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Acetic acid, ethyl ester

RTECS #: AH5425000

CAS #: 141-78-6


UPDATE: May 2009 MW: 88.12 MF: C4H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acetic ether
  2. Acetidin
  3. Acetoxyethane
  4. Aethylacetat (German)
  5. Essigester (German)
  6. Ethyl acetate
  7. Ethyl acetate (ACGIH:OSHA)
  8. Ethyl acetic ester
  1. Ethyl ethanoate
  2. Ethylacetaat (Dutch)
  3. Ethyle (acetate d') (French)
  4. Ethylester kyseliny octove (Czech)
  5. Etile (acetato di) (Italian)
  6. Octan etylu (Polish)
  7. RCRA waste number U112
  8. Vinegar naphtha


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
400 ppm N/R JIHTAB 25,282,1943


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster fibroblast 9 gm/L FCTOD7 22,623,1984
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 24,400 ppm MUREAV 149,339,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 61 gm/m3 N/R HBTXAC 1,336,1955
inhalation
human
lowest published toxic concentration: 400 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
JIHTAB 25,282,1943
inhalation
mouse
lethal concentration (50 percent kill): 45 gm/m3/2 hour N/R 85GMAT -,65,1982
inhalation
mouse
lowest published toxic concentration: 200 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
rat
lethal concentration (50 percent kill): 200 gm/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands
SRTCAC 36(1-4),10,1989
inhalation
rat
lethal concentration (50 percent kill): 1,600 ppm/8 hour N/R ENTOX* -,277,2005
inhalation
rat
lethal concentration (50 percent kill): >6,000 ppm/6 hour N/R ENTOX* -,277,2005
intraperitoneal
mouse
lethal dose (50 percent kill): 709 mg/kg N/R SCCUR* -,5,1961
oral
guinea pig
lethal dose (50 percent kill): 5,500 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma
GISAAA 48(4),66,1983
oral
guinea pig
lethal dose (50 percent kill): 5.5 gm/kg N/R ENTOX* -,277,2005
oral
mouse
lethal dose (50 percent kill): 4,100 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma
GISAAA 48(4),66,1983
oral
mouse
lethal dose (50 percent kill): 4.1 gm/kg N/R ENTOX* -,277,2005
oral
rat
lethal dose (50 percent kill): 5,620 mg/kg N/R YKYUA6 32,1241,1981
oral
rabbit
lethal dose (50 percent kill): 4,935 mg/kg N/R IMSUAI 41,31,1972
subcutaneous
cat
lethal dose (50 percent kill): 3 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Nausea or vomiting

Blood: Other changes
AGGHAR 5,1,1933
subcutaneous
guinea pig
lethal dose (50 percent kill): 3 gm/kg Behavioral: Somnolence (general depressed activity) AGGHAR 5,1,1933
subcutaneous
rat
lowest published lethal dose: 5 gm/kg N/R BSIBAC 18,45,1943
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R UCDS** 10/4/1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 22 gm/m3/40 minute/4 week- intermittent Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature decrease
NTIS** OTS0572401
inhalation
rat
lowest published toxic concentration: 1,500 ppm/90 day- intermittent Olfaction: Change in sensation of smell

Olfaction: Other olfaction effects
TOPADD 27,618,1999
intraperitoneal
rat
lowest published toxic dose: 8 mL/kg/8 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Other carbohydrates
BECTA6 12,612,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 400 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AMIHAB 21,28,1960
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
CHHSA* 9,6,2002
TOXICOLOGY REVIEW
ENTOX* -,277,2005
TOXICOLOGY REVIEW
HUTOX* -,577,1996
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,292,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 400 ppm (1400 mg/m3) DTLVS* 3,102,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 400 ppm (1400 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 400 ppm (1400 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 400 ppm (1400 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 400 ppm (1400 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (720 mg/m3), short term exposure limit 400 ppm (1440 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 400 ppm (1461 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (540 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 300 ppm (1100 mg/m3), short term exposure limit 500 ppm (1800 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 400 ppm (1400 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1500 mg/m3 (400 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 1400 mg/m3, short term exposure limit 1400 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (720 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 400 ppm (1400 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 400 ppm (1400 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 550 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 200 ppm (720 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 150 ppm (550 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 400 ppm (1400 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 200 ppm, MAC(short term exposure limit) 600 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 50 mg/m3, short term exposure limit 200 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 150 ppm (500 mg/m3);
short term exposure limit 300 ppm (1100 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 400 ppm (1400 mg/m3),KZG- week 800 ppm (2800 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 400 ppm (1400 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm;
short term exposure limit 400 ppm, 2005
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 400 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ACETATE-air 10 hour time-weighted average 400 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 31470;
Number of Industries 234;
Total Number of Facilities 37,072;
Number of Occupations 152;
Total Number of Employees Exposed 407,816
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 31470;
Number of Industries 234;
Total Number of Facilities 40,728;
Number of Occupations 154;
Total Number of Employees Exposed 504,448;
Total Number of Female Employees Exposed 119,505


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for NITROCELLULOSE
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl acetate, 1457
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHHSA* Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
HUTOX*
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a solvent for NITROCELLULOSE

NIOSH PROFILE (ACETATES), SRI, 2/77

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data
   Primary Irritant

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