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Acetic acid, tert - butyl ester

RTECS #: AF7400000

CAS #: 540-88-5


UPDATE: May 2009 MW: 116.18 MF: C6H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethyl acetate
  2. Acetic acid, 1,1 - dimethylethyl ester (9CI)
  3. TLA
  4. Texaco lead appreciator
  1. t - Butyl acetate
  2. tert - Butyl acetate
  3. tert - Butyl acetate (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 ÁL mild NTIS** OTS0573684-1
skin
rabbit
500 ÁL/24 hour mild NTIS** OTS0573684-1


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >2,230 mg/m3/4 hour N/R NTIS** OTS0573684-1
inhalation
rat
lowest published lethal concentration: 1,000 mg/m3 Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
RTOPDW 40,168,2004
oral
rat
lethal dose (50 percent kill): 4,100 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0573684-1
oral
rat
lethal dose (50 percent kill): 4,500 mg/kg N/R USXXAM #6673157
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0573684-1


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (950 mg/m3) DTLVS* 3,31,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (950 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (950 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (950 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (950 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (950 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (964 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (710 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 200 ppm (950 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 96 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - INDIA time-weighted average 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - KOREA time-weighted average 200 ppm (950 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 200 ppm (950 mg/m3);
short term exposure limit 250 ppm (1190 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 950 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 200 ppm (950 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 900 mg/m3, MAC(short term exposure limit) 900 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 100 ppm (500 mg/m3);
short term exposure limit 150 ppm (700 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (96 mg/m3);
KZG- week 80 ppm (384 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (966 mg/m3);
short term exposure limit 250 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO t-BUTYL ACETATE-air 10 hour time-weighted average 200 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

RTECS Compound Description:
   Primary Irritant

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