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Research Using DNA

DNA specimens were collected in the NHANES III Phase II (1991-1994) and in subsequent NHANES cycles (1999-2002, 2007-2008, 2009-2010, and 2011-2012). Research has been conducted on samples from 1991-1994, 1999-2002, and 2007-2008. Results of research studies conducted with the DNA specimens appear on this webpage.

Projects using 1991-1994 Samples

Type 2 Diabetes Genetic Predisposition, Obesity, and All-Cause Mortality Risk in the U.S.: A Multiethnic Analysis
Journal: Diabetes Care
Year Published: 2016

Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data
Journal: Frontiers in Genetics
Year Published: 2016

Kidney disease genetics and the importance of diversity in precision medicine
Journal: Pacific Symposium on Biocomputing 2015
Year Published: 2016

Cryptic relatedness in epidemiologic collections accessed for genetic association studies: experiences from the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study and the National Health and Nutrition Examination Surveys (NHANES)
Journal: Frontiers in Genetics
Year Published: 2015

Evidence of Heterogeneity by Race/Ethnicity in Genetic Determinants of QT Interval
Journal: Epidemiology
Year Published: 2015

Apolipoprotein E and protection against hepatitis E virus infection in American, non-Hispanic blacks
Journal: Hepatology
Year Published: 2015

Mitochondrial variation and the risk of age-related macular degeneration across diverse populations.
Journal: Pacific Symposium on Biocomputing 2015
Year Published: 2015

Identification of gene-gene and gene-environment interactions within the fibrinogen gene cluster for fibrinogen levels in three ethnically diverse populations.
Journal: Pacific Symposium on Biocomputing 2015
Year Published: 2015

Measures of exposure impact genetic association studies: an example in vitamin K levels and VKORC1.
Journal: Pacific Symposium on Biocomputing 2015
Year Published: 2015

Characterization of mitochondrial haplogroups in a large population-based sample from the United States
Journal: Human Genetics
Year Published: 2014

Genetic determinants of age-related macular degeneration in diverse populations from the PAGE Study
Journal: Investigative Ophthalmology and visual science
Year Published: 2014

Rare Variant APOC3 R19X Is Associated with Cardio-Protective Profiles in a Diverse Population-Based Survey as Part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study
Journal: Circulation Genetics
Year Published: 2014

Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study
Journal: PLOS Genetics
Year Published: 2014

Gene-carbohydrate and gene-fiberinteractions and type 2 diabetes in diverse populations from theNational Health and Nutrition Examination Surveys (NHANES) as part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study.
Journal: BMC Medical Genetics
Year Published: 2014

Evidence of Heterogeneity by Race/Ethnicity in Genetic Determinants of QT Interval
Journal: Epidemiology
Year Published: 2014

The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course
Journal: Diabetes
Year Published: 2013

Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
Journal: BioMed Central
Year Published: 2013

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
Journal: PLOS Genetics
Year Published: 2013

Association Between Variants in or Near PNPLA3, GCKR, and PPP1R3B with Ultrasound-Defined Steatosis Based on Data from the NHANES III
Journal: Clinical Gastroenterology and Hepatology
Year Published: 2013

Replication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: Human Reproduction
Year Published: 2013

Association of the FTO Obesity Risk Variant rs8050136With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations
Journal: American Journal of Epidemiology
Year Published: 2013

Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four U.S. populations: The Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: Atherosclerosis
Year Published: 2013

Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations
Journal: American Journal of Epidemiology
Year Published: 2013

Post-Genome-Wide Association Study Challenges for Lipid Traits: Describing Age as a Modifier of Gene-Lipid Associations in the Population Architecture Using Genomics and Epidemiology (PAGE) Study
Journal: Annals of Human Genetics
Year Published: 2013

Genetic risk factors for BMI and obesity in an ethnically diverse population: Results from the population architecture using genomics and epidemiology (PAGE) study
Journal: Obesity
Year Published: 2013

Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: BioMed Central
Year Published: 2013

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study
Journal: PLOS Biology
Year Published: 2013

Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III)
Journal: BMC Medical Genetics
Year Published: 2013

Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in mexican americans
Journal: Hepatology
Year Published: 2012

Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey
Journal: Thromb Haemost
Year Published: 2012

Estimating the contribution of genetic variants to difference in incidence of disease between population groups
Journal: European Journal of Human Genetics
Year Published: 2012

Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III)
Journal: Clin Interv Aging
Year Published: 2012

Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: Human Genetics
Year Published: 2012

Genetic Risk Factors for BMI and Obesity in an Ethnically Diverse Population: Results From the Population Architecture Using Genomics and Epidemiology (PAGE) Study. 
Journal: Obesity
Year Published: 2012

Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)
Journal: BMC Medical Genetics
Year Published: 2012

Prospective study of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of all-cause and cardiovascular disease mortality among 6000 US adults
Journal: American Journal of Clinical Nutrition
Year Published: 2012

Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations PAGE
Journal: Diabetes
Year Published: 2012

Why Have Tobacco Control Policies Stalled? Using Genetic Moderation to Examine Policy Impacts
Journal: PLOS one
Year Published: 2012

Variation in LPA Is Associated with Lp(a) Levels in Three Populations from the Third National Health and Nutrition Examination Survey
Journal: PloS one
Year Published: 2011

Blood Lead Levels, ALAD Gene Polymorphisms, and Mortality
Journal: Epidemiology
Year Published: 2011

Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project
Journal: PloS Genetic
Year Published: 2011

CRP Polymorphisms and Chronic Kidney Disease in the Third National Health and Nutrition Examination Survey
Journal: BMC Medical
Year Published: 2011

Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study
Journal: PloS Genetic
Year Published: 2011

Variants at the Endocannnabinoid Receptor CB1 Gene (CNR1) and Insulin Sensitivity, Type 2 Diabetes, and Coronary Heart Disease
Journal: Obesity
Year Published: 2011

The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery
Journal: Genetic Epidemiology
Year Published: 2011

Race/Ethnic Variation in the Association of Lipid-Related Genetic Variants with Blood Lipids in the Adult U.S. Population
Journal: Circulation: Cardiovascular Genetics
Year Published: 2011

Genetic Associations with Metabolic Syndrome and Its Quantitative Traits by Race/Ethnicity in the United States
Journal: Metabolic Syndrome and Related Disorders
Year Published: 2011

Evidence for Age As a Modifier of Genetic Associations for Lipid Levels
Journal: Annals of Human Genetics
Year Published: 2011

The ACE I/D Polymorphism in US Adults: Limited Evidence of Association With Hypertension-Related Traits and Sex-Specific Effects by Race/Ethnicity
Journal: American Journal of Hypertension
Year Published: 2011

Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.
Journal: BMC Medical Genetics
Year Published: 2010

CRP polymorphisms and progression of chronic kidney disease in African Americans.
Journal: American Society of Nephrology
Year Published: 2010

Genetic variants associated with fasting blood lipids in the U.S. population:Third National Health and Nutrition Examination Survey
Journal: BMC Medical
Year Published: 2010

Modification by ALAD of the Association between Blood Lead and Blood Pressure in the U.S. Population: Results from the Third National Health and Nutrition Examination Survey
Journal: Environ Health Perspect
Year Published: 2010

Trend tests for genetic association using population-based cross-sectional complex survey data.
Journal: Biostatistics
Year Published: 2010

A Hardy-Weinberg Equilibrium Test for Analyzing Population Genetic Surveys With Complex Sample Designs
Journal: American Journal of Epidemiology
Year Published: 2010

Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. with self-reported stroke in US adults
Journal: The Application of Clinical Genetics
Year Published: 2010

Using DNA Figerprints to Inter Familial Relationships Within NHANES III Households
Journal: Journal of the American Statistical Association
Year Published: 2010

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups
Journal: Blood
Year Published: 2010

Testing Hardy-Weinberg equilibrium using family data from complex surveys.
Journal: Ann Hum Genet.
Year Published: 2010

Lead and cognitive function in VDR genotypes in the third National Health and Nutrition Examination Survey.
Journal: Neurotoxicol Teratol
Year Published: 2010

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups
Journal: Blood
Year Published: 2010

Racial/Ethnic Differences in Association of Fasting Glucose-Associated Genomic Loci with Fasting Glucose, HOMA-B and Impaired Fasting Glucose in U.S. Adult Population
Journal: Diabetes Care
Year Published: 2010

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Journal: Diabetes
Year Published: 2010

Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994
Journal: BMC Medical
Year Published: 2010

Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey.
Journal: Neurotoxicology
Year Published: 2009

Association of Blood Lipids With Common DNA Sequence Variants at 19 Genetic Loci in the Multiethnic United States National Health and Nutrition Examination Survey III
Journal: Circulation: Cardiovascular Genetics
Year Published: 2009

Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study
Journal: BMC Medical Genetics
Year Published: 2009

Rapid detection of the CYP2A6*12 hybrid allele by Pyrosequencing® technology
Journal: BMC Medical Genetics
Year Published: 2009

Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
Journal: American Journal of Epidemiology
Year Published: 2009

Testing Hardy-Weinberg equilibrium and homogeneity of Hardy-Weinberg disequilibrium using complex survey data.
Journal: Biometrics
Year Published: 2009

Testing Hardy-Weinberg equilibrium using family data from complex surveys.
Journal: Ann Hum Genet
Year Published: 2009

Family History of Diabetes and Prevalence of the Metabolic Syndrome in U.S. Adults without Diabetes: 6-Year Results from the National Health and Nutrition Examination Survey (1999-2004).
Journal: Public Health Genomics.
Year Published: 2009

Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank.
Journal: Am J Clin Nutr
Year Published: 2008

Genetic Variation Is Associated With C-Reactive Protein Levels in the Third National Health and Nutrition Examination Survey
Journal: Circulation
Year Published: 2006

Allelic spectrum of the natural variation in CRP.
Journal: Human Genetics
Year Published: 2006

Consent for genetic research in a general population: an update on the National Health and Nutrition Examination Survey experience.
Journal: Genet Med.
Year Published: 2006

Consent for genetic research in a general population: the NHANES experience.
Journal: Genet Med.
Year Published: 2003

HFE genotype and transferrin saturation in the United States.
Journal: Genet Med
Year Published: 2003

Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States.
Journal: JAMA
Year Published: 2001

Projects using NHANES 1999-2002 Samples

Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data
Journal: Frontiers in Genetics
Year Published: 2016

Kidney disease genetics and the importance of diversity in precision medicine
Journal: Pacific Symposium on Biocomputing 2015
Year Published: 2016

Cryptic relatedness in epidemiologic collections accessed for genetic association studies: experiences from the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study and the National Health and Nutrition Examination Surveys (NHANES)
Journal: Frontiers in Genetics
Year Published: 2015

Evidence of Heterogeneity by Race/Ethnicity in Genetic Determinants of QT Interval
Journal: Epidemiology
Year Published: 2015

Characterization of mitochondrial haplogroups in a large population-based sample from the United States
Journal: Human Genetics
Year Published: 2014

Multi-Ancestral Analysis of Inflammation-Related Genetic Variants and C Reactive Protein in Population Architecture using Genomics and Epidemiology (PAGE) Study
Journal: Circulation Genetics
Year Published: 2014

Rare Variant APOC3 R19X Is Associated with Cardio-Protective Profiles in a Diverse Population-Based Survey as Part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study
Journal: Circulation Genetics
Year Published: 2014

Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study
Journal: PLOS Genetics
Year Published: 2014

Gene-carbohydrate and gene-fiberinteractions and type 2 diabetes in diverse populations from theNational Health and Nutrition Examination Surveys (NHANES) as part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study.
Journal: BMC Medical Genetics
Year Published: 2014

The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course
Journal: Diabetes
Year Published: 2013

Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002
Journal: Social Science and Medicine
Year Published: 2013

Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus
Journal: Human Genetics
Year Published: 2013

Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations
Journal: American Journal of Epidemiology
Year Published: 2013

Genetic risk factors for BMI and obesity in an ethnically diverse population: Results from the population architecture using genomics and epidemiology (PAGE) study
Journal: Obesity
Year Published: 2013

Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: BioMed Central
Year Published: 2013

Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study
Journal: Human Genetics
Year Published: 2012

Genetic Risk Factors for BMI and Obesity in an Ethnically Diverse Population: Results From the Population Architecture Using Genomics and Epidemiology (PAGE) Study. 
Journal: Obesity
Year Published: 2012

Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations PAGE
Journal: Diabetes
Year Published: 2012

 

 

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