Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options
CDC Home

National Health and Nutrition Examination Survey

Research Using DNA Samples

DNA was collected in the second phase of NHANES III from 1991 to 1994 and from 1999 to 2002 in the continuous NHANES program. Beginning in 2007, DNA was again collected and stored. Research has been conducted on samples from 1991-1994 and 1999-2002. As research studies are conducted with the later DNA samples, those results will appear on the website.

The projects are grouped by survey time periods. Click the hyperlinked title to view the research abstract on PubMed.

 

Projects using NHANES 1999-2002 Samples

 

Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: Human Genetics
Year Published: 2012

Genetic Risk Factors for BMI and Obesity in an Ethnically Diverse Population: Results From the Population Architecture Using Genomics and Epidemiology (PAGE) Study.
Journal: Obesity
Year Published: 2012

Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations PAGE
Journal: Diabetes
Year Published: 2012

The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course
Journal: Diabetes
Year Published: 2013

Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002
Journal: Social Science and Medicine
Year Published: 2013

Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus
Journal: Human Genetics
Year Published: 2013

Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations
Journal: American Journal of Epidemiology
Year Published: 2013

Genetic risk factors for BMI and obesity in an ethnically diverse population: Results from the population architecture using genomics and epidemiology (PAGE) study
Journal: Obesity
Year Published: 2013

Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: BioMed Central
Year Published: 2013

 

Projects using NHANES III Samples

 

Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States.
Journal: JAMA
Year Published: 2001

Consent for genetic research in a general population: the NHANES experience.
Journal: Genetics in Medicine
Year Published: 2003

HFE genotype and transferrin saturation in the United States.
Journal: Genetics in Medicine
Year Published: 2003

Genetic Variation Is Associated With C-Reactive Protein Levels in the Third National Health and Nutrition Examination Survey
Journal: Circulation
Year Published: 2006

Allelic spectrum of the natural variation in CRP.
Journal: Human Genetics
Year Published: 2006

Consent for genetic research in a general population: an update on the National Health and Nutrition Examination Survey experience.
Journal: Genetics in Medicine
Year Published: 2006

Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank.
Journal: American Journal Clinical Nutrition
Year Published: 2008

Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey.
Journal: Neurotoxicology
Year Published: 2009

Association of Blood Lipids With Common DNA Sequence Variants at 19 Genetic Loci in the Multiethnic United States National Health and Nutrition Examination Survey III
Journal: Circulation: Cardiovascular Genetics
Year Published: 2009

Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study
Journal: BMC Medical Genetics
Year Published: 2009

Rapid detection of the CYP2A6*12 hybrid allele by Pyrosequencing® technology
Journal: BMC Medical Genetics
Year Published: 2009

Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
Journal: American Journal of Epidemiology
Year Published: 2009

Testing Hardy-Weinberg equilibrium and homogeneity of Hardy-Weinberg disequilibrium using complex survey data.
Journal: Biometrics
Year Published: 2009

Testing Hardy-Weinberg equilibrium using family data from complex surveys.
Journal: Annals Human Genetics
Year Published: 2009

Family History of Diabetes and Prevalence of the Metabolic Syndrome in U.S. Adults without Diabetes: 6-Year Results from the National Health and Nutrition Examination Survey (1999-2004).
Journal: Public Health Genomics.
Year Published: 2009

Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.
Journal: BMC Medical Genetics
Year Published: 2010

CRP polymorphisms and progression of chronic kidney disease in African Americans.
Journal: American Society of Nephrology
Year Published: 2010

Genetic variants associated with fasting blood lipids in the U.S. population:Third National Health and Nutrition Examination Survey
Journal: BMC Medical
Year Published: 2010

Modification by ALAD of the Association between Blood Lead and Blood Pressure in the U.S. Population: Results from the Third National Health and Nutrition Examination Survey
Journal: Environ Health Perspect
Year Published: 2010

Trend tests for genetic association using population-based cross-sectional complex survey data.
Journal: Biostatistics
Year Published: 2010

A Hardy-Weinberg Equilibrium Test for Analyzing Population Genetic Surveys With Complex Sample Designs
Journal: American Journal of Epidemiology
Year Published: 2010

Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. with self-reported stroke in US adults
Journal: The Application of Clinical Genetics
Year Published: 2010

Using DNA Figerprints to Inter Familial Relationships Within NHANES III Households
Journal: Journal of the American Statistical Association
Year Published: 2010

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups
Journal: Blood
Year Published: 2010

Testing Hardy-Weinberg equilibrium using family data from complex surveys.
Journal: Ann Hum Genet.
Year Published: 2010

Lead and cognitive function in VDR genotypes in the third National Health and Nutrition Examination Survey.
Journal: Neurotoxicol Teratol
Year Published: 2010

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups
Journal: Blood
Year Published: 2010

Racial/Ethnic Differences in Association of Fasting Glucose-Associated Genomic Loci with Fasting Glucose, HOMA-B and Impaired Fasting Glucose in U.S. Adult Population
Journal: Diabetes Care
Year Published: 2010

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Journal: Diabetes
Year Published: 2010

Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994
Journal: BMC Medical
Year Published: 2010

Variation in LPA Is Associated with Lp(a) Levels in Three Populations from the Third National Health and Nutrition Examination Survey
Journal: PloS one
Year Published: 2011

Blood Lead Levels, ALAD Gene Polymorphisms, and Mortality
Journal: Epidemiology
Year Published: 2011

Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project
Journal: PloS Genetic
Year Published: 2011

CRP Polymorphisms and Chronic Kidney Disease in the Third National Health and Nutrition Examination Survey
Journal: BMC Medical
Year Published: 2011

Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study
Journal: PloS Genetic
Year Published: 2011

Variants at the Endocannnabinoid Receptor CB1 Gene (CNR1) and Insulin Sensitivity, Type 2 Diabetes, and Coronary Heart Disease
Journal: Obesity
Year Published: 2011

The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery
Journal: Genetic Epidemiology
Year Published: 2011

Race/Ethnic Variation in the Association of Lipid-Related Genetic Variants with Blood Lipids in the Adult U.S. Population
Journal: Circulation: Cardiovascular Genetics
Year Published: 2011

Genetic Associations with Metabolic Syndrome and Its Quantitative Traits by Race/Ethnicity in the United States
Journal: Metabolic Syndrome and Related Disorders
Year Published: 2011

Evidence for Age As a Modifier of Genetic Associations for Lipid Levels
Journal: Annals of Human Genetics
Year Published: 2011

The ACE I/D Polymorphism in US Adults: Limited Evidence of Association With Hypertension-Related Traits and Sex-Specific Effects by Race/Ethnicity
Journal: American Journal of Hypertension
Year Published: 2011

Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in mexican americans
Journal: Hepatology
Year Published: 2012

Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey
Journal: Thombosis and Haemostasis
Year Published: 2012

Estimating the contribution of genetic variants to difference in incidence of disease between population groups
Journal: European Journal of Human Genetics
Year Published: 2012

Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)
Journal: Clinical Interventions in Aging
Year Published: 2012

Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: Human Genetics
Year Published: 2012

Genetic Risk Factors for BMI and Obesity in an Ethnically Diverse Population: Results From the Population Architecture Using Genomics and Epidemiology (PAGE) Study.
Journal: Obesity
Year Published: 2012

Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)
Journal: BMC Medical Genetics
Year Published: 2012

Prospective study of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of all-cause and cardiovascular disease mortality among 6000 US adults
Journal: American Journal of Clinical Nutrition
Year Published: 2012

Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations PAGE
Journal: Diabetes
Year Published: 2012

Why Have Tobacco Control Policies Stalled? Using Genetic Moderation to Examine Policy Impacts
Journal: PLOS one
Year Published: 2012

The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course
Journal: Diabetes
Year Published: 2013

Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
Journal: BioMed Central
Year Published: 2013

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
Journal: PLOS Genetics
Year Published: 2013

Association Between Variants in or Near PNPLA3, GCKR, and PPP1R3B with Ultrasound-Defined Steatosis Based on Data from the NHANES III
Journal: Clinical Gastroenterology and Hepatology
Year Published: 2013

Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: Human Reproduction
Year Published: 2013

Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four U.S. populations: The Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: Atherosclerosis
Year Published: 2013

Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations
Journal: American Journal of Epidemiology
Year Published: 2013

Post-Genome-Wide Association Study Challenges for Lipid Traits: Describing Age as a Modifier of Gene-Lipid Associations in the Population Architecture Using Genomics and Epidemiology (PAGE) Study
Journal: Annals of Human Genetics
Year Published: 2013

Genetic risk factors for BMI and obesity in an ethnically diverse population: Results from the population architecture using genomics and epidemiology (PAGE) study
Journal: Obesity
Year Published: 2013

Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: BioMed Central
Year Published: 2013

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study
Journal: PLOS Biology
Year Published: 2013

 

 

 

National Health and Nutrition Examination Survey logo

Contact Us:
  • National Center for Health Statistics
    3311 Toledo Rd
    Room 5419
    Hyattsville, MD 20782
  • 1 (800) 232-4636
  • Contact CDC–INFO
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO
A-Z Index
  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #