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Acrylic acid

RTECS #: AS4375000

CAS #: 79-10-7


UPDATE: May 2009 MW: 72.07 MF: C3H4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - Propenoic acid (9CI)
  2. Acroleic acid
  3. Acrylic acid, glacial
  4. Acrylic acid (ACGIH)
  5. Ethylenecarboxylic acid
  6. Glacial acrylic acid
  1. Kyselina akrylova (Czech)
  2. Propene acid
  3. Propenoic acid
  4. RCRA waste number U008
  5. Vinylformic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
1 mg severe UCDS** 2/2/1965
eye
rabbit
250 g/24 hour severe 85JCAE -,309,1986
skin
rabbit
500 mg open irritation test severe UCDS** 2/2/1965
skin
rabbit
5 mg/24 hour severe 85JCAE -,309,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 116 mg/L FCTOD7 30,505,1992
cytogenetic analysis mouse lymphocyte 450 mg/L EMMUEG 11,49,1988
mutation in mammalian somatic cells mouse lymphocyte 500 mg/L EMMUEG 11,49,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 300 ppm (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female
TOSCF2 48,240,1999
intraperitoneal
rat
lowest published toxic dose: 14,340 g/kg (5-15 day pregnant) Reproductive: Other developmental abnormalities JDREAF 51,1632,1972
intraperitoneal
rat
lowest published toxic dose: 7,329 g/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JDREAF 51,1632,1972
oral
rat
lowest published toxic dose: 169 gm/kg (13 week male/13 week prior to copulation-3 week after birth) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
DCTODJ 6,1,1983
oral
rat
lowest published toxic dose: 43,680 mg/kg (multigeneration) Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** OTS0573007


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 2,912 mg/kg/52 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CBINA8 61,189,1987
skin
mouse
lowest published toxic dose: 37,440 mg/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
EPASR* 8EHQ-0386-0592
skin
mouse
toxic dose : 37,440 mg/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
EPASR* 8EHQ-0386-0592


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 40 mg/m3 Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TOVEFN (4),23,2000
inhalation
monkey
lethal concentration : >75 ppm/6 hour Olfaction: Deviated nasal septum

Olfaction: Ulcerated nasal septum
TOXID9 36(1 Pt2),113,1997
inhalation
mouse
lethal concentration (50 percent kill): 5,300 mg/m3/2 hour N/R 85GMAT -,16,1982
inhalation
rat
lowest published lethal concentration: 4,000 ppm/4 hour N/R TXAPA9 28,313,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 144 mg/kg N/R YKKZAJ 104,793,1984
intraperitoneal
rat
lethal dose (50 percent kill): 22 mg/kg N/R JDREAF 51,1632,1972
oral
mouse
lethal dose (50 percent kill): 2,400 mg/kg Tumorigenic: Active as anti-cancer agent BIJOAK 34,1196,1940
oral
rat
lethal dose (50 percent kill): 33,500 g/kg N/R 85GMAT -,16,1982
subcutaneous
mouse
lethal dose (50 percent kill): 1,590 mg/kg N/R JPPMAB 21,85,1969
skin
rabbit
lethal dose (50 percent kill): 280 L/kg N/R TXAPA9 28,313,1974
unreported route
mouse
lethal dose (50 percent kill): 830 mg/kg N/R GISAAA 49(10),64,1984
unreported route
rat
lethal dose (50 percent kill): 1,250 mg/kg N/R GISAAA 49(10),64,1984
unreported route
rabbit
lethal dose (50 percent kill): 250 mg/kg N/R GISAAA 49(10),64,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 223 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 1,271,1981
inhalation
mouse
lowest published toxic concentration: 25 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 1,271,1981
inhalation
mouse
lowest published toxic concentration: 225 ppm/6 hour/10 day- intermittent Olfaction: Other olfaction effects

Behavioral: Muscle contraction or spasticity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555707
inhalation
rat
lowest published toxic concentration: 223 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 1,271,1981
inhalation
rat
lowest published toxic concentration: 75 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects FAATDF 1,271,1981
inhalation
rat
lowest published toxic concentration: 225 ppm/6 hour/10 day- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555707
oral
rat
lowest published toxic dose: 22,500 mg/kg/90 day- continuous Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight
DCTODJ 6,1,1983
skin
guinea pig
lowest published toxic dose: 5 pph/12 week- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 9,55,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 19,47,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 71,1223,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,47,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1223,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1223,1999
TOXICOLOGY REVIEW
ENTOX* -,45,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (5.9 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (6 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (5.9 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 2 ppm (6 mg/m3), VLE 10 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 30 mg/m3 (10 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (30 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5.9 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 ppm (5.9 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 5 mg/m3, short term exposure limit 15 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (30 mg/m3);
short term exposure limit 15 ppm (45 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (30 mg/m3);
KZG- week 10 ppm (30 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACRYLIC ACID-air 10 hour time-weighted average 2 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 03570;
Number of Industries 44;
Total Number of Facilities 1,679;
Number of Occupations 41;
Total Number of Employees Exposed 28,576
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 03570;
Number of Industries 74;
Total Number of Facilities 4,826;
Number of Occupations 67;
Total Number of Employees Exposed 96,535;
Total Number of Female Employees Exposed 28,146


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of plastics, acrylates, polyacrylic acids, polymers and resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8796
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #28


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used in manufacture of plastics, acrylates, polyacrylic acids, polymers and resins

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ACRYLIC ACID and ESTERS), SRC, 12/79

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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