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Acetimidic acid, thio - N - ( (methylcarbamoyl) oxy) - , methyl ester

RTECS #: AK2975000

CAS #: 16752-77-5


UPDATE: May 2009 MW: 162.23 MF: C5H10N2O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1N - X1179 - 412
  2. 2 - Methylthio - acetaldehyd - O - (methylcarbamoyl) - oxim (German)
  3. 2 - Methylthio - propionaldehyd - O - (methylcarbamoyl) - oxim (German)
  4. 3 - Thiabutan - 2 - one, O - (methylcarbamoyl) oxime
  5. Acetimidic acid, N - ( (methylcarbamoyl) oxy) thio - , methyl ester (8CI)
  6. Acetimidothioic acid, methyl - , N - (methylcarbamoyl) ester
  7. DPX - X1179 - 412
  8. Du Pont insecticide 1179
  9. Dupont 1179
  10. ENT 27,341
  11. Ethanimidothioic acid, N - ( ( (methylamino) carbonyl) oxy) - , methyl ester (9CI)
  12. IN 1179
  13. Insecticide 1,179
  14. Lannate
  15. Lannate 10L candidate
  16. Lannate L
  17. Lannate LV
  1. Mesomile
  2. Methomex
  3. Methomyl
  4. Methomyl (ACGIH)
  5. Methyl N - ( ( (methylamino) carbonyl) oxy) ethanimidothioate
  6. Methyl O - (methylcarbamoyl) thiolacethohydroxamate
  7. Methyl - N - ( (methylcarbamoyl) oxy) thioacetimidate
  8. Metomil (Italian)
  9. N - ( ( (Methylamino) carbonyl) oxy) ethanimidothioic acid methyl ester
  10. N - ( (Methylcarbamoyl) oxy) thioacetimidic acid methyl ester
  11. NU - Bait II
  12. Nudrin
  13. RCRA waste number P066
  14. S - Methyl N - (methylcarbamoyloxy) thioacetimidate
  15. S - Methyl N - (methylcarbamoyloxy) thioacetimidate
  16. SD 14999
  17. WL 18236


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 1.3 mg/L/2 hour FCTOD7 45,928,2007
cytogenetic analysis human lymphocyte 180 µmol/L EMMUEG 23,306,1994
cytogenetic analysis oral
mouse
20 mg/kg ENVRAL 42,362,1987
DNA damage human lymphocyte 500 µmol/L EMMUEG 23,306,1994
DNA damage human lymphocyte 1 mmol/L EMMUEG 23,306,1994
DNA damage intraperitoneal
mouse
5 mg/kg EMMUEG 24,235,1994
DNA damage intraperitoneal
mouse
10 mg/kg EMMUEG 24,235,1994
mutation in microorganisms Saccharomyes cerevisiae 50 ppm (-enzymatic activation step) RSTUDV 6,161,1976
micronucleus test human lymphocyte 10 µmol/L EMMUEG 23,306,1994
sperm morphology oral
mouse
20 mg/kg ENVRAL 42,362,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
duck
lethal concentration (50 percent kill): 1,890 ppm N/R TXAPA9 40,1,1977
inhalation
quail
lethal concentration (50 percent kill): 3,680 ppm N/R TXAPA9 40,1,1977
inhalation
rat
lethal concentration (50 percent kill): 77 ppm/4 hour Eye: Lacrimation

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 40,1,1977
inhalation
rat
lethal concentration (50 percent kill): 450 mg/m3 N/R HBPTO* 2,1094,2001
inhalation
rat
lethal concentration (50 percent kill): 0.3 gm/m3/4 hour N/R ENTOX* -,57,2005
intraperitoneal
mouse
lowest published toxic dose: 5.2 mg/kg Behavioral: Convulsions or effect on seizure threshold TOSCF2 72,289,2003
intraperitoneal
mouse
lowest published lethal dose: 6.4 mg/kg Behavioral: Convulsions or effect on seizure threshold TOSCF2 72,289,2003
intraperitoneal
rat
lethal dose (50 percent kill): 6,290 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Straub Tail
ETOPFR 7,119,1999
intraperitoneal
rat
lowest published toxic dose: 7.5 mg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TXAPA9 219,122,2007
oral
wild bird
lethal dose (50 percent kill): 10 mg/kg N/R TXAPA9 21,315,1972
oral
chicken
lethal dose (50 percent kill): 28 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 40,1,1977
oral
chicken
lethal dose (50 percent kill): 28 mg/kg N/R ENTOX* -,57,2005
oral
duck
lethal dose (50 percent kill): 15 mg/kg N/R SHELL*
oral
dog
lethal dose (50 percent kill): 20 mg/kg N/R 85INA8 6,906,1991
oral
guinea pig
lowest published lethal dose: 15 mg/kg N/R TXAPA9 40,1,1977
oral
human
lethal dose : 12 mg/kg Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1097,2001
oral
monkey
lowest published lethal dose: 40 mg/kg N/R TXAPA9 40,1,1977
oral
mouse
lethal dose (50 percent kill): 10 mg/kg N/R JAFCAU 26,550,1978
oral
pigeon
lethal dose (50 percent kill): 10 mg/kg N/R ASTTA8 (680),157,1979
oral
quail
lethal dose (50 percent kill): 23,700 µg/kg N/R ASTTA8 (680),157,1979
oral
rat
lethal dose (50 percent kill): 12 mg/kg N/R HBPTO* 2,1094,2001
oral
rat
lowest published toxic dose: 0.6 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 44,395,2005
oral
rat
lowest published toxic dose: 0.1 mg/kg Behavioral: Change in motor activity (specific assay) TOXID9 44,397,2005
subcutaneous
rat
lethal dose (50 percent kill): 9 mg/kg N/R TXAPA9 25,569,1973
skin
rat
lethal dose (50 percent kill): 1,000 mg/kg N/R HBPTO* 2,1094,2001
skin
rabbit
lethal dose (50 percent kill): 556 mg/kg N/R HBPTO* 2,1094,2001
unreported route
rat
lethal dose (50 percent kill): 17 mg/kg N/R VCVGK* -,512,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 18,200 mg/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in bone marrow not included in above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 40,1,1977
oral
rat
lowest published toxic dose: 14,700 µg/kg/5 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
WDZAEK 6,37,1992
oral
rat
lowest published toxic dose: 102 mg/kg/60 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
JDGRAX 22,259,1998
oral
rat
lowest published toxic dose: 15,960 mg/kg/95 week- continuous Blood: Changes in bone marrow not included in above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 40,1,1977
oral
rat
lowest published toxic dose: 264 mg/kg/33 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
CMSHAF 23,375,1991
oral
rat
lowest published toxic dose: 9 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JDGRAX 18,145,1989
skin
rabbit
lowest published toxic dose: 3 gm/kg/3 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 40,1,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,57,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
FEREAC 71,43906,2006
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,131,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 2.5 mg/m3, Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 2.5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2.5 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2.5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, MAR2004
Occupational Exposure Limit - SWITZERLAND MAK- week 2.5 mg/m3, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHOMYL-air 10 hour time-weighted average 2.5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: B0027;
Number of Industries 1;
Total Number of Facilities 15;
Number of Occupations 1;
Total Number of Employees Exposed 2,367;
Total Number of Female Employees Exposed 1,288


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
Used as insecticide in many vegetables, field crops, certain fruit crops and ornamentals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used as insecticide in many vegetables, field crops, certain fruit crops and ornamentals

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

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