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Allyl alcohol

RTECS #: BA5075000

CAS #: 107-18-6


UPDATE: May 2009 MW: 58.09 MF: C3H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Propenol - 3
  2. 1 - Propen - 3 - ol
  3. 2 - Propene - 1 - ol
  4. 2 - Propen - 1 - ol
  5. 2 - Propenyl alcohol
  6. 3 - Hydroxypropene
  7. AA
  8. Alcool allilco (Italian)
  9. Alcool allylique (French)
  10. Allilowy alkohol (Polish)
  11. Allyl alcohol (ACGIH:OSHA)
  1. Allylalkohol (German)
  2. Allylic alcohol
  3. Orvinylcarbinol
  4. Propen - 1 - ol - 3
  5. Propenol
  6. Propenyl alcohol
  7. RCRA waste number P005
  8. Shell unkrautted A
  9. Vinylcarbinol
  10. Weed drench


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
25 ppm severe AMIHAB 18,303,1958
eye
rabbit
20 mg severe AJOPAA 29,1363,1946
skin
rabbit
10 mg/24 hour open irritation test severe JIHTAB 30,63,1948


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 µmol/L (+enzymatic activation step) MUREAV 93,305,1982
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) TCMUD8 1,259,1980
mutation in mammalian somatic cells hamster lung 1 µmol/L CRNGDP 11,497,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 1 gm/m3 N/R GTPZAB 32(10),25,1988
inhalation
monkey
lowest published lethal concentration: 1,000 ppm/4 hour Gastrointestinal: Hypermotility, diarrhea

Blood: Hemorrhage

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JAMAAP 98,2269,1932
inhalation
mouse
lethal concentration (50 percent kill): 500 mg/m3/2 hour N/R 85GMAT -,17,1982
inhalation
mouse
lethal concentration (50 percent kill): 500 mg/m3/2 hour Cardiac: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse
VCVGK* -,121,1984
inhalation
rat
lethal concentration (50 percent kill): 76 ppm/8 hour Lung, Thorax, or Respiration: Acute pulmonary edema AMIHAB 18,303,1958
inhalation
rat
lowest published toxic concentration: 140 mg/m3 Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVGK* -,121,1984
inhalation
rat
lowest published toxic concentration: 200 mg/m3 Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVGK* -,121,1984
inhalation
rabbit
lowest published lethal concentration: 1,000 ppm/3.5 hour Eye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Blood: Hemorrhage
JAMAAP 98,2269,1932
intraperitoneal
mouse
lethal dose (50 percent kill): 60 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia
AMIHAB 18,303,1958
intraperitoneal
mouse
lowest published toxic dose: 64 mg/kg N/R ETOPFR 3,129,1997
intraperitoneal
mouse
lowest published toxic dose: 64 mg/kg Liver: Liver function tests impaired ETOPFR 3,129,1997
intraperitoneal
rat
lethal dose (50 percent kill): 37 mg/kg N/R TXAPA9 83,108,1986
intraperitoneal
rat
lowest published toxic dose: 5 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ETOPFR 18,149,2004
intraperitoneal
rat
lowest published toxic dose: 0.62 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 196,155,2004
intravenous
mouse
lethal dose (50 percent kill): 78 mg/kg N/R AIPTAK 135,330,1962
intravenous
rat
lowest published toxic dose: 125 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BCPCA6 67,2141,2004
oral
human
lowest published lethal dose: 0.43 mL/kg Lung, Thorax, or Respiration: Emphysema

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,121,1984
oral
mammal (species unspecified)
lethal dose (50 percent kill): 70 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse
lethal dose (50 percent kill): 96 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Behavioral: Ataxia
AMIHAB 18,303,1958
oral
mouse
lethal dose (50 percent kill): 75 mg/kg N/R VCVGK* -,121,1984
oral
rat
lethal dose (50 percent kill): 64 mg/kg N/R JIHTAB 30,63,1948
oral
rat
lowest published toxic dose: 0.5 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVGK* -,121,1984
oral
rat
lowest published toxic dose: 50 mg/kg Liver: Multiple effects FATOAO 50,100,1987
oral
rat
lowest published toxic dose: 50 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Liver function tests impaired
FATOAO 50,100,1987
oral
rat
lowest published toxic dose: 60 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Liver: Hepatitis (hepatocellular necrosis), zonal

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,199,2002
oral
rat
lowest published toxic dose: 0.1 mL/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
JTPAE7 15,95,2002
oral
rabbit
lethal dose (50 percent kill): 52 mg/kg N/R NTIS** OTS0571508
parenteral
frog
lowest published lethal dose: 51 mg/kg Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
AIPTAK 50,296,1935
subcutaneous
rabbit
lowest published lethal dose: 100 mg/kg N/R BDBU** -,-,1930
skin
rabbit
lethal dose (50 percent kill): 45 mg/kg N/R JIHTAB 30,63,1948
unreported route
dog
lowest published lethal dose: 4,270 µg/kg Behavioral: Coma

Gastrointestinal: Nausea or vomiting

Blood: Other changes
JPETAB 25,144,1925
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 66 mg/kg N/R GISAAA 51(5),61,1986
unreported route
rat
lowest published toxic dose: 120 mg/kg Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 44,104,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 60 ppm/7 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHAB 18,303,1958
oral
rat
lowest published toxic dose: 4,200 mg/kg/15 week- continuous Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 9,29,1978
oral
rat
lowest published toxic dose: 610 mg/kg/244 day- intermittent Liver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
VCVGK* -,121,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CHHSA* 9,6,2002
TOXICOLOGY REVIEW
ENTOX* -,80,2005
TOXICOLOGY REVIEW
DIMON* 39,678,1993


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (5 mg/m3) (skin) DTLVS* 3,7,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (4.8 mg/m3), short term exposure limit 4 ppm (9.5 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (4.8 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 4 ppm (9.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (5 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 2 ppm (4.8 mg/m3);
short term exposure limit 5 ppm (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 2 ppm (5 mg/m3), short term exposure limit 4 ppm (10 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 0.2 ppm (0.48 mg/m3), VLE 2 ppm (4.8 mg/m3), Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 4.8 mg/m3, short term exposure limit 12.1 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 1 ppm (2.4 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 2 ppm (5 mg/m3), short term exposure limit 4 ppm (10 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 2 ppm (5 mg/m3);
short term exposure limit 4 ppm (10 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 ppm (4.8 mg/m3);
short term exposure limit 4 ppm (9.5 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 1 ppm, JUN2003
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 ppm (5 mg/m3);
short term exposure limit 6 ppm (14 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (5 mg/m3),KZG- week 4 ppm (10 mg/m3), Skin, dayEC2006
Occupational Exposure Limit - TURKEY time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (4.8 mg/m3);
short term exposure limit 4 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALLYL ALCOHOL-air 10 hour time-weighted average 2 ppm (Sk);
short term exposure limit 4 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 04370;
Number of Industries 3;
Total Number of Facilities 69;
Number of Occupations 7;
Total Number of Employees Exposed 780
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 04370;
Number of Industries 3;
Total Number of Facilities 60;
Number of Occupations 4;
Total Number of Employees Exposed 3,246;
Total Number of Female Employees Exposed 157


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used without formulation for weed control and applied as a drench to tobacco beds
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BDBU** "Zur Pharmakologie Ungesattigter Alkohole, Dissertation," Bock, H., Pharmakologischen Institut der Universitat Breslau, Poland, 1930
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHHSA* Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used without formulation for weed control and applied as a drench to tobacco beds

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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