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Acetamide, N,N - dimethyl -

RTECS #: AB7700000

CAS #: 127-19-5


UPDATE: May 2009 MW: 87.14 MF: C4H9NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Acetdimethylamide
  2. Acetic acid, dimethylamide
  3. DMA
  4. DMAc
  5. Dimethylacetamide
  6. Dimethyl acetamide (ACGIH:OSHA)
  1. Dimethylacetone amide
  2. Dimethylamide acetate
  3. Dimethylamid kyseliny octove (Czech)
  4. N,N - Dimethylacetamide
  5. NSC 3138
  6. U - 5954


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild DCTODJ 9,147,1986
skin
rabbit
10 mg/24 hour open irritation test mild AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition unreported route
mouse
4,400 mg/kg APHGAO 56,97,1986
sister chromatid exchange hamster ovary 10 gm/L APHGAO 56,97,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 288 ppm/6 hour (10 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TOXID9 4,65,1984
inhalation
rat
lowest published toxic concentration: 281 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 29(2),59A,1984
inhalation
rat
lowest published toxic concentration: 300 ppm/6 hour (10 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 7,132,1986
inhalation
rat
lowest published toxic concentration: 282 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 16,414,1991
inhalation
rat
lowest published toxic concentration: 282 ppm (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
CRTXB2 31,139,2001
inhalation
rabbit
lowest published toxic concentration: 570 ppm (7-19 day pregnant) Reproductive: Other effects to embryo or fetus CRTXB2 31,139,2001
intraperitoneal
rat
lowest published toxic dose: 2 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
85DJA5 -,95,1971
oral
rat
lowest published toxic dose: 5,600 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
FAATDF 9,550,1987
oral
rat
lowest published toxic dose: 5,600 mg/kg (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Homeostasis
FAATDF 9,550,1987
oral
rat
lowest published toxic dose: 5,600 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
CRTXB2 31,139,2001
oral
rat
lowest published toxic dose: 2,240 mg/kg (6-19 day pregnant) Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
CRTXB2 31,139,2001
oral
rat
lowest published toxic dose: 5,600 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
CRTXB2 31,139,2001
oral
rat
lowest published toxic dose: 6 gm/kg (7-21 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
CRTXB2 31,139,2001
oral
rabbit
lowest published toxic dose: 3,900 mg/kg (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 30,1557,1980
oral
rabbit
lowest published toxic dose: 3,900 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
ARZNAD 30,1557,1980
skin
rat
lowest published toxic dose: 2,400 mg/kg (10-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
TXAPA9 41,35,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published lethal concentration: 406 ppm Liver: Fatty liver degeneration TXAPA9 3,12,1961
inhalation
mouse
lethal concentration (50 percent kill): 7,200 mg/m3 Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
CHYCDW 13,29,1979
inhalation
rat
lethal concentration (50 percent kill): 2,475 ppm/1 hour Nutritional and Gross Metabolic: Weight loss or decreased weight gain DCTODJ 9,147,1986
intraperitoneal
mouse
lethal dose (50 percent kill): 2,800 mg/kg N/R YKIGAK 31,327,1980
intraperitoneal
rat
lethal dose (50 percent kill): 2,750 mg/kg N/R JRPFA4 4,219,1962
intravenous
chicken
lowest published lethal dose: 12 gm/kg N/R ARZNAD 20,1242,1970
intravenous
mouse
lethal dose (50 percent kill): 3,020 mg/kg N/R ARZNAD 26,1581,1976
intravenous
rat
lethal dose (50 percent kill): 2,640 mg/kg N/R ARZNAD 26,1581,1976
intravenous
rabbit
lowest published lethal dose: 8,340 mg/kg N/R ARZNAD 20,1242,1970
oral
mouse
lethal dose (50 percent kill): 4,620 mg/kg N/R ARZNAD 26,1581,1976
oral
rat
lethal dose (50 percent kill): 4,300 mg/kg N/R GISAAA 45(6),76,1980
skin
mouse
lethal dose (50 percent kill): 9,600 mg/kg Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
CHYCDW 13,29,1979
skin
rat
lethal dose (50 percent kill): >2 gm/kg N/R EPASR* 8EHQ-1190-0981
skin
rabbit
lethal dose (50 percent kill): 2,240 mg/kg Skin: After topical application: Primary irritation AIHAAP 23,95,1962
unreported route
rat
lethal dose (50 percent kill): 3 gm/kg N/R ARZNAD 19,1073,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 700 mg/m3/4 hour/2 week- intermittent Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INHTE5 9,141,1997
inhalation
mouse
lowest published toxic concentration: 375 ppm/6 hour/78 week- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other)

Liver: Other changes

Liver: Changes in liver weight
FAATDF 28,80,1995
inhalation
rat
lowest published toxic dose: 103 ppm/6 hour/26 week- intermittent Liver: Other changes TXAPA9 3,12,1961
inhalation
rat
lowest published toxic concentration: 300 ppm/6 hour/12 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport
DCTODJ 16,175,1993
inhalation
rat
lowest published toxic concentration: 120 ppm/6 hour/64 day- intermittent Liver: Changes in liver weight JTEHD6 27,297,1989
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour/2 year- intermittent Liver: Other changes FAATDF 28,80,1995
oral
rat
lowest published toxic dose: 15 gm/kg/10 day- continuous Gastrointestinal: Other changes

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0572893
oral
rat
lowest published toxic dose: 364 mg/kg/26 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 45(6),76,1980
oral
rat
lowest published toxic dose: 4,500 mg/kg/90 day- continuous Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
DCTODJ 9,147,1986
skin
dog
lowest published toxic dose: 113 gm/kg/6 week- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 3,12,1961
skin
rabbit
lowest published toxic dose: 8 gm/kg/4 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 9,147,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (35 mg/m3) (skin) DTLVS* 3,88,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (36 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (36 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 20 ppm (72 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (35 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 10 ppm (36 mg/m3);
short term exposure limit 20 ppm (72 mg/m3) (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (35 mg/m3), short term exposure limit 20 ppm (70 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 2 ppm (7.2 mg/m3), VLE 10 ppm (36 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 36 mg/m3 (10 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 36 mg/m3, short term exposure limit 72 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (36 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (35 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (35 mg/m3);
short term exposure limit 15 ppm (50 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 36 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (36 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (35 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (35 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 35 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (35 mg/m3);
short term exposure limit 20 ppm (70 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (35 mg/m3);
KZG- week 20 ppm (70 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (36 mg/m3);
short term exposure limit 20 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYL ACETAMIDE-air 10 hour time-weighted average 10 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26095;
Number of Industries 5;
Total Number of Facilities 66;
Number of Occupations 13;
Total Number of Employees Exposed 7,658
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 26095;
Number of Industries 14;
Total Number of Facilities 907;
Number of Occupations 27;
Total Number of Employees Exposed 28,943;
Total Number of Female Employees Exposed 15,028


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for resins and to make ALKYL DIMETHYLAMINE OXIDE and rubber chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dimethylacetamide, 2004


REFERENCES:

CODEN
REFERENCE

85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
APHGAO Acta Pharmaceutica Hungarica. (Kultura, POB 149, H-1389 Budapest, Hungary) 1953- Adopts V.24 in 1955.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YKIGAK Yokohama Igaku. Yokohama Medicine. (Yokohama-Shiritsu Daigaku Igakkai, 2-33 Urafune-cho, Minami-ku, Yokohama 232, Japan) V.1- 1948-

Used as a solvent for resins and to make ALKYL DIMETHYLAMINE OXIDE and rubber chemicals

NIOSH PROFILE (N,N-DIMETHYL ACETAMIDE), SRC, 12/79

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

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