CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Acetic anhydride

RTECS #: AK1925000

CAS #: 108-24-7


UPDATE: May 2009 MW: 102.10 MF: C4H6O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acetanhydride
  2. Acetic acid, anhydride (9CI)
  3. Acetic anhydride (ACGIH:OSHA)
  4. Acetic oxide
  5. Acetyl ether
  6. Acetyl anhydride
  7. Acetyl oxide
  1. Anhydride acetique (French)
  2. Anhydrid kyseliny octove (Czech)
  3. Anidride acetica (Italian)
  4. Azijnzuuranhydride (Dutch)
  5. Essigsaeureanhydrid (German)
  6. Ethanoic anhydrate
  7. Octowy bezwodnik (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
540 mg open irritation test mild UCDS** 8/7/1963


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 1,000 ppm/4 hour N/R 34ZIAG -,607,1969
oral
rat
lethal dose (50 percent kill): 1,780 mg/kg N/R AMIHBC 4,119,1951
skin
rabbit
lethal dose (50 percent kill): 4 mL/kg N/R UCDS** 8/7/1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2,470 g/m3/24 hour/95 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 34(4),103,1969
inhalation
rat
lowest published toxic concentration: 400 ppm/6 hour/2 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0556144


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 5 ppm (20 mg/m3) DTLWS* 3,2,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (20 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA ceiling concentration 5 ppm (21 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (21 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 5 ppm (20 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VLE 5 ppm (20 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 21 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 20 mg/m3, short term exposure limit 20 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 5 ppm (21 mg/m3), APR2007
Occupational Exposure Limit - KOREA ceiling concentration 5 ppm (20 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (20 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 5ppm (21 mg/m3), JAN2002
Occupational Exposure Limit - POLAND time-weighted average 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN ceiling concentration 5 ppm (20 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m3),KZG- week 5 ppm (20 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 ppm (2.5 mg/m3);
short term exposure limit 2 ppm, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETIC ANHYDRIDE-air ceiling concentration 5 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 02740;
Number of Industries 23;
Total Number of Facilities 3,012;
Number of Occupations 16;
Total Number of Employees Exposed 19,365
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 02740;
Number of Industries 73;
Total Number of Facilities 7,514;
Number of Occupations 59;
Total Number of Employees Exposed 92,428;
Total Number of Female Employees Exposed 11,630


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in application and synthesis of CELLULOSE ACETATE, films and fibers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acetic anhydride, 3506
OSHA ANALYTICAL METHOD #102


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in application and synthesis of CELLULOSE ACETATE, films and fibers

NIOSH PROFILE (ORGANIC ANHYDRIDES), SRC, 2/82

RTECS Compound Description:
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us