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Acetic acid, mercapto -

RTECS #: AI5950000

CAS #: 68-11-1


UPDATE: May 2009 MW: 92.12 MF: C2H4O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Mercaptoacetic acid
  2. 2 - Thioglycolic acid
  3. Acide thioglycolique (French)
  4. Glycolic acid, thio -
  5. Glycolic acid, 2 - thio -
  6. Kyselina merkaptooctova (Czech)
  7. Kyselina thioglykolova (Czech)
  8. Mercaptoacetate
  1. Mercaptoacetic acid
  2. Thioglycolic acid
  3. Thioglycolic acid (ACGIH)
  4. Thioglycollic acid
  5. Thiovanic acid
  6. USAF CB - 35
  7. alpha - Mercaptoacetic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
human
3% INMEAF 15,669,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published lethal concentration: 7 mg/m3/2 hour N/R 85GMAT -,111,1982
inhalation
rat
lethal concentration (50 percent kill): 210 mg/m3/4 hour Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Changes in lung weight
NTIS** OTS0554077
intraperitoneal
guinea pig
lethal dose (50 percent kill): 157 mg/kg N/R ZHYGAM 20,575,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 138 mg/kg N/R ARZNAD 31,1713,1981
intraperitoneal
rat
lethal dose (50 percent kill): 70 mg/kg N/R ZHYGAM 20,575,1974
intravenous
mouse
lethal dose (50 percent kill): 145 mg/kg N/R NYKZAU 60,278,1964
intravenous
rabbit
lethal dose (50 percent kill): 100 mg/kg N/R BIJOAK 41,325,1947
oral
guinea pig
lethal dose (50 percent kill): 126 mg/kg N/R 34ZIAG -,586,1969
oral
mammal (species unspecified)
lethal dose (50 percent kill): 250 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse
lethal dose (50 percent kill): 242 mg/kg N/R ZHYGAM 20,575,1974
oral
rat
lethal dose (50 percent kill): 114 mg/kg N/R ZHYGAM 20,575,1974
oral
rabbit
lethal dose (50 percent kill): 119 mg/kg N/R ZHYGAM 20,575,1974
skin
mouse
lethal dose (50 percent kill): 47 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
SRTCAC 36(1-4),10,1989
skin
rabbit
lowest published lethal dose: 300 mg/kg Skin: After systemic exposure: Dermatitis, other GTPZAB 13(1),48,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
guinea pig
lowest published toxic dose: 210 mg/kg/14 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests
TXAPA9 177,103,2001
subcutaneous
guinea pig
lowest published toxic dose: 105 mg/kg/7 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)
TXAPA9 177,103,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (3.8 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (3.9 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (5 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (5 mg/m3), short term exposure limit 3 ppm (15 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 1 ppm (5 mg/m3), Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 4 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (4 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 ppm (5 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (3.8 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (4 mg/m3);
short term exposure limit 2 ppm (8 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (4 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (3.8 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THIOGLYCOLIC ACID-air 10 hour time-weighted average 1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83835;
Number of Industries 10;
Total Number of Facilities 5,167;
Number of Occupations 9;
Total Number of Employees Exposed 35,238
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83835;
Number of Industries 10;
Total Number of Facilities 2,428;
Number of Occupations 12;
Total Number of Employees Exposed 30,055;
Total Number of Female Employees Exposed 15,141


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make thioglycolates, also used in sensitivity tests for iron
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955-

Used to make thioglycolates, also used in sensitivity tests for iron

NIOSH PROFILE (THIOGLYCOLIC ACID), SRC, 4/81

RTECS Compound Description:
   Agricultural Chemical
   Human Data
   Primary Irritant

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