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Acetic acid, fluoro - , sodium salt

RTECS #: AH9100000

CAS #: 62-74-8


UPDATE: May 2009 MW: 100.03 MF: C2H2FO2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Compound 1080
  2. Compound No. 1080
  3. Fluorakil 3
  4. Fluoressigaeure (German)
  5. Fluoroacetic acid, sodium salt
  6. Fluoroctan sodny (Czech)
  7. Fratol
  8. Furatol
  9. Latka 1080 (Czech)
  10. Monofluoressigsaures natrium (German)
  11. Natriumfluoracetaat (Dutch)
  12. Natriumfluoracetat (German)
  1. RCRA waste number P058
  2. Ratbane 1080
  3. Sodio, fluoracetato di (Italian)
  4. Sodium fluoacetate
  5. Sodium fluoacetic acid
  6. Sodium fluoracetate
  7. Sodium fluoroacetate
  8. Sodium fluoroacetate (ACGIH:OSHA)
  9. Sodium fluoroacetate de (French)
  10. Sodium monofluoroacetate
  11. TL 869
  12. Yasoknock


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
host-mediated assay mouse
other cell types
5 mg/kg FOBLAN 21,244,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 27,500 g/kg (11 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EXPEAM 21,446,1965
oral
rat
lowest published toxic dose: 210 g/kg (3 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 56,201,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
domestic animal
lethal dose (50 percent kill): 700 g/kg N/R AJPEAG 36,1427,1946
intraperitoneal
wild bird
lethal dose (50 percent kill): 102 mg/kg N/R AWLRAO 15,239,1988
intraperitoneal
cat
lethal dose (50 percent kill): 300 g/kg N/R AJPEAG 36,1427,1946
intraperitoneal
domestic animal
lethal dose (50 percent kill): 200 g/kg N/R AJPEAG 36,1427,1946
intraperitoneal
guinea pig
lethal dose (50 percent kill): 378 g/kg N/R JPETAB 95,62,1949
intraperitoneal
mammal (species unspecified)
lethal dose (50 percent kill): 100 g/kg Behavioral: Convulsions or effect on seizure threshold JAPMA8 36,59,1947
intraperitoneal
mouse
lethal dose (50 percent kill): 7 mg/kg N/R NEZAAQ 34,193,1979
intraperitoneal
pig
lethal dose (50 percent kill): 300 g/kg N/R AJPEAG 36,1427,1946
intraperitoneal
rat
lethal dose (50 percent kill): 1,940 g/kg N/R BJEPA5 50,277,1969
intraperitoneal
squirrel
lethal dose (50 percent kill): 400 g/kg Behavioral: Somnolence (general depressed activity) JAPMA8 36,59,1947
intravenous
dog
lethal dose (50 percent kill): 60 g/kg N/R YKYUA6 31,1385,1980
intravenous
domestic animal
lowest published lethal dose: 519 g/kg Liver: Other changes

Endocrine: Hyperglycemia

Musculoskeletal: Other changes
JCPTA9 70,145,1960
intravenous
monkey
lethal dose (50 percent kill): 5 mg/kg N/R AJPEAG 36,1427,1946
intravenous
rabbit
lethal dose (50 percent kill): 300 g/kg N/R AJPEAG 36,1427,1946
oral
wild bird
lethal dose (50 percent kill): 2,370 g/kg N/R AECTCV 12,355,1983
oral
cat
lethal dose (50 percent kill): 350 g/kg N/R JAPMA8 37,307,1948
oral
chicken
lowest published lethal dose: 5,900 g/kg N/R JAPMA8 36,59,1947
oral
duck
lethal dose (50 percent kill): 4,810 g/kg N/R TXAPA9 22,556,1972
oral
dog
lethal dose (50 percent kill): 66 g/kg N/R JPETAB 101,82,1951
oral
domestic animal
lethal dose (50 percent kill): 500 g/kg Cardiac: Other changes AWLRAO 9,487,1982
oral
frog
lowest published lethal dose: 54 mg/kg N/R VHTODE 15,6,1973
oral
guinea pig
lethal dose (50 percent kill): 300 g/kg N/R AJPEAG 36,1427,1946
oral
human
lowest published lethal dose: 714 g/kg N/R ENTOX* ,62,2005
oral
mammal (species unspecified)
lethal dose (50 percent kill): 110 g/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
AWLRAO 8,385,1981
oral
monkey
lethal dose (50 percent kill): 300 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NYKZAU 65,182,1969
oral
mouse
lethal dose (50 percent kill): 100 g/kg N/R YKYUA6 28,329,1977
oral
pigeon
lethal dose (50 percent kill): 2 mg/kg N/R JAPMA8 36,59,1947
oral
quail
lethal dose (50 percent kill): 18 mg/kg N/R TXAPA9 20,57,1971
oral
rat
lethal dose (50 percent kill): 100 g/kg N/R AJPEAG 36,1427,1946
oral
rabbit
lethal dose (50 percent kill): 340 g/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
AWLRAO 9,487,1982
oral
squirrel
lethal dose (50 percent kill): 300 g/kg N/R AJPEAG 36,1427,1946
subcutaneous
wild bird
lethal dose (50 percent kill): 630 g/kg Eye: Ptosis

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AWLRAO 11,373,1984
subcutaneous
frog
lethal dose (50 percent kill): 1 gm/kg N/R AJPEAG 36,1427,1946
subcutaneous
guinea pig
lethal dose (50 percent kill): 250 g/kg N/R BCPCA6 6,169,1961
subcutaneous
mouse
lethal dose (50 percent kill): 7,200 g/kg N/R NDRC** 30101,2,1945
subcutaneous
rabbit
lethal dose (50 percent kill): 281 g/kg N/R JPETAB 95,62,1949
skin
guinea pig
lethal dose (50 percent kill): 1,600 g/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea
NYKZAU 65,182,1969
skin
mouse
lethal dose (50 percent kill): 25,300 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
NYKZAU 65,182,1969
skin
rat
lethal dose (50 percent kill): 48 mg/kg N/R NYKZAU 65,182,1969
unreported route
horse, donkey
lethal dose (50 percent kill): 1 mg/kg N/R AJPEAG 36,1427,1946
unreported route
man
lowest published lethal dose: 5 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes
AJPEAG 36,1427,1946
unreported route
mouse
lethal dose (50 percent kill): 10 mg/kg N/R YKYUA6 30,397,1979
unreported route
rat
lethal dose (50 percent kill): 15 mg/kg N/R YKYUA6 30,397,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 6 mg/kg/3 day- intermittent Blood: Change in clotting factors

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JEMAAJ 45,694,1962
intravenous
domestic animal
lowest published toxic dose: 519 g/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JCPTA9 70,145,1960
oral
chicken
lowest published toxic dose: 20 mg/kg/3 day- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JAVMA4 111,301,1947
oral
dog
lowest published toxic dose: 0.15 mg/kg/5 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
JTSCDR 29,155,2004
oral
dog
lowest published toxic dose: 0.69 mg/kg/23 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTSCDR 29,155,2004
oral
dog
lowest published toxic dose: 2.73 mg/kg/91 day- intermittent Brain and Coverings: Other degenerative changes JTSCDR 29,155,2004
oral
domestic animal
lowest published toxic dose: 649 g/kg/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JCPTA9 70,145,1960
oral
mammal (species unspecified)
lowest published toxic dose: 686 mg/kg/28 day- continuous Cardiac: Changes in heart weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
ETOCDK 5,213,1986
oral
mammal (species unspecified)
lowest published toxic dose: 8,500 g/kg/28 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight
TOXID9 3,147,1983
oral
mouse
lowest published toxic dose: 51 mg/kg/30 day- intermittent Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Alteration in gastric secretion
NHOZAX 26,203,1972
oral
rat
lowest published toxic dose: 19.25 mg/kg/77 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 69,439,2002
oral
rat
lowest published toxic dose: 22.5 mg/kg/90 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Cardiac: Cardiomyopathy including infarction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 69,439,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
IMSUAI 21,440,1952
TOXICOLOGY REVIEW
AMSSAQ 400,5,1963
TOXICOLOGY REVIEW
IMSUAI 19,535,1950
TOXICOLOGY REVIEW
EMCPT* 2,89,2005
TOXICOLOGY REVIEW
AEMED3 45,609,2005
TOXICOLOGY REVIEW
JJATDK 26,148,2006
TOXICOLOGY REVIEW
ENTOX* -,62,2005
TOXICOLOGY REVIEW
HUTOX* -,561,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,255,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 mg/m3 (skin) DTLVS* 3,232,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 0.05 mg/m3, Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.05 mg/m3 (inhalable), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.05 mg/m3;
short term exposure limit 0.15 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg/m3,KZG- week 0.1 mg/m3, Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 mg/m3 (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air time-weighted average 0.05 mg/m3;
short term exposure limit 0.15 mg/m3 (Sk)
NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as highly toxic, immediate action rodenticide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AJPEAG American Journal of Public Health and the Nation's Health. (New York, NY) V.18-60, 1928-70. For publisher information, see AJHEAA.
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88.
AWLRAO Australian Wildlife Research. (Commonwealth Scientific and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic. 3002, Australia) V.1- 1974-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMCPT* EMC-Toxicologie Pathologie (Elsevier) V.1- 2004-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETOCDK Environmental Toxicology and Chemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1982-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1955-
HUTOX*
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
JCPTA9 Journal of Comparative Pathology and Therapeutics. (Liverpool, UK) V.1-74, 1883-1964. For publisher information, see JCVPAR.
JEMAAJ Journal of the Egyptian Medical Association. (Egyptian Medical Assoc., 42, Sharia Kasr-El- Aini, Cairo, Egypt) V.11- 1928-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report.
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as highly toxic, immediate action rodenticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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