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Acrylamide

RTECS #: AS3325000

CAS #: 79-06-1


UPDATE: May 2009 MW: 71.09 MF: C3H5NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - Propenamide
  2. 2 - Propenamide (9CI)
  3. Acrylamide (ACGIH:OSHA)
  4. Acrylamide monomer
  5. Acrylic amide
  6. Akrylamid (Czech)
  1. Amid kyseliny akrylove (Czech)
  2. Ethylenecarboxamide
  3. Propenamide
  4. Propenoic acid amide
  5. RCRA waste number U007
  6. Vinyl amide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
10 mg/30S rinse mild TXAPA9 6,172,1964
eye
rabbit
100 mg/24 hour moderate 28ZPAK -,54,1972
skin
rabbit
50 mg/3 day mild TXAPA9 6,172,1964
skin
rabbit
500 mg/24 hour mild 85JCAE -,337,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 150 mg/L ESKHA5 (103),64,1985
cytogenetic analysis hamster fibroblast 500 mg/L MUREAV 245,191,1990
cytogenetic analysis hamster lung 2 mmol/L MUREAV 577S,1,2005
cytogenetic analysis oral
mouse
500 ppm/2 week- intermittent MUREAV 57,313,1978
cytogenetic analysis mouse lymphocyte 750 mg/L ENMUDM 9,261,1987
cytogenetic analysis intraperitoneal
mouse
100 mg/kg MUREAV 209,91,1988
cytogenetic analysis mouse lung 50 mg/kg TOVEFN (4),25,1998
dominant lethal test intraperitoneal
mouse
125 mg/kg MUREAV 173,35,1986
dominant lethal test oral
mouse
840 mg/kg/20 week- continuous EMMUEG 17(Suppl 19),11,1991
dominant lethal test oral
rat
150 mg/kg/5 day- continuous MUTAEX 2,215,1987
DNA adduct human lung 320 mol/L/4 hour JNCIEQ 96,1023,2004
DNA adduct oral
mouse
3 mg/kg/3 day- intermittent MUREAV 580,131,2005
DNA adduct oral
mouse
50 mg/kg MUREAV 580,131,2005
DNA adduct intraperitoneal
mouse
1 mg/kg CRTOEC 16,1328,2003
DNA adduct mouse fibroblast 3.2 mmol/L/4 hour JNCIEQ 95,889,2003
DNA adduct unreported route
mouse
100 g/kg MUTAEX 19,499,2004
DNA adduct oral
rat
3 mg/kg/3 day- intermittent MUREAV 580,131,2005
DNA adduct intraperitoneal
rat
50 mg/kg MUREAV 580,131,2005
DNA adduct oral
rat
0.1 mg/kg TXAPA9 208,199,2005
DNA damage hamster lung 6 mmol/L/24 hour MUREAV 580,71,2005
DNA damage human other cell types 6 mmol/L/24 hour MUREAV 580,71,2005
DNA damage human mammary gland 2.1 mg/L/24 hour (-enzymatic activation step) MUREAV 588,47,2005
DNA damage human other cell types 10 mmol/L/4 hour (-enzymatic activation step) MUREAV 577S,1,2005
DNA damage human liver 10 mmol/L NSAPCC 372(Suppl 1),115,2006
DNA damage oral
mouse
50 mg/kg/4 day MUREAV 577S,1,2005
DNA damage unreported route
mouse
5 mg/kg MUREAV 577S,1,2005
DNA damage intraperitoneal
mouse
125 mg/kg/5 day MUREAV 577S,1,2005
DNA damage intraperitoneal
mouse
50 mg/kg MUREAV 603,145,2006
DNA damage mouse other cell types 12 mmol/L/4 hour FCTOD7 46,628,2008
DNA damage mouse fibroblast 3.2 mol/L/4 hour JNCIEQ 95,889,2003
DNA damage oral
rat
36 mg/kg MUREAV 580,119,2005
DNA damage oral
rat
50 mg/kg/4 day MUREAV 577S,1,2005
DNA inhibition rat other cell types 1 mmol/L TIVIEQ 2,69,1988
unscheduled DNA synthesis human mammary gland 1 mmol/L EMMUEG 20,148,1992
unscheduled DNA synthesis intraperitoneal
mouse
62,500 g/kg EMMUEG 16,137,1990
unscheduled DNA synthesis oral
rat
150 mg/kg/5 day- continuous EMMUEG 20,148,1992
unscheduled DNA synthesis oral
rat
14 mg/kg/7 day- continuous TOXID9 66,182,2002
host-mediated assay unreported route
mouse
500 mg/kg MUREAV 577S,1,2005
mutation in microorganisms mouse lymphocyte 300 mg/L (+enzymatic activation step) MUTAEX 3,263,1988
micronucleus test human other cell types 10 mmol/L/4 hour (-enzymatic activation step) MUREAV 577S,1,2005
micronucleus test mouse fibroblast 100 mg/L MUTAEX 16,145,2001
micronucleus test intraperitoneal
mouse
30 mg/kg MUREAV 535,215,2003
micronucleus test subcutaneous
mouse
50 mg/kg MUREAV 580,111,2005
micronucleus test oral
mouse
84 mg/kg/28 day EMMUEG 44,179,2004
micronucleus test oral
mouse
50 mg/kg/4 day MUREAV 577S,1,2005
micronucleus test intraperitoneal
mouse
125 mg/kg/5 day MUREAV 577S,1,2005
micronucleus test oral
mouse
125 mg/kg/3 week- continuous EMMUEG 47,6,2006
micronucleus test oral
mouse
75 mg/kg/3 day- intermittent MUREAV 649,101,2008
micronucleus test intraperitoneal
rat
100 mg/kg MUREAV 309,245,1994
micronucleus test oral
rat
75 mg/kg/3 day- intermittent MUREAV 649,101,2008
mutation in mammalian somatic cells mouse lymphocyte 500 mg/L ENMUDM 9,261,1987
morphological transform hamster embryo 0.5 mmol/L/7 day TOSCF2 65,177,2002
morphological transform mouse fibroblast 12,500 g/L CALEDQ 32,293,1986
morphological transform mouse embryo 25 mg/L CALEDQ 32,293,1986
sister chromatid exchange hamster lung 300 mg/L MUTAEX 3,263,1988
sister chromatid exchange hamster lung 200 mol/L/32 hour MUREAV 580,41,2005
sister chromatid exchange hamster lung 2 mmol/L MUREAV 577S,1,2005
sister chromatid exchange intraperitoneal
mouse
125 g/kg EMMUEG 13,218,1989
sister chromatid exchange oral
rat
600 mg/kg/10 day- continuous ENMUDM 7(Suppl 3),79,1985
sex chromosome loss and nondisjunction hamster lung 500 mg/L MUREAV 245,191,1990
sex chromosome loss and nondisjunction intraperitoneal
mouse
120 mg/kg MUREAV 367,195,1996
specific locus test oral
Drosophila melanogaster
1 mmol/L MUTAEX 3,263,1988
specific locus test human other cell types 10 mmol/L/4 hour (-enzymatic activation step) MUREAV 577S,1,2005
specific locus test intraperitoneal
mouse
50 mg/kg MUREAV 226,157,1989
specific locus test intraperitoneal
mouse
175 mg/kg/7 day MUREAV 540,141,2003
specific locus test oral
mouse
16.8 mg/kg/28 day EMMUEG 44,179,2004
specific locus test oral
mouse
25 mg/kg/3 week- continuous EMMUEG 47,6,2006
specific locus test oral
mouse
125 mg/kg/4 week- continuous EMMUEG 47,6,2006
sperm morphology intraperitoneal
mouse
100 mg/kg MUREAV 57,313,1978
sperm morphology oral
mouse
96,634 g/kg/4 week- continuous ARTODN 59,201,1986
heritable translocation test intraperitoneal
mouse
50 mg/kg MUREAV 309,285,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic dose: 225 mg/kg (5 day male) Reproductive: Other effects on male

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
REPTED 14,147,2000
inhalation
rat
lowest published toxic concentration: 300 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOSCF2 48,240,1999
intraperitoneal
mammal (species unspecified)
lowest published toxic dose: 75 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system MUREAV 226,157,1989
intraperitoneal
mammal (species unspecified)
lowest published toxic dose: 225 mg/kg (10-12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
MUREAV 226,157,1989
intraperitoneal
mouse
lowest published toxic dose: 225 mg/kg (10-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
MUREAV 226,157,1989
intraperitoneal
mouse
lowest published toxic dose: 125 mg/kg (1 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CGANE7 34,35,1994
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg (5 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
CGANE7 34,35,1994
intraperitoneal
mouse
lowest published toxic dose: 300 mg/kg (8-10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CGANE7 34,35,1994
intraperitoneal
mouse
lowest published toxic dose: 125 mg/kg (1 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) REPTED 17,1,2003
intraperitoneal
rat
lowest published toxic dose: 350 mg/kg (7 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NRTXDN 13,219,1992
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg (8 day male) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Behavioral
NRTXDN 13,219,1992
oral
mouse
lowest published toxic dose: 571 mg/kg (16 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ARTODN 47,179,1981
oral
mouse
lowest published toxic dose: 95 gm/kg (4 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
ARTODN 59,201,1986
oral
mouse
lowest published toxic dose: 95 gm/kg (4 week prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ARTODN 59,201,1986
oral
mouse
lowest published toxic dose: 71 gm/kg (4 week male) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) ARTODN 59,201,1986
oral
mouse
lowest published toxic dose: 840 mg/kg (20 week male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) EMMUEG 17,11,1991
oral
mouse
lowest published toxic dose: 3,462.48 mg/kg (189 day male/189 day prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** PB93-158285
oral
mouse
lowest published toxic dose: 1,282.4 mg/kg (140 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
NTIS** PB93-158285
oral
mouse
lowest published toxic dose: 2.39 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** PB93-158285
oral
mouse
lowest published toxic dose: 540 mg/kg (6-17 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** #PB89-140008/AS
oral
mouse
lowest published toxic dose: 180 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB89-140008/AS
oral
mouse
lowest published toxic dose: 308 mg/kg (1 week male/1 week prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) REPTED 17,1,2003
oral
mouse
lowest published toxic dose: 8.8 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) REPTED 17,1,2003
oral
mouse
lowest published toxic dose: 8.8 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 17,1,2003
oral
mouse
lowest published toxic dose: 862.4 mg/kg (98 day male) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 17,1,2003
oral
mouse
lowest published toxic dose: 862.4 mg/kg (98 day prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Other measures of fertility
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 200 mg/kg (7-16 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TOLED5 7,233,1981
oral
rat
lowest published toxic dose: 560 mg/kg (6-21 day pregnant/10 day after birth) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
NETEEC 17,189,1995
oral
rat
lowest published toxic dose: 75 mg/kg (5 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TJADAB 35,37A,1987
oral
rat
lowest published toxic dose: 140 mg/kg (2 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JTEHD6 17,457,1986
oral
rat
lowest published toxic dose: 150 mg/kg (5 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
MUTAEX 2,215,1987
oral
rat
lowest published toxic dose: 225 mg/kg (5 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 14,147,2000
oral
rat
lowest published toxic dose: 945 mg/kg (70 day male/70 day prior to copulation-4 week after birth) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 14,385,2000
oral
rat
lowest published toxic dose: 945 mg/kg (70 day male/70 day prior to copulation-4 week after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
REPTED 14,385,2000
oral
rat
lowest published toxic dose: 378 mg/kg (70 day male/70 day prior to copulation-4 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
REPTED 14,385,2000
oral
rat
lowest published toxic dose: 945 mg/kg (multigeneration)) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 14,385,2000
oral
rat
lowest published toxic dose: 945 mg/kg (multigeneration)) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
REPTED 14,385,2000
oral
rat
lowest published toxic dose: 35 mg/kg (70 day male/70 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) REPTED 14,385,2000
oral
rat
lowest published toxic dose: 700 mg/kg (10 week male/10 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) REPTED 17,1,2003
oral
rat
lowest published toxic dose: 810 mg/kg (10 week male/10 week prior to copulation/22 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 2 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) REPTED 17,1,2003
oral
rat
lowest published toxic dose: 5 mg/kg (multigenerations) Reproductive: Other developmental abnormalities REPTED 17,1,2003
oral
rat
lowest published toxic dose: 5 mg/kg (multigenerations) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 2 mg/kg (multigenerations) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 350 mg/kg (10 week male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 700 mg/kg (56 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 700 mg/kg (56 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 560 mg/kg (2 week prior to copulation/21 day pregnant/21 day after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 280 mg/kg (2 week prior to copulation/21 day pregnant/21 day after birth) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) REPTED 17,1,2003
oral
rat
lowest published toxic dose: 336 mg/kg (4 week male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 35 mg/kg (4 week male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) REPTED 17,1,2003
oral
rat
lowest published toxic dose: 70 mg/kg (4 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 17,1,2003
oral
rat
lowest published toxic dose: 16 mg/kg (7-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NETEEC 27,553,2005
oral
rat
lowest published toxic dose: 160 mg/kg (7-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
NETEEC 27,553,2005
oral
rat
lowest published toxic dose: 32.1 mg/kg (6 day pregnant-91 day after birth) Reproductive: Effects on newborn: Behavioral NETEEC 29,407,2007
oral
rat
lowest published toxic dose: 80 mg/kg (6 day pregnant-22 day after birth) Reproductive: Effects on newborn: Behavioral NETEEC 29,407,2007
oral
rat
lowest published toxic dose: 150 mg/kg (7-21 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TERP2* -,312,2004
oral
rat
lowest published toxic dose: 148.5 mg/kg (10-22 day pregnant/2 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JTSCDR 33,11,2008
oral
rat
lowest published toxic dose: 567.8 mg/kg (10-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
JTSCDR 33,11,2008
oral
rat
lowest published toxic dose: 567.8 mg/kg (10-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JTSCDR 33,11,2008
oral
rat
lowest published toxic dose: 754.8 mg/kg (10-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
JTSCDR 33,11,2008
oral
rat
lowest published toxic dose: 754.8 mg/kg (10-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JTSCDR 33,11,2008


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 24 mg/kg/8 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 44,107,1984
intraperitoneal
mouse
toxic dose : 72 mg/kg/8 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 44,107,1984
oral
mouse
lowest published toxic dose: 300 mg/kg/2 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
CALEDQ 24,209,1984
oral
rat
lowest published toxic dose: 1,456 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Testicular tumors
TXAPA9 85,154,1986
oral
rat
toxic dose : 1,456 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors
TXAPA9 85,154,1986
oral
rat
toxic dose : 1,460 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors
NTIS** OTS0555720


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 170 mg/kg N/R TXAPA9 33,142,1975
intraperitoneal
rat
lethal dose (50 percent kill): 90 mg/kg N/R AMPMAR 36,58,1975
intravenous
mammal (species unspecified)
lowest published lethal dose: 190 mg/kg N/R COREAF 153,895,1911
oral
guinea pig
lethal dose (50 percent kill): 150 mg/kg N/R TXAPA9 6,172,1964
oral
mammal (species unspecified)
lethal dose (50 percent kill): 100 mg/kg N/R KASEAA 17,495,1979
oral
mouse
lethal dose (50 percent kill): 107 mg/kg N/R ARTODN 47,179,1981
oral
quail
lethal dose (50 percent kill): 186 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Change in motor activity (specific assay)
JTEHD6 7,935,1981
oral
rat
lethal dose (50 percent kill): 124 mg/kg N/R AMPMAR 36,58,1975
oral
rat
lowest published toxic dose: 50 mg/kg Blood: Other changes TOXID9 72(Suppl 1),248,2003
oral
rat
lowest published toxic dose: 50 mg/kg Blood: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOSCF2 71,164,2003
oral
rabbit
lethal dose (50 percent kill): 150 mg/kg N/R TXAPA9 6,172,1964
subcutaneous
guinea pig
lethal dose (50 percent kill): 170 mg/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Gastrointestinal: Nausea or vomiting
MELAAD 47,192,1956
skin
rat
lethal dose (50 percent kill): 400 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases
GISAAA 44(10),73,1979
skin
rabbit
lethal dose (50 percent kill): 1,680 L/kg Behavioral: Hallucinations, distorted perceptions ATDAEI 1,115,1990
skin
rabbit
lethal dose (50 percent kill): 1,150 mg/kg N/R ENTOX* -,42,2005
unreported route
guinea pig
lethal dose (50 percent kill): 173 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
GISAAA 43(9),38,1978
unreported route
mouse
lethal dose (50 percent kill): 156 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
GISAAA 43(9),38,1978
unreported route
rat
lethal dose (50 percent kill): 208 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
GISAAA 43(9),38,1978
unreported route
rabbit
lethal dose (50 percent kill): 280 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
GISAAA 43(9),38,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
cat
lowest published toxic dose: 300 mg/kg/10 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Muscle weakness
TXAPA9 88,175,1987
intraperitoneal
monkey
lowest published toxic dose: 200 mg/kg/2 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 6,172,1964
intraperitoneal
mouse
lowest published toxic dose: 1,200 mg/kg/4 week- intermittent Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 63,470,1982
intraperitoneal
mouse
lowest published toxic dose: 400 mg/kg/8 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NEZAAQ 50,292,1995
intraperitoneal
mouse
lowest published toxic dose: 400 mg/kg/8 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NRTXDN 28,252,2007
intraperitoneal
rat
lowest published toxic dose: 108 mg/kg/3 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
NETEEC 14,273,1992
intraperitoneal
rat
lowest published toxic dose: 168 mg/kg/2 week- continuous Behavioral: Muscle weakness TXAPA9 40,589,1977
intraperitoneal
rat
lowest published toxic dose: 780 mg/kg/13 week- intermittent Spinal Cord: Demyelination

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Ataxia
FAATDF 18,343,1992
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg/8 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
ENVRAL 61,37,1993
intraperitoneal
rat
lowest published toxic dose: 120 mg/kg/12 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
WDZAEK 6,71,1992
intraperitoneal
rat
lowest published toxic dose: 550 mg/kg/11 day- intermittent Behavioral: Ataxia

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
NRTXDN 22,341,2001
intraperitoneal
rat
lowest published toxic dose: 300 mg/kg/2 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Muscle weakness

Biochemical: Metabolism (intermediary): Other
NETEEC 22,247,2000
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg/8 day- intermittent Behavioral: Muscle weakness

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 23,95,2002
intraperitoneal
rat
lowest published toxic dose: 550 mg/kg/11 day- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 23,397,2002
intraperitoneal
rat
lowest published toxic dose: 550 mg/kg/11 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Behavioral: Ataxia
TXAPA9 188,135,2003
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg/8 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Ataxia
NRTXDN 23,397,2002
intraperitoneal
rat
lowest published toxic dose: 550 mg/kg/11 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 23,397,2002
intraperitoneal
rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent Spinal Cord: Other degenerative changes NRTXDN 23,415,2002
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg/8 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Ataxia
NRTXDN 23,415,2002
intraperitoneal
rat
lowest published toxic dose: 550 mg/kg/11 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 23,415,2002
intraperitoneal
rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 23,95,2002
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg/8 day- intermittent Behavioral: Muscle weakness NRTXDN 23,95,2002
intraperitoneal
rat
lowest published toxic dose: 500 mg/kg/10 day- intermittent Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 44,316,2005
intraperitoneal
rat
lowest published toxic dose: 600 mg/kg/12 day- intermittent Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 44,317,2005
intraperitoneal
rat
lowest published toxic dose: 500 mg/kg/10 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Ataxia

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,62,2004
intraperitoneal
rat
lowest published toxic dose: 450 mg/kg/9 day- intermittent Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia

Biochemical: Metabolism (intermediary): Effect on Na-K pump
TOXID9 66,15,2002
intraperitoneal
rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent Brain and Coverings: Other degenerative changes TOXID9 66,17,2002
intraperitoneal
rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Muscle weakness

Behavioral: Ataxia
TOXID9 60,366,2001
intraperitoneal
rat
lowest published toxic dose: 480 mg/kg/8 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 217,46,2006
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg/8 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Muscle weakness

Behavioral: Ataxia
NRTXDN 28,252,2007
intraperitoneal
rat
lowest published toxic dose: 450 mg/kg/3 week- intermittent Behavioral: Ataxia FCTOD7 45,2126,2007
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg/1 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) FCTOD7 45,2126,2007
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg/2 week- intermittent Kidney, Ureter, and Bladder: Proteinuria FCTOD7 45,2126,2007
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg/1 week- intermittent Kidney, Ureter, and Bladder: Proteinuria FCTOD7 45,2126,2007
intravenous
monkey
lowest published toxic dose: 200 mg/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 6,172,1964
multiple
non-mammalian species
lowest published toxic dose: 59 gm/m3/4 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 22,263,2006
oral
cat
lowest published toxic dose: 771 mg/kg/1 year- intermittent Behavioral: Muscle weakness TXAPA9 6,172,1964
oral
chicken
lowest published toxic dose: 450 mg/kg/3 week- intermittent Behavioral: Muscle weakness

Behavioral: Ataxia
BJIMAG 32,31,1975
oral
dog
lowest published toxic dose: 330 mg/kg/22 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Muscle weakness

Behavioral: Ataxia
ARZNAD 23,1566,1973
oral
dog
lowest published toxic dose: 392 mg/kg/8 week- intermittent Behavioral: Muscle weakness

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting
JNNPAU 44,906,1981
oral
monkey
lowest published toxic dose: 671 mg/kg/75 week- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Change in motor activity (specific assay)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 6,172,1964
oral
monkey
lowest published toxic dose: 450 mg/kg/61 day- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve TXAPA9 71,266,1983
oral
mouse
lowest published toxic dose: 568 mg/kg/8 week- intermittent Related to Chronic Data: Changes in testicular weight ARTODN 47,179,1981
oral
mouse
lowest published toxic dose: 5.04 mg/kg/1 week- continuous Behavioral: Fluid intake NTIS** PB93-158285
oral
mouse
lowest published toxic dose: 451.71 mg/kg/27 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** PB93-158285
oral
mouse
lowest published toxic dose: 105 mg/kg/3 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Change in motor activity (specific assay)
TOLED5 135,S52,2002
oral
mouse
lowest published toxic dose: 210 mg/kg/3 week- intermittent Behavioral: Muscle weakness

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 135,S52,2002
oral
mouse
lowest published toxic dose: 540 mg/kg/12 day- intermittent Behavioral: Muscle weakness

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB89-140008/AS
oral
mouse
lowest published toxic dose: 238 mg/kg/17 week- continuous Behavioral: Muscle weakness REPTED 17,1,2003
oral
mouse
lowest published toxic dose: 238 mg/kg/17 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct REPTED 17,1,2003
oral
mouse
lowest published toxic dose: 2,058 mg/kg/3 week- continuous Behavioral: Fluid intake EMMUEG 47,6,2006
oral
mouse
lowest published toxic dose: 2,100 mg/kg/3 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 -,78,2008
oral
rat
lowest published toxic dose: 1,035 mg/kg/15 week- intermittent Behavioral: Muscle weakness

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTOTDY 5,91,1983
oral
rat
lowest published toxic dose: 608 mg/kg/16 day- continuous Spinal Cord: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTOTDY 3,487,1981
oral
rat
lowest published toxic dose: 1,800 mg/kg/90 day- continuous Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JEPTDQ 4(5/6),157,1980
oral
rat
lowest published toxic dose: 600 mg/kg/6 week- continuous Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
NTOTDY 4,355,1982
oral
rat
lowest published toxic dose: 286 mg/kg/28 day- continuous Brain and Coverings: Changes in brain weight

Cardiac: Changes in heart weight

Blood: Pigmented or nucleated red blood cells
WATRAG 24,661,1990
oral
rat
lowest published toxic dose: 680 mg/kg/34 day- continuous Behavioral: Ataxia

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
NRTXDN 22,341,2001
oral
rat
lowest published toxic dose: 75 mg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 14,147,2000
oral
rat
lowest published toxic dose: 225 mg/kg/5 day- intermittent Behavioral: Alteration of classical conditioning REPTED 14,147,2000
oral
rat
lowest published toxic dose: 300 mg/kg/5 day- intermittent Behavioral: Sleep

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
REPTED 14,147,2000
oral
rat
lowest published toxic dose: 56 mg/kg/28 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 14,385,2000
oral
rat
lowest published toxic dose: 28 mg/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 14,385,2000
oral
rat
lowest published toxic dose: 84 mg/kg/42 day- continuous Behavioral: Food intake (animal) REPTED 14,385,2000
oral
rat
lowest published toxic dose: 3.5 mg/kg/70 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Change in motor activity (specific assay)
REPTED 14,385,2000
oral
rat
lowest published toxic dose: 112.5 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB89-164669/AS
oral
rat
lowest published toxic dose: 546 mg/kg/26 day- intermittent Behavioral: Muscle weakness

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 23,95,2002
oral
rat
lowest published toxic dose: 294 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Ataxia
NRTXDN 23,397,2002
oral
rat
lowest published toxic dose: 798 mg/kg/38 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NRTXDN 23,397,2002
oral
rat
lowest published toxic dose: 21 mg/kg/4 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 17,1,2003
oral
rat
lowest published toxic dose: 21 mg/kg/4 week- continuous Brain and Coverings: Other degenerative changes REPTED 17,1,2003
oral
rat
lowest published toxic dose: 460 mg/kg/92 day- continuous Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 17,1,2003
oral
rat
lowest published toxic dose: 560 mg/kg/56 day- continuous Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) REPTED 17,1,2003
oral
rat
lowest published toxic dose: 280 mg/kg/56 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 17,1,2003
oral
rat
lowest published toxic dose: 336 mg/kg/4 week- continuous Behavioral: Muscle weakness REPTED 17,1,2003
oral
rat
lowest published toxic dose: 597.2 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JESEDU A22,639,1987
oral
rat
lowest published toxic dose: 298.6 mg/kg/10 day- intermittent Liver: Changes in liver weight JESEDU A22,639,1987
oral
rat
lowest published toxic dose: 588 mg/kg/28 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Behavioral: Ataxia
TXAPA9 188,135,2003
oral
rat
lowest published toxic dose: 294 mg/kg/14 day- continuous Brain and Coverings: Other degenerative changes

Behavioral: Ataxia
NRTXDN 23,397,2002
oral
rat
lowest published toxic dose: 798 mg/kg/38 day- continuous Brain and Coverings: Other degenerative changes

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 23,397,2002
oral
rat
lowest published toxic dose: 588 mg/kg/28 day- continuous Spinal Cord: Other degenerative changes

Behavioral: Ataxia
NRTXDN 23,415,2002
oral
rat
lowest published toxic dose: 798 mg/kg/38 day- continuous Spinal Cord: Other degenerative changes

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 23,415,2002
oral
rat
lowest published toxic dose: 231 mg/kg/11 day- continuous Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 23,95,2002
oral
rat
lowest published toxic dose: 378 mg/kg/18 day- continuous Behavioral: Muscle weakness NRTXDN 23,95,2002
oral
rat
lowest published toxic dose: 150 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 19,527,2005
oral
rat
lowest published toxic dose: 25 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Endocrine: Androgenic
REPTED 19,527,2005
oral
rat
lowest published toxic dose: 300 mg/kg/5 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct REPTED 19,527,2005
oral
rat
lowest published toxic dose: 980 mg/kg/49 day- continuous Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 44,316,2005
oral
rat
lowest published toxic dose: 980 mg/kg/49 day- continuous Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 44,317,2005
oral
rat
lowest published toxic dose: 980 mg/kg/49 day- continuous Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,62,2004
oral
rat
lowest published toxic dose: 1,219 mg/kg/49 day- continuous Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia

Biochemical: Metabolism (intermediary): Effect on Na-K pump
TOXID9 66,15,2002
oral
rat
lowest published toxic dose: 560 mg/kg/4 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
ARTODN 79,531,2005
oral
rat
: 550 mg/kg/11 day- intermittent Brain and Coverings: Other degenerative changes

Endocrine: Evidence of thyroid hypofunction

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPTO* 26,198,2006
oral
rat
: 350 mg/kg/7 day- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAPTO* 26,198,2006
oral
rat
: 250 mg/kg/5 day- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change JAPTO* 26,198,2006
oral
rat
lowest published toxic dose: 12,250 g/kg/7 week- continuous Behavioral: Muscle weakness TXCYAC 219,133,2006
oral
rat
lowest published toxic dose: 1,750 g/kg/10 week- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
TXCYAC 219,133,2006
oral
rat
lowest published toxic dose: 350 g/kg/10 week- continuous Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes
TXCYAC 219,133,2006
oral
rat
lowest published toxic dose: 35 g/kg/10 week- continuous Liver: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 219,133,2006
oral
rat
lowest published toxic dose: 210 mg/kg/1 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTPAE7 17,37,2004
oral
rat
lowest published toxic dose: 1,050 mg/kg/5 week- intermittent Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 17,37,2004
oral
rat
lowest published toxic dose: 1,890 mg/kg/9 week- intermittent Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 17,37,2004
oral
rat
lowest published toxic dose: 630 mg/kg/3 week- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change JTPAE7 17,37,2004
oral
rat
lowest published toxic dose: 1,050 mg/kg/5 week- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change JTPAE7 17,37,2004
oral
rat
lowest published toxic dose: 111 mg/kg/5 day- continuous Behavioral: Fluid intake JTSCDR 33,11,2008
oral
rat
lowest published toxic dose: 244.2 mg/kg/11 day- continuous Behavioral: Fluid intake

Behavioral: Ataxia
JTSCDR 33,11,2008
oral
rat
lowest published toxic dose: 344 mg/kg/20 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 33,11,2008
oral
rat
lowest published toxic dose: 567.8 mg/kg/34 day- continuous Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath
JTSCDR 33,11,2008
oral
rat
lowest published toxic dose: 450.9 mg/kg/27 day- continuous Behavioral: Ataxia JTSCDR 33,11,2008
oral
rat
lowest published toxic dose: 700 mg/kg/14 day- continuous Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 230,208,2008
oral
rat
lowest published toxic dose: 35 mg/kg/14 day- continuous Endocrine: Other changes TXAPA9 230,208,2008
subcutaneous
cat
lowest published toxic dose: 150 mg/kg/10 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXAPA9 60,324,1981
subcutaneous
rat
lowest published toxic dose: 1,155 mg/kg/13 week- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ENVRAL 63,229,1993
subcutaneous
rat
lowest published toxic dose: 1 gm/kg/8 week- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Peripheral Nerve and Sensation: Structural change in nerve or sheath
TXAPA9 139,15,1996
subcutaneous
rat
lowest published toxic dose: 400 mg/kg/10 day- intermittent Behavioral: Muscle weakness

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JOCHFV 41,181,1999
unreported route
rat
lowest published toxic dose: 42 mg/kg/3 week- intermittent Brain and Coverings: Changes in cerebral spinal fluid

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 197,318,2004
unreported route
rat
lowest published toxic dose: 400 mg/kg/8 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum TOXID9 44,315,2005
unreported route
rat
lowest published toxic dose: 441 mg/kg/21 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum TOXID9 44,315,2005
unreported route
rat
lowest published toxic dose: 714 mg/kg/34 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 90,495,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.03 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 39,41,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,389,1994
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,41,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,389,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 60,389,1994
TOXICOLOGY REVIEW
NRTXDN 23,265,2002
TOXICOLOGY REVIEW
NRTXDN 23,259,2002
TOXICOLOGY REVIEW
NRTXDN 23,253,2002
TOXICOLOGY REVIEW
NRTXDN 23,43,2002
TOXICOLOGY REVIEW
NRTXDN 23,223,2002
TOXICOLOGY REVIEW
NTOTDY 3,445,1981
TOXICOLOGY REVIEW
TOPADD 14,279,2001
TOXICOLOGY REVIEW
TOLED5 140-141,43,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 580,21,2005
TOXICOLOGY REVIEW
MUREAV 580,143,2005
TOXICOLOGY REVIEW
MUREAV 580,167,2005
TOXICOLOGY REVIEW
ENTOX* -,42,2005
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
IJTOFN 24,21,2005
TOXICOLOGY REVIEW
CRTXB2 36,481,2006
TOXICOLOGY REVIEW
HETOEA 23,357,2004
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 580,31,2005
TOXICOLOGY REVIEW
MUREAV 580,21,2005
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
BDERB* 74,17,2005
TOXICOLOGY REVIEW
CRNGDP 28,519,2007
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 659,68,2008
TOXICOLOGY REVIEW
FCTOD7 46,1360,2008
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.3 mg/m3 (skin) DTLVS* 3,5,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.3 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.3 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.3 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.3 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.3 mg/m3, Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.03 mg/m3, JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.06 mg/m3, JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.03 mg/m3, Skin, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.03 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.3 mg/m3, short term exposure limit 0.9 mg/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.3 mg/m3), Skin, continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY ceiling concentration 0.03 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg/m3, skin, 2A carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.03 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.03 mg/m3;
short term exposure limit 0.06 mg/m3 (skin), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.03 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.3 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.3 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.03 mg/m3;
short term exposure limit 0.1 mg/m3, Carcinogen, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.03 mg/m3, Skin, Carcinogen, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.3 mg/m3 (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACRYLAMIDE-air Carcinogen;
10 hour time-weighted average 0.03 mg/m3 (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 03540;
Number of Industries 10;
Total Number of Facilities 442;
Number of Occupations 24;
Total Number of Employees Exposed 7,047
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 03540;
Number of Industries 19;
Total Number of Facilities 453;
Number of Occupations 22;
Total Number of Employees Exposed 10,651;
Total Number of Female Employees Exposed 721


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Cytogenetics-male germ cell
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in the manufacture of plastics, resins, rubber, synthetic textiles, as a dye, pigment
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 10th Report on Carcinogens,2002:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #21


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BDERB*
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HTOPA*
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JESEDU Journal of Environmental Science and Health, Part A: Environmental Science and Engineering. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.A11- 1976-
JNCIEQ Journal of the National Cancer Institute (1988). (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.80- 1988-
JNNPAU Journal of Neurology, Neurosurgery and Psychiatry. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.7- 1944-
JOCHFV Journal of Occupational Health. (Japan Society for Occupational Health, 1-29-8 Shinjuku, Shinjuku-ku, Tokyo, 160, Japan) V.38- 1996-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
KASEAA Kagaku to Seibutsu. Chemistry and Biology. (Gakkai Shuppan Senta, 6-2-10 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1962-
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TERP2*
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WATRAG Water Research. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1967-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used in the manufacture of plastics, resins, rubber, synthetic textiles, as a dye, pigment

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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