 93.14 MF: C6H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Aminobenzene
  2. Aminophen
  3. Anilin (Czech)
  4. Anilina (Italian, Polish)
  5. Aniline oil
  6. Aniline and homologues (ACGIH:OSHA)
  7. Anyvim
  8. Benzenamine
  9. Benzene, amino
  10. Benzidam
  1. Blue Oil
  2. C.I. 76000
  3. C.I. Oxidation Base 1
  4. Cyanol
  5. Huile d'aniline (French)
  6. Krystallin
  7. Kyanol
  8. NCI - C03736
  9. Phenylamine
  10. RCRA waste number U012


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg/24 hour moderate 85JCAE -,456,1986
skin
rabbit
20 mg/24 hour moderate 85JCAE -,456,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium
300 mg/kg MUREAV 79,173,1980
cytogenetic analysis hamster ovary 444 mg/L EMMUEG 27,67,1996
DNA damage intraperitoneal
mouse
300 mg/kg ATSUDG 5,355,1982
DNA damage mouse lymphocyte 21,500 mol/L MUREAV 203,155,1988
DNA damage oral
mouse
1 gm/kg MUREAV 440,1,1999
DNA damage intraperitoneal
rat
105 mg/kg CNREA8 42,2277,1982
DNA damage other cell types
rat
1,397.1 mg/kg/30 day- continuous TOXID9 -,15,2008
DNA repair Escherichia coli 39,658 g/well/16 hour CBINA8 15,219,1976
mutation in microorganisms mouse lymphocyte 500 mol/L (+enzymatic activation step) MUTAEX 3,193,1988
mutation in microorganisms Salmonella typhimurium 100 g/plate (-enzymatic activation step) PJABDW 53,34,1977
mutation in microorganisms Salmonella typhimurium 344 nmol/plate/48 hour (+enzymatic activation step) MUREAV 541,123,2003
mutation in microorganisms Salmonella typhimurium 1 g/plate MUREAV 577S,1,2005
micronucleus test intraperitoneal
mouse
50 mg/kg JPMSAE 80,761,1991
micronucleus test unreported route
mouse
23 mg/kg JAPTO* 25,514,2005
mutation in mammalian somatic cells hamster lung 500 g/L BLFSBY 39,359,1986
mutation in mammalian somatic cells mouse lymphocyte 2,500 mol/L MUTAEX 3,193,1988
morphological transform mouse fibroblast 800 g/L JJIND8 67,1303,1981
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
sister chromatid exchange hamster ovary 50 mg/L EMMUEG 10(Suppl 10),1,1987
sister chromatid exchange human lymphocyte 300 mol/L MUREAV 395,159,1997
sister chromatid exchange intraperitoneal
mouse
210 mg/kg CNREA8 42,2277,1982
sister chromatid exchange rat liver 200 mol/L TOLED5 16,235,1983
specific locus test mouse lymphocyte 500 mg/L EMMUEG 17,196,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 4,480 mg/kg (6-13 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TCMUD8 7,29,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 11 gm/kg/29 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
APMIAL 26,472,1949
oral
rat
toxic dose : 72,800 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
FCTOD7 25,619,1987


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 180 ppm/8 hour N/R XPHBAO 271,4,1941
inhalation
dog
lowest published toxic concentration: 23.6 mg/m3 Blood: Methemoglobinemia- Carboxhemoglobinemia TXCYAC 214,140,2005
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 2,500 mg/m3 N/R GTPZAB 32(10),25,1988
inhalation
mouse
lethal concentration (50 percent kill): 175 ppm/7 hour N/R NTIS** PB214-270
inhalation
rat
lowest published lethal concentration: 250 ppm/4 hour N/R JIHTAB 31,343,1949
inhalation
rat
lethal concentration (50 percent kill): 250 ppm/1 hour N/R ENTOX* -,136,2005
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness
TPKVAL 12,54,1971
inhalation
rat
lowest published toxic concentration: 0.9 gm/m3/4 hour Behavioral: Alteration of classical conditioning

Vascular: Other changes

Gastrointestinal: Ulceration or bleeding from stomach
TPKVAL 12,54,1971
inhalation
rat
lowest published toxic concentration: 0.6 gm/m3/4 hour N/R TPKVAL 12,54,1971
intraperitoneal
guinea pig
lethal dose (50 percent kill): 100 mg/kg N/R TSCAT* OTS 206512
intraperitoneal
mouse
lethal dose (50 percent kill): 492 mg/kg N/R IZSBAI 3,91,1965
intraperitoneal
rat
lethal dose (50 percent kill): 420 mg/kg N/R AGGHAR 15,447,1957
intravenous
dog
lowest published lethal dose: 200 mg/kg N/R NTIS** PB214-270
intravenous
rabbit
lethal dose (50 percent kill): 64 mg/kg N/R NTIS** PB214-270
oral
wild bird
lethal dose (50 percent kill): 562 mg/kg N/R AECTCV 12,355,1983
oral
cat
lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1301,1935
oral
child
lowest published toxic dose: 3,125 mg/kg Lung, Thorax, or Respiration: Cyanosis JTCTDW 26,357,1988
oral
dog
lethal dose (50 percent kill): 195 mg/kg N/R NTIS** PB214-270
oral
guinea pig
lethal dose (50 percent kill): 400 mg/kg N/R TSCAT* OTS 206512
oral
mammal (species unspecified)
lethal dose (50 percent kill): 500 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse
lethal dose (50 percent kill): 464 mg/kg N/R ENTOX* -,136,2005
oral
quail
lethal dose (50 percent kill): 750 mg/kg N/R AECTCV 12,355,1983
oral
rat
lethal dose (50 percent kill): 250 mg/kg N/R JPETAB 90,260,1947
oral
rat
lowest published toxic dose: 1,000 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Spinal Cord: Demyelination

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOPADD 14,19,2001
oral
rat
lowest published toxic dose: 1,118 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia TPKVAL 14,118,1975
oral
rat
lowest published toxic dose: 1,000 mg/kg Spinal Cord: Other degenerative changes

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
TOXID9 12,470,2008
oral
rabbit
lowest published lethal dose: 500 mg/kg N/R HBAMAK 4,1301,1935
subcutaneous
cat
lowest published lethal dose: 100 mg/kg N/R HBAMAK 4,1301,1935
subcutaneous
mouse
lethal dose (50 percent kill): 200 mg/kg N/R ARZNAD 8,107,1958
subcutaneous
rabbit
lowest published lethal dose: 1 gm/kg Lung, Thorax, or Respiration: Other changes MELAAD 28,112,1937
skin
cat
lethal dose (50 percent kill): 254 mg/kg N/R GTPZAB 13(5),29,1969
skin
dog
lowest published lethal dose: 1,540 mg/kg N/R NTIS** PB214-270
skin
guinea pig
lethal dose (50 percent kill): 1,290 mg/kg N/R TXAPA9 7,559,1965
skin
rat
lethal dose (50 percent kill): 1,400 mg/kg N/R ENTOX* -,136,2005
skin
rabbit
lethal dose (50 percent kill): 820 L/kg N/R TXAPA9 7,559,1965
unreported route
man
lowest published lethal dose: 350 mg/kg N/R JIDHAN 13,87,1931
unreported route
man
lowest published lethal dose: 150 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 3 mg/m3/22 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes
GISAAA 37(5),31,1972
inhalation
rat
lowest published toxic concentration: 87 ppm/6 hour/2 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
TOXID9 2,164,1982
inhalation
rat
lowest published toxic concentration: 300 g/m3/24 hour/80 day- continuous Behavioral: Muscle contraction or spasticity GISAAA 35(4),44,1970
inhalation
rat
lowest published toxic concentration: 5 mg/m3/24 hour/21 day- continuous Blood: Methemoglobinemia- Carboxhemoglobinemia GISAAA 37(12),53,1972
intraperitoneal
mouse
lowest published toxic dose: 894 mg/kg/6 week- intermittent Immunological Including Allergic: Autoimmune (multiple organ involvement) TOXID9 44,187,2005
oral
rat
lowest published toxic dose: 913 mg/kg/2 week- intermittent Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FAATDF 25,224,1995
oral
rat
lowest published toxic dose: 550 mg/kg/5 day- continuous Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 3,285,1983
oral
rat
lowest published toxic dose: 210 mg/kg/12 week- continuous Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
GISAAA 24(7),44,1959
oral
rat
lowest published toxic dose: 1,950 mg/kg/30 day- continuous Blood: Changes in spleen TOXID9 66,90,2002
oral
rat
lowest published toxic dose: 1,397.1 mg/kg/30 day- continuous Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 -,22,2008
oral
rat
lowest published toxic dose: 651.98 mg/kg/7 day- intermittent Blood: Changes in spleen TXAPA9 230,227,2008
subcutaneous
rat
lowest published toxic dose: 900 mg/kg/6 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
BCTKAG 13,99,1980


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMSUDL 7,99,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 4,27,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,99,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,99,1987
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
TOLED5 140-141,229,2003
TOXICOLOGY REVIEW
TOLED5 140-141,183,2003
TOXICOLOGY REVIEW
TXAPA9 197,144,2004
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,136,2005
TOXICOLOGY REVIEW
ENTOX* -,104,2005
TOXICOLOGY REVIEW
MUREAV 627,78,2007
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (19 mg/m3) DTLVS* 3,13,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (19 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (19 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (19 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (19 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 2 ppm (10 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (7.6 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (7.7 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (4 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 2 ppm (7.6 mg/m3), short term exposure limit 4 ppm, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 2 ppm (10 mg/m3), Skin, continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - GERMANY MAK 7.7 mg/m3 (2 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 8 mg/m3, short term exposure limit 32 mg/m3, Skin, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 1 ppm (3.8 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 2 ppm (10 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 2 ppm (10 mg/m3);
short term exposure limit 5 ppm (20 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (4 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (19 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 20 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (4 mg/m3);
short term exposure limit 2 ppm (8 mg/m3), Skin, Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (8 mg/m3);
KZG- week 4 ppm (16 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (19 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (4 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANILINE AND HOMOLOGS-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 06580;
Number of Industries 25;
Total Number of Facilities 1,868;
Number of Occupations 46;
Total Number of Employees Exposed 21,859
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 06580;
Number of Industries 21;
Total Number of Facilities 748;
Number of Occupations 39;
Total Number of Employees Exposed 41,988;
Total Number of Female Employees Exposed 14,949


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate or a starting material in the production of other chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aromatic, 2002


REFERENCES:

CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
APMIAL Acta Pathologica et Microbiologica Scandinavica. (Copenhagen, Denmark) V.1-77, 1924-69. For publisher information, see ACPADQ.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
IZSBAI Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Biologomeditsinskikh Nauk. (Novosibirsk, USSR) No.1-3, 1963-68. For publisher information, see ISBNBN.
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PJABDW Proceedings of the Japan Academy, Series B: Physical and Biological Sciences. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.53- 1977-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used as an intermediate or a starting material in the production of other chemicals

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us